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Protein

Cell adhesion molecule 3

Gene

CADM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: GO_Central
  • protein homodimerization activity Source: HGNC
  • receptor activity Source: GO_Central
  • receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.
R-HSA-420597. Nectin/Necl trans heterodimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 3
Alternative name(s):
Brain immunoglobulin receptor
Immunoglobulin superfamily member 4B
Short name:
IgSF4B
Nectin-like protein 1
Short name:
NECL-1
Synaptic cell adhesion molecule 3
Short name:
SynCAM3
TSLC1-like protein 1
Short name:
TSLL1
Gene namesi
Name:CADM3
Synonyms:IGSF4B, NECL1, SYNCAM3, TSLL1
ORF Names:UNQ225/PRO258
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162706.12.
HGNCiHGNC:17601. CADM3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 330ExtracellularSequence analysisAdd BLAST306
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 398CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57863.
OpenTargetsiENSG00000162706.
PharmGKBiPA162380906.

Polymorphism and mutation databases

BioMutaiCADM3.
DMDMi74759761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000004606725 – 398Cell adhesion molecule 3Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 110PROSITE-ProRule annotation1 Publication
Disulfide bondi152 ↔ 209PROSITE-ProRule annotation
Disulfide bondi254 ↔ 299PROSITE-ProRule annotation
Glycosylationi290N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei388PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei25Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8N126.
MaxQBiQ8N126.
PeptideAtlasiQ8N126.
PRIDEiQ8N126.

PTM databases

iPTMnetiQ8N126.
PhosphoSitePlusiQ8N126.

Expressioni

Tissue specificityi

Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.3 Publications

Inductioni

Markedly in glioma cell lines and prostate cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000162706.
CleanExiHS_CADM3.
ExpressionAtlasiQ8N126. baseline and differential.
GenevisibleiQ8N126. HS.

Organism-specific databases

HPAiCAB025746.
HPA002981.

Interactioni

Subunit structurei

Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: GO_Central
  • protein homodimerization activity Source: HGNC
  • receptor binding Source: GO_Central

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 41Combined sources4
Beta strandi46 – 51Combined sources6
Beta strandi60 – 63Combined sources4
Beta strandi69 – 72Combined sources4
Beta strandi83 – 88Combined sources6
Beta strandi90 – 97Combined sources8
Helixi102 – 104Combined sources3
Beta strandi106 – 112Combined sources7
Beta strandi114 – 116Combined sources3
Beta strandi118 – 127Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z9MX-ray2.40A/B25-135[»]
ProteinModelPortaliQ8N126.
SMRiQ8N126.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N126.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 126Ig-like V-typeAdd BLAST102
Domaini130 – 228Ig-like C2-type 1Add BLAST99
Domaini233 – 315Ig-like C2-type 2Add BLAST83

Domaini

The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.By similarity

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00880000137897.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8N126.
KOiK06780.
OMAiAAQLTWR.
OrthoDBiEOG091G0BHE.
PhylomeDBiQ8N126.
TreeFamiTF326804.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003585. Neurexin-like.
PfamiView protein in Pfam
PF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
SMARTiView protein in SMART
SM00294. 4.1m. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N126-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAPAASLLL LLLLFACCWA PGGANLSQDD SQPWTSDETV VAGGTVVLKC
60 70 80 90 100
QVKDHEDSSL QWSNPAQQTL YFGEKRALRD NRIQLVTSTP HELSISISNV
110 120 130 140 150
ALADEGEYTC SIFTMPVRTA KSLVTVLGIP QKPIITGYKS SLREKDTATL
160 170 180 190 200
NCQSSGSKPA ARLTWRKGDQ ELHGEPTRIQ EDPNGKTFTV SSSVTFQVTR
210 220 230 240 250
EDDGASIVCS VNHESLKGAD RSTSQRIEVL YTPTAMIRPD PPHPREGQKL
260 270 280 290 300
LLHCEGRGNP VPQQYLWEKE GSVPPLKMTQ ESALIFPFLN KSDSGTYGCT
310 320 330 340 350
ATSNMGSYKA YYTLNVNDPS PVPSSSSTYH AIIGGIVAFI VFLLLIMLIF
360 370 380 390
LGHYLIRHKG TYLTHEAKGS DDAPDADTAI INAEGGQSGG DDKKEYFI
Length:398
Mass (Da):43,300
Last modified:October 1, 2002 - v1
Checksum:i601B2FB5D512DB6C
GO
Isoform 2 (identifier: Q8N126-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-29: D → DGYWQEQDLELGTLAPLDEAISSTVWSSPDMLASQ

Show »
Length:432
Mass (Da):47,021
Checksum:iAC474EFECC4C518C
GO
Isoform 3 (identifier: Q8N126-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-231: GKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLY → D

Show »
Length:352
Mass (Da):38,326
Checksum:i74F2F5CD5FDB353D
GO

Sequence cautioni

The sequence BAA91756 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059383162R → W. Corresponds to variant dbSNP:rs3026987Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01722129D → DGYWQEQDLELGTLAPLDEA ISSTVWSSPDMLASQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_022008185 – 231GKTFT…IEVLY → D in isoform 3. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363367 mRNA. Translation: AAM60749.1.
AF062733 mRNA. Translation: AAD17540.2.
AY046418 mRNA. Translation: AAL02143.1.
AY358332 mRNA. Translation: AAQ88698.1.
AL035403 Genomic DNA. Translation: CAB56227.1.
AF529206 mRNA. Translation: AAN75603.1.
AK001560 mRNA. Translation: BAA91756.1. Different initiation.
CCDSiCCDS1182.1. [Q8N126-2]
CCDS44251.1. [Q8N126-1]
RefSeqiNP_001120645.1. NM_001127173.2. [Q8N126-1]
NP_001333439.1. NM_001346510.1. [Q8N126-3]
NP_067012.1. NM_021189.4. [Q8N126-2]
UniGeneiHs.365689.

Genome annotation databases

EnsembliENST00000368124; ENSP00000357106; ENSG00000162706. [Q8N126-2]
ENST00000368125; ENSP00000357107; ENSG00000162706. [Q8N126-1]
GeneIDi57863.
KEGGihsa:57863.
UCSCiuc001ftk.3. human. [Q8N126-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCADM3_HUMAN
AccessioniPrimary (citable) accession number: Q8N126
Secondary accession number(s): Q8IZQ9, Q9NVJ5, Q9UJP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families