ID   CPXCR_HUMAN             Reviewed;         301 AA.
AC   Q8N123; B2R9F9; D3DTE7; Q96RS3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   24-JAN-2024, entry version 138.
DE   RecName: Full=CPX chromosomal region candidate gene 1 protein;
DE   AltName: Full=Cancer/testis antigen 77;
DE            Short=CT77;
GN   Name=CPXCR1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-3 AND HIS-131, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=11499681; DOI=10.1007/s004390100518;
RA   Braybrook C., Warry G., Howell G., Mandryko V., Arnason A., Bjornsson A.,
RA   Ross M.T., Moore G.E., Stanier P.;
RT   "Physical and transcriptional mapping of the X-linked cleft palate and
RT   ankyloglossia (CPX) critical region.";
RL   Hum. Genet. 108:537-545(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-3.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-3.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-3.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of fetal tissues.
CC       {ECO:0000269|PubMed:11499681}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF284767; AAK69720.1; -; mRNA.
DR   EMBL; AK098646; BAC05363.1; -; mRNA.
DR   EMBL; AK313768; BAG36506.1; -; mRNA.
DR   EMBL; AL031116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471104; EAW98549.1; -; Genomic_DNA.
DR   EMBL; CH471104; EAW98550.1; -; Genomic_DNA.
DR   EMBL; CH471104; EAW98551.1; -; Genomic_DNA.
DR   EMBL; BC027614; AAH27614.1; -; mRNA.
DR   CCDS; CCDS14458.1; -.
DR   RefSeq; NP_001171700.1; NM_001184771.1.
DR   RefSeq; NP_149037.4; NM_033048.5.
DR   AlphaFoldDB; Q8N123; -.
DR   BioGRID; 119738; 6.
DR   IntAct; Q8N123; 1.
DR   MINT; Q8N123; -.
DR   STRING; 9606.ENSP00000276127; -.
DR   PhosphoSitePlus; Q8N123; -.
DR   BioMuta; CPXCR1; -.
DR   DMDM; 158706462; -.
DR   PaxDb; 9606-ENSP00000276127; -.
DR   PeptideAtlas; Q8N123; -.
DR   ProteomicsDB; 71523; -.
DR   Antibodypedia; 14397; 147 antibodies from 28 providers.
DR   DNASU; 53336; -.
DR   Ensembl; ENST00000276127.9; ENSP00000276127.4; ENSG00000147183.10.
DR   Ensembl; ENST00000373111.5; ENSP00000362203.1; ENSG00000147183.10.
DR   Ensembl; ENST00000614120.1; ENSP00000484986.1; ENSG00000147183.10.
DR   GeneID; 53336; -.
DR   KEGG; hsa:53336; -.
DR   MANE-Select; ENST00000276127.9; ENSP00000276127.4; NM_033048.6; NP_149037.5.
DR   UCSC; uc004efc.5; human.
DR   AGR; HGNC:2332; -.
DR   CTD; 53336; -.
DR   DisGeNET; 53336; -.
DR   GeneCards; CPXCR1; -.
DR   HGNC; HGNC:2332; CPXCR1.
DR   HPA; ENSG00000147183; Tissue enriched (testis).
DR   MIM; 301055; gene.
DR   neXtProt; NX_Q8N123; -.
DR   OpenTargets; ENSG00000147183; -.
DR   PharmGKB; PA26852; -.
DR   VEuPathDB; HostDB:ENSG00000147183; -.
DR   eggNOG; ENOG502TDNH; Eukaryota.
DR   GeneTree; ENSGT00390000003732; -.
DR   HOGENOM; CLU_924280_0_0_1; -.
DR   InParanoid; Q8N123; -.
DR   OMA; IPIPRKW; -.
DR   OrthoDB; 5262118at2759; -.
DR   PhylomeDB; Q8N123; -.
DR   TreeFam; TF341435; -.
DR   PathwayCommons; Q8N123; -.
DR   SignaLink; Q8N123; -.
DR   BioGRID-ORCS; 53336; 9 hits in 760 CRISPR screens.
DR   GenomeRNAi; 53336; -.
DR   Pharos; Q8N123; Tdark.
DR   PRO; PR:Q8N123; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q8N123; Protein.
DR   Bgee; ENSG00000147183; Expressed in sperm and 17 other cell types or tissues.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
DR   Genevisible; Q8N123; HS.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..301
FT                   /note="CPX chromosomal region candidate gene 1 protein"
FT                   /id="PRO_0000305343"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         3
FT                   /note="Y -> S (in dbSNP:rs5940915)"
FT                   /evidence="ECO:0000269|PubMed:11499681,
FT                   ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|Ref.4"
FT                   /id="VAR_035218"
FT   VARIANT         131
FT                   /note="R -> H (in dbSNP:rs5984611)"
FT                   /evidence="ECO:0000269|PubMed:11499681"
FT                   /id="VAR_035219"
SQ   SEQUENCE   301 AA;  34727 MW;  DB2A6AB3F225564B CRC64;
     MSYPTKEGSD TAGNAHKNSE NEPPNDCSTD IESPSADPNM IYQVETNPIN REPGTATSQE
     DVVPQAAENS ELETEIQKDQ REEDLKEELL LLQTPIPRKL VSHKPLNDRS RSHSGKVEMK
     ANNFPINHKT RFRLSTSWRV PFINSHEIRS MILHLLCDRY FSQAAGCQNT MWVKRKYIAC
     LYHPNSFTHH ERAITFRRPS RVHYYRPLTE RMTSGKFCKS TDTKGKCRFR AIVRSVLFVS
     QIQIESIFNI KGFVDILTYI HTMNVMITNT NNGWKYFCPI CGRLFNTYSE LRQHSCSSSG
     N
//