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Q8N123

- CPXCR_HUMAN

UniProt

Q8N123 - CPXCR_HUMAN

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Protein
CPX chromosomal region candidate gene 1 protein
Gene
CPXCR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metal ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CPX chromosomal region candidate gene 1 protein
Alternative name(s):
Cancer/testis antigen 77
Short name:
CT77
Gene namesi
Name:CPXCR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:2332. CPXCR1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301CPX chromosomal region candidate gene 1 protein
PRO_0000305343Add
BLAST

Proteomic databases

PaxDbiQ8N123.
PRIDEiQ8N123.

PTM databases

PhosphoSiteiQ8N123.

Expressioni

Tissue specificityi

Expressed in a variety of fetal tissues.1 Publication

Gene expression databases

BgeeiQ8N123.
CleanExiHS_CPXCR1.
GenevestigatoriQ8N123.

Organism-specific databases

HPAiHPA027089.

Interactioni

Protein-protein interaction databases

BioGridi119738. 1 interaction.
IntActiQ8N123. 1 interaction.
MINTiMINT-7970392.
STRINGi9606.ENSP00000276127.

Structurei

3D structure databases

ProteinModelPortaliQ8N123.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG125569.
HOGENOMiHOG000060271.
HOVERGENiHBG096805.
InParanoidiQ8N123.
OMAiHEIRSMI.
OrthoDBiEOG7DZ8K7.
PhylomeDBiQ8N123.
TreeFamiTF341435.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N123-1 [UniParc]FASTAAdd to Basket

« Hide

MSYPTKEGSD TAGNAHKNSE NEPPNDCSTD IESPSADPNM IYQVETNPIN    50
REPGTATSQE DVVPQAAENS ELETEIQKDQ REEDLKEELL LLQTPIPRKL 100
VSHKPLNDRS RSHSGKVEMK ANNFPINHKT RFRLSTSWRV PFINSHEIRS 150
MILHLLCDRY FSQAAGCQNT MWVKRKYIAC LYHPNSFTHH ERAITFRRPS 200
RVHYYRPLTE RMTSGKFCKS TDTKGKCRFR AIVRSVLFVS QIQIESIFNI 250
KGFVDILTYI HTMNVMITNT NNGWKYFCPI CGRLFNTYSE LRQHSCSSSG 300
N 301
Length:301
Mass (Da):34,727
Last modified:October 2, 2007 - v2
Checksum:iDB2A6AB3F225564B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31Y → S.4 Publications
Corresponds to variant rs5940915 [ dbSNP | Ensembl ].
VAR_035218
Natural varianti131 – 1311R → H.1 Publication
Corresponds to variant rs5984611 [ dbSNP | Ensembl ].
VAR_035219

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284767 mRNA. Translation: AAK69720.1.
AK098646 mRNA. Translation: BAC05363.1.
AK313768 mRNA. Translation: BAG36506.1.
AL031116 Genomic DNA. Translation: CAI43119.1.
CH471104 Genomic DNA. Translation: EAW98549.1.
CH471104 Genomic DNA. Translation: EAW98550.1.
CH471104 Genomic DNA. Translation: EAW98551.1.
BC027614 mRNA. Translation: AAH27614.1.
CCDSiCCDS14458.1.
RefSeqiNP_001171700.1. NM_001184771.1.
NP_149037.4. NM_033048.5.
UniGeneiHs.458292.

Genome annotation databases

EnsembliENST00000276127; ENSP00000276127; ENSG00000147183.
ENST00000373111; ENSP00000362203; ENSG00000147183.
GeneIDi53336.
KEGGihsa:53336.
UCSCiuc004efc.4. human.

Polymorphism databases

DMDMi158706462.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284767 mRNA. Translation: AAK69720.1 .
AK098646 mRNA. Translation: BAC05363.1 .
AK313768 mRNA. Translation: BAG36506.1 .
AL031116 Genomic DNA. Translation: CAI43119.1 .
CH471104 Genomic DNA. Translation: EAW98549.1 .
CH471104 Genomic DNA. Translation: EAW98550.1 .
CH471104 Genomic DNA. Translation: EAW98551.1 .
BC027614 mRNA. Translation: AAH27614.1 .
CCDSi CCDS14458.1.
RefSeqi NP_001171700.1. NM_001184771.1.
NP_149037.4. NM_033048.5.
UniGenei Hs.458292.

3D structure databases

ProteinModelPortali Q8N123.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119738. 1 interaction.
IntActi Q8N123. 1 interaction.
MINTi MINT-7970392.
STRINGi 9606.ENSP00000276127.

PTM databases

PhosphoSitei Q8N123.

Polymorphism databases

DMDMi 158706462.

Proteomic databases

PaxDbi Q8N123.
PRIDEi Q8N123.

Protocols and materials databases

DNASUi 53336.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276127 ; ENSP00000276127 ; ENSG00000147183 .
ENST00000373111 ; ENSP00000362203 ; ENSG00000147183 .
GeneIDi 53336.
KEGGi hsa:53336.
UCSCi uc004efc.4. human.

Organism-specific databases

CTDi 53336.
GeneCardsi GC0XP088002.
HGNCi HGNC:2332. CPXCR1.
HPAi HPA027089.
neXtProti NX_Q8N123.
PharmGKBi PA26852.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG125569.
HOGENOMi HOG000060271.
HOVERGENi HBG096805.
InParanoidi Q8N123.
OMAi HEIRSMI.
OrthoDBi EOG7DZ8K7.
PhylomeDBi Q8N123.
TreeFami TF341435.

Miscellaneous databases

GenomeRNAii 53336.
NextBioi 55958.
PROi Q8N123.

Gene expression databases

Bgeei Q8N123.
CleanExi HS_CPXCR1.
Genevestigatori Q8N123.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region."
    Braybrook C., Warry G., Howell G., Mandryko V., Arnason A., Bjornsson A., Ross M.T., Moore G.E., Stanier P.
    Hum. Genet. 108:537-545(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-3 AND HIS-131, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3.
    Tissue: Testis.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-3.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3.
    Tissue: Testis.

Entry informationi

Entry nameiCPXCR_HUMAN
AccessioniPrimary (citable) accession number: Q8N123
Secondary accession number(s): B2R9F9, D3DTE7, Q96RS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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