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Protein

CPX chromosomal region candidate gene 1 protein

Gene

CPXCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CPX chromosomal region candidate gene 1 protein
Alternative name(s):
Cancer/testis antigen 77
Short name:
CT77
Gene namesi
Name:CPXCR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:2332. CPXCR1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26852.

Polymorphism and mutation databases

BioMutaiCPXCR1.
DMDMi158706462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301CPX chromosomal region candidate gene 1 proteinPRO_0000305343Add
BLAST

Proteomic databases

PaxDbiQ8N123.
PRIDEiQ8N123.

PTM databases

PhosphoSiteiQ8N123.

Expressioni

Tissue specificityi

Expressed in a variety of fetal tissues.1 Publication

Gene expression databases

BgeeiQ8N123.
CleanExiHS_CPXCR1.
GenevisibleiQ8N123. HS.

Organism-specific databases

HPAiHPA027089.

Interactioni

Protein-protein interaction databases

BioGridi119738. 1 interaction.
IntActiQ8N123. 1 interaction.
MINTiMINT-7970392.
STRINGi9606.ENSP00000276127.

Structurei

3D structure databases

ProteinModelPortaliQ8N123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG125569.
GeneTreeiENSGT00390000003732.
HOGENOMiHOG000060271.
HOVERGENiHBG096805.
InParanoidiQ8N123.
OMAiHEIRSMI.
OrthoDBiEOG7DZ8K7.
PhylomeDBiQ8N123.
TreeFamiTF341435.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPTKEGSD TAGNAHKNSE NEPPNDCSTD IESPSADPNM IYQVETNPIN
60 70 80 90 100
REPGTATSQE DVVPQAAENS ELETEIQKDQ REEDLKEELL LLQTPIPRKL
110 120 130 140 150
VSHKPLNDRS RSHSGKVEMK ANNFPINHKT RFRLSTSWRV PFINSHEIRS
160 170 180 190 200
MILHLLCDRY FSQAAGCQNT MWVKRKYIAC LYHPNSFTHH ERAITFRRPS
210 220 230 240 250
RVHYYRPLTE RMTSGKFCKS TDTKGKCRFR AIVRSVLFVS QIQIESIFNI
260 270 280 290 300
KGFVDILTYI HTMNVMITNT NNGWKYFCPI CGRLFNTYSE LRQHSCSSSG

N
Length:301
Mass (Da):34,727
Last modified:October 2, 2007 - v2
Checksum:iDB2A6AB3F225564B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31Y → S.4 Publications
Corresponds to variant rs5940915 [ dbSNP | Ensembl ].
VAR_035218
Natural varianti131 – 1311R → H.1 Publication
Corresponds to variant rs5984611 [ dbSNP | Ensembl ].
VAR_035219

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284767 mRNA. Translation: AAK69720.1.
AK098646 mRNA. Translation: BAC05363.1.
AK313768 mRNA. Translation: BAG36506.1.
AL031116 Genomic DNA. Translation: CAI43119.1.
CH471104 Genomic DNA. Translation: EAW98549.1.
CH471104 Genomic DNA. Translation: EAW98550.1.
CH471104 Genomic DNA. Translation: EAW98551.1.
BC027614 mRNA. Translation: AAH27614.1.
CCDSiCCDS14458.1.
RefSeqiNP_001171700.1. NM_001184771.1.
NP_149037.4. NM_033048.5.
UniGeneiHs.458292.

Genome annotation databases

EnsembliENST00000276127; ENSP00000276127; ENSG00000147183.
ENST00000373111; ENSP00000362203; ENSG00000147183.
ENST00000614120; ENSP00000484986; ENSG00000147183.
GeneIDi53336.
KEGGihsa:53336.
UCSCiuc004efc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284767 mRNA. Translation: AAK69720.1.
AK098646 mRNA. Translation: BAC05363.1.
AK313768 mRNA. Translation: BAG36506.1.
AL031116 Genomic DNA. Translation: CAI43119.1.
CH471104 Genomic DNA. Translation: EAW98549.1.
CH471104 Genomic DNA. Translation: EAW98550.1.
CH471104 Genomic DNA. Translation: EAW98551.1.
BC027614 mRNA. Translation: AAH27614.1.
CCDSiCCDS14458.1.
RefSeqiNP_001171700.1. NM_001184771.1.
NP_149037.4. NM_033048.5.
UniGeneiHs.458292.

3D structure databases

ProteinModelPortaliQ8N123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119738. 1 interaction.
IntActiQ8N123. 1 interaction.
MINTiMINT-7970392.
STRINGi9606.ENSP00000276127.

PTM databases

PhosphoSiteiQ8N123.

Polymorphism and mutation databases

BioMutaiCPXCR1.
DMDMi158706462.

Proteomic databases

PaxDbiQ8N123.
PRIDEiQ8N123.

Protocols and materials databases

DNASUi53336.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276127; ENSP00000276127; ENSG00000147183.
ENST00000373111; ENSP00000362203; ENSG00000147183.
ENST00000614120; ENSP00000484986; ENSG00000147183.
GeneIDi53336.
KEGGihsa:53336.
UCSCiuc004efc.4. human.

Organism-specific databases

CTDi53336.
GeneCardsiGC0XP088002.
HGNCiHGNC:2332. CPXCR1.
HPAiHPA027089.
neXtProtiNX_Q8N123.
PharmGKBiPA26852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG125569.
GeneTreeiENSGT00390000003732.
HOGENOMiHOG000060271.
HOVERGENiHBG096805.
InParanoidiQ8N123.
OMAiHEIRSMI.
OrthoDBiEOG7DZ8K7.
PhylomeDBiQ8N123.
TreeFamiTF341435.

Miscellaneous databases

GenomeRNAii53336.
NextBioi55958.
PROiQ8N123.

Gene expression databases

BgeeiQ8N123.
CleanExiHS_CPXCR1.
GenevisibleiQ8N123. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region."
    Braybrook C., Warry G., Howell G., Mandryko V., Arnason A., Bjornsson A., Ross M.T., Moore G.E., Stanier P.
    Hum. Genet. 108:537-545(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-3 AND HIS-131, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3.
    Tissue: Testis.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-3.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3.
    Tissue: Testis.

Entry informationi

Entry nameiCPXCR_HUMAN
AccessioniPrimary (citable) accession number: Q8N123
Secondary accession number(s): B2R9F9, D3DTE7, Q96RS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 24, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.