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Q8N123

- CPXCR_HUMAN

UniProt

Q8N123 - CPXCR_HUMAN

Protein

CPX chromosomal region candidate gene 1 protein

Gene

CPXCR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metal ion binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CPX chromosomal region candidate gene 1 protein
    Alternative name(s):
    Cancer/testis antigen 77
    Short name:
    CT77
    Gene namesi
    Name:CPXCR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:2332. CPXCR1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26852.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301CPX chromosomal region candidate gene 1 proteinPRO_0000305343Add
    BLAST

    Proteomic databases

    PaxDbiQ8N123.
    PRIDEiQ8N123.

    PTM databases

    PhosphoSiteiQ8N123.

    Expressioni

    Tissue specificityi

    Expressed in a variety of fetal tissues.1 Publication

    Gene expression databases

    BgeeiQ8N123.
    CleanExiHS_CPXCR1.
    GenevestigatoriQ8N123.

    Organism-specific databases

    HPAiHPA027089.

    Interactioni

    Protein-protein interaction databases

    BioGridi119738. 1 interaction.
    IntActiQ8N123. 1 interaction.
    MINTiMINT-7970392.
    STRINGi9606.ENSP00000276127.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG125569.
    HOGENOMiHOG000060271.
    HOVERGENiHBG096805.
    InParanoidiQ8N123.
    OMAiHEIRSMI.
    OrthoDBiEOG7DZ8K7.
    PhylomeDBiQ8N123.
    TreeFamiTF341435.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N123-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYPTKEGSD TAGNAHKNSE NEPPNDCSTD IESPSADPNM IYQVETNPIN    50
    REPGTATSQE DVVPQAAENS ELETEIQKDQ REEDLKEELL LLQTPIPRKL 100
    VSHKPLNDRS RSHSGKVEMK ANNFPINHKT RFRLSTSWRV PFINSHEIRS 150
    MILHLLCDRY FSQAAGCQNT MWVKRKYIAC LYHPNSFTHH ERAITFRRPS 200
    RVHYYRPLTE RMTSGKFCKS TDTKGKCRFR AIVRSVLFVS QIQIESIFNI 250
    KGFVDILTYI HTMNVMITNT NNGWKYFCPI CGRLFNTYSE LRQHSCSSSG 300
    N 301
    Length:301
    Mass (Da):34,727
    Last modified:October 2, 2007 - v2
    Checksum:iDB2A6AB3F225564B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31Y → S.4 Publications
    Corresponds to variant rs5940915 [ dbSNP | Ensembl ].
    VAR_035218
    Natural varianti131 – 1311R → H.1 Publication
    Corresponds to variant rs5984611 [ dbSNP | Ensembl ].
    VAR_035219

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284767 mRNA. Translation: AAK69720.1.
    AK098646 mRNA. Translation: BAC05363.1.
    AK313768 mRNA. Translation: BAG36506.1.
    AL031116 Genomic DNA. Translation: CAI43119.1.
    CH471104 Genomic DNA. Translation: EAW98549.1.
    CH471104 Genomic DNA. Translation: EAW98550.1.
    CH471104 Genomic DNA. Translation: EAW98551.1.
    BC027614 mRNA. Translation: AAH27614.1.
    CCDSiCCDS14458.1.
    RefSeqiNP_001171700.1. NM_001184771.1.
    NP_149037.4. NM_033048.5.
    UniGeneiHs.458292.

    Genome annotation databases

    EnsembliENST00000276127; ENSP00000276127; ENSG00000147183.
    ENST00000373111; ENSP00000362203; ENSG00000147183.
    GeneIDi53336.
    KEGGihsa:53336.
    UCSCiuc004efc.4. human.

    Polymorphism databases

    DMDMi158706462.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284767 mRNA. Translation: AAK69720.1 .
    AK098646 mRNA. Translation: BAC05363.1 .
    AK313768 mRNA. Translation: BAG36506.1 .
    AL031116 Genomic DNA. Translation: CAI43119.1 .
    CH471104 Genomic DNA. Translation: EAW98549.1 .
    CH471104 Genomic DNA. Translation: EAW98550.1 .
    CH471104 Genomic DNA. Translation: EAW98551.1 .
    BC027614 mRNA. Translation: AAH27614.1 .
    CCDSi CCDS14458.1.
    RefSeqi NP_001171700.1. NM_001184771.1.
    NP_149037.4. NM_033048.5.
    UniGenei Hs.458292.

    3D structure databases

    ProteinModelPortali Q8N123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119738. 1 interaction.
    IntActi Q8N123. 1 interaction.
    MINTi MINT-7970392.
    STRINGi 9606.ENSP00000276127.

    PTM databases

    PhosphoSitei Q8N123.

    Polymorphism databases

    DMDMi 158706462.

    Proteomic databases

    PaxDbi Q8N123.
    PRIDEi Q8N123.

    Protocols and materials databases

    DNASUi 53336.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276127 ; ENSP00000276127 ; ENSG00000147183 .
    ENST00000373111 ; ENSP00000362203 ; ENSG00000147183 .
    GeneIDi 53336.
    KEGGi hsa:53336.
    UCSCi uc004efc.4. human.

    Organism-specific databases

    CTDi 53336.
    GeneCardsi GC0XP088002.
    HGNCi HGNC:2332. CPXCR1.
    HPAi HPA027089.
    neXtProti NX_Q8N123.
    PharmGKBi PA26852.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG125569.
    HOGENOMi HOG000060271.
    HOVERGENi HBG096805.
    InParanoidi Q8N123.
    OMAi HEIRSMI.
    OrthoDBi EOG7DZ8K7.
    PhylomeDBi Q8N123.
    TreeFami TF341435.

    Miscellaneous databases

    GenomeRNAii 53336.
    NextBioi 55958.
    PROi Q8N123.

    Gene expression databases

    Bgeei Q8N123.
    CleanExi HS_CPXCR1.
    Genevestigatori Q8N123.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region."
      Braybrook C., Warry G., Howell G., Mandryko V., Arnason A., Bjornsson A., Ross M.T., Moore G.E., Stanier P.
      Hum. Genet. 108:537-545(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-3 AND HIS-131, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3.
      Tissue: Testis.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-3.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3.
      Tissue: Testis.

    Entry informationi

    Entry nameiCPXCR_HUMAN
    AccessioniPrimary (citable) accession number: Q8N123
    Secondary accession number(s): B2R9F9, D3DTE7, Q96RS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3