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Q8N119

- MMP21_HUMAN

UniProt

Q8N119 - MMP21_HUMAN

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Protein

Matrix metalloproteinase-21

Gene

MMP21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.

Cofactori

Binds 1 zinc ion per subunit.By similarity
Calcium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Zinc; in inhibited formBy similarity
Metal bindingi283 – 2831Zinc; catalyticPROSITE-ProRule annotation
Active sitei284 – 2841PROSITE-ProRule annotation
Metal bindingi287 – 2871Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi293 – 2931Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. hematopoietic progenitor cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM10.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinase-21 (EC:3.4.24.-)
Short name:
MMP-21
Gene namesi
Name:MMP21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14357. MMP21.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular matrix Source: InterPro
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 144120By similarityPRO_0000028839Add
BLAST
Chaini145 – 569425Matrix metalloproteinase-21PRO_0000028840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi329 ↔ 560By similarity
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8N119.
PRIDEiQ8N119.

PTM databases

PhosphoSiteiQ8N119.

Expressioni

Tissue specificityi

Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.2 Publications

Gene expression databases

BgeeiQ8N119.
CleanExiHS_MMP21.
GenevestigatoriQ8N119.

Organism-specific databases

HPAiHPA024429.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357798.

Structurei

3D structure databases

ProteinModelPortaliQ8N119.
SMRiQ8N119. Positions 76-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati330 – 38960Hemopexin 1Add
BLAST
Repeati391 – 44757Hemopexin 2Add
BLAST
Repeati448 – 49649Hemopexin 3Add
BLAST
Repeati503 – 55957Hemopexin 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi115 – 1228Cysteine switchBy similarity

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated
Contains 4 hemopexin repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG115777.
GeneTreeiENSGT00760000119132.
HOGENOMiHOG000113608.
HOVERGENiHBG052483.
InParanoidiQ8N119.
KOiK08000.
OMAiLYENRNN.
OrthoDBiEOG7X9G6K.
PhylomeDBiQ8N119.
TreeFamiTF315428.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N119-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAASIFRPT LLLCWLAAPW PTQPESLFHS RDRSDLEPSP LRQAKPIADL
60 70 80 90 100
HAAQRFLSRY GWSGVWAAWG PSPEGPPETP KGAALAEAVR RFQRANALPA
110 120 130 140 150
SGELDAATLA AMNRPRCGVP DMRPPPPSAP PSPPGPPPRA RSRRSPRAPL
160 170 180 190 200
SLSRRGWQPR GYPDGGAAQA FSKRTLSWRL LGEALSSQLS VADQRRIVAL
210 220 230 240 250
AFRMWSEVTP LDFREDLAAP GAAVDIKLGF GRGRHLGCPR AFDGSGQEFA
260 270 280 290 300
HAWRLGDIHF DDDEHFTPPT SDTGISLLKV AVHEIGHVLG LPHTYRTGSI
310 320 330 340 350
MQPNYIPQEP AFELDWSDRK AIQKLYGSCE GSFDTAFDWI RKERNQYGEV
360 370 380 390 400
MVRFSTYFFR NSWYWLYENR NNRTRYGDPI QILTGWPGIP THNIDAFVHI
410 420 430 440 450
WTWKRDERYF FQGNQYWRYD SDKDQALTED EQGKSYPKLI SEGFPGIPSP
460 470 480 490 500
LDTAFYDRRQ KLIYFFKESL VFAFDVNRNR VLNSYPKRIT EVFPAVIPQN
510 520 530 540 550
HPFRNIDSAY YSYAYNSIFF FKGNAYWKVV NDKDKQQNSW LPANGLFPKK
560
FISEKWFDVC DVHISTLNM
Length:569
Mass (Da):65,043
Last modified:January 11, 2011 - v2
Checksum:i6785EF34F5B5105E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951A → E.1 Publication
Corresponds to variant rs28381282 [ dbSNP | Ensembl ].
VAR_022291
Natural varianti115 – 1151P → Q.1 Publication
Corresponds to variant rs28381284 [ dbSNP | Ensembl ].
VAR_022292
Natural varianti191 – 1911V → A.2 Publications
Corresponds to variant rs10901425 [ dbSNP | Ensembl ].
VAR_019393
Natural varianti263 – 2631D → E.
Corresponds to variant rs34811493 [ dbSNP | Ensembl ].
VAR_032824
Natural varianti311 – 3111A → T.
Corresponds to variant rs17173746 [ dbSNP | Ensembl ].
VAR_057803
Natural varianti349 – 3491E → G.1 Publication
Corresponds to variant rs28381302 [ dbSNP | Ensembl ].
VAR_022293
Natural varianti360 – 3601R → H.
Corresponds to variant rs17153524 [ dbSNP | Ensembl ].
VAR_057804
Natural varianti454 – 4541A → V.1 Publication
Corresponds to variant rs28381319 [ dbSNP | Ensembl ].
VAR_022294

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331526 mRNA. Translation: AAM92903.1.
AY121358 Genomic DNA. Translation: AAM78033.1.
AF520613 mRNA. Translation: AAM75352.1.
AY885252 Genomic DNA. Translation: AAW62254.1.
AL158835, AL360176 Genomic DNA. Translation: CAH73211.1.
AL360176, AL158835 Genomic DNA. Translation: CAI12086.1.
CCDSiCCDS7647.1.
RefSeqiNP_671724.1. NM_147191.1.
UniGeneiHs.314141.

Genome annotation databases

EnsembliENST00000368808; ENSP00000357798; ENSG00000154485.
GeneIDi118856.
KEGGihsa:118856.
UCSCiuc001liu.3. human.

Polymorphism databases

DMDMi317373390.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331526 mRNA. Translation: AAM92903.1 .
AY121358 Genomic DNA. Translation: AAM78033.1 .
AF520613 mRNA. Translation: AAM75352.1 .
AY885252 Genomic DNA. Translation: AAW62254.1 .
AL158835 , AL360176 Genomic DNA. Translation: CAH73211.1 .
AL360176 , AL158835 Genomic DNA. Translation: CAI12086.1 .
CCDSi CCDS7647.1.
RefSeqi NP_671724.1. NM_147191.1.
UniGenei Hs.314141.

3D structure databases

ProteinModelPortali Q8N119.
SMRi Q8N119. Positions 76-526.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000357798.

Chemistry

DrugBanki DB00786. Marimastat.

Protein family/group databases

MEROPSi M10.026.

PTM databases

PhosphoSitei Q8N119.

Polymorphism databases

DMDMi 317373390.

Proteomic databases

PaxDbi Q8N119.
PRIDEi Q8N119.

Protocols and materials databases

DNASUi 118856.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368808 ; ENSP00000357798 ; ENSG00000154485 .
GeneIDi 118856.
KEGGi hsa:118856.
UCSCi uc001liu.3. human.

Organism-specific databases

CTDi 118856.
GeneCardsi GC10M127445.
HGNCi HGNC:14357. MMP21.
HPAi HPA024429.
MIMi 608416. gene.
neXtProti NX_Q8N119.
PharmGKBi PA134885721.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG115777.
GeneTreei ENSGT00760000119132.
HOGENOMi HOG000113608.
HOVERGENi HBG052483.
InParanoidi Q8N119.
KOi K08000.
OMAi LYENRNN.
OrthoDBi EOG7X9G6K.
PhylomeDBi Q8N119.
TreeFami TF315428.

Miscellaneous databases

GeneWikii MMP21.
GenomeRNAii 118856.
NextBioi 80358.
PROi Q8N119.
SOURCEi Search...

Gene expression databases

Bgeei Q8N119.
CleanExi HS_MMP21.
Genevestigatori Q8N119.

Family and domain databases

Gene3Di 1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
Pfami PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEi PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer."
    Ahokas K., Lohi J., Lohi H., Elomaa O., Karjalainen-Lindsberg M.-L., Kere J., Saarialho-Kere U.
    Gene 301:31-41(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein."
    Marchenko G.N., Marchenko N.D., Strongin A.Y.
    Biochem. J. 372:503-515(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANT ALA-191.
    Tissue: Kidney.
  3. NIEHS SNPs program
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-95; GLN-115; ALA-191; GLY-349 AND VAL-454.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMMP21_HUMAN
AccessioniPrimary (citable) accession number: Q8N119
Secondary accession number(s): Q5VZP9, Q8NG02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3