Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8N118

- CP4X1_HUMAN

UniProt

Q8N118 - CP4X1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome P450 4X1

Gene

CYP4X1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi454 – 4541Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4X1 (EC:1.14.14.1)
Alternative name(s):
CYPIVX1
Gene namesi
Name:CYP4X1
ORF Names:UNQ1929/PRO4404
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20244. CYP4X1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Cytochrome P450 4X1PRO_0000051862Add
BLAST

Proteomic databases

MaxQBiQ8N118.
PaxDbiQ8N118.
PRIDEiQ8N118.

PTM databases

PhosphoSiteiQ8N118.

Expressioni

Tissue specificityi

Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the heart, very high level levels in aorta, but very levels in other heart regions.1 Publication

Gene expression databases

BgeeiQ8N118.
CleanExiHS_CYP4X1.
GenevestigatoriQ8N118.

Organism-specific databases

HPAiHPA017661.

Interactioni

Protein-protein interaction databases

BioGridi129254. 2 interactions.
STRINGi9606.ENSP00000360968.

Structurei

3D structure databases

ProteinModelPortaliQ8N118.
SMRiQ8N118. Positions 47-504.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ8N118.
KOiK07428.
OMAiTHWFLGH.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ8N118.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N118-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFSWLETRW ARPFYLAFVF CLALGLLQAI KLYLRRQRLL RDLRPFPAPP
60 70 80 90 100
THWFLGHQKF IQDDNMEKLE EIIEKYPRAF PFWIGPFQAF FCIYDPDYAK
110 120 130 140 150
TLLSRTDPKS QYLQKFSPPL LGKGLAALDG PKWFQHRRLL TPGFHFNILK
160 170 180 190 200
AYIEVMAHSV KMMLDKWEKI CSTQDTSVEV YEHINSMSLD IIMKCAFSKE
210 220 230 240 250
TNCQTNSTHD PYAKAIFELS KIIFHRLYSL LYHSDIIFKL SPQGYRFQKL
260 270 280 290 300
SRVLNQYTDT IIQERKKSLQ AGVKQDNTPK RKYQDFLDIV LSAKDESGSS
310 320 330 340 350
FSDIDVHSEV STFLLAGHDT LAASISWILY CLALNPEHQE RCREEVRGIL
360 370 380 390 400
GDGSSITWDQ LGEMSYTTMC IKETCRLIPA VPSISRDLSK PLTFPDGCTL
410 420 430 440 450
PAGITVVLSI WGLHHNPAVW KNPKVFDPLR FSQENSDQRH PYAYLPFSAG
460 470 480 490 500
SRNCIGQEFA MIELKVTIAL ILLHFRVTPD PTRPLTFPNH FILKPKNGMY

LHLKKLSEC
Length:509
Mass (Da):58,875
Last modified:October 1, 2002 - v1
Checksum:i702470A76E814278
GO
Isoform 2 (identifier: Q8N118-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MEFSWLETRW...PTHWFLGHQK → MMWGGGLDLC...ICMTSSSSGL

Note: No experimental confirmation available.

Show »
Length:508
Mass (Da):57,901
Checksum:i8E66A23B0353DC06
GO
Isoform 3 (identifier: Q8N118-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: No experimental confirmation available.

Show »
Length:444
Mass (Da):50,944
Checksum:i8162580C640B5813
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921I → V in BAD18508. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565Missing in isoform 3. 1 PublicationVSP_045889Add
BLAST
Alternative sequencei1 – 5959MEFSW…LGHQK → MMWGGGLDLCPMPGQLKFPP CLSRCLLWEPPSLYLTQPTS SLAEPQALICMTSSSSGL in isoform 2. 1 PublicationVSP_045890Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040940 mRNA. Translation: CAJ13826.1.
AY358537 mRNA. Translation: AAQ88901.1.
AK091806 mRNA. Translation: BAC03751.1.
AK098065 mRNA. Translation: BAC05226.1.
AK131355 mRNA. Translation: BAD18508.1.
AL450996 Genomic DNA. Translation: CAH71035.1.
AL731892 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06882.1.
CH471059 Genomic DNA. Translation: EAX06883.1.
CH471059 Genomic DNA. Translation: EAX06884.1.
BC028102 mRNA. Translation: AAH28102.1.
CCDSiCCDS544.1. [Q8N118-1]
RefSeqiNP_828847.1. NM_178033.1. [Q8N118-1]
UniGeneiHs.439760.

Genome annotation databases

EnsembliENST00000371901; ENSP00000360968; ENSG00000186377. [Q8N118-1]
GeneIDi260293.
KEGGihsa:260293.
UCSCiuc001cqr.3. human.
uc001cqs.3. human. [Q8N118-1]

Polymorphism databases

DMDMi48428082.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040940 mRNA. Translation: CAJ13826.1 .
AY358537 mRNA. Translation: AAQ88901.1 .
AK091806 mRNA. Translation: BAC03751.1 .
AK098065 mRNA. Translation: BAC05226.1 .
AK131355 mRNA. Translation: BAD18508.1 .
AL450996 Genomic DNA. Translation: CAH71035.1 .
AL731892 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06882.1 .
CH471059 Genomic DNA. Translation: EAX06883.1 .
CH471059 Genomic DNA. Translation: EAX06884.1 .
BC028102 mRNA. Translation: AAH28102.1 .
CCDSi CCDS544.1. [Q8N118-1 ]
RefSeqi NP_828847.1. NM_178033.1. [Q8N118-1 ]
UniGenei Hs.439760.

3D structure databases

ProteinModelPortali Q8N118.
SMRi Q8N118. Positions 47-504.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129254. 2 interactions.
STRINGi 9606.ENSP00000360968.

Chemistry

BindingDBi Q8N118.
ChEMBLi CHEMBL6048.

PTM databases

PhosphoSitei Q8N118.

Polymorphism databases

DMDMi 48428082.

Proteomic databases

MaxQBi Q8N118.
PaxDbi Q8N118.
PRIDEi Q8N118.

Protocols and materials databases

DNASUi 260293.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371901 ; ENSP00000360968 ; ENSG00000186377 . [Q8N118-1 ]
GeneIDi 260293.
KEGGi hsa:260293.
UCSCi uc001cqr.3. human.
uc001cqs.3. human. [Q8N118-1 ]

Organism-specific databases

CTDi 260293.
GeneCardsi GC01P047489.
HGNCi HGNC:20244. CYP4X1.
HPAi HPA017661.
MIMi 614999. gene.
neXtProti NX_Q8N118.
PharmGKBi PA134933184.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118816.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi Q8N118.
KOi K07428.
OMAi THWFLGH.
OrthoDBi EOG7CNZFK.
PhylomeDBi Q8N118.
TreeFami TF105088.

Miscellaneous databases

GeneWikii CYP4X1.
GenomeRNAii 260293.
NextBioi 35516628.
PROi Q8N118.
SOURCEi Search...

Gene expression databases

Bgeei Q8N118.
CleanExi HS_CYP4X1.
Genevestigatori Q8N118.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Aorta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Liver, Lung and Trachea.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCP4X1_HUMAN
AccessioniPrimary (citable) accession number: Q8N118
Secondary accession number(s): G3V1U1
, Q5VVE5, Q6ZN67, Q8NAZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3