Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N118

- CP4X1_HUMAN

UniProt

Q8N118 - CP4X1_HUMAN

Protein

Cytochrome P450 4X1

Gene

CYP4X1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi454 – 4541Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4X1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVX1
    Gene namesi
    Name:CYP4X1
    ORF Names:UNQ1929/PRO4404
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20244. CYP4X1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933184.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Cytochrome P450 4X1PRO_0000051862Add
    BLAST

    Proteomic databases

    MaxQBiQ8N118.
    PaxDbiQ8N118.
    PRIDEiQ8N118.

    PTM databases

    PhosphoSiteiQ8N118.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the heart, very high level levels in aorta, but very levels in other heart regions.1 Publication

    Gene expression databases

    BgeeiQ8N118.
    CleanExiHS_CYP4X1.
    GenevestigatoriQ8N118.

    Organism-specific databases

    HPAiHPA017661.

    Interactioni

    Protein-protein interaction databases

    BioGridi129254. 1 interaction.
    STRINGi9606.ENSP00000360968.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N118.
    SMRiQ8N118. Positions 47-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiQ8N118.
    KOiK07428.
    OMAiTHWFLGH.
    OrthoDBiEOG7CNZFK.
    PhylomeDBiQ8N118.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N118-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFSWLETRW ARPFYLAFVF CLALGLLQAI KLYLRRQRLL RDLRPFPAPP    50
    THWFLGHQKF IQDDNMEKLE EIIEKYPRAF PFWIGPFQAF FCIYDPDYAK 100
    TLLSRTDPKS QYLQKFSPPL LGKGLAALDG PKWFQHRRLL TPGFHFNILK 150
    AYIEVMAHSV KMMLDKWEKI CSTQDTSVEV YEHINSMSLD IIMKCAFSKE 200
    TNCQTNSTHD PYAKAIFELS KIIFHRLYSL LYHSDIIFKL SPQGYRFQKL 250
    SRVLNQYTDT IIQERKKSLQ AGVKQDNTPK RKYQDFLDIV LSAKDESGSS 300
    FSDIDVHSEV STFLLAGHDT LAASISWILY CLALNPEHQE RCREEVRGIL 350
    GDGSSITWDQ LGEMSYTTMC IKETCRLIPA VPSISRDLSK PLTFPDGCTL 400
    PAGITVVLSI WGLHHNPAVW KNPKVFDPLR FSQENSDQRH PYAYLPFSAG 450
    SRNCIGQEFA MIELKVTIAL ILLHFRVTPD PTRPLTFPNH FILKPKNGMY 500
    LHLKKLSEC 509
    Length:509
    Mass (Da):58,875
    Last modified:October 1, 2002 - v1
    Checksum:i702470A76E814278
    GO
    Isoform 2 (identifier: Q8N118-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: MEFSWLETRW...PTHWFLGHQK → MMWGGGLDLC...ICMTSSSSGL

    Note: No experimental confirmation available.

    Show »
    Length:508
    Mass (Da):57,901
    Checksum:i8E66A23B0353DC06
    GO
    Isoform 3 (identifier: Q8N118-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:444
    Mass (Da):50,944
    Checksum:i8162580C640B5813
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921I → V in BAD18508. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565Missing in isoform 3. 1 PublicationVSP_045889Add
    BLAST
    Alternative sequencei1 – 5959MEFSW…LGHQK → MMWGGGLDLCPMPGQLKFPP CLSRCLLWEPPSLYLTQPTS SLAEPQALICMTSSSSGL in isoform 2. 1 PublicationVSP_045890Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040940 mRNA. Translation: CAJ13826.1.
    AY358537 mRNA. Translation: AAQ88901.1.
    AK091806 mRNA. Translation: BAC03751.1.
    AK098065 mRNA. Translation: BAC05226.1.
    AK131355 mRNA. Translation: BAD18508.1.
    AL450996 Genomic DNA. Translation: CAH71035.1.
    AL731892 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX06882.1.
    CH471059 Genomic DNA. Translation: EAX06883.1.
    CH471059 Genomic DNA. Translation: EAX06884.1.
    BC028102 mRNA. Translation: AAH28102.1.
    CCDSiCCDS544.1. [Q8N118-1]
    RefSeqiNP_828847.1. NM_178033.1. [Q8N118-1]
    UniGeneiHs.439760.

    Genome annotation databases

    EnsembliENST00000371901; ENSP00000360968; ENSG00000186377. [Q8N118-1]
    GeneIDi260293.
    KEGGihsa:260293.
    UCSCiuc001cqr.3. human.
    uc001cqs.3. human. [Q8N118-1]

    Polymorphism databases

    DMDMi48428082.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040940 mRNA. Translation: CAJ13826.1 .
    AY358537 mRNA. Translation: AAQ88901.1 .
    AK091806 mRNA. Translation: BAC03751.1 .
    AK098065 mRNA. Translation: BAC05226.1 .
    AK131355 mRNA. Translation: BAD18508.1 .
    AL450996 Genomic DNA. Translation: CAH71035.1 .
    AL731892 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX06882.1 .
    CH471059 Genomic DNA. Translation: EAX06883.1 .
    CH471059 Genomic DNA. Translation: EAX06884.1 .
    BC028102 mRNA. Translation: AAH28102.1 .
    CCDSi CCDS544.1. [Q8N118-1 ]
    RefSeqi NP_828847.1. NM_178033.1. [Q8N118-1 ]
    UniGenei Hs.439760.

    3D structure databases

    ProteinModelPortali Q8N118.
    SMRi Q8N118. Positions 47-504.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129254. 1 interaction.
    STRINGi 9606.ENSP00000360968.

    Chemistry

    BindingDBi Q8N118.
    ChEMBLi CHEMBL6048.

    PTM databases

    PhosphoSitei Q8N118.

    Polymorphism databases

    DMDMi 48428082.

    Proteomic databases

    MaxQBi Q8N118.
    PaxDbi Q8N118.
    PRIDEi Q8N118.

    Protocols and materials databases

    DNASUi 260293.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371901 ; ENSP00000360968 ; ENSG00000186377 . [Q8N118-1 ]
    GeneIDi 260293.
    KEGGi hsa:260293.
    UCSCi uc001cqr.3. human.
    uc001cqs.3. human. [Q8N118-1 ]

    Organism-specific databases

    CTDi 260293.
    GeneCardsi GC01P047489.
    HGNCi HGNC:20244. CYP4X1.
    HPAi HPA017661.
    MIMi 614999. gene.
    neXtProti NX_Q8N118.
    PharmGKBi PA134933184.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi Q8N118.
    KOi K07428.
    OMAi THWFLGH.
    OrthoDBi EOG7CNZFK.
    PhylomeDBi Q8N118.
    TreeFami TF105088.

    Miscellaneous databases

    GeneWikii CYP4X1.
    GenomeRNAii 260293.
    NextBioi 35516628.
    PROi Q8N118.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N118.
    CleanExi HS_CYP4X1.
    Genevestigatori Q8N118.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Aorta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Liver, Lung and Trachea.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiCP4X1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N118
    Secondary accession number(s): G3V1U1
    , Q5VVE5, Q6ZN67, Q8NAZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3