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Protein

Protein shisa-5

Gene

SHISA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.1 Publication

GO - Molecular functioni

  • signal transducer activity Source: UniProtKB
  • WW domain binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-5
Alternative name(s):
Putative NF-kappa-B-activating protein 120
Scotin
Gene namesi
Name:SHISA5
Synonyms:SCOTIN
ORF Names:PSEC0133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164054.15
HGNCiHGNC:30376 SHISA5
MIMi607290 gene
neXtProtiNX_Q8N114

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 105ExtracellularSequence analysisAdd BLAST77
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 240CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51246
OpenTargetsiENSG00000164054
PharmGKBiPA162403295

Polymorphism and mutation databases

DMDMi74714697

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000031287829 – 240Protein shisa-5Add BLAST212

Proteomic databases

PaxDbiQ8N114
PeptideAtlasiQ8N114
PRIDEiQ8N114

PTM databases

iPTMnetiQ8N114
PhosphoSitePlusiQ8N114

Expressioni

Inductioni

Induced in a p53/TP53-dependent manner in response to cellular stress.1 Publication

Gene expression databases

BgeeiENSG00000164054
CleanExiHS_SHISA5
ExpressionAtlasiQ8N114 baseline and differential
GenevisibleiQ8N114 HS

Organism-specific databases

HPAiHPA042295

Interactioni

Subunit structurei

Interacts with PDCD6; PDCD6 can stabilze SHISA5.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119403, 3 interactors
ELMiQ8N114
IntActiQ8N114, 5 interactors
STRINGi9606.ENSP00000296444

Structurei

3D structure databases

ProteinModelPortaliQ8N114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 153Poly-Thr7
Compositional biasi158 – 230Pro-richAdd BLAST73

Domaini

The proline-rich region is required for endoplasmic reticulum localization.1 Publication

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1CW Eukaryota
ENOG410YNKU LUCA
GeneTreeiENSGT00730000111362
HOVERGENiHBG106208
InParanoidiQ8N114
KOiK10135
OMAiAYMDPPK
OrthoDBiEOG091G0T0K
PhylomeDBiQ8N114
TreeFamiTF332572

Family and domain databases

InterProiView protein in InterPro
IPR026910 Shisa
PANTHERiPTHR31395 PTHR31395, 1 hit
PfamiView protein in Pfam
PF13908 Shisa, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N114-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG
60 70 80 90 100
TCDDQYCCSD VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN
110 120 130 140 150
DPMSGFGATL AVGLTIFVLS VVTIIICFTC SCCCLYKTCR RPRPVVTTTT
160 170 180 190 200
STTVVHAPYP QPPSVPPSYP GPSYQGYHTM PPQPGMPAAP YPMQYPPPYP
210 220 230 240
AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL
Length:240
Mass (Da):25,582
Last modified:October 1, 2002 - v1
Checksum:i7C4A8E7A2AD8E272
GO
Isoform 2 (identifier: Q8N114-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:209
Mass (Da):22,367
Checksum:i523A68BE70B836AF
GO
Isoform 3 (identifier: Q8N114-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-104: S → M

Show »
Length:137
Mass (Da):14,502
Checksum:i7DB8894F341443AD
GO
Isoform 4 (identifier: Q8N114-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-104: S → M
     216-240: GAAAPYPASQPPYNPAYMDAPKAAL → ECPCQL

Show »
Length:118
Mass (Da):12,661
Checksum:i028379F596023F38
GO
Isoform 5 (identifier: Q8N114-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-77: Missing.

Note: Gene prediction based on EST data.
Show »
Length:233
Mass (Da):24,855
Checksum:i8302434F0F5AF946
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054031216G → R. Corresponds to variant dbSNP:rs35750010Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0299531 – 103Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST103
Alternative sequenceiVSP_0299541 – 31Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_05571271 – 77Missing in isoform 5. Curated7
Alternative sequenceiVSP_029955104S → M in isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_029956216 – 240GAAAP…PKAAL → ECPCQL in isoform 4. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520698 mRNA Translation: AAM74232.1
AH011688 Genomic DNA Translation: AAM74235.1
AB097007 mRNA Translation: BAC77360.1
AK056328 mRNA Translation: BAB71152.1
AK075441 mRNA Translation: BAC11623.1
AK124652 mRNA Translation: BAG54061.1
AL117413 mRNA Translation: CAH10718.1
AL832568 mRNA Translation: CAH10587.1
AC104448 Genomic DNA No translation available.
AC134772 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64885.1
CH471055 Genomic DNA Translation: EAW64887.1
BC001463 mRNA Translation: AAH01463.2
CCDSiCCDS2770.1 [Q8N114-1]
CCDS63621.1 [Q8N114-3]
CCDS63622.1 [Q8N114-2]
CCDS63623.1 [Q8N114-5]
RefSeqiNP_001258994.1, NM_001272065.1 [Q8N114-5]
NP_001258995.1, NM_001272066.1 [Q8N114-2]
NP_001258996.1, NM_001272067.1 [Q8N114-2]
NP_001258997.1, NM_001272068.1 [Q8N114-2]
NP_001259011.1, NM_001272082.1 [Q8N114-3]
NP_001259012.1, NM_001272083.1 [Q8N114-4]
NP_057563.3, NM_016479.4 [Q8N114-1]
XP_005265262.1, XM_005265205.1 [Q8N114-2]
XP_006713251.1, XM_006713188.2 [Q8N114-2]
XP_011532098.1, XM_011533796.1 [Q8N114-2]
UniGeneiHs.414579
Hs.664265

Genome annotation databases

EnsembliENST00000296444; ENSP00000296444; ENSG00000164054 [Q8N114-1]
ENST00000426002; ENSP00000390388; ENSG00000164054 [Q8N114-3]
ENST00000442747; ENSP00000408223; ENSG00000164054 [Q8N114-2]
ENST00000443308; ENSP00000395373; ENSG00000164054 [Q8N114-5]
ENST00000444115; ENSP00000407957; ENSG00000164054 [Q8N114-2]
ENST00000619810; ENSP00000484992; ENSG00000164054 [Q8N114-2]
GeneIDi51246
KEGGihsa:51246
UCSCiuc003ctm.4 human [Q8N114-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSHSA5_HUMAN
AccessioniPrimary (citable) accession number: Q8N114
Secondary accession number(s): B3KW99
, F8W9N8, Q69YY9, Q7Z433, Q8NHL9, Q96MW8, Q9BV58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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