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Q8N114

- SHSA5_HUMAN

UniProt

Q8N114 - SHSA5_HUMAN

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Protein
Protein shisa-5
Gene
SHISA5, SCOTIN, PSEC0133
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.1 Publication

GO - Molecular functioni

  1. WW domain binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-5
Alternative name(s):
Putative NF-kappa-B-activating protein 120
Scotin
Gene namesi
Name:SHISA5
Synonyms:SCOTIN
ORF Names:PSEC0133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30376. SHISA5.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 10577Extracellular Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Topological domaini127 – 240114Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 240212Protein shisa-5
PRO_0000312878Add
BLAST

Proteomic databases

PaxDbiQ8N114.
PRIDEiQ8N114.

PTM databases

PhosphoSiteiQ8N114.

Expressioni

Inductioni

Induced in a p53/TP53-dependent manner in response to cellular stress.1 Publication

Gene expression databases

ArrayExpressiQ8N114.
BgeeiQ8N114.
CleanExiHS_SHISA5.
GenevestigatoriQ8N114.

Organism-specific databases

HPAiHPA042295.

Interactioni

Subunit structurei

Interacts with PDCD6; PDCD6 can stabilze SHISA5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pdcd6P128155EBI-2115556,EBI-309164From a different organism.
WWOXQ9NZC72EBI-2115556,EBI-4320739

Protein-protein interaction databases

BioGridi119403. 3 interactions.
IntActiQ8N114. 3 interactions.
STRINGi9606.ENSP00000296444.

Structurei

3D structure databases

ProteinModelPortaliQ8N114.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi147 – 1537Poly-Thr
Compositional biasi158 – 23073Pro-rich
Add
BLAST

Domaini

The proline-rich region is required for endoplasmic reticulum localization.1 Publication

Sequence similaritiesi

Belongs to the shisa family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42686.
HOVERGENiHBG106208.
InParanoidiQ8N114.
KOiK10135.
OMAiMDPPKAA.
OrthoDBiEOG7ZKSD0.
PhylomeDBiQ8N114.
TreeFamiTF332572.

Family and domain databases

InterProiIPR026910. Shisa.
[Graphical view]
PfamiPF13908. Shisa. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N114-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG    50
TCDDQYCCSD VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN 100
DPMSGFGATL AVGLTIFVLS VVTIIICFTC SCCCLYKTCR RPRPVVTTTT 150
STTVVHAPYP QPPSVPPSYP GPSYQGYHTM PPQPGMPAAP YPMQYPPPYP 200
AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL 240
Length:240
Mass (Da):25,582
Last modified:October 1, 2002 - v1
Checksum:i7C4A8E7A2AD8E272
GO
Isoform 2 (identifier: Q8N114-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:209
Mass (Da):22,367
Checksum:i523A68BE70B836AF
GO
Isoform 3 (identifier: Q8N114-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-104: S → M

Show »
Length:137
Mass (Da):14,502
Checksum:i7DB8894F341443AD
GO
Isoform 4 (identifier: Q8N114-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-104: S → M
     216-240: GAAAPYPASQPPYNPAYMDAPKAAL → ECPCQL

Show »
Length:118
Mass (Da):12,661
Checksum:i028379F596023F38
GO
Isoform 5 (identifier: Q8N114-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-77: Missing.

Note: Gene prediction based on EST data.

Show »
Length:233
Mass (Da):24,855
Checksum:i8302434F0F5AF946
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161G → R.
Corresponds to variant rs35750010 [ dbSNP | Ensembl ].
VAR_054031

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 103103Missing in isoform 3 and isoform 4.
VSP_029953Add
BLAST
Alternative sequencei1 – 3131Missing in isoform 2.
VSP_029954Add
BLAST
Alternative sequencei71 – 777Missing in isoform 5.
VSP_055712
Alternative sequencei104 – 1041S → M in isoform 3 and isoform 4.
VSP_029955
Alternative sequencei216 – 24025GAAAP…PKAAL → ECPCQL in isoform 4.
VSP_029956Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF520698 mRNA. Translation: AAM74232.1.
AH011688 Genomic DNA. Translation: AAM74235.1.
AB097007 mRNA. Translation: BAC77360.1.
AK056328 mRNA. Translation: BAB71152.1.
AK075441 mRNA. Translation: BAC11623.1.
AK124652 mRNA. Translation: BAG54061.1.
AL117413 mRNA. Translation: CAH10718.1.
AL832568 mRNA. Translation: CAH10587.1.
AC104448 Genomic DNA. No translation available.
AC134772 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64885.1.
CH471055 Genomic DNA. Translation: EAW64887.1.
BC001463 mRNA. Translation: AAH01463.2.
CCDSiCCDS2770.1. [Q8N114-1]
CCDS63621.1. [Q8N114-3]
CCDS63622.1. [Q8N114-2]
RefSeqiNP_001258994.1. NM_001272065.1.
NP_001258995.1. NM_001272066.1. [Q8N114-2]
NP_001258996.1. NM_001272067.1. [Q8N114-2]
NP_001258997.1. NM_001272068.1. [Q8N114-2]
NP_001259011.1. NM_001272082.1. [Q8N114-3]
NP_001259012.1. NM_001272083.1. [Q8N114-4]
NP_057563.3. NM_016479.4. [Q8N114-1]
XP_005265262.1. XM_005265205.1. [Q8N114-2]
XP_006713251.1. XM_006713188.1. [Q8N114-2]
UniGeneiHs.414579.
Hs.664265.

Genome annotation databases

EnsembliENST00000296444; ENSP00000296444; ENSG00000164054. [Q8N114-1]
ENST00000426002; ENSP00000390388; ENSG00000164054. [Q8N114-3]
ENST00000442747; ENSP00000408223; ENSG00000164054. [Q8N114-2]
ENST00000443308; ENSP00000395373; ENSG00000164054.
ENST00000444115; ENSP00000407957; ENSG00000164054. [Q8N114-2]
GeneIDi51246.
KEGGihsa:51246.
UCSCiuc003ctm.3. human. [Q8N114-3]
uc003cto.1. human. [Q8N114-1]
uc003ctt.4. human. [Q8N114-4]

Polymorphism databases

DMDMi74714697.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF520698 mRNA. Translation: AAM74232.1 .
AH011688 Genomic DNA. Translation: AAM74235.1 .
AB097007 mRNA. Translation: BAC77360.1 .
AK056328 mRNA. Translation: BAB71152.1 .
AK075441 mRNA. Translation: BAC11623.1 .
AK124652 mRNA. Translation: BAG54061.1 .
AL117413 mRNA. Translation: CAH10718.1 .
AL832568 mRNA. Translation: CAH10587.1 .
AC104448 Genomic DNA. No translation available.
AC134772 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64885.1 .
CH471055 Genomic DNA. Translation: EAW64887.1 .
BC001463 mRNA. Translation: AAH01463.2 .
CCDSi CCDS2770.1. [Q8N114-1 ]
CCDS63621.1. [Q8N114-3 ]
CCDS63622.1. [Q8N114-2 ]
RefSeqi NP_001258994.1. NM_001272065.1.
NP_001258995.1. NM_001272066.1. [Q8N114-2 ]
NP_001258996.1. NM_001272067.1. [Q8N114-2 ]
NP_001258997.1. NM_001272068.1. [Q8N114-2 ]
NP_001259011.1. NM_001272082.1. [Q8N114-3 ]
NP_001259012.1. NM_001272083.1. [Q8N114-4 ]
NP_057563.3. NM_016479.4. [Q8N114-1 ]
XP_005265262.1. XM_005265205.1. [Q8N114-2 ]
XP_006713251.1. XM_006713188.1. [Q8N114-2 ]
UniGenei Hs.414579.
Hs.664265.

3D structure databases

ProteinModelPortali Q8N114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119403. 3 interactions.
IntActi Q8N114. 3 interactions.
STRINGi 9606.ENSP00000296444.

PTM databases

PhosphoSitei Q8N114.

Polymorphism databases

DMDMi 74714697.

Proteomic databases

PaxDbi Q8N114.
PRIDEi Q8N114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296444 ; ENSP00000296444 ; ENSG00000164054 . [Q8N114-1 ]
ENST00000426002 ; ENSP00000390388 ; ENSG00000164054 . [Q8N114-3 ]
ENST00000442747 ; ENSP00000408223 ; ENSG00000164054 . [Q8N114-2 ]
ENST00000443308 ; ENSP00000395373 ; ENSG00000164054 .
ENST00000444115 ; ENSP00000407957 ; ENSG00000164054 . [Q8N114-2 ]
GeneIDi 51246.
KEGGi hsa:51246.
UCSCi uc003ctm.3. human. [Q8N114-3 ]
uc003cto.1. human. [Q8N114-1 ]
uc003ctt.4. human. [Q8N114-4 ]

Organism-specific databases

CTDi 51246.
GeneCardsi GC03M048485.
HGNCi HGNC:30376. SHISA5.
HPAi HPA042295.
MIMi 607290. gene.
neXtProti NX_Q8N114.
PharmGKBi PA162403295.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42686.
HOVERGENi HBG106208.
InParanoidi Q8N114.
KOi K10135.
OMAi MDPPKAA.
OrthoDBi EOG7ZKSD0.
PhylomeDBi Q8N114.
TreeFami TF332572.

Miscellaneous databases

ChiTaRSi SHISA5. human.
GenomeRNAii 51246.
NextBioi 54370.
PROi Q8N114.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N114.
Bgeei Q8N114.
CleanExi HS_SHISA5.
Genevestigatori Q8N114.

Family and domain databases

InterProi IPR026910. Shisa.
[Graphical view ]
Pfami PF13908. Shisa. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane."
    Bourdon J.-C., Renzing J., Robertson P.L., Fernandes K.N., Lane D.P.
    J. Cell Biol. 158:235-246(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION, INDUCTION, DOMAIN, SUBCELLULAR LOCATION.
  2. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala, Placenta and Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Brain and Kidney.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  8. "The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane."
    Draeby I., Woods Y.L., la Cour J.M., Mollerup J., Bourdon J.C., Berchtold M.W.
    Arch. Biochem. Biophys. 467:87-94(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WITH PDCD6.

Entry informationi

Entry nameiSHSA5_HUMAN
AccessioniPrimary (citable) accession number: Q8N114
Secondary accession number(s): B3KW99
, F8W9N8, Q69YY9, Q7Z433, Q8NHL9, Q96MW8, Q9BV58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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