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Protein

Cell cycle exit and neuronal differentiation protein 1

Gene

CEND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neuronal differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

BioCyciZFISH:G66-31639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle exit and neuronal differentiation protein 1
Alternative name(s):
BM88 antigen
Gene namesi
Name:CEND1
Synonyms:BM88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24153. CEND1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 125CytoplasmicSequence analysisAdd BLAST125
Transmembranei126 – 146Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini147 – 149ExtracellularSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51286.
OpenTargetsiENSG00000184524.
PharmGKBiPA145149163.

Polymorphism and mutation databases

BioMutaiCEND1.
DMDMi28376966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649511 – 149Cell cycle exit and neuronal differentiation protein 1Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N111.
MaxQBiQ8N111.
PaxDbiQ8N111.
PeptideAtlasiQ8N111.
PRIDEiQ8N111.

PTM databases

iPTMnetiQ8N111.
PhosphoSitePlusiQ8N111.

Expressioni

Tissue specificityi

Neuron specific.1 Publication

Gene expression databases

BgeeiENSG00000184524.
CleanExiHS_CEND1.
GenevisibleiQ8N111. HS.

Organism-specific databases

HPAiHPA042527.

Interactioni

Subunit structurei

Homodimer (PubMed:11311134). Interacts with AHI1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi119438. 3 interactors.
IntActiQ8N111. 2 interactors.
MINTiMINT-2873097.
STRINGi9606.ENSP00000328336.

Structurei

3D structure databases

ProteinModelPortaliQ8N111.
SMRiQ8N111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CEND1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ8N111.
OMAiGPWPCEN.
OrthoDBiEOG091G11FY.
PhylomeDBiQ8N111.
TreeFamiTF336209.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q8N111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRGKSASS PKPDTKVPQV TTEAKVPPAA DGKAPLTKPS KKEAPAEKQQ
60 70 80 90 100
PPAAPTTAPA KKTSAKADPA LLNNHSNLKP APTVPSSPDA TPEPKGPGDG
110 120 130 140
AEEDEAASGG PGGRGPWSCE NFNPLLVAGG VAVAAIALIL GVAFLVRKK
Length:149
Mass (Da):14,954
Last modified:October 1, 2002 - v1
Checksum:i8251BCDD5A10E7BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116P → S in AAF60309 (PubMed:11311134).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235030 mRNA. Translation: AAF60309.1.
AY304478 Genomic DNA. Translation: AAP57306.1.
AK074547 mRNA. Translation: BAC11051.1.
BC034732 mRNA. Translation: AAH34732.1.
CCDSiCCDS7714.1.
RefSeqiNP_057648.2. NM_016564.3.
UniGeneiHs.22140.

Genome annotation databases

EnsembliENST00000330106; ENSP00000328336; ENSG00000184524.
GeneIDi51286.
KEGGihsa:51286.
UCSCiuc001lrh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235030 mRNA. Translation: AAF60309.1.
AY304478 Genomic DNA. Translation: AAP57306.1.
AK074547 mRNA. Translation: BAC11051.1.
BC034732 mRNA. Translation: AAH34732.1.
CCDSiCCDS7714.1.
RefSeqiNP_057648.2. NM_016564.3.
UniGeneiHs.22140.

3D structure databases

ProteinModelPortaliQ8N111.
SMRiQ8N111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119438. 3 interactors.
IntActiQ8N111. 2 interactors.
MINTiMINT-2873097.
STRINGi9606.ENSP00000328336.

PTM databases

iPTMnetiQ8N111.
PhosphoSitePlusiQ8N111.

Polymorphism and mutation databases

BioMutaiCEND1.
DMDMi28376966.

Proteomic databases

EPDiQ8N111.
MaxQBiQ8N111.
PaxDbiQ8N111.
PeptideAtlasiQ8N111.
PRIDEiQ8N111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330106; ENSP00000328336; ENSG00000184524.
GeneIDi51286.
KEGGihsa:51286.
UCSCiuc001lrh.2. human.

Organism-specific databases

CTDi51286.
DisGeNETi51286.
GeneCardsiCEND1.
HGNCiHGNC:24153. CEND1.
HPAiHPA042527.
MIMi608213. gene.
neXtProtiNX_Q8N111.
OpenTargetsiENSG00000184524.
PharmGKBiPA145149163.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ8N111.
OMAiGPWPCEN.
OrthoDBiEOG091G11FY.
PhylomeDBiQ8N111.
TreeFamiTF336209.

Enzyme and pathway databases

BioCyciZFISH:G66-31639-MONOMER.

Miscellaneous databases

GenomeRNAii51286.
PROiQ8N111.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184524.
CleanExiHS_CEND1.
GenevisibleiQ8N111. HS.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCEND_HUMAN
AccessioniPrimary (citable) accession number: Q8N111
Secondary accession number(s): Q9NYM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.