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Protein

Cell cycle exit and neuronal differentiation protein 1

Gene

CEND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in neuroblastoma cell differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle exit and neuronal differentiation protein 1
Alternative name(s):
BM88 antigen
Gene namesi
Name:CEND1
Synonyms:BM88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24153. CEND1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 125125CytoplasmicSequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini147 – 1493ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149163.

Polymorphism and mutation databases

BioMutaiCEND1.
DMDMi28376966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Cell cycle exit and neuronal differentiation protein 1PRO_0000064951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N111.
MaxQBiQ8N111.
PaxDbiQ8N111.
PeptideAtlasiQ8N111.
PRIDEiQ8N111.

PTM databases

iPTMnetiQ8N111.
PhosphoSiteiQ8N111.

Expressioni

Tissue specificityi

Neuron specific.1 Publication

Gene expression databases

BgeeiQ8N111.
CleanExiHS_CEND1.
GenevisibleiQ8N111. HS.

Organism-specific databases

HPAiHPA042527.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi119438. 3 interactions.
IntActiQ8N111. 2 interactions.
MINTiMINT-2873097.
STRINGi9606.ENSP00000328336.

Structurei

3D structure databases

ProteinModelPortaliQ8N111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CEND1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ8N111.
OMAiGPWPCEN.
OrthoDBiEOG7P02MQ.
PhylomeDBiQ8N111.
TreeFamiTF336209.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q8N111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRGKSASS PKPDTKVPQV TTEAKVPPAA DGKAPLTKPS KKEAPAEKQQ
60 70 80 90 100
PPAAPTTAPA KKTSAKADPA LLNNHSNLKP APTVPSSPDA TPEPKGPGDG
110 120 130 140
AEEDEAASGG PGGRGPWSCE NFNPLLVAGG VAVAAIALIL GVAFLVRKK
Length:149
Mass (Da):14,954
Last modified:October 1, 2002 - v1
Checksum:i8251BCDD5A10E7BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161P → S in AAF60309 (PubMed:11311134).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235030 mRNA. Translation: AAF60309.1.
AY304478 Genomic DNA. Translation: AAP57306.1.
AK074547 mRNA. Translation: BAC11051.1.
BC034732 mRNA. Translation: AAH34732.1.
CCDSiCCDS7714.1.
RefSeqiNP_057648.2. NM_016564.3.
UniGeneiHs.22140.

Genome annotation databases

EnsembliENST00000330106; ENSP00000328336; ENSG00000184524.
GeneIDi51286.
KEGGihsa:51286.
UCSCiuc001lrh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235030 mRNA. Translation: AAF60309.1.
AY304478 Genomic DNA. Translation: AAP57306.1.
AK074547 mRNA. Translation: BAC11051.1.
BC034732 mRNA. Translation: AAH34732.1.
CCDSiCCDS7714.1.
RefSeqiNP_057648.2. NM_016564.3.
UniGeneiHs.22140.

3D structure databases

ProteinModelPortaliQ8N111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119438. 3 interactions.
IntActiQ8N111. 2 interactions.
MINTiMINT-2873097.
STRINGi9606.ENSP00000328336.

PTM databases

iPTMnetiQ8N111.
PhosphoSiteiQ8N111.

Polymorphism and mutation databases

BioMutaiCEND1.
DMDMi28376966.

Proteomic databases

EPDiQ8N111.
MaxQBiQ8N111.
PaxDbiQ8N111.
PeptideAtlasiQ8N111.
PRIDEiQ8N111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330106; ENSP00000328336; ENSG00000184524.
GeneIDi51286.
KEGGihsa:51286.
UCSCiuc001lrh.2. human.

Organism-specific databases

CTDi51286.
GeneCardsiCEND1.
HGNCiHGNC:24153. CEND1.
HPAiHPA042527.
MIMi608213. gene.
neXtProtiNX_Q8N111.
PharmGKBiPA145149163.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ8N111.
OMAiGPWPCEN.
OrthoDBiEOG7P02MQ.
PhylomeDBiQ8N111.
TreeFamiTF336209.

Miscellaneous databases

GenomeRNAii51286.
PROiQ8N111.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N111.
CleanExiHS_CEND1.
GenevisibleiQ8N111. HS.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis."
    Gaitanou M., Buanne P., Pappa C., Georgopoulou N., Mamalaki A., Tirone F., Matsas R.
    Biochem. J. 355:715-724(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Structural and functional characterization of human BM88."
    Papadodima O., Mamalaki A., Matsas R.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Testis.

Entry informationi

Entry nameiCEND_HUMAN
AccessioniPrimary (citable) accession number: Q8N111
Secondary accession number(s): Q9NYM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.