ID   KI2LA_HUMAN             Reviewed;         375 AA.
AC   Q8N109;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 144.
DE   RecName: Full=Killer cell immunoglobulin-like receptor 2DL5A;
DE   AltName: CD_antigen=CD158f1;
DE   Flags: Precursor;
GN   Name=KIR2DL5A; Synonyms=CD158F, CD158F1, KIR2DL5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   GENE FAMILY.
RX   PubMed=12185535; DOI=10.1007/s00251-002-0476-2;
RA   Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C.;
RT   "Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and
RT   KIR2DL5B.";
RL   Immunogenetics 54:314-319(2002).
CC   -!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles.
CC       Inhibits the activity of NK cells thus preventing cell lysis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR   EMBL; AL133414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_065396.1; NM_020535.3.
DR   AlphaFoldDB; Q8N109; -.
DR   SMR; Q8N109; -.
DR   BioGRID; 110007; 2.
DR   GlyCosmos; Q8N109; 3 sites, No reported glycans.
DR   GlyGen; Q8N109; 3 sites.
DR   iPTMnet; Q8N109; -.
DR   PhosphoSitePlus; Q8N109; -.
DR   BioMuta; KIR2DL5A; -.
DR   DMDM; 74759760; -.
DR   MassIVE; Q8N109; -.
DR   PeptideAtlas; Q8N109; -.
DR   DNASU; 57292; -.
DR   Ensembl; ENST00000611422.1; ENSP00000479384.1; ENSG00000274676.1.
DR   Ensembl; ENST00000612730.1; ENSP00000483324.1; ENSG00000274143.1.
DR   Ensembl; ENST00000613155.1; ENSP00000484296.1; ENSG00000275596.1.
DR   Ensembl; ENST00000639225.1; ENSP00000491352.1; ENSG00000288357.1.
DR   Ensembl; ENST00000644241.1; ENSP00000496435.1; ENSG00000288357.1.
DR   GeneID; 57292; -.
DR   KEGG; hsa:57292; -.
DR   MANE-Select; ENST00000613155.1; ENSP00000484296.1; NM_020535.3; NP_065396.1.
DR   UCSC; uc032ivi.2; human.
DR   AGR; HGNC:16345; -.
DR   CTD; 57292; -.
DR   DisGeNET; 57292; -.
DR   GeneCards; KIR2DL5A; -.
DR   HGNC; HGNC:16345; KIR2DL5A.
DR   MIM; 605305; gene.
DR   neXtProt; NX_Q8N109; -.
DR   OpenTargets; ENSG00000274143; -.
DR   PharmGKB; PA142671590; -.
DR   InParanoid; Q8N109; -.
DR   PathwayCommons; Q8N109; -.
DR   SignaLink; Q8N109; -.
DR   BioGRID-ORCS; 57292; 1 hit in 27 CRISPR screens.
DR   GenomeRNAi; 57292; -.
DR   Pharos; Q8N109; Tdark.
DR   PRO; PR:Q8N109; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8N109; Protein.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   PANTHER; PTHR11738:SF169; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL5A-RELATED; 1.
DR   PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..375
FT                   /note="Killer cell immunoglobulin-like receptor 2DL5A"
FT                   /id="PRO_0000300638"
FT   TOPO_DOM        22..238
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..375
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..102
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          137..200
FT                   /note="Ig-like C2-type 2"
FT   REGION          213..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        218
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..95
FT                   /evidence="ECO:0000250"
FT   DISULFID        144..193
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   375 AA;  40678 MW;  84B53DFCEE473293 CRC64;
     MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL
     YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL
     FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVNGTFQADF
     PLGPATHGGT YTCFGSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH
     ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
     LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL
     SQNRVASSHV PAAGI
//