Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Killer cell immunoglobulin-like receptor 2DL5A

Gene

KIR2DL5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Keywords - Molecular functioni

Receptor

Protein family/group databases

MEROPSiI43.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL5A
Alternative name(s):
CD_antigen: CD158f1
Gene namesi
Name:KIR2DL5A
Synonyms:CD158F, CD158F1, KIR2DL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16345. KIR2DL5A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 238217ExtracellularSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 375116CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671590.

Polymorphism and mutation databases

DMDMi74759760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 375354Killer cell immunoglobulin-like receptor 2DL5APRO_0000300638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 95By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi144 ↔ 193By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8N109.

Expressioni

Gene expression databases

BgeeiQ8N109.
CleanExiHS_KIR2DL5A.
GenevisibleiQ8N109. HS.

Interactioni

Protein-protein interaction databases

BioGridi110007. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8N109.
SMRiQ8N109. Positions 28-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10261Ig-like C2-type 1Add
BLAST
Domaini137 – 20064Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2257Poly-Ser

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ8N109.
KOiK07981.
OMAiSCPGGHD.
OrthoDBiEOG7H792J.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR
60 70 80 90 100
SRLGFTIFSL YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP
110 120 130 140 150
RSPIEWSAPS NPLVIVVTGL FGKPSLSAQP GPTVRTGENV TLSCSSRSSF
160 170 180 190 200
DMYHLSREGR AHEPRLPAVP SVNGTFQADF PLGPATHGGT YTCFGSLHDS
210 220 230 240 250
PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH ILIGTSVAII
260 270 280 290 300
LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
310 320 330 340 350
LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL
360 370
RGSSRETTAL SQNRVASSHV PAAGI
Length:375
Mass (Da):40,678
Last modified:October 1, 2002 - v1
Checksum:i84B53DFCEE473293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133414 Genomic DNA. Translation: CAC40714.1.
RefSeqiNP_065396.1. NM_020535.3.
UniGeneiHs.740906.

Genome annotation databases

EnsembliENST00000611422; ENSP00000479384; ENSG00000274676.
ENST00000612730; ENSP00000483324; ENSG00000274143.
ENST00000613155; ENSP00000484296; ENSG00000275596.
GeneIDi57292.
KEGGihsa:57292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133414 Genomic DNA. Translation: CAC40714.1.
RefSeqiNP_065396.1. NM_020535.3.
UniGeneiHs.740906.

3D structure databases

ProteinModelPortaliQ8N109.
SMRiQ8N109. Positions 28-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110007. 2 interactions.

Protein family/group databases

MEROPSiI43.951.

Polymorphism and mutation databases

DMDMi74759760.

Proteomic databases

PRIDEiQ8N109.

Protocols and materials databases

DNASUi57292.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611422; ENSP00000479384; ENSG00000274676.
ENST00000612730; ENSP00000483324; ENSG00000274143.
ENST00000613155; ENSP00000484296; ENSG00000275596.
GeneIDi57292.
KEGGihsa:57292.

Organism-specific databases

CTDi57292.
GeneCardsiGC19P9Q0450.
HGNCiHGNC:16345. KIR2DL5A.
MIMi605305. gene.
neXtProtiNX_Q8N109.
PharmGKBiPA142671590.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ8N109.
KOiK07981.
OMAiSCPGGHD.
OrthoDBiEOG7H792J.

Miscellaneous databases

NextBioi63416.
PROiQ8N109.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N109.
CleanExiHS_KIR2DL5A.
GenevisibleiQ8N109. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B."
    Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C.
    Immunogenetics 54:314-319(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiKI2LA_HUMAN
AccessioniPrimary (citable) accession number: Q8N109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.