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Q8N109 (KI2LA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell immunoglobulin-like receptor 2DL5A
Alternative name(s):
CD_antigen=CD158f1
Gene names
Name:KIR2DL5A
Synonyms:CD158F, CD158F1, KIR2DL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 375354Killer cell immunoglobulin-like receptor 2DL5A
PRO_0000300638

Regions

Topological domain22 – 238217Extracellular Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 375116Cytoplasmic Potential
Domain42 – 10261Ig-like C2-type 1
Domain137 – 20064Ig-like C2-type 2
Compositional bias219 – 2257Poly-Ser

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 95 By similarity
Disulfide bond144 ↔ 193 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8N109 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 84B53DFCEE473293

FASTA37540,678
        10         20         30         40         50         60 
MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL 

        70         80         90        100        110        120 
YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL 

       130        140        150        160        170        180 
FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVNGTFQADF 

       190        200        210        220        230        240 
PLGPATHGGT YTCFGSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH 

       250        260        270        280        290        300 
ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ 

       310        320        330        340        350        360 
LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL 

       370 
SQNRVASSHV PAAGI 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B."
Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C.
Immunogenetics 54:314-319(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL133414 Genomic DNA. Translation: CAC40714.1.
RefSeqNP_065396.1. NM_020535.3.
XP_006725502.1. XM_006725439.1.
XP_006725705.1. XM_006725642.1.
XP_006725855.1. XM_006725792.1.
UniGeneHs.740906.
Hs.744319.

3D structure databases

ProteinModelPortalQ8N109.
SMRQ8N109. Positions 28-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000383645.

Polymorphism databases

DMDM74759760.

Proteomic databases

PRIDEQ8N109.

Protocols and materials databases

DNASU57292.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3806.
57292.
KEGGhsa:3809.
hsa:57292.

Organism-specific databases

CTD57292.
GeneCardsGC19P9Q0450.
HGNCHGNC:16345. KIR2DL5A.
MIM605305. gene.
neXtProtNX_Q8N109.
PharmGKBPA142671590.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG074353.
InParanoidQ8N109.
KOK07981.
OrthoDBEOG7H792J.

Gene expression databases

BgeeQ8N109.
CleanExHS_KIR2DL5A.
GenevestigatorQ8N109.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio63416.
PROQ8N109.
SOURCESearch...

Entry information

Entry nameKI2LA_HUMAN
AccessionPrimary (citable) accession number: Q8N109
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries