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Q8N109

- KI2LA_HUMAN

UniProt

Q8N109 - KI2LA_HUMAN

Protein

Killer cell immunoglobulin-like receptor 2DL5A

Gene

KIR2DL5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DL5A
    Alternative name(s):
    CD_antigen: CD158f1
    Gene namesi
    Name:KIR2DL5A
    Synonyms:CD158F, CD158F1, KIR2DL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:16345. KIR2DL5A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671590.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 375354Killer cell immunoglobulin-like receptor 2DL5APRO_0000300638Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 95By similarity
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi144 ↔ 193By similarity
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8N109.

    Expressioni

    Gene expression databases

    BgeeiQ8N109.
    CleanExiHS_KIR2DL5A.
    GenevestigatoriQ8N109.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000383645.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N109.
    SMRiQ8N109. Positions 28-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 238217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 375116CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10261Ig-like C2-type 1Add
    BLAST
    Domaini137 – 20064Ig-like C2-type 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 2257Poly-Ser

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG074353.
    InParanoidiQ8N109.
    KOiK07981.
    K07982.
    OrthoDBiEOG7H792J.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N109-1 [UniParc]FASTAAdd to Basket

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    MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR    50
    SRLGFTIFSL YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP 100
    RSPIEWSAPS NPLVIVVTGL FGKPSLSAQP GPTVRTGENV TLSCSSRSSF 150
    DMYHLSREGR AHEPRLPAVP SVNGTFQADF PLGPATHGGT YTCFGSLHDS 200
    PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH ILIGTSVAII 250
    LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ 300
    LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL 350
    RGSSRETTAL SQNRVASSHV PAAGI 375
    Length:375
    Mass (Da):40,678
    Last modified:October 1, 2002 - v1
    Checksum:i84B53DFCEE473293
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133414 Genomic DNA. Translation: CAC40714.1.
    RefSeqiNP_065396.1. NM_020535.3.
    XP_006725502.1. XM_006725439.1.
    XP_006725705.1. XM_006725642.1.
    XP_006725855.1. XM_006725792.1.
    UniGeneiHs.740906.
    Hs.744319.

    Genome annotation databases

    GeneIDi3806.
    57292.
    KEGGihsa:3806.
    hsa:57292.

    Polymorphism databases

    DMDMi74759760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133414 Genomic DNA. Translation: CAC40714.1 .
    RefSeqi NP_065396.1. NM_020535.3.
    XP_006725502.1. XM_006725439.1.
    XP_006725705.1. XM_006725642.1.
    XP_006725855.1. XM_006725792.1.
    UniGenei Hs.740906.
    Hs.744319.

    3D structure databases

    ProteinModelPortali Q8N109.
    SMRi Q8N109. Positions 28-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000383645.

    Polymorphism databases

    DMDMi 74759760.

    Proteomic databases

    PRIDEi Q8N109.

    Protocols and materials databases

    DNASUi 57292.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3806.
    57292.
    KEGGi hsa:3806.
    hsa:57292.

    Organism-specific databases

    CTDi 3806.
    57292.
    GeneCardsi GC19P9Q0450.
    HGNCi HGNC:16345. KIR2DL5A.
    MIMi 605305. gene.
    neXtProti NX_Q8N109.
    PharmGKBi PA142671590.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG074353.
    InParanoidi Q8N109.
    KOi K07981.
    K07982.
    OrthoDBi EOG7H792J.

    Miscellaneous databases

    NextBioi 63416.
    PROi Q8N109.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N109.
    CleanExi HS_KIR2DL5A.
    Genevestigatori Q8N109.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B."
      Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C.
      Immunogenetics 54:314-319(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiKI2LA_HUMAN
    AccessioniPrimary (citable) accession number: Q8N109
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3