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Q8N109

- KI2LA_HUMAN

UniProt

Q8N109 - KI2LA_HUMAN

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Protein

Killer cell immunoglobulin-like receptor 2DL5A

Gene

KIR2DL5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Keywords - Molecular functioni

Receptor

Protein family/group databases

MEROPSiI43.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL5A
Alternative name(s):
CD_antigen: CD158f1
Gene namesi
Name:KIR2DL5A
Synonyms:CD158F, CD158F1, KIR2DL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:16345. KIR2DL5A.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 375354Killer cell immunoglobulin-like receptor 2DL5APRO_0000300638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 95By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi144 ↔ 193By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8N109.

Expressioni

Gene expression databases

BgeeiQ8N109.
CleanExiHS_KIR2DL5A.
GenevestigatoriQ8N109.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383645.

Structurei

3D structure databases

ProteinModelPortaliQ8N109.
SMRiQ8N109. Positions 28-216.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 238217ExtracellularSequence AnalysisAdd
BLAST
Topological domaini260 – 375116CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10261Ig-like C2-type 1Add
BLAST
Domaini137 – 20064Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2257Poly-Ser

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ8N109.
KOiK07981.
K07982.
OrthoDBiEOG7H792J.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N109 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR
60 70 80 90 100
SRLGFTIFSL YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP
110 120 130 140 150
RSPIEWSAPS NPLVIVVTGL FGKPSLSAQP GPTVRTGENV TLSCSSRSSF
160 170 180 190 200
DMYHLSREGR AHEPRLPAVP SVNGTFQADF PLGPATHGGT YTCFGSLHDS
210 220 230 240 250
PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH ILIGTSVAII
260 270 280 290 300
LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
310 320 330 340 350
LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL
360 370
RGSSRETTAL SQNRVASSHV PAAGI
Length:375
Mass (Da):40,678
Last modified:October 1, 2002 - v1
Checksum:i84B53DFCEE473293
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133414 Genomic DNA. Translation: CAC40714.1.
RefSeqiNP_065396.1. NM_020535.3.
XP_006725502.1. XM_006725439.1.
XP_006725705.1. XM_006725642.1.
XP_006725855.1. XM_006725792.1.
UniGeneiHs.740906.
Hs.744319.

Genome annotation databases

EnsembliENST00000611422; ENSP00000479384; ENSG00000274676.
ENST00000612730; ENSP00000483324; ENSG00000274143.
ENST00000613155; ENSP00000484296; ENSG00000275596.
GeneIDi3806.
57292.
KEGGihsa:3806.
hsa:57292.

Polymorphism databases

DMDMi74759760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133414 Genomic DNA. Translation: CAC40714.1 .
RefSeqi NP_065396.1. NM_020535.3.
XP_006725502.1. XM_006725439.1.
XP_006725705.1. XM_006725642.1.
XP_006725855.1. XM_006725792.1.
UniGenei Hs.740906.
Hs.744319.

3D structure databases

ProteinModelPortali Q8N109.
SMRi Q8N109. Positions 28-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000383645.

Protein family/group databases

MEROPSi I43.951.

Polymorphism databases

DMDMi 74759760.

Proteomic databases

PRIDEi Q8N109.

Protocols and materials databases

DNASUi 57292.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000611422 ; ENSP00000479384 ; ENSG00000274676 .
ENST00000612730 ; ENSP00000483324 ; ENSG00000274143 .
ENST00000613155 ; ENSP00000484296 ; ENSG00000275596 .
GeneIDi 3806.
57292.
KEGGi hsa:3806.
hsa:57292.

Organism-specific databases

CTDi 3806.
57292.
GeneCardsi GC19P9Q0450.
HGNCi HGNC:16345. KIR2DL5A.
MIMi 605305. gene.
neXtProti NX_Q8N109.
PharmGKBi PA142671590.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG074353.
InParanoidi Q8N109.
KOi K07981.
K07982.
OrthoDBi EOG7H792J.

Miscellaneous databases

NextBioi 63416.
PROi Q8N109.
SOURCEi Search...

Gene expression databases

Bgeei Q8N109.
CleanExi HS_KIR2DL5A.
Genevestigatori Q8N109.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B."
    Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C.
    Immunogenetics 54:314-319(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiKI2LA_HUMAN
AccessioniPrimary (citable) accession number: Q8N109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3