Q8N104 (D106A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 106

Alternative name(s):
Beta-defensin 6
Short name=BD-6
Short name=DEFB-6
Defensin, beta 106

Gene names

Name:	DEFB106A
Synonyms:	BD6, DEFB106, DEFB6
AND
Name:	DEFB106B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	65 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity. Ref.3
Subcellular location	Secreted.
Tissue specificity	Expressed specifically in epididymis and lung. Ref.3
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Non-traceable author statement. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Peptide	21 – 65	45	Beta-defensin 106		PRO_0000006977
Amino acid modifications
	Disulfide bond	26 ↔ 53		By similarity
	Disulfide bond	33 ↔ 47		By similarity
	Disulfide bond	37 ↔ 54		By similarity
Experimental info
	Sequence conflict	50	1	S → F in AAQ09526. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8N104 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9D1C89BB0041E02D	FASTA	65	7,369
	10 20 30 40 50 60 MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS LKCCRTIQPC GSIID

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Discovery of five conserved beta-defensin gene clusters using a computational search strategy." Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr. Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: B-cell, Fetal lung and Testis.
[2]	"Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice." Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y. J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.
[3]	"ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes." Kao C.Y., Chen Y., Zhao Y.H., Wu R. Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Duplication and selection in the evolution of primate beta-defensin genes." Semple C.A.M., Rolfe M., Dorin J.R. Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-57.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY122466 mRNA. Translation: AAM93908.1. AB089181 mRNA. Translation: BAC10631.1. AF529417 mRNA. Translation: AAQ09526.1. BC100844 mRNA. Translation: AAI00845.1. BC100845 mRNA. Translation: AAI00846.1. BC100846 mRNA. Translation: AAI00847.1. BC100847 mRNA. Translation: AAI00848.1. BC110062 mRNA. Translation: AAI10063.1. BC111688 mRNA. Translation: AAI11689.1. AF540978 mRNA. Translation: AAN33114.1.
IPI	IPI00166034.
RefSeq	NP_001035794.1. NM_001040704.1. NP_689464.1. NM_152251.3.
UniGene	Hs.511958. Hs.535925.
3D structure databases
ProteinModelPortal	Q8N104.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000334364.
Proteomic databases
PRIDE	Q8N104.
Protocols and materials databases
DNASU	245909.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335186; ENSP00000335307; ENSG00000186579. ENST00000335479; ENSP00000334364; ENSG00000187082.
GeneID	245909. 503841.
KEGG	hsa:245909. hsa:503841.
UCSC	uc003wro.1. human.
Organism-specific databases
CTD	245909. 503841.
GeneCards	GC08M007340. GC08P007682.
HGNC	HGNC:18088. DEFB106A. HGNC:28879. DEFB106B.
neXtProt	NX_Q8N104.
PharmGKB	PA142671992.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42673.
HOGENOM	HOG000112137.
HOVERGEN	HBG051285.
InParanoid	Q8N104.
OMA	SLKCCLT.
OrthoDB	EOG451DSG.
PhylomeDB	Q8N104.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q8N104.
CleanEx	HS_DEFB106A. HS_DEFB106B.
Genevestigator	Q8N104.
GermOnline	ENSG00000186579. Homo sapiens. ENSG00000187082. Homo sapiens.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91749.

Entry information

Entry name

D106A_HUMAN

Accession

Primary (citable) accession number: Q8N104
Secondary accession number(s): Q2NKR0, Q496I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.