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Q8N104 (D106A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 106
Alternative name(s):
Beta-defensin 6
Short name=BD-6
Short name=DEFB-6
Defensin, beta 106
Gene names
Name:DEFB106A
Synonyms:BD6, DEFB106, DEFB6
AND
Name:DEFB106B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length65 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has antibacterial activity. Ref.3

Subcellular location

Secreted.

Tissue specificity

Expressed specifically in epididymis and lung. Ref.3

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Peptide21 – 6545Beta-defensin 106
PRO_0000006977

Amino acid modifications

Disulfide bond26 ↔ 53 By similarity
Disulfide bond33 ↔ 47 By similarity
Disulfide bond37 ↔ 54 By similarity

Experimental info

Sequence conflict501S → F in AAQ09526. Ref.3

Secondary structure

........... 65
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8N104 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9D1C89BB0041E02D

FASTA657,369
        10         20         30         40         50         60 
MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS LKCCRTIQPC 


GSIID 

« Hide

References

« Hide 'large scale' references
[1]"Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: B-cell, Fetal lung and Testis.
[2]"Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice."
Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y.
J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epididymis.
[3]"ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes."
Kao C.Y., Chen Y., Zhao Y.H., Wu R.
Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Duplication and selection in the evolution of primate beta-defensin genes."
Semple C.A.M., Rolfe M., Dorin J.R.
Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-57.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY122466 mRNA. Translation: AAM93908.1.
AB089181 mRNA. Translation: BAC10631.1.
AF529417 mRNA. Translation: AAQ09526.1.
BC100844 mRNA. Translation: AAI00845.1.
BC100845 mRNA. Translation: AAI00846.1.
BC100846 mRNA. Translation: AAI00847.1.
BC100847 mRNA. Translation: AAI00848.1.
BC110062 mRNA. Translation: AAI10063.1.
BC111688 mRNA. Translation: AAI11689.1.
AF540978 mRNA. Translation: AAN33114.1.
RefSeqNP_001035794.1. NM_001040704.1.
NP_689464.1. NM_152251.3.
UniGeneHs.511958.
Hs.535925.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LWLNMR-A21-65[»]
ProteinModelPortalQ8N104.
SMRQ8N104. Positions 21-65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334364.

Polymorphism databases

DMDM26392715.

Proteomic databases

PRIDEQ8N104.

Protocols and materials databases

DNASU245909.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335186; ENSP00000335307; ENSG00000186579.
ENST00000335479; ENSP00000334364; ENSG00000187082.
GeneID245909.
503841.
KEGGhsa:245909.
hsa:503841.
UCSCuc003wro.1. human.

Organism-specific databases

CTD245909.
503841.
GeneCardsGC08M007340.
GC08P007682.
HGNCHGNC:18088. DEFB106A.
HGNC:28879. DEFB106B.
HPAHPA045592.
neXtProtNX_Q8N104.
PharmGKBPA142671992.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42673.
HOGENOMHOG000112137.
HOVERGENHBG051285.
InParanoidQ8N104.
OMASLKCCLT.
OrthoDBEOG77DJ91.
PhylomeDBQ8N104.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ8N104.
CleanExHS_DEFB106A.
HS_DEFB106B.
GenevestigatorQ8N104.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDEFB106A.
NextBio91749.
PROQ8N104.

Entry information

Entry nameD106A_HUMAN
AccessionPrimary (citable) accession number: Q8N104
Secondary accession number(s): Q2NKR0, Q496I8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM