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Q8N104

- D106A_HUMAN

UniProt

Q8N104 - D106A_HUMAN

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Protein

Beta-defensin 106

Gene

DEFB106A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Has antibacterial activity.1 Publication

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 106
Alternative name(s):
Beta-defensin 6
Short name:
BD-6
Short name:
DEFB-6
Defensin, beta 106
Gene namesi
Name:DEFB106A
Synonyms:BD6, DEFB106, DEFB6
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:18088. DEFB106A.
HGNC:28879. DEFB106B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Peptidei21 – 6545Beta-defensin 106PRO_0000006977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 53By similarity
Disulfide bondi33 ↔ 47By similarity
Disulfide bondi37 ↔ 54By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8N104.

Expressioni

Tissue specificityi

Expressed specifically in epididymis and lung.1 Publication

Gene expression databases

BgeeiQ8N104.
CleanExiHS_DEFB106A.
HS_DEFB106B.
GenevestigatoriQ8N104.

Organism-specific databases

HPAiHPA045592.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334364.

Structurei

Secondary structure

1
65
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 287
Beta strandi32 – 365
Beta strandi41 – 466
Beta strandi52 – 565
Beta strandi59 – 613

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LWLNMR-A21-65[»]
ProteinModelPortaliQ8N104.
SMRiQ8N104. Positions 21-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42673.
GeneTreeiENSGT00390000005938.
HOGENOMiHOG000112137.
HOVERGENiHBG051285.
InParanoidiQ8N104.
OMAiSLKCCLT.
OrthoDBiEOG77DJ91.
PhylomeDBiQ8N104.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N104-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS
60
LKCCRTIQPC GSIID
Length:65
Mass (Da):7,369
Last modified:October 1, 2002 - v1
Checksum:i9D1C89BB0041E02D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501S → F in AAQ09526. (PubMed:12600824)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY122466 mRNA. Translation: AAM93908.1.
AB089181 mRNA. Translation: BAC10631.1.
AF529417 mRNA. Translation: AAQ09526.1.
BC100844 mRNA. Translation: AAI00845.1.
BC100845 mRNA. Translation: AAI00846.1.
BC100846 mRNA. Translation: AAI00847.1.
BC100847 mRNA. Translation: AAI00848.1.
BC110062 mRNA. Translation: AAI10063.1.
BC111688 mRNA. Translation: AAI11689.1.
AF540978 mRNA. Translation: AAN33114.1.
CCDSiCCDS34813.1.
CCDS34833.1.
RefSeqiNP_001035794.1. NM_001040704.1.
NP_689464.1. NM_152251.3.
UniGeneiHs.511958.
Hs.535925.

Genome annotation databases

EnsembliENST00000335186; ENSP00000335307; ENSG00000186579.
ENST00000335479; ENSP00000334364; ENSG00000187082.
GeneIDi245909.
503841.
KEGGihsa:245909.
hsa:503841.
UCSCiuc003wro.1. human.

Polymorphism databases

DMDMi26392715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY122466 mRNA. Translation: AAM93908.1 .
AB089181 mRNA. Translation: BAC10631.1 .
AF529417 mRNA. Translation: AAQ09526.1 .
BC100844 mRNA. Translation: AAI00845.1 .
BC100845 mRNA. Translation: AAI00846.1 .
BC100846 mRNA. Translation: AAI00847.1 .
BC100847 mRNA. Translation: AAI00848.1 .
BC110062 mRNA. Translation: AAI10063.1 .
BC111688 mRNA. Translation: AAI11689.1 .
AF540978 mRNA. Translation: AAN33114.1 .
CCDSi CCDS34813.1.
CCDS34833.1.
RefSeqi NP_001035794.1. NM_001040704.1.
NP_689464.1. NM_152251.3.
UniGenei Hs.511958.
Hs.535925.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LWL NMR - A 21-65 [» ]
ProteinModelPortali Q8N104.
SMRi Q8N104. Positions 21-65.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334364.

Polymorphism databases

DMDMi 26392715.

Proteomic databases

PRIDEi Q8N104.

Protocols and materials databases

DNASUi 245909.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335186 ; ENSP00000335307 ; ENSG00000186579 .
ENST00000335479 ; ENSP00000334364 ; ENSG00000187082 .
GeneIDi 245909.
503841.
KEGGi hsa:245909.
hsa:503841.
UCSCi uc003wro.1. human.

Organism-specific databases

CTDi 245909.
503841.
GeneCardsi GC08M007340.
GC08P007682.
HGNCi HGNC:18088. DEFB106A.
HGNC:28879. DEFB106B.
HPAi HPA045592.
neXtProti NX_Q8N104.
PharmGKBi PA142671992.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42673.
GeneTreei ENSGT00390000005938.
HOGENOMi HOG000112137.
HOVERGENi HBG051285.
InParanoidi Q8N104.
OMAi SLKCCLT.
OrthoDBi EOG77DJ91.
PhylomeDBi Q8N104.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GeneWikii DEFB106A.
NextBioi 91749.
PROi Q8N104.

Gene expression databases

Bgeei Q8N104.
CleanExi HS_DEFB106A.
HS_DEFB106B.
Genevestigatori Q8N104.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: B-cell, Fetal lung and Testis.
  2. "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice."
    Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y.
    J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epididymis.
  3. "ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes."
    Kao C.Y., Chen Y., Zhao Y.H., Wu R.
    Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Duplication and selection in the evolution of primate beta-defensin genes."
    Semple C.A.M., Rolfe M., Dorin J.R.
    Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-57.

Entry informationi

Entry nameiD106A_HUMAN
AccessioniPrimary (citable) accession number: Q8N104
Secondary accession number(s): Q2NKR0, Q496I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3