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Protein

Beta-defensin 106

Gene

DEFB106A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203).2 Publications

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: UniProtKB
  • heparin binding Source: UniProtKB
  • lipopolysaccharide binding Source: UniProtKB

GO - Biological processi

  • antifungal innate immune response Source: UniProtKB
  • defense response to bacterium Source: GO_Central
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 106
Alternative name(s):
Beta-defensin 6
Short name:
BD-6
Short name:
DEFB-6
Defensin, beta 106
Gene namesi
Name:DEFB106A
Synonyms:BD6, DEFB106, DEFB6
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000186579.2
HostDB:ENSG00000187082.2
HGNCiHGNC:18088 DEFB106A
HGNC:28879 DEFB106B
neXtProtiNX_Q8N104

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi245909
503841
OpenTargetsiENSG00000187082
PharmGKBiPA142671992

Polymorphism and mutation databases

BioMutaiDEFB106A
DMDMi26392715

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
PeptideiPRO_000000697721 – 65Beta-defensin 106Add BLAST45

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 53Combined sources1 Publication
Disulfide bondi33 ↔ 47By similarity
Disulfide bondi37 ↔ 54By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8N104
PRIDEiQ8N104

Expressioni

Tissue specificityi

Expressed specifically in epididymis and lung.1 Publication

Gene expression databases

BgeeiENSG00000186579
CleanExiHS_DEFB106A
HS_DEFB106B
GenevisibleiQ8N104 HS

Organism-specific databases

HPAiHPA045592

Interactioni

Subunit structurei

Monomer (PubMed:23938203). Interacts with CCR2 (via extracellular N-terminal region); this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203).1 Publication

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128834, 19 interactors
STRINGi9606.ENSP00000335307

Structurei

Secondary structure

165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 28Combined sources7
Beta strandi32 – 36Combined sources5
Beta strandi41 – 46Combined sources6
Beta strandi52 – 56Combined sources5
Beta strandi59 – 61Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LWLNMR-A21-65[»]
ProteinModelPortaliQ8N104
SMRiQ8N104
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J77C Eukaryota
ENOG4111545 LUCA
GeneTreeiENSGT00390000005938
HOGENOMiHOG000112137
HOVERGENiHBG051285
InParanoidiQ8N104
OMAiNKCQINE
OrthoDBiEOG091G18F8
PhylomeDBiQ8N104

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS
60
LKCCRTIQPC GSIID
Length:65
Mass (Da):7,369
Last modified:October 1, 2002 - v1
Checksum:i9D1C89BB0041E02D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50S → F in AAQ09526 (PubMed:12600824).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY122466 mRNA Translation: AAM93908.1
AB089181 mRNA Translation: BAC10631.1
AF529417 mRNA Translation: AAQ09526.1
BC100844 mRNA Translation: AAI00845.1
BC100845 mRNA Translation: AAI00846.1
BC100846 mRNA Translation: AAI00847.1
BC100847 mRNA Translation: AAI00848.1
BC110062 mRNA Translation: AAI10063.1
BC111688 mRNA Translation: AAI11689.1
AF540978 mRNA Translation: AAN33114.1
CCDSiCCDS34813.1
CCDS34833.1
RefSeqiNP_001035794.1, NM_001040704.1
NP_689464.1, NM_152251.3
UniGeneiHs.511958
Hs.535925

Genome annotation databases

EnsembliENST00000335186; ENSP00000335307; ENSG00000186579
ENST00000335479; ENSP00000334364; ENSG00000187082
ENST00000621252; ENSP00000477883; ENSG00000275794
GeneIDi245909
503841
KEGGihsa:245909
hsa:503841
UCSCiuc003wro.2 human

Similar proteinsi

Entry informationi

Entry nameiD106A_HUMAN
AccessioniPrimary (citable) accession number: Q8N104
Secondary accession number(s): Q2NKR0, Q496I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health