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Q8N104

- D106A_HUMAN

UniProt

Q8N104 - D106A_HUMAN

Protein

Beta-defensin 106

Gene

DEFB106A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has antibacterial activity.1 Publication

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 106
    Alternative name(s):
    Beta-defensin 6
    Short name:
    BD-6
    Short name:
    DEFB-6
    Defensin, beta 106
    Gene namesi
    Name:DEFB106A
    Synonyms:BD6, DEFB106, DEFB6
    AND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18088. DEFB106A.
    HGNC:28879. DEFB106B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671992.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Peptidei21 – 6545Beta-defensin 106PRO_0000006977Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 53By similarity
    Disulfide bondi33 ↔ 47By similarity
    Disulfide bondi37 ↔ 54By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8N104.

    Expressioni

    Tissue specificityi

    Expressed specifically in epididymis and lung.1 Publication

    Gene expression databases

    BgeeiQ8N104.
    CleanExiHS_DEFB106A.
    HS_DEFB106B.
    GenevestigatoriQ8N104.

    Organism-specific databases

    HPAiHPA045592.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334364.

    Structurei

    Secondary structure

    1
    65
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi22 – 287
    Beta strandi32 – 365
    Beta strandi41 – 466
    Beta strandi52 – 565
    Beta strandi59 – 613

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LWLNMR-A21-65[»]
    ProteinModelPortaliQ8N104.
    SMRiQ8N104. Positions 21-65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42673.
    HOGENOMiHOG000112137.
    HOVERGENiHBG051285.
    InParanoidiQ8N104.
    OMAiSLKCCLT.
    OrthoDBiEOG77DJ91.
    PhylomeDBiQ8N104.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS   50
    LKCCRTIQPC GSIID 65
    Length:65
    Mass (Da):7,369
    Last modified:October 1, 2002 - v1
    Checksum:i9D1C89BB0041E02D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501S → F in AAQ09526. (PubMed:12600824)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY122466 mRNA. Translation: AAM93908.1.
    AB089181 mRNA. Translation: BAC10631.1.
    AF529417 mRNA. Translation: AAQ09526.1.
    BC100844 mRNA. Translation: AAI00845.1.
    BC100845 mRNA. Translation: AAI00846.1.
    BC100846 mRNA. Translation: AAI00847.1.
    BC100847 mRNA. Translation: AAI00848.1.
    BC110062 mRNA. Translation: AAI10063.1.
    BC111688 mRNA. Translation: AAI11689.1.
    AF540978 mRNA. Translation: AAN33114.1.
    CCDSiCCDS34813.1.
    CCDS34833.1.
    RefSeqiNP_001035794.1. NM_001040704.1.
    NP_689464.1. NM_152251.3.
    UniGeneiHs.511958.
    Hs.535925.

    Genome annotation databases

    EnsembliENST00000335186; ENSP00000335307; ENSG00000186579.
    ENST00000335479; ENSP00000334364; ENSG00000187082.
    GeneIDi245909.
    503841.
    KEGGihsa:245909.
    hsa:503841.
    UCSCiuc003wro.1. human.

    Polymorphism databases

    DMDMi26392715.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY122466 mRNA. Translation: AAM93908.1 .
    AB089181 mRNA. Translation: BAC10631.1 .
    AF529417 mRNA. Translation: AAQ09526.1 .
    BC100844 mRNA. Translation: AAI00845.1 .
    BC100845 mRNA. Translation: AAI00846.1 .
    BC100846 mRNA. Translation: AAI00847.1 .
    BC100847 mRNA. Translation: AAI00848.1 .
    BC110062 mRNA. Translation: AAI10063.1 .
    BC111688 mRNA. Translation: AAI11689.1 .
    AF540978 mRNA. Translation: AAN33114.1 .
    CCDSi CCDS34813.1.
    CCDS34833.1.
    RefSeqi NP_001035794.1. NM_001040704.1.
    NP_689464.1. NM_152251.3.
    UniGenei Hs.511958.
    Hs.535925.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LWL NMR - A 21-65 [» ]
    ProteinModelPortali Q8N104.
    SMRi Q8N104. Positions 21-65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334364.

    Polymorphism databases

    DMDMi 26392715.

    Proteomic databases

    PRIDEi Q8N104.

    Protocols and materials databases

    DNASUi 245909.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335186 ; ENSP00000335307 ; ENSG00000186579 .
    ENST00000335479 ; ENSP00000334364 ; ENSG00000187082 .
    GeneIDi 245909.
    503841.
    KEGGi hsa:245909.
    hsa:503841.
    UCSCi uc003wro.1. human.

    Organism-specific databases

    CTDi 245909.
    503841.
    GeneCardsi GC08M007340.
    GC08P007682.
    HGNCi HGNC:18088. DEFB106A.
    HGNC:28879. DEFB106B.
    HPAi HPA045592.
    neXtProti NX_Q8N104.
    PharmGKBi PA142671992.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42673.
    HOGENOMi HOG000112137.
    HOVERGENi HBG051285.
    InParanoidi Q8N104.
    OMAi SLKCCLT.
    OrthoDBi EOG77DJ91.
    PhylomeDBi Q8N104.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    GeneWikii DEFB106A.
    NextBioi 91749.
    PROi Q8N104.

    Gene expression databases

    Bgeei Q8N104.
    CleanExi HS_DEFB106A.
    HS_DEFB106B.
    Genevestigatori Q8N104.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
      Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: B-cell, Fetal lung and Testis.
    2. "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice."
      Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y.
      J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epididymis.
    3. "ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes."
      Kao C.Y., Chen Y., Zhao Y.H., Wu R.
      Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Duplication and selection in the evolution of primate beta-defensin genes."
      Semple C.A.M., Rolfe M., Dorin J.R.
      Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-57.

    Entry informationi

    Entry nameiD106A_HUMAN
    AccessioniPrimary (citable) accession number: Q8N104
    Secondary accession number(s): Q2NKR0, Q496I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3