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Q8N103 (TAGAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell activation Rho GTPase-activating protein
Alternative name(s):
T-cell activation GTPase-activating protein
Gene names
Name:TAGAP
Synonyms:TAGAP1
ORF Names:FKSG15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length731 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a GTPase-activating protein and may play important roles during T-cell activation. Ref.1

Sequence similarities

Contains 1 Rho-GAP domain.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N103-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N103-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
Isoform 3 (identifier: Q8N103-3)

Also known as: FKSG15;

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     210-261: KHLVYVLHLI...FEAQKDLNNK → MAATAAAVVA...LALEEQEKVE
Note: No experimental confirmation available. Dubious isoform. The N-terminus appears to be derived from exons of the FGFR1OP locus which is located on the opposing strand of chromosome 6 at a distance of several Mb.
Isoform 4 (identifier: Q8N103-4)

The sequence of this isoform differs from the canonical sequence as follows:
     263-266: KTLV → CSAY
     267-731: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 731731T-cell activation Rho GTPase-activating protein
PRO_0000056719

Regions

Domain88 – 277190Rho-GAP

Natural variations

Alternative sequence1 – 209209Missing in isoform 3.
VSP_015868
Alternative sequence1 – 178178Missing in isoform 2.
VSP_015869
Alternative sequence210 – 26152KHLVY…DLNNK → MAATAAAVVAEEDTELRDLL VQTLENSGVLNRIKAELRAA VFLALEEQEKVE in isoform 3.
VSP_015870
Alternative sequence263 – 2664KTLV → CSAY in isoform 4.
VSP_015871
Alternative sequence267 – 731465Missing in isoform 4.
VSP_015872
Natural variant3461G → D.
Corresponds to variant rs35263580 [ dbSNP | Ensembl ].
VAR_049146

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9D8768258A0A681E

FASTA73180,703
        10         20         30         40         50         60 
MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE VKKRKKVLSW 

        70         80         90        100        110        120 
PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL PRPIQDILTI LCLKGPSTEG 

       130        140        150        160        170        180 
IFRRAANEKA RKELKEELNS GDAVDLERLP VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG 

       190        200        210        220        230        240 
ALEMQDEEDR IEALKQVADK LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN 

       250        260        270        280        290        300 
MLTLENDQSL SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD 

       310        320        330        340        350        360 
VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA REVSPEPIVS 

       370        380        390        400        410        420 
TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS EGDFPVPRVG SRLESEEAED 

       430        440        450        460        470        480 
PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV LPRALVLKAF SSSSLDASSD SSPVASPSSP 

       490        500        510        520        530        540 
KRNFFSRHQS FTTKTEKGKP SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP 

       550        560        570        580        590        600 
RGVRKESQLA GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM 

       610        620        630        640        650        660 
QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG SKEPLPGHGL 

       670        680        690        700        710        720 
SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES VQRNKRDCLV RRCSQPVFEA 

       730 
DQFQYAKESY I 

« Hide

Isoform 2 [UniParc].

Checksum: 9728446CFC104C5D
Show »

FASTA55360,669
Isoform 3 (FKSG15) [UniParc].

Checksum: 813D0EF6C7956A16
Show »

FASTA52256,919
Isoform 4 [UniParc].

Checksum: 93A7C4A94871F9A0
Show »

FASTA26629,977

References

« Hide 'large scale' references
[1]"T lymphocyte activation gene identification by coregulated expression on DNA microarrays."
Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J., Schelter J.M., Dai H., He Y.D., Linsley P.S.
Genomics 83:989-999(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
[2]"FKSG15, a novel 57 kDa protein, shares the N-terminal region with FOP."
Wang Y.-G., Gong L.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF385429 mRNA. Translation: AAM43830.1.
AF385430 mRNA. Translation: AAM43831.1.
AF314817 mRNA. Translation: AAL16675.1.
AK097090 mRNA. Translation: BAC04947.1.
AL035530 Genomic DNA. Translation: CAI19231.1.
AL035530 Genomic DNA. Translation: CAI19232.1.
AL035530 Genomic DNA. Translation: CAI19233.1.
BC015859 mRNA. Translation: AAH15859.1.
BC111731 mRNA. Translation: AAI11732.1.
RefSeqNP_001265662.1. NM_001278733.1.
NP_473455.2. NM_054114.4.
NP_620165.1. NM_138810.3.
NP_687034.1. NM_152133.2.
UniGeneHs.529984.

3D structure databases

ProteinModelPortalQ8N103.
SMRQ8N103. Positions 83-277.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000356033.

PTM databases

PhosphoSiteQ8N103.

Polymorphism databases

DMDM74750874.

Proteomic databases

PaxDbQ8N103.
PRIDEQ8N103.

Protocols and materials databases

DNASU117289.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326965; ENSP00000322650; ENSG00000164691. [Q8N103-2]
ENST00000338313; ENSP00000340217; ENSG00000164691. [Q8N103-4]
ENST00000367066; ENSP00000356033; ENSG00000164691. [Q8N103-1]
GeneID117289.
KEGGhsa:117289.
UCSCuc003qrz.3. human. [Q8N103-1]
uc003qsb.3. human. [Q8N103-4]

Organism-specific databases

CTD117289.
GeneCardsGC06M159457.
H-InvDBHIX0006337.
HGNCHGNC:15669. TAGAP.
HPAHPA031000.
MIM609667. gene.
neXtProtNX_Q8N103.
PharmGKBPA38016.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282252.
HOGENOMHOG000139745.
HOVERGENHBG071607.
InParanoidQ8N103.
OMAKHSMSFS.
OrthoDBEOG7NCV2Q.
PhylomeDBQ8N103.
TreeFamTF331062.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8N103.
CleanExHS_TAGAP.
GenevestigatorQ8N103.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
PROSITEPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTAGAP. human.
GenomeRNAi117289.
NextBio80198.
PROQ8N103.
SOURCESearch...

Entry information

Entry nameTAGAP_HUMAN
AccessionPrimary (citable) accession number: Q8N103
Secondary accession number(s): Q2NKM8 expand/collapse secondary AC list , Q8NI40, Q96KZ2, Q96QA2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM