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Q8N103

- TAGAP_HUMAN

UniProt

Q8N103 - TAGAP_HUMAN

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Protein

T-cell activation Rho GTPase-activating protein

Gene

TAGAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May function as a GTPase-activating protein and may play important roles during T-cell activation.1 Publication

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: Reactome
  2. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell activation Rho GTPase-activating protein
Alternative name(s):
T-cell activation GTPase-activating protein
Gene namesi
Name:TAGAP
Synonyms:TAGAP1
ORF Names:FKSG15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:15669. TAGAP.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731T-cell activation Rho GTPase-activating proteinPRO_0000056719Add
BLAST

Proteomic databases

PaxDbiQ8N103.
PRIDEiQ8N103.

PTM databases

PhosphoSiteiQ8N103.

Expressioni

Gene expression databases

BgeeiQ8N103.
CleanExiHS_TAGAP.
GenevestigatoriQ8N103.

Organism-specific databases

HPAiHPA031000.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356033.

Structurei

3D structure databases

ProteinModelPortaliQ8N103.
SMRiQ8N103. Positions 83-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 277190Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG282252.
GeneTreeiENSGT00530000063299.
HOGENOMiHOG000139745.
HOVERGENiHBG071607.
InParanoidiQ8N103.
OMAiKHSMSFS.
OrthoDBiEOG7NCV2Q.
PhylomeDBiQ8N103.
TreeFamiTF331062.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N103-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE
60 70 80 90 100
VKKRKKVLSW PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL
110 120 130 140 150
PRPIQDILTI LCLKGPSTEG IFRRAANEKA RKELKEELNS GDAVDLERLP
160 170 180 190 200
VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG ALEMQDEEDR IEALKQVADK
210 220 230 240 250
LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN MLTLENDQSL
260 270 280 290 300
SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD
310 320 330 340 350
VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA
360 370 380 390 400
REVSPEPIVS TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS
410 420 430 440 450
EGDFPVPRVG SRLESEEAED PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV
460 470 480 490 500
LPRALVLKAF SSSSLDASSD SSPVASPSSP KRNFFSRHQS FTTKTEKGKP
510 520 530 540 550
SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP RGVRKESQLA
560 570 580 590 600
GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM
610 620 630 640 650
QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG
660 670 680 690 700
SKEPLPGHGL SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES
710 720 730
VQRNKRDCLV RRCSQPVFEA DQFQYAKESY I
Length:731
Mass (Da):80,703
Last modified:October 1, 2002 - v1
Checksum:i9D8768258A0A681E
GO
Isoform 2 (identifier: Q8N103-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:553
Mass (Da):60,669
Checksum:i9728446CFC104C5D
GO
Isoform 3 (identifier: Q8N103-3) [UniParc]FASTAAdd to Basket

Also known as: FKSG15

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     210-261: KHLVYVLHLI...FEAQKDLNNK → MAATAAAVVA...LALEEQEKVE

Note: No experimental confirmation available. Dubious isoform. The N-terminus appears to be derived from exons of the FGFR1OP locus which is located on the opposing strand of chromosome 6 at a distance of several Mb.

Show »
Length:522
Mass (Da):56,919
Checksum:i813D0EF6C7956A16
GO
Isoform 4 (identifier: Q8N103-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-266: KTLV → CSAY
     267-731: Missing.

Note: No experimental confirmation available.

Show »
Length:266
Mass (Da):29,977
Checksum:i93A7C4A94871F9A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti346 – 3461G → D.
Corresponds to variant rs35263580 [ dbSNP | Ensembl ].
VAR_049146

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 209209Missing in isoform 3. 1 PublicationVSP_015868Add
BLAST
Alternative sequencei1 – 178178Missing in isoform 2. 1 PublicationVSP_015869Add
BLAST
Alternative sequencei210 – 26152KHLVY…DLNNK → MAATAAAVVAEEDTELRDLL VQTLENSGVLNRIKAELRAA VFLALEEQEKVE in isoform 3. 1 PublicationVSP_015870Add
BLAST
Alternative sequencei263 – 2664KTLV → CSAY in isoform 4. 1 PublicationVSP_015871
Alternative sequencei267 – 731465Missing in isoform 4. 1 PublicationVSP_015872Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF385429 mRNA. Translation: AAM43830.1.
AF385430 mRNA. Translation: AAM43831.1.
AF314817 mRNA. Translation: AAL16675.1.
AK097090 mRNA. Translation: BAC04947.1.
AL035530 Genomic DNA. Translation: CAI19231.1.
AL035530 Genomic DNA. Translation: CAI19232.1.
AL035530 Genomic DNA. Translation: CAI19233.1.
BC015859 mRNA. Translation: AAH15859.1.
BC111731 mRNA. Translation: AAI11732.1.
CCDSiCCDS5261.1. [Q8N103-1]
CCDS5262.1. [Q8N103-2]
CCDS5263.1. [Q8N103-4]
RefSeqiNP_001265662.1. NM_001278733.1.
NP_473455.2. NM_054114.4. [Q8N103-1]
NP_620165.1. NM_138810.3. [Q8N103-4]
NP_687034.1. NM_152133.2. [Q8N103-2]
UniGeneiHs.529984.

Genome annotation databases

EnsembliENST00000326965; ENSP00000322650; ENSG00000164691. [Q8N103-2]
ENST00000338313; ENSP00000340217; ENSG00000164691. [Q8N103-4]
ENST00000367066; ENSP00000356033; ENSG00000164691. [Q8N103-1]
GeneIDi117289.
KEGGihsa:117289.
UCSCiuc003qrz.3. human. [Q8N103-1]
uc003qsb.3. human. [Q8N103-4]

Polymorphism databases

DMDMi74750874.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF385429 mRNA. Translation: AAM43830.1 .
AF385430 mRNA. Translation: AAM43831.1 .
AF314817 mRNA. Translation: AAL16675.1 .
AK097090 mRNA. Translation: BAC04947.1 .
AL035530 Genomic DNA. Translation: CAI19231.1 .
AL035530 Genomic DNA. Translation: CAI19232.1 .
AL035530 Genomic DNA. Translation: CAI19233.1 .
BC015859 mRNA. Translation: AAH15859.1 .
BC111731 mRNA. Translation: AAI11732.1 .
CCDSi CCDS5261.1. [Q8N103-1 ]
CCDS5262.1. [Q8N103-2 ]
CCDS5263.1. [Q8N103-4 ]
RefSeqi NP_001265662.1. NM_001278733.1.
NP_473455.2. NM_054114.4. [Q8N103-1 ]
NP_620165.1. NM_138810.3. [Q8N103-4 ]
NP_687034.1. NM_152133.2. [Q8N103-2 ]
UniGenei Hs.529984.

3D structure databases

ProteinModelPortali Q8N103.
SMRi Q8N103. Positions 83-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000356033.

PTM databases

PhosphoSitei Q8N103.

Polymorphism databases

DMDMi 74750874.

Proteomic databases

PaxDbi Q8N103.
PRIDEi Q8N103.

Protocols and materials databases

DNASUi 117289.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326965 ; ENSP00000322650 ; ENSG00000164691 . [Q8N103-2 ]
ENST00000338313 ; ENSP00000340217 ; ENSG00000164691 . [Q8N103-4 ]
ENST00000367066 ; ENSP00000356033 ; ENSG00000164691 . [Q8N103-1 ]
GeneIDi 117289.
KEGGi hsa:117289.
UCSCi uc003qrz.3. human. [Q8N103-1 ]
uc003qsb.3. human. [Q8N103-4 ]

Organism-specific databases

CTDi 117289.
GeneCardsi GC06M159457.
H-InvDB HIX0006337.
HGNCi HGNC:15669. TAGAP.
HPAi HPA031000.
MIMi 609667. gene.
neXtProti NX_Q8N103.
PharmGKBi PA38016.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282252.
GeneTreei ENSGT00530000063299.
HOGENOMi HOG000139745.
HOVERGENi HBG071607.
InParanoidi Q8N103.
OMAi KHSMSFS.
OrthoDBi EOG7NCV2Q.
PhylomeDBi Q8N103.
TreeFami TF331062.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi TAGAP. human.
GenomeRNAii 117289.
NextBioi 80198.
PROi Q8N103.
SOURCEi Search...

Gene expression databases

Bgeei Q8N103.
CleanExi HS_TAGAP.
Genevestigatori Q8N103.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "T lymphocyte activation gene identification by coregulated expression on DNA microarrays."
    Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J., Schelter J.M., Dai H., He Y.D., Linsley P.S.
    Genomics 83:989-999(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
  2. "FKSG15, a novel 57 kDa protein, shares the N-terminal region with FOP."
    Wang Y.-G., Gong L.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Lung.

Entry informationi

Entry nameiTAGAP_HUMAN
AccessioniPrimary (citable) accession number: Q8N103
Secondary accession number(s): Q2NKM8
, Q8NI40, Q96KZ2, Q96QA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3