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Q8N103

- TAGAP_HUMAN

UniProt

Q8N103 - TAGAP_HUMAN

Protein

T-cell activation Rho GTPase-activating protein

Gene

TAGAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May function as a GTPase-activating protein and may play important roles during T-cell activation.1 Publication

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: Reactome
    2. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell activation Rho GTPase-activating protein
    Alternative name(s):
    T-cell activation GTPase-activating protein
    Gene namesi
    Name:TAGAP
    Synonyms:TAGAP1
    ORF Names:FKSG15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:15669. TAGAP.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 731731T-cell activation Rho GTPase-activating proteinPRO_0000056719Add
    BLAST

    Proteomic databases

    PaxDbiQ8N103.
    PRIDEiQ8N103.

    PTM databases

    PhosphoSiteiQ8N103.

    Expressioni

    Gene expression databases

    BgeeiQ8N103.
    CleanExiHS_TAGAP.
    GenevestigatoriQ8N103.

    Organism-specific databases

    HPAiHPA031000.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356033.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N103.
    SMRiQ8N103. Positions 83-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 277190Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG282252.
    HOGENOMiHOG000139745.
    HOVERGENiHBG071607.
    InParanoidiQ8N103.
    OMAiKHSMSFS.
    OrthoDBiEOG7NCV2Q.
    PhylomeDBiQ8N103.
    TreeFamiTF331062.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    InterProiIPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N103-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE    50
    VKKRKKVLSW PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL 100
    PRPIQDILTI LCLKGPSTEG IFRRAANEKA RKELKEELNS GDAVDLERLP 150
    VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG ALEMQDEEDR IEALKQVADK 200
    LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN MLTLENDQSL 250
    SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD 300
    VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA 350
    REVSPEPIVS TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS 400
    EGDFPVPRVG SRLESEEAED PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV 450
    LPRALVLKAF SSSSLDASSD SSPVASPSSP KRNFFSRHQS FTTKTEKGKP 500
    SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP RGVRKESQLA 550
    GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM 600
    QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG 650
    SKEPLPGHGL SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES 700
    VQRNKRDCLV RRCSQPVFEA DQFQYAKESY I 731
    Length:731
    Mass (Da):80,703
    Last modified:October 1, 2002 - v1
    Checksum:i9D8768258A0A681E
    GO
    Isoform 2 (identifier: Q8N103-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-178: Missing.

    Show »
    Length:553
    Mass (Da):60,669
    Checksum:i9728446CFC104C5D
    GO
    Isoform 3 (identifier: Q8N103-3) [UniParc]FASTAAdd to Basket

    Also known as: FKSG15

    The sequence of this isoform differs from the canonical sequence as follows:
         1-209: Missing.
         210-261: KHLVYVLHLI...FEAQKDLNNK → MAATAAAVVA...LALEEQEKVE

    Note: No experimental confirmation available. Dubious isoform. The N-terminus appears to be derived from exons of the FGFR1OP locus which is located on the opposing strand of chromosome 6 at a distance of several Mb.

    Show »
    Length:522
    Mass (Da):56,919
    Checksum:i813D0EF6C7956A16
    GO
    Isoform 4 (identifier: Q8N103-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         263-266: KTLV → CSAY
         267-731: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:266
    Mass (Da):29,977
    Checksum:i93A7C4A94871F9A0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti346 – 3461G → D.
    Corresponds to variant rs35263580 [ dbSNP | Ensembl ].
    VAR_049146

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 209209Missing in isoform 3. 1 PublicationVSP_015868Add
    BLAST
    Alternative sequencei1 – 178178Missing in isoform 2. 1 PublicationVSP_015869Add
    BLAST
    Alternative sequencei210 – 26152KHLVY…DLNNK → MAATAAAVVAEEDTELRDLL VQTLENSGVLNRIKAELRAA VFLALEEQEKVE in isoform 3. 1 PublicationVSP_015870Add
    BLAST
    Alternative sequencei263 – 2664KTLV → CSAY in isoform 4. 1 PublicationVSP_015871
    Alternative sequencei267 – 731465Missing in isoform 4. 1 PublicationVSP_015872Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385429 mRNA. Translation: AAM43830.1.
    AF385430 mRNA. Translation: AAM43831.1.
    AF314817 mRNA. Translation: AAL16675.1.
    AK097090 mRNA. Translation: BAC04947.1.
    AL035530 Genomic DNA. Translation: CAI19231.1.
    AL035530 Genomic DNA. Translation: CAI19232.1.
    AL035530 Genomic DNA. Translation: CAI19233.1.
    BC015859 mRNA. Translation: AAH15859.1.
    BC111731 mRNA. Translation: AAI11732.1.
    CCDSiCCDS5261.1. [Q8N103-1]
    CCDS5262.1. [Q8N103-2]
    CCDS5263.1. [Q8N103-4]
    RefSeqiNP_001265662.1. NM_001278733.1.
    NP_473455.2. NM_054114.4. [Q8N103-1]
    NP_620165.1. NM_138810.3. [Q8N103-4]
    NP_687034.1. NM_152133.2. [Q8N103-2]
    UniGeneiHs.529984.

    Genome annotation databases

    EnsembliENST00000326965; ENSP00000322650; ENSG00000164691. [Q8N103-2]
    ENST00000338313; ENSP00000340217; ENSG00000164691. [Q8N103-4]
    ENST00000367066; ENSP00000356033; ENSG00000164691. [Q8N103-1]
    GeneIDi117289.
    KEGGihsa:117289.
    UCSCiuc003qrz.3. human. [Q8N103-1]
    uc003qsb.3. human. [Q8N103-4]

    Polymorphism databases

    DMDMi74750874.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385429 mRNA. Translation: AAM43830.1 .
    AF385430 mRNA. Translation: AAM43831.1 .
    AF314817 mRNA. Translation: AAL16675.1 .
    AK097090 mRNA. Translation: BAC04947.1 .
    AL035530 Genomic DNA. Translation: CAI19231.1 .
    AL035530 Genomic DNA. Translation: CAI19232.1 .
    AL035530 Genomic DNA. Translation: CAI19233.1 .
    BC015859 mRNA. Translation: AAH15859.1 .
    BC111731 mRNA. Translation: AAI11732.1 .
    CCDSi CCDS5261.1. [Q8N103-1 ]
    CCDS5262.1. [Q8N103-2 ]
    CCDS5263.1. [Q8N103-4 ]
    RefSeqi NP_001265662.1. NM_001278733.1.
    NP_473455.2. NM_054114.4. [Q8N103-1 ]
    NP_620165.1. NM_138810.3. [Q8N103-4 ]
    NP_687034.1. NM_152133.2. [Q8N103-2 ]
    UniGenei Hs.529984.

    3D structure databases

    ProteinModelPortali Q8N103.
    SMRi Q8N103. Positions 83-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000356033.

    PTM databases

    PhosphoSitei Q8N103.

    Polymorphism databases

    DMDMi 74750874.

    Proteomic databases

    PaxDbi Q8N103.
    PRIDEi Q8N103.

    Protocols and materials databases

    DNASUi 117289.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326965 ; ENSP00000322650 ; ENSG00000164691 . [Q8N103-2 ]
    ENST00000338313 ; ENSP00000340217 ; ENSG00000164691 . [Q8N103-4 ]
    ENST00000367066 ; ENSP00000356033 ; ENSG00000164691 . [Q8N103-1 ]
    GeneIDi 117289.
    KEGGi hsa:117289.
    UCSCi uc003qrz.3. human. [Q8N103-1 ]
    uc003qsb.3. human. [Q8N103-4 ]

    Organism-specific databases

    CTDi 117289.
    GeneCardsi GC06M159457.
    H-InvDB HIX0006337.
    HGNCi HGNC:15669. TAGAP.
    HPAi HPA031000.
    MIMi 609667. gene.
    neXtProti NX_Q8N103.
    PharmGKBi PA38016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282252.
    HOGENOMi HOG000139745.
    HOVERGENi HBG071607.
    InParanoidi Q8N103.
    OMAi KHSMSFS.
    OrthoDBi EOG7NCV2Q.
    PhylomeDBi Q8N103.
    TreeFami TF331062.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi TAGAP. human.
    GenomeRNAii 117289.
    NextBioi 80198.
    PROi Q8N103.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N103.
    CleanExi HS_TAGAP.
    Genevestigatori Q8N103.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    InterProi IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "T lymphocyte activation gene identification by coregulated expression on DNA microarrays."
      Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J., Schelter J.M., Dai H., He Y.D., Linsley P.S.
      Genomics 83:989-999(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
    2. "FKSG15, a novel 57 kDa protein, shares the N-terminal region with FOP."
      Wang Y.-G., Gong L.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Lung.

    Entry informationi

    Entry nameiTAGAP_HUMAN
    AccessioniPrimary (citable) accession number: Q8N103
    Secondary accession number(s): Q2NKM8
    , Q8NI40, Q96KZ2, Q96QA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3