Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tetratricopeptide repeat protein 5

Gene

TTC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136319-MONOMER.
ReactomeiR-HSA-6804760. Regulation of TP53 Activity through Methylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 5
Short name:
TPR repeat protein 5
Alternative name(s):
Stress-responsive activator of p300
Short name:
Strap
Gene namesi
Name:TTC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19274. TTC5.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi91875.
OpenTargetsiENSG00000136319.
PharmGKBiPA134919164.

Polymorphism and mutation databases

BioMutaiTTC5.
DMDMi229462802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063811 – 440Tetratricopeptide repeat protein 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N0Z6.
MaxQBiQ8N0Z6.
PaxDbiQ8N0Z6.
PeptideAtlasiQ8N0Z6.
PRIDEiQ8N0Z6.

PTM databases

iPTMnetiQ8N0Z6.
PhosphoSitePlusiQ8N0Z6.

Expressioni

Gene expression databases

BgeeiENSG00000136319.
CleanExiHS_TTC5.
ExpressionAtlasiQ8N0Z6. baseline and differential.
GenevisibleiQ8N0Z6. HS.

Organism-specific databases

HPAiHPA045008.
HPA054198.

Interactioni

Subunit structurei

Interacts with JMY and p300/EP300.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAMK2BQ135543EBI-9526213,EBI-1058722
CAMK2DQ135573EBI-9526213,EBI-351018

Protein-protein interaction databases

BioGridi124889. 34 interactors.
IntActiQ8N0Z6. 8 interactors.
STRINGi9606.ENSP00000258821.

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi262 – 280Combined sources19
Helixi281 – 283Combined sources3
Helixi286 – 294Combined sources9
Helixi298 – 304Combined sources7
Helixi324 – 326Combined sources3
Beta strandi329 – 331Combined sources3
Beta strandi335 – 345Combined sources11
Beta strandi352 – 362Combined sources11
Beta strandi365 – 369Combined sources5
Beta strandi383 – 388Combined sources6
Beta strandi390 – 398Combined sources9
Beta strandi401 – 411Combined sources11
Helixi413 – 415Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XVSX-ray1.80A261-424[»]
ProteinModelPortaliQ8N0Z6.
SMRiQ8N0Z6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N0Z6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 61TPR 1PROSITE-ProRule annotation1 PublicationAdd BLAST55
Repeati68 – 98TPR 2PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati103 – 130TPR 3PROSITE-ProRule annotation1 PublicationAdd BLAST28
Repeati136 – 174TPR 4PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati179 – 216TPR 5PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati224 – 253TPR 6PROSITE-ProRule annotation1 PublicationAdd BLAST30

Sequence similaritiesi

Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ8N0Z6.
OMAiAVMVYNM.
OrthoDBiEOG091G0ARR.
PhylomeDBiQ8N0Z6.
TreeFamiTF316804.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N0Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADEEEEVK PILQKLQELV DQLYSFRDCY FETHSVEDAG RKQQDVQKEM
60 70 80 90 100
EKTLQQMEEV VGSVQGKAQV LMLTGKALNV TPDYSPKAEE LLSKAVKLEP
110 120 130 140 150
ELVEAWNQLG EVYWKKGDVA AAHTCFSGAL THCRNKVSLQ NLSMVLRQLR
160 170 180 190 200
TDTEDEHSHH VMDSVRQAKL AVQMDVHDGR SWYILGNSYL SLYFSTGQNP
210 220 230 240 250
KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY GEALEGFSRA
260 270 280 290 300
AALDPAWPEP RQREQQLLEF LDRLTSLLES KGKVKTKKLQ SMLGSLRPAH
310 320 330 340 350
LGPCSDGHYQ SASGQKVTLE LKPLSTLQPG VNSGAVILGK VVFSLTTEEK
360 370 380 390 400
VPFTFGLVDS DGPCYAVMVY NIVQSWGVLI GDSVAIPEPN LRLHRIQHKG
410 420 430 440
KDYSFSSVRV ETPLLLVVNG KPQGSSSQAV ATVASRPQCE
Length:440
Mass (Da):48,928
Last modified:May 5, 2009 - v2
Checksum:iDB4505A217811BD0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03413114Q → H.Corresponds to variant rs34675160dbSNPEnsembl.1
Natural variantiVAR_05529347Q → R.2 PublicationsCorresponds to variant rs3742945dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074553 mRNA. Translation: BAC11056.1.
AL356019 Genomic DNA. No translation available.
BC008647 mRNA. Translation: AAH08647.1.
BC030822 mRNA. Translation: AAH30822.1.
BC053538 mRNA. Translation: AAH53538.1.
CCDSiCCDS9546.1.
RefSeqiNP_612385.2. NM_138376.2.
UniGeneiHs.98553.

Genome annotation databases

EnsembliENST00000258821; ENSP00000258821; ENSG00000136319.
GeneIDi91875.
KEGGihsa:91875.
UCSCiuc001vwt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074553 mRNA. Translation: BAC11056.1.
AL356019 Genomic DNA. No translation available.
BC008647 mRNA. Translation: AAH08647.1.
BC030822 mRNA. Translation: AAH30822.1.
BC053538 mRNA. Translation: AAH53538.1.
CCDSiCCDS9546.1.
RefSeqiNP_612385.2. NM_138376.2.
UniGeneiHs.98553.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XVSX-ray1.80A261-424[»]
ProteinModelPortaliQ8N0Z6.
SMRiQ8N0Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124889. 34 interactors.
IntActiQ8N0Z6. 8 interactors.
STRINGi9606.ENSP00000258821.

PTM databases

iPTMnetiQ8N0Z6.
PhosphoSitePlusiQ8N0Z6.

Polymorphism and mutation databases

BioMutaiTTC5.
DMDMi229462802.

Proteomic databases

EPDiQ8N0Z6.
MaxQBiQ8N0Z6.
PaxDbiQ8N0Z6.
PeptideAtlasiQ8N0Z6.
PRIDEiQ8N0Z6.

Protocols and materials databases

DNASUi91875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258821; ENSP00000258821; ENSG00000136319.
GeneIDi91875.
KEGGihsa:91875.
UCSCiuc001vwt.5. human.

Organism-specific databases

CTDi91875.
DisGeNETi91875.
GeneCardsiTTC5.
H-InvDBHIX0202086.
HGNCiHGNC:19274. TTC5.
HPAiHPA045008.
HPA054198.
neXtProtiNX_Q8N0Z6.
OpenTargetsiENSG00000136319.
PharmGKBiPA134919164.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ8N0Z6.
OMAiAVMVYNM.
OrthoDBiEOG091G0ARR.
PhylomeDBiQ8N0Z6.
TreeFamiTF316804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136319-MONOMER.
ReactomeiR-HSA-6804760. Regulation of TP53 Activity through Methylation.

Miscellaneous databases

EvolutionaryTraceiQ8N0Z6.
GenomeRNAii91875.
PROiQ8N0Z6.

Gene expression databases

BgeeiENSG00000136319.
CleanExiHS_TTC5.
ExpressionAtlasiQ8N0Z6. baseline and differential.
GenevisibleiQ8N0Z6. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC5_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Z6
Secondary accession number(s): A8MQ18, Q96HF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.