Q8N0Z6 (TTC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetratricopeptide repeat protein 5
Short name=TPR repeat protein 5

Alternative name(s):
Stress-responsive activator of p300
Short name=Strap

Gene names

Name:

TTC5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 By similarity.
Subunit structure	Interacts with JMY and p300/EP300 By similarity.
Subcellular location	Nucleus. Cytoplasm. Note: Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm By similarity.
Post-translational modification	Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300 By similarity.
Sequence similarities	Contains 6 TPR repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat TPR repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: Compara chromatin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 440

440

Tetratricopeptide repeat protein 5

PRO_0000106381

Regions

Repeat

7 – 61

55

TPR 1

Repeat

68 – 98

31

TPR 2

Repeat

103 – 130

28

TPR 3

Repeat

136 – 174

39

TPR 4

Repeat

179 – 216

38

TPR 5

Repeat

224 – 253

30

TPR 6

Amino acid modifications

Modified residue

203

1

Phosphoserine By similarity

Modified residue

221

1

Phosphoserine By similarity

Natural variations

Natural variant

14

1

Q → H.
Corresponds to variant rs34675160 [ dbSNP | Ensembl ].

VAR_034131

Natural variant

47

1

Q → R. Ref.1 Ref.3
Corresponds to variant rs3742945 [ dbSNP | Ensembl ].

VAR_055293

Secondary structure

1

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440

Helix Strand Turn

Details...

Helix

262 – 280

19

Helix

281 – 283

3

Helix

286 – 294

9

Helix

298 – 304

7

Helix

324 – 326

3

Beta strand

329 – 331

3

Beta strand

335 – 345

11

Beta strand

352 – 362

11

Beta strand

365 – 369

5

Beta strand

383 – 388

6

Beta strand

390 – 398

9

Beta strand

401 – 411

11

Helix

413 – 415

3

Sequences

	Sequence		Length	Mass (Da)
	Q8N0Z6 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: DB4505A217811BD0	FASTA	440	48,928
	10 20 30 40 50 60 MMADEEEEVK PILQKLQELV DQLYSFRDCY FETHSVEDAG RKQQDVQKEM EKTLQQMEEV 70 80 90 100 110 120 VGSVQGKAQV LMLTGKALNV TPDYSPKAEE LLSKAVKLEP ELVEAWNQLG EVYWKKGDVA 130 140 150 160 170 180 AAHTCFSGAL THCRNKVSLQ NLSMVLRQLR TDTEDEHSHH VMDSVRQAKL AVQMDVHDGR 190 200 210 220 230 240 SWYILGNSYL SLYFSTGQNP KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY 250 260 270 280 290 300 GEALEGFSRA AALDPAWPEP RQREQQLLEF LDRLTSLLES KGKVKTKKLQ SMLGSLRPAH 310 320 330 340 350 360 LGPCSDGHYQ SASGQKVTLE LKPLSTLQPG VNSGAVILGK VVFSLTTEEK VPFTFGLVDS 370 380 390 400 410 420 DGPCYAVMVY NIVQSWGVLI GDSVAIPEPN LRLHRIQHKG KDYSFSSVRV ETPLLLVVNG 430 440 KPQGSSSQAV ATVASRPQCE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-47. Tissue: Embryo.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-47. Tissue: Eye, Pancreas and Skin.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]	"The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure." Adams C.J., Pike A.C., Maniam S., Sharpe T.D., Coutts A.S., Knapp S., La Thangue N.B., Bullock A.N. Proc. Natl. Acad. Sci. U.S.A. 109:3778-3783(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 261-424, TPR REPEATS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK074553 mRNA. Translation: BAC11056.1.
AL356019 Genomic DNA. No translation available.
BC008647 mRNA. Translation: AAH08647.1.
BC030822 mRNA. Translation: AAH30822.1.
BC053538 mRNA. Translation: AAH53538.1.

IPI

IPI00166123.

RefSeq

NP_612385.2. NM_138376.2.

UniGene

Hs.98553.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2XVS	X-ray	1.80	A	261-424	[»]

ProteinModelPortal

Q8N0Z6.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000258821.

PTM databases

PhosphoSite

Q8N0Z6.

Polymorphism databases

DMDM

229462802.

Proteomic databases

PaxDb

Q8N0Z6.

PRIDE

Q8N0Z6.

Protocols and materials databases

DNASU

91875.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000258821; ENSP00000258821; ENSG00000136319.

GeneID

91875.

KEGG

hsa:91875.

UCSC

uc001vwt.3. human.

Organism-specific databases

CTD

91875.

GeneCards

GC14M020757.

H-InvDB

HIX0202086.

HGNC

HGNC:19274. TTC5.

HPA

HPA045008.

neXtProt

NX_Q8N0Z6.

PharmGKB

PA134919164.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG83672.

HOGENOM

HOG000006922.

HOVERGEN

HBG054388.

InParanoid

Q8N0Z6.

OMA

GKDYSFS.

PhylomeDB

Q8N0Z6.

Gene expression databases

ArrayExpress

Q8N0Z6.

Bgee

Q8N0Z6.

CleanEx

HS_TTC5.

Genevestigator

Q8N0Z6.

GermOnline

ENSG00000136319. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.10. 2 hits.

InterPro

IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]

Pfam

PF07719. TPR_2. 1 hit.
[Graphical view]

PROSITE

PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8N0Z6.

GenomeRNAi

91875.

NextBio

77508.

Entry information

Entry name

TTC5_HUMAN

Accession

Primary (citable) accession number: Q8N0Z6
Secondary accession number(s): A8MQ18, Q96HF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.