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Protein

Tetratricopeptide repeat protein 5

Gene

TTC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-HSA-6804760. Regulation of TP53 Activity through Methylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 5
Short name:
TPR repeat protein 5
Alternative name(s):
Stress-responsive activator of p300
Short name:
Strap
Gene namesi
Name:TTC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19274. TTC5.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919164.

Polymorphism and mutation databases

BioMutaiTTC5.
DMDMi229462802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Tetratricopeptide repeat protein 5PRO_0000106381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031PhosphoserineBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N0Z6.
MaxQBiQ8N0Z6.
PaxDbiQ8N0Z6.
PRIDEiQ8N0Z6.

PTM databases

iPTMnetiQ8N0Z6.
PhosphoSiteiQ8N0Z6.

Expressioni

Gene expression databases

BgeeiQ8N0Z6.
CleanExiHS_TTC5.
ExpressionAtlasiQ8N0Z6. baseline and differential.
GenevisibleiQ8N0Z6. HS.

Organism-specific databases

HPAiHPA045008.
HPA054198.

Interactioni

Subunit structurei

Interacts with JMY and p300/EP300.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAMK2BQ135543EBI-9526213,EBI-1058722
CAMK2DQ135573EBI-9526213,EBI-351018

Protein-protein interaction databases

BioGridi124889. 34 interactions.
IntActiQ8N0Z6. 4 interactions.
STRINGi9606.ENSP00000258821.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi262 – 28019Combined sources
Helixi281 – 2833Combined sources
Helixi286 – 2949Combined sources
Helixi298 – 3047Combined sources
Helixi324 – 3263Combined sources
Beta strandi329 – 3313Combined sources
Beta strandi335 – 34511Combined sources
Beta strandi352 – 36211Combined sources
Beta strandi365 – 3695Combined sources
Beta strandi383 – 3886Combined sources
Beta strandi390 – 3989Combined sources
Beta strandi401 – 41111Combined sources
Helixi413 – 4153Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XVSX-ray1.80A261-424[»]
ProteinModelPortaliQ8N0Z6.
SMRiQ8N0Z6. Positions 1-429.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N0Z6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 6155TPR 1PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati68 – 9831TPR 2PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati103 – 13028TPR 3PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati136 – 17439TPR 4PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati179 – 21638TPR 5PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati224 – 25330TPR 6PROSITE-ProRule annotation1 PublicationAdd
BLAST

Sequence similaritiesi

Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ8N0Z6.
OMAiAVMVYNM.
OrthoDBiEOG79SDXP.
PhylomeDBiQ8N0Z6.
TreeFamiTF316804.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N0Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADEEEEVK PILQKLQELV DQLYSFRDCY FETHSVEDAG RKQQDVQKEM
60 70 80 90 100
EKTLQQMEEV VGSVQGKAQV LMLTGKALNV TPDYSPKAEE LLSKAVKLEP
110 120 130 140 150
ELVEAWNQLG EVYWKKGDVA AAHTCFSGAL THCRNKVSLQ NLSMVLRQLR
160 170 180 190 200
TDTEDEHSHH VMDSVRQAKL AVQMDVHDGR SWYILGNSYL SLYFSTGQNP
210 220 230 240 250
KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY GEALEGFSRA
260 270 280 290 300
AALDPAWPEP RQREQQLLEF LDRLTSLLES KGKVKTKKLQ SMLGSLRPAH
310 320 330 340 350
LGPCSDGHYQ SASGQKVTLE LKPLSTLQPG VNSGAVILGK VVFSLTTEEK
360 370 380 390 400
VPFTFGLVDS DGPCYAVMVY NIVQSWGVLI GDSVAIPEPN LRLHRIQHKG
410 420 430 440
KDYSFSSVRV ETPLLLVVNG KPQGSSSQAV ATVASRPQCE
Length:440
Mass (Da):48,928
Last modified:May 5, 2009 - v2
Checksum:iDB4505A217811BD0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141Q → H.
Corresponds to variant rs34675160 [ dbSNP | Ensembl ].
VAR_034131
Natural varianti47 – 471Q → R.2 Publications
Corresponds to variant rs3742945 [ dbSNP | Ensembl ].
VAR_055293

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074553 mRNA. Translation: BAC11056.1.
AL356019 Genomic DNA. No translation available.
BC008647 mRNA. Translation: AAH08647.1.
BC030822 mRNA. Translation: AAH30822.1.
BC053538 mRNA. Translation: AAH53538.1.
CCDSiCCDS9546.1.
RefSeqiNP_612385.2. NM_138376.2.
UniGeneiHs.98553.

Genome annotation databases

EnsembliENST00000258821; ENSP00000258821; ENSG00000136319.
GeneIDi91875.
KEGGihsa:91875.
UCSCiuc001vwt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074553 mRNA. Translation: BAC11056.1.
AL356019 Genomic DNA. No translation available.
BC008647 mRNA. Translation: AAH08647.1.
BC030822 mRNA. Translation: AAH30822.1.
BC053538 mRNA. Translation: AAH53538.1.
CCDSiCCDS9546.1.
RefSeqiNP_612385.2. NM_138376.2.
UniGeneiHs.98553.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XVSX-ray1.80A261-424[»]
ProteinModelPortaliQ8N0Z6.
SMRiQ8N0Z6. Positions 1-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124889. 34 interactions.
IntActiQ8N0Z6. 4 interactions.
STRINGi9606.ENSP00000258821.

PTM databases

iPTMnetiQ8N0Z6.
PhosphoSiteiQ8N0Z6.

Polymorphism and mutation databases

BioMutaiTTC5.
DMDMi229462802.

Proteomic databases

EPDiQ8N0Z6.
MaxQBiQ8N0Z6.
PaxDbiQ8N0Z6.
PRIDEiQ8N0Z6.

Protocols and materials databases

DNASUi91875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258821; ENSP00000258821; ENSG00000136319.
GeneIDi91875.
KEGGihsa:91875.
UCSCiuc001vwt.5. human.

Organism-specific databases

CTDi91875.
GeneCardsiTTC5.
H-InvDBHIX0202086.
HGNCiHGNC:19274. TTC5.
HPAiHPA045008.
HPA054198.
neXtProtiNX_Q8N0Z6.
PharmGKBiPA134919164.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ8N0Z6.
OMAiAVMVYNM.
OrthoDBiEOG79SDXP.
PhylomeDBiQ8N0Z6.
TreeFamiTF316804.

Enzyme and pathway databases

ReactomeiR-HSA-6804760. Regulation of TP53 Activity through Methylation.

Miscellaneous databases

EvolutionaryTraceiQ8N0Z6.
GenomeRNAii91875.
PROiQ8N0Z6.

Gene expression databases

BgeeiQ8N0Z6.
CleanExiHS_TTC5.
ExpressionAtlasiQ8N0Z6. baseline and differential.
GenevisibleiQ8N0Z6. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-47.
    Tissue: Embryo.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-47.
    Tissue: Eye, Pancreas and Skin.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure."
    Adams C.J., Pike A.C., Maniam S., Sharpe T.D., Coutts A.S., Knapp S., La Thangue N.B., Bullock A.N.
    Proc. Natl. Acad. Sci. U.S.A. 109:3778-3783(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 261-424, TPR REPEATS.

Entry informationi

Entry nameiTTC5_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Z6
Secondary accession number(s): A8MQ18, Q96HF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.