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Protein

Spindle and centriole-associated protein 1

Gene

SPICE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • metaphase plate congression Source: UniProtKB
  • mitotic spindle assembly Source: UniProtKB
  • regulation of centriole replication Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163611-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Spindle and centriole-associated protein 1
Alternative name(s):
Coiled-coil domain-containing protein 52
Spindle and centriole-associated protein
Gene namesi
Name:SPICE1
Synonyms:CCDC52, SPICE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25083. SPICE1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163611.
PharmGKBiPA142672168.

Polymorphism and mutation databases

BioMutaiSPICE1.
DMDMi74728478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002824131 – 855Spindle and centriole-associated protein 1Add BLAST855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235PhosphothreonineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei819PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N0Z3.
MaxQBiQ8N0Z3.
PaxDbiQ8N0Z3.
PeptideAtlasiQ8N0Z3.
PRIDEiQ8N0Z3.

PTM databases

iPTMnetiQ8N0Z3.
PhosphoSitePlusiQ8N0Z3.

Expressioni

Gene expression databases

BgeeiENSG00000163611.
CleanExiHS_CCDC52.
ExpressionAtlasiQ8N0Z3. baseline and differential.
GenevisibleiQ8N0Z3. HS.

Organism-specific databases

HPAiHPA064843.

Interactioni

Subunit structurei

Interacts with CEP120.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP135Q66GS94EBI-2361917,EBI-1046993

Protein-protein interaction databases

BioGridi127433. 162 interactors.
IntActiQ8N0Z3. 155 interactors.
MINTiMINT-4994846.
STRINGi9606.ENSP00000295872.

Structurei

3D structure databases

ProteinModelPortaliQ8N0Z3.
SMRiQ8N0Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili325 – 437Sequence analysisAdd BLAST113
Coiled coili725 – 751Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJW0. Eukaryota.
ENOG410YWRG. LUCA.
GeneTreeiENSGT00390000006207.
HOGENOMiHOG000111420.
HOVERGENiHBG102011.
InParanoidiQ8N0Z3.
KOiK16490.
OMAiDQYQMQD.
OrthoDBiEOG091G0M0K.
PhylomeDBiQ8N0Z3.
TreeFamiTF333301.

Family and domain databases

InterProiIPR031387. SPICE1.
[Graphical view]
PfamiPF15678. SPICE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N0Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVRVNRCG PRVGVRKTPK VKKKKTSVKQ EWDNTVTDLT VHRATPEDLV
60 70 80 90 100
RRHEIHKSKN RALVHWELQE KALKRKWRKQ KPETLNLEKR RLSIMKEILS
110 120 130 140 150
DQYQMQDVLE KSDHLIAAAK ELFPRRRTGF PNVTVAPDSS QGPIVVNQDP
160 170 180 190 200
ITQSIFNESV IEPQALNDVD GEEEGTVNSQ SGESENENEL DNSLNSQSNT
210 220 230 240 250
NTDRFLQQLT EENFELISKL WTDIQQKIAT QSQITPPGTP SSALSSGEQR
260 270 280 290 300
AALNATNAVK RLQTRLQPEE STETLDSSYV VGHVLNSRKQ KQLLNKVKRK
310 320 330 340 350
PNLHALSKPK KNISSGSTTS ADLPNRTNSN LDVLKHMIHE VEHEMEEYER
360 370 380 390 400
WTGREVKGLQ SSQGLTGFTL SLVSSLCRLV RYLKESEIQL RKEVETRQQL
410 420 430 440 450
EQVLGDHREL IDALTAEILR LREENAATQA RLQQYMVTTD EQLISLTHAI
460 470 480 490 500
KNCPVINNRQ EIQASESGAT GRRVMDSPER PVVNANVSVP LMFREEVAEF
510 520 530 540 550
PQEELPVKLS QVPDPPDNMN LAKNFPAHIF EPAVLLTPPR QKSNLKFSPL
560 570 580 590 600
QDVLRRTVQT RPAPRLPPTV EIIEKEQNWE EKTLPIDTDI QNSSEENRLF
610 620 630 640 650
TQRWRVSHMG EDLENKTQAP FVNLSQPLCN SHSNTQQSRS PTFSEELPVL
660 670 680 690 700
GDGQQLRTNE SLIQRKDIMT RIADLTLQNS AIKAHMNNII EPRGEQGDGL
710 720 730 740 750
RELNKQESAS DMTSTFPVAQ SLTPGSMEER IAELNRQSME ARGKLLQLIE
760 770 780 790 800
QQKLVGLNLS PPMSPVQLPL RAWTEGAKRT IEVSIPGAEA PESSKCSTVS
810 820 830 840 850
PVSGINTRRS SGATGNSCSP LNATSGSGRF TPLNPRAKIE KQNEEGWFAL

STHVS
Length:855
Mass (Da):96,264
Last modified:October 1, 2002 - v1
Checksum:iAAA88E1E220DF400
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti739M → G in AAH19232 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050756275L → V.Corresponds to variant rs16861032dbSNPEnsembl.1
Natural variantiVAR_050757472R → G.Corresponds to variant rs7614751dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099107 mRNA. Translation: AAM34495.1.
AL832148 mRNA. Translation: CAD91167.1.
CH471052 Genomic DNA. Translation: EAW79634.1.
CH471052 Genomic DNA. Translation: EAW79636.1.
CH471052 Genomic DNA. Translation: EAW79637.1.
BC019232 mRNA. Translation: AAH19232.1.
BC036951 mRNA. Translation: AAH36951.1.
CCDSiCCDS2973.1.
RefSeqiNP_653319.1. NM_144718.3.
XP_016861267.1. XM_017005778.1.
UniGeneiHs.477144.

Genome annotation databases

EnsembliENST00000295872; ENSP00000295872; ENSG00000163611.
GeneIDi152185.
KEGGihsa:152185.
UCSCiuc003eag.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099107 mRNA. Translation: AAM34495.1.
AL832148 mRNA. Translation: CAD91167.1.
CH471052 Genomic DNA. Translation: EAW79634.1.
CH471052 Genomic DNA. Translation: EAW79636.1.
CH471052 Genomic DNA. Translation: EAW79637.1.
BC019232 mRNA. Translation: AAH19232.1.
BC036951 mRNA. Translation: AAH36951.1.
CCDSiCCDS2973.1.
RefSeqiNP_653319.1. NM_144718.3.
XP_016861267.1. XM_017005778.1.
UniGeneiHs.477144.

3D structure databases

ProteinModelPortaliQ8N0Z3.
SMRiQ8N0Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127433. 162 interactors.
IntActiQ8N0Z3. 155 interactors.
MINTiMINT-4994846.
STRINGi9606.ENSP00000295872.

PTM databases

iPTMnetiQ8N0Z3.
PhosphoSitePlusiQ8N0Z3.

Polymorphism and mutation databases

BioMutaiSPICE1.
DMDMi74728478.

Proteomic databases

EPDiQ8N0Z3.
MaxQBiQ8N0Z3.
PaxDbiQ8N0Z3.
PeptideAtlasiQ8N0Z3.
PRIDEiQ8N0Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295872; ENSP00000295872; ENSG00000163611.
GeneIDi152185.
KEGGihsa:152185.
UCSCiuc003eag.5. human.

Organism-specific databases

CTDi152185.
GeneCardsiSPICE1.
HGNCiHGNC:25083. SPICE1.
HPAiHPA064843.
MIMi613447. gene.
neXtProtiNX_Q8N0Z3.
OpenTargetsiENSG00000163611.
PharmGKBiPA142672168.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJW0. Eukaryota.
ENOG410YWRG. LUCA.
GeneTreeiENSGT00390000006207.
HOGENOMiHOG000111420.
HOVERGENiHBG102011.
InParanoidiQ8N0Z3.
KOiK16490.
OMAiDQYQMQD.
OrthoDBiEOG091G0M0K.
PhylomeDBiQ8N0Z3.
TreeFamiTF333301.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163611-MONOMER.

Miscellaneous databases

GenomeRNAii152185.
PROiQ8N0Z3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163611.
CleanExiHS_CCDC52.
ExpressionAtlasiQ8N0Z3. baseline and differential.
GenevisibleiQ8N0Z3. HS.

Family and domain databases

InterProiIPR031387. SPICE1.
[Graphical view]
PfamiPF15678. SPICE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPICE_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Z3
Secondary accession number(s): D3DN72, Q8WUX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.