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Q8N0Z2

- ABRA_HUMAN

UniProt

Q8N0Z2 - ABRA_HUMAN

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Protein

Actin-binding Rho-activating protein

Gene

ABRA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.By similarity

GO - Molecular functioni

  1. actin binding Source: HGNC
  2. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. positive regulation of Rho protein signal transduction Source: HGNC
  2. positive regulation of sequence-specific DNA binding transcription factor activity Source: HGNC
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. protein import into nucleus, translocation Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Protein transport, Transcription, Transcription regulation, Translocation, Transport

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding Rho-activating protein
Alternative name(s):
Striated muscle activator of Rho-dependent signaling
Short name:
STARS
Gene namesi
Name:ABRAImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:30655. ABRA.

Subcellular locationi

Cytoplasmmyofibrilsarcomere By similarity. Cytoplasmcytoskeleton By similarity
Note: Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines.By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: HGNC
  2. plasma membrane Source: LIFEdb
  3. sarcomere Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Actin-binding Rho-activating proteinPRO_0000247739Add
BLAST

Proteomic databases

PaxDbiQ8N0Z2.
PRIDEiQ8N0Z2.

PTM databases

PhosphoSiteiQ8N0Z2.

Expressioni

Gene expression databases

BgeeiQ8N0Z2.
CleanExiHS_ABRA.
GenevestigatoriQ8N0Z2.

Organism-specific databases

HPAiHPA017724.

Interactioni

Subunit structurei

Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity By similarity.By similarity

Protein-protein interaction databases

BioGridi126483. 4 interactions.
IntActiQ8N0Z2. 2 interactions.
STRINGi9606.ENSP00000311436.

Structurei

3D structure databases

ProteinModelPortaliQ8N0Z2.
SMRiQ8N0Z2. Positions 301-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 299101Actin-binding 1By similarityAdd
BLAST
Regioni240 – 28546Interaction with actinBy similarityAdd
BLAST
Regioni300 – 38182Actin-binding 2By similarityAdd
BLAST
Regioni352 – 38130Interaction with actinBy similarityAdd
BLAST

Domaini

The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2.By similarity

Phylogenomic databases

eggNOGiNOG327934.
GeneTreeiENSGT00390000015984.
HOGENOMiHOG000033774.
HOVERGENiHBG060846.
InParanoidiQ8N0Z2.
OMAiDMCFIIR.
OrthoDBiEOG7PGDTD.
PhylomeDBiQ8N0Z2.
TreeFamiTF328879.

Family and domain databases

InterProiIPR026111. Abra.
IPR027817. Costars_dom.
[Graphical view]
PANTHERiPTHR22739:SF7. PTHR22739:SF7. 1 hit.
PfamiPF14705. Costars. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N0Z2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPGEKESGE GPAKSALRKI RTATLVISLA RGWQQWANEN SIRQAQEPTG
60 70 80 90 100
WLPGGTQDSP QAPKPITPPT SHQKAQSAPK SPPRLPEGHG DGQSSEKAPE
110 120 130 140 150
VSHIKKKEVS KTVVSKTYER GGDVSHLSHR YERDAGVLEP GQPENDIDRI
160 170 180 190 200
LHSHGSPTRR RKCANLVSEL TKGWRVMEQE EPTWRSDSVD TEDSGYGGEA
210 220 230 240 250
EERPEQDGVQ VAVVRIKRPL PSQVNRFTEK LNCKAQQKYS PVGNLKGRWQ
260 270 280 290 300
QWADEHIQSQ KLNPFSEEFD YELAMSTRLH KGDEGYGRPK EGTKTAERAK
310 320 330 340 350
RAEEHIYREM MDMCFIICTM ARHRRDGKIQ VTFGDLFDRY VRISDKVVGI
360 370 380
LMRARKHGLV DFEGEMLWQG RDDHVVITLL K
Length:381
Mass (Da):43,117
Last modified:October 1, 2002 - v1
Checksum:iAC5B8D4D9A267C46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503617 mRNA. Translation: AAM27268.1.
AK092694 mRNA. Translation: BAC03948.1.
AL833422 mRNA. No translation available.
BC105103 mRNA. Translation: AAI05104.1.
BC105105 mRNA. Translation: AAI05106.1.
CCDSiCCDS6305.1.
RefSeqiNP_631905.1. NM_139166.4.
UniGeneiHs.374668.

Genome annotation databases

EnsembliENST00000311955; ENSP00000311436; ENSG00000174429.
GeneIDi137735.
KEGGihsa:137735.
UCSCiuc003ymm.4. human.

Polymorphism databases

DMDMi74728477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503617 mRNA. Translation: AAM27268.1 .
AK092694 mRNA. Translation: BAC03948.1 .
AL833422 mRNA. No translation available.
BC105103 mRNA. Translation: AAI05104.1 .
BC105105 mRNA. Translation: AAI05106.1 .
CCDSi CCDS6305.1.
RefSeqi NP_631905.1. NM_139166.4.
UniGenei Hs.374668.

3D structure databases

ProteinModelPortali Q8N0Z2.
SMRi Q8N0Z2. Positions 301-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126483. 4 interactions.
IntActi Q8N0Z2. 2 interactions.
STRINGi 9606.ENSP00000311436.

PTM databases

PhosphoSitei Q8N0Z2.

Polymorphism databases

DMDMi 74728477.

Proteomic databases

PaxDbi Q8N0Z2.
PRIDEi Q8N0Z2.

Protocols and materials databases

DNASUi 137735.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311955 ; ENSP00000311436 ; ENSG00000174429 .
GeneIDi 137735.
KEGGi hsa:137735.
UCSCi uc003ymm.4. human.

Organism-specific databases

CTDi 137735.
GeneCardsi GC08M107841.
HGNCi HGNC:30655. ABRA.
HPAi HPA017724.
MIMi 609747. gene.
neXtProti NX_Q8N0Z2.
PharmGKBi PA143485290.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327934.
GeneTreei ENSGT00390000015984.
HOGENOMi HOG000033774.
HOVERGENi HBG060846.
InParanoidi Q8N0Z2.
OMAi DMCFIIR.
OrthoDBi EOG7PGDTD.
PhylomeDBi Q8N0Z2.
TreeFami TF328879.

Miscellaneous databases

GeneWikii ABRA_(gene).
GenomeRNAii 137735.
NextBioi 83667.
PROi Q8N0Z2.
SOURCEi Search...

Gene expression databases

Bgeei Q8N0Z2.
CleanExi HS_ABRA.
Genevestigatori Q8N0Z2.

Family and domain databases

InterProi IPR026111. Abra.
IPR027817. Costars_dom.
[Graphical view ]
PANTHERi PTHR22739:SF7. PTHR22739:SF7. 1 hit.
Pfami PF14705. Costars. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription."
    Arai A., Spencer J.A., Olson E.N.
    J. Biol. Chem. 277:24453-24459(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscleImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiABRA_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3