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Protein

Actin-binding Rho-activating protein

Gene

ABRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Activator
Biological processProtein transport, Transcription, Transcription regulation, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding Rho-activating protein
Alternative name(s):
Striated muscle activator of Rho-dependent signaling
Short name:
STARS
Gene namesi
Name:ABRAImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000174429.3
HGNCiHGNC:30655 ABRA
MIMi609747 gene
neXtProtiNX_Q8N0Z2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi137735
OpenTargetsiENSG00000174429
PharmGKBiPA143485290

Polymorphism and mutation databases

BioMutaiABRA
DMDMi74728477

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002477391 – 381Actin-binding Rho-activating proteinAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156PhosphoserineBy similarity1
Modified residuei188PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N0Z2
PeptideAtlasiQ8N0Z2
PRIDEiQ8N0Z2

PTM databases

iPTMnetiQ8N0Z2
PhosphoSitePlusiQ8N0Z2

Expressioni

Gene expression databases

BgeeiENSG00000174429
CleanExiHS_ABRA
GenevisibleiQ8N0Z2 HS

Organism-specific databases

HPAiHPA017724

Interactioni

Subunit structurei

Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126483, 4 interactors
IntActiQ8N0Z2, 2 interactors
STRINGi9606.ENSP00000311436

Structurei

3D structure databases

ProteinModelPortaliQ8N0Z2
SMRiQ8N0Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 299Actin-binding 1By similarityAdd BLAST101
Regioni240 – 285Interaction with actinBy similarityAdd BLAST46
Regioni300 – 381Actin-binding 2By similarityAdd BLAST82
Regioni352 – 381Interaction with actinBy similarityAdd BLAST30

Domaini

The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2.By similarity

Phylogenomic databases

eggNOGiKOG3376 Eukaryota
ENOG410XR7V LUCA
GeneTreeiENSGT00390000015984
HOGENOMiHOG000033774
HOVERGENiHBG060846
InParanoidiQ8N0Z2
OMAiARGWQQW
OrthoDBiEOG091G0OKB
PhylomeDBiQ8N0Z2
TreeFamiTF328879

Family and domain databases

Gene3Di1.10.10.1540, 1 hit
InterProiView protein in InterPro
IPR026111 Abra
IPR027817 Costars_dom
IPR038095 Costars_sf
PANTHERiPTHR22739:SF20 PTHR22739:SF20, 1 hit
PfamiView protein in Pfam
PF14705 Costars, 1 hit
SMARTiView protein in SMART
SM01283 Costars, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N0Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGEKESGE GPAKSALRKI RTATLVISLA RGWQQWANEN SIRQAQEPTG
60 70 80 90 100
WLPGGTQDSP QAPKPITPPT SHQKAQSAPK SPPRLPEGHG DGQSSEKAPE
110 120 130 140 150
VSHIKKKEVS KTVVSKTYER GGDVSHLSHR YERDAGVLEP GQPENDIDRI
160 170 180 190 200
LHSHGSPTRR RKCANLVSEL TKGWRVMEQE EPTWRSDSVD TEDSGYGGEA
210 220 230 240 250
EERPEQDGVQ VAVVRIKRPL PSQVNRFTEK LNCKAQQKYS PVGNLKGRWQ
260 270 280 290 300
QWADEHIQSQ KLNPFSEEFD YELAMSTRLH KGDEGYGRPK EGTKTAERAK
310 320 330 340 350
RAEEHIYREM MDMCFIICTM ARHRRDGKIQ VTFGDLFDRY VRISDKVVGI
360 370 380
LMRARKHGLV DFEGEMLWQG RDDHVVITLL K
Length:381
Mass (Da):43,117
Last modified:October 1, 2002 - v1
Checksum:iAC5B8D4D9A267C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503617 mRNA Translation: AAM27268.1
AK092694 mRNA Translation: BAC03948.1
AL833422 mRNA No translation available.
BC105103 mRNA Translation: AAI05104.1
BC105105 mRNA Translation: AAI05106.1
CCDSiCCDS6305.1
RefSeqiNP_631905.1, NM_139166.4
UniGeneiHs.374668

Genome annotation databases

EnsembliENST00000311955; ENSP00000311436; ENSG00000174429
GeneIDi137735
KEGGihsa:137735
UCSCiuc003ymm.5 human

Similar proteinsi

Entry informationi

Entry nameiABRA_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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