Q8N0Z2 (ABRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-binding Rho-activating protein

Alternative name(s):
Striated muscle activator of Rho-dependent signaling
Short name=STARS

Gene names

Name:

ABRA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling By similarity. UniProtKB Q8BUZ1
Subunit structure	Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity By similarity.
Subcellular location	Cytoplasm › myofibril › sarcomere By similarity. Cytoplasm › cytoskeleton By similarity. Note: Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines By similarity.
Domain	The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2 By similarity.

Ontologies

Keywords
Biological process	Protein transport Transcription Transcription regulation Translocation Transport
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of Rho protein signal transduction Inferred from sequence or structural similarity. Source: HGNC positive regulation of sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: HGNC positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	actin cytoskeleton Inferred from sequence or structural similarity. Source: HGNC plasma membrane Inferred from direct assay. Source: LIFEdb sarcomere Inferred from sequence or structural similarity. Source: HGNC
Molecular_function	actin binding Inferred from sequence or structural similarity. Source: HGNC transcription coactivator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Actin-binding Rho-activating protein		PRO_0000247739
Regions
	Region	199 – 299	101	Actin-binding 1 By similarity
	Region	240 – 285	46	Interaction with actin By similarity UniProtKB Q8BUZ1
	Region	300 – 381	82	Actin-binding 2 By similarity
	Region	352 – 381	30	Interaction with actin By similarity UniProtKB Q8BUZ1

Sequences

	Sequence		Length	Mass (Da)
	Q8N0Z2 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: AC5B8D4D9A267C46	FASTA	381	43,117
	10 20 30 40 50 60 MAPGEKESGE GPAKSALRKI RTATLVISLA RGWQQWANEN SIRQAQEPTG WLPGGTQDSP 70 80 90 100 110 120 QAPKPITPPT SHQKAQSAPK SPPRLPEGHG DGQSSEKAPE VSHIKKKEVS KTVVSKTYER 130 140 150 160 170 180 GGDVSHLSHR YERDAGVLEP GQPENDIDRI LHSHGSPTRR RKCANLVSEL TKGWRVMEQE 190 200 210 220 230 240 EPTWRSDSVD TEDSGYGGEA EERPEQDGVQ VAVVRIKRPL PSQVNRFTEK LNCKAQQKYS 250 260 270 280 290 300 PVGNLKGRWQ QWADEHIQSQ KLNPFSEEFD YELAMSTRLH KGDEGYGRPK EGTKTAERAK 310 320 330 340 350 360 RAEEHIYREM MDMCFIICTM ARHRRDGKIQ VTFGDLFDRY VRISDKVVGI LMRARKHGLV 370 380 DFEGEMLWQG RDDHVVITLL K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription." Arai A., Spencer J.A., Olson E.N. J. Biol. Chem. 277:24453-24459(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF503617 mRNA. Translation: AAM27268.1. AK092694 mRNA. Translation: BAC03948.1. AL833422 mRNA. No translation available. BC105103 mRNA. Translation: AAI05104.1. BC105105 mRNA. Translation: AAI05106.1.
IPI	IPI00166119.
RefSeq	NP_631905.1. NM_139166.4.
UniGene	Hs.374668.
3D structure databases
ProteinModelPortal	Q8N0Z2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N0Z2. 2 interactions.
STRING	9606.ENSP00000311436.
PTM databases
PhosphoSite	Q8N0Z2.
Polymorphism databases
DMDM	74728477.
Proteomic databases
PaxDb	Q8N0Z2.
PRIDE	Q8N0Z2.
Protocols and materials databases
DNASU	137735.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311955; ENSP00000311436; ENSG00000174429.
GeneID	137735.
KEGG	hsa:137735.
UCSC	uc003ymm.4. human.
Organism-specific databases
CTD	137735.
GeneCards	GC08M107841.
HGNC	HGNC:30655. ABRA.
HPA	HPA017724.
MIM	609747. gene.
neXtProt	NX_Q8N0Z2.
PharmGKB	PA143485290.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327934.
HOGENOM	HOG000033774.
HOVERGEN	HBG060846.
InParanoid	Q8N0Z2.
OMA	INLARGW.
OrthoDB	EOG4NVZKT.
PhylomeDB	Q8N0Z2.
Gene expression databases
Bgee	Q8N0Z2.
CleanEx	HS_ABRA.
Genevestigator	Q8N0Z2.
GermOnline	ENSG00000174429. Homo sapiens.
Family and domain databases
InterPro	IPR026111. Abra. [Graphical view]
PANTHER	PTHR22739:SF0. PTHR22739:SF0. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	137735.
NextBio	83667.
SOURCE	Search...

Entry information

Entry name

ABRA_HUMAN

Accession

Primary (citable) accession number: Q8N0Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.