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Q8N0Z2 (ABRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-binding Rho-activating protein
Alternative name(s):
Striated muscle activator of Rho-dependent signaling
Short name=STARS
Gene names
Name:ABRA
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling By similarity. UniProtKB Q8BUZ1

Subunit structure

Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity By similarity.

Subcellular location

Cytoplasm › myofibril › sarcomere By similarity. Cytoplasm › cytoskeleton By similarity. Note: Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Actin-binding Rho-activating protein
PRO_0000247739

Regions

Region240 – 28546Interaction with actin By similarity UniProtKB Q8BUZ1
Region352 – 38130Interaction with actin By similarity UniProtKB Q8BUZ1

Sequences

Sequence LengthMass (Da)Tools
Q8N0Z2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: AC5B8D4D9A267C46

FASTA38143,117
        10         20         30         40         50         60 
MAPGEKESGE GPAKSALRKI RTATLVISLA RGWQQWANEN SIRQAQEPTG WLPGGTQDSP 

        70         80         90        100        110        120 
QAPKPITPPT SHQKAQSAPK SPPRLPEGHG DGQSSEKAPE VSHIKKKEVS KTVVSKTYER 

       130        140        150        160        170        180 
GGDVSHLSHR YERDAGVLEP GQPENDIDRI LHSHGSPTRR RKCANLVSEL TKGWRVMEQE 

       190        200        210        220        230        240 
EPTWRSDSVD TEDSGYGGEA EERPEQDGVQ VAVVRIKRPL PSQVNRFTEK LNCKAQQKYS 

       250        260        270        280        290        300 
PVGNLKGRWQ QWADEHIQSQ KLNPFSEEFD YELAMSTRLH KGDEGYGRPK EGTKTAERAK 

       310        320        330        340        350        360 
RAEEHIYREM MDMCFIICTM ARHRRDGKIQ VTFGDLFDRY VRISDKVVGI LMRARKHGLV 

       370        380 
DFEGEMLWQG RDDHVVITLL K

« Hide

References

« Hide 'large scale' references
[1]"STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription."
Arai A., Spencer J.A., Olson E.N.
J. Biol. Chem. 277:24453-24459(2002) [PubMed: 11983702] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF503617 mRNA. Translation: AAM27268.1.
AK092694 mRNA. Translation: BAC03948.1.
AL833422 mRNA. No translation available.
BC105103 mRNA. Translation: AAI05104.1.
BC105105 mRNA. Translation: AAI05106.1.
IPIIPI00166119.
RefSeqNP_631905.1. NM_139166.4.
UniGeneHs.374668.

3D structure databases

ProteinModelPortalQ8N0Z2.
SMRQ8N0Z2. Positions 301-381.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8N0Z2. 1 interaction.
STRINGQ8N0Z2.

PTM databases

PhosphoSiteQ8N0Z2.

Polymorphism databases

DMDM74728477.

Proteomic databases

PRIDEQ8N0Z2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311955; ENSP00000311436; ENSG00000174429.
GeneID137735.
KEGGhsa:137735.
UCSCuc003ymm.2. human.

Organism-specific databases

CTD137735.
GeneCardsGC08M107841.
H-InvDBHIX0007719.
HGNCHGNC:30655. ABRA.
HPAHPA017724.
MIM609747. gene.
neXtProtNX_Q8N0Z2.
PharmGKBPA143485290.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG17769.
GeneTreeENSGT00390000015984.
HOGENOMHBG446674.
HOVERGENHBG060846.
InParanoidQ8N0Z2.
OMADMCFIIR.
OrthoDBEOG4NVZKT.
PhylomeDBQ8N0Z2.

Gene expression databases

ArrayExpressQ8N0Z2.
BgeeQ8N0Z2.
CleanExHS_ABRA.
GenevestigatorQ8N0Z2.
GermOnlineENSG00000174429. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other

NextBio83667.
SOURCESearch...

Entry information

Entry nameABRA_HUMAN
AccessionPrimary (citable) accession number: Q8N0Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents