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Protein

Probable phosphoglycerate mutase 4

Gene

PGAM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.
2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Tele-phosphohistidine intermediateBy similarity
Binding sitei62 – 621SubstrateBy similarity
Active sitei89 – 891Proton donor/acceptorBy similarity
Binding sitei100 – 1001SubstrateBy similarity
Sitei186 – 1861Transition state stabilizerBy similarity

GO - Molecular functioni

GO - Biological processi

  • gluconeogenesis Source: GO_Central
  • glycolytic process Source: UniProtKB
  • positive regulation of sperm motility Source: UniProtKB
  • regulation of pentose-phosphate shunt Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Isomerase

Keywords - Biological processi

Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglycerate mutase 4 (EC:3.1.3.13, EC:5.4.2.11, EC:5.4.2.4)
Gene namesi
Name:PGAM4
Synonyms:PGAM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:21731. PGAM4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • sperm principal piece Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671183.

Polymorphism and mutation databases

BioMutaiPGAM4.
DMDMi26006838.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 254253Probable phosphoglycerate mutase 4PRO_0000179832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei26 – 261PhosphotyrosineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei106 – 1061N6-acetyllysineBy similarity
Modified residuei118 – 1181PhosphoserineBy similarity
Modified residuei251 – 2511N6-acetyllysine; alternateBy similarity
Modified residuei251 – 2511N6-succinyllysine; alternateBy similarity
Modified residuei253 – 2531N6-acetyllysineBy similarity
Modified residuei254 – 2541N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N0Y7.
MaxQBiQ8N0Y7.
PaxDbiQ8N0Y7.
PRIDEiQ8N0Y7.

PTM databases

DEPODiQ8N0Y7.
iPTMnetiQ8N0Y7.
PhosphoSiteiQ8N0Y7.

Expressioni

Gene expression databases

BgeeiQ8N0Y7.
CleanExiHS_PGAM4.
GenevisibleiQ8N0Y7. HS.

Organism-specific databases

HPAiHPA042528.
HPA049237.

Interactioni

Protein-protein interaction databases

BioGridi137555. 2 interactions.
IntActiQ8N0Y7. 1 interaction.
STRINGi9606.ENSP00000412189.

Structurei

3D structure databases

ProteinModelPortaliQ8N0Y7.
SMRiQ8N0Y7. Positions 3-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 178Substrate bindingBy similarity
Regioni23 – 242Substrate bindingBy similarity
Regioni89 – 924Substrate bindingBy similarity
Regioni116 – 1172Substrate bindingBy similarity
Regioni187 – 1882Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 13110Pro-rich

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0235. Eukaryota.
COG0588. LUCA.
GeneTreeiENSGT00390000016700.
HOGENOMiHOG000221682.
HOVERGENiHBG027528.
InParanoidiQ8N0Y7.
KOiK01834.
OMAiNISKYKC.
OrthoDBiEOG7XM2ZV.
PhylomeDBiQ8N0Y7.
TreeFamiTF300007.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N0Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY
60 70 80 90 100
EFDICLTSVQ KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK
110 120 130 140 150
AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL
160 170 180 190 200
PSYESPKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL QGIAKHVEGL
210 220 230 240 250
SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC KAIEAVAAQG

KAKK
Length:254
Mass (Da):28,777
Last modified:October 1, 2002 - v1
Checksum:iBB589CDEAAC2E706
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401R → C.1 Publication
VAR_014355
Natural varianti90 – 901R → Q.1 Publication
Corresponds to variant rs5959129 [ dbSNP | Ensembl ].
VAR_014356
Natural varianti175 – 1751I → T.1 Publication
VAR_014357

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465731 Genomic DNA. Translation: AAM27282.1.
AF465732 Genomic DNA. Translation: AAM27283.1.
AF465733 Genomic DNA. Translation: AAM27284.1.
AF465734 Genomic DNA. Translation: AAM27285.1.
AF465735 Genomic DNA. Translation: AAM27286.1.
AF465736 Genomic DNA. Translation: AAM27287.1.
AF465737 Genomic DNA. Translation: AAM27288.1.
AF465738 Genomic DNA. Translation: AAM27289.1.
AF465739 Genomic DNA. Translation: AAM27290.1.
AF465740 Genomic DNA. Translation: AAM27291.1.
AF465741 Genomic DNA. Translation: AAM27292.1.
AF465742 Genomic DNA. Translation: AAM27293.1.
AF465743 Genomic DNA. Translation: AAM27294.1.
AF465744 Genomic DNA. Translation: AAM27295.1.
AF465745 Genomic DNA. Translation: AAM27296.1.
DQ120647 Genomic DNA. Translation: ABB92432.1.
AL772330 Genomic DNA. Translation: CAI42111.1.
CCDSiCCDS35338.1.
RefSeqiNP_001025062.1. NM_001029891.2.
UniGeneiHs.632822.

Genome annotation databases

EnsembliENST00000458128; ENSP00000412189; ENSG00000226784.
GeneIDi441531.
KEGGihsa:441531.
UCSCiuc004ecy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465731 Genomic DNA. Translation: AAM27282.1.
AF465732 Genomic DNA. Translation: AAM27283.1.
AF465733 Genomic DNA. Translation: AAM27284.1.
AF465734 Genomic DNA. Translation: AAM27285.1.
AF465735 Genomic DNA. Translation: AAM27286.1.
AF465736 Genomic DNA. Translation: AAM27287.1.
AF465737 Genomic DNA. Translation: AAM27288.1.
AF465738 Genomic DNA. Translation: AAM27289.1.
AF465739 Genomic DNA. Translation: AAM27290.1.
AF465740 Genomic DNA. Translation: AAM27291.1.
AF465741 Genomic DNA. Translation: AAM27292.1.
AF465742 Genomic DNA. Translation: AAM27293.1.
AF465743 Genomic DNA. Translation: AAM27294.1.
AF465744 Genomic DNA. Translation: AAM27295.1.
AF465745 Genomic DNA. Translation: AAM27296.1.
DQ120647 Genomic DNA. Translation: ABB92432.1.
AL772330 Genomic DNA. Translation: CAI42111.1.
CCDSiCCDS35338.1.
RefSeqiNP_001025062.1. NM_001029891.2.
UniGeneiHs.632822.

3D structure databases

ProteinModelPortaliQ8N0Y7.
SMRiQ8N0Y7. Positions 3-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137555. 2 interactions.
IntActiQ8N0Y7. 1 interaction.
STRINGi9606.ENSP00000412189.

PTM databases

DEPODiQ8N0Y7.
iPTMnetiQ8N0Y7.
PhosphoSiteiQ8N0Y7.

Polymorphism and mutation databases

BioMutaiPGAM4.
DMDMi26006838.

Proteomic databases

EPDiQ8N0Y7.
MaxQBiQ8N0Y7.
PaxDbiQ8N0Y7.
PRIDEiQ8N0Y7.

Protocols and materials databases

DNASUi441531.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458128; ENSP00000412189; ENSG00000226784.
GeneIDi441531.
KEGGihsa:441531.
UCSCiuc004ecy.2. human.

Organism-specific databases

CTDi441531.
GeneCardsiPGAM4.
HGNCiHGNC:21731. PGAM4.
HPAiHPA042528.
HPA049237.
MIMi300567. gene.
neXtProtiNX_Q8N0Y7.
PharmGKBiPA142671183.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0235. Eukaryota.
COG0588. LUCA.
GeneTreeiENSGT00390000016700.
HOGENOMiHOG000221682.
HOVERGENiHBG027528.
InParanoidiQ8N0Y7.
KOiK01834.
OMAiNISKYKC.
OrthoDBiEOG7XM2ZV.
PhylomeDBiQ8N0Y7.
TreeFamiTF300007.

Miscellaneous databases

GenomeRNAii441531.
PROiQ8N0Y7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N0Y7.
CleanExiHS_PGAM4.
GenevisibleiQ8N0Y7. HS.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene."
    Betran E., Wang W., Jin L., Long M.
    Mol. Biol. Evol. 19:654-663(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-40; GLN-90 AND THR-175.
  2. "Emergence of young human genes after a burst of retroposition in primates."
    Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
    PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPGAM4_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Y7
Secondary accession number(s): Q5JPN2
, Q8NI24, Q8NI25, Q8NI26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This is the product of a processed gene created by retroposition from mRNA of an expressed gene. This gene seems to be expressed.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.