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Protein

Olfactory receptor 8I2

Gene

OR8I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172154-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8I2
Alternative name(s):
Olfactory receptor OR11-170
Gene namesi
Name:OR8I2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15310. OR8I2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi120586.
OpenTargetsiENSG00000172154.
PharmGKBiPA32771.

Polymorphism and mutation databases

BioMutaiOR8I2.
DMDMi38372639.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506681 – 310Olfactory receptor 8I2Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N0Y5.
PeptideAtlasiQ8N0Y5.
PRIDEiQ8N0Y5.

Expressioni

Gene expression databases

CleanExiHS_OR8I2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303864.

Structurei

3D structure databases

ProteinModelPortaliQ8N0Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU6. Eukaryota.
ENOG4111BJM. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8N0Y5.
KOiK04257.
OMAiMAGNNFT.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8N0Y5.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N0Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNNFTEVT VFILSGFANH PELQVSLFLM FLFIYLFTVL GNLGLITLIR
60 70 80 90 100
MDSQLHTPMY FFLSNLAFID IFYSSTVTPK ALVNFQSNRR SISFVGCFVQ
110 120 130 140 150
MYFFVGLVCC ECFLLGSMAY NRYIAICNPL LYSVVMSQKV SNWLGVMPYV
160 170 180 190 200
IGFTSSLISV WVISSLAFCD SSINHFFCDT TALLALSCVD TFGTEMVSFV
210 220 230 240 250
LAGFTLLSSL LIITVTYIII ISAILRIQSA AGRQKAFSTC ASHLMAVTIF
260 270 280 290 300
YGSLIFTYLQ PDNTSSLTQA QVASVFYTIV IPMLNPLIYS LRNKDVKNAL
310
LRVIHRKLFP
Length:310
Mass (Da):34,661
Last modified:October 1, 2002 - v1
Checksum:iBF92BD882CFD7263
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034266124I → V.Corresponds to variant rs17603011dbSNPEnsembl.1
Natural variantiVAR_034267139K → N.Corresponds to variant rs17150021dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065656 Genomic DNA. Translation: BAC05882.1.
AB065844 Genomic DNA. Translation: BAC06062.1.
CH471076 Genomic DNA. Translation: EAW73697.1.
BC137007 mRNA. Translation: AAI37008.1.
BC137008 mRNA. Translation: AAI37009.1.
AF399513 Genomic DNA. Translation: AAK94998.1.
BK004342 Genomic DNA. Translation: DAA04740.1.
CCDSiCCDS31517.1.
RefSeqiNP_001003750.1. NM_001003750.1.
UniGeneiHs.554524.

Genome annotation databases

EnsembliENST00000302124; ENSP00000303864; ENSG00000172154.
GeneIDi120586.
KEGGihsa:120586.
UCSCiuc010rix.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065656 Genomic DNA. Translation: BAC05882.1.
AB065844 Genomic DNA. Translation: BAC06062.1.
CH471076 Genomic DNA. Translation: EAW73697.1.
BC137007 mRNA. Translation: AAI37008.1.
BC137008 mRNA. Translation: AAI37009.1.
AF399513 Genomic DNA. Translation: AAK94998.1.
BK004342 Genomic DNA. Translation: DAA04740.1.
CCDSiCCDS31517.1.
RefSeqiNP_001003750.1. NM_001003750.1.
UniGeneiHs.554524.

3D structure databases

ProteinModelPortaliQ8N0Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303864.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8I2.
DMDMi38372639.

Proteomic databases

PaxDbiQ8N0Y5.
PeptideAtlasiQ8N0Y5.
PRIDEiQ8N0Y5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302124; ENSP00000303864; ENSG00000172154.
GeneIDi120586.
KEGGihsa:120586.
UCSCiuc010rix.2. human.

Organism-specific databases

CTDi120586.
DisGeNETi120586.
GeneCardsiOR8I2.
HGNCiHGNC:15310. OR8I2.
neXtProtiNX_Q8N0Y5.
OpenTargetsiENSG00000172154.
PharmGKBiPA32771.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIU6. Eukaryota.
ENOG4111BJM. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8N0Y5.
KOiK04257.
OMAiMAGNNFT.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8N0Y5.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172154-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8I2.
GenomeRNAii120586.
PROiQ8N0Y5.

Gene expression databases

CleanExiHS_OR8I2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8I2_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Y5
Secondary accession number(s): B2RNN4, Q6IFC0, Q96RC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.