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Protein

Olfactory receptor 4N4

Gene

OR4N4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4N4
Alternative name(s):
Olfactory receptor OR15-1
Olfactory receptor OR15-5
Gene namesi
Name:OR4N4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15375. OR4N4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 31627CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32332.

Polymorphism and mutation databases

BioMutaiOR4N4.
DMDMi218511730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 4N4PRO_0000150564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N0Y3.
PeptideAtlasiQ8N0Y3.
PRIDEiQ8N0Y3.

PTM databases

iPTMnetiQ8N0Y3.
PhosphoSiteiQ8N0Y3.

Expressioni

Gene expression databases

CleanExiHS_OR4N4.
GenevisibleiQ8N0Y3. HS.

Organism-specific databases

HPAiHPA057442.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332500.

Structurei

3D structure databases

ProteinModelPortaliQ8N0Y3.
SMRiQ8N0Y3. Positions 55-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKT. Eukaryota.
ENOG41117FS. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8N0Y3.
KOiK04257.
OMAiSTCITHV.
OrthoDBiEOG091G0FBN.
PhylomeDBiQ8N0Y3.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N0Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIANNTVVT EFILLGLTQS QDIQLLVFVL ILIFYLIILP GNFLIIFTIR
60 70 80 90 100
SDPGLTAPLY LFLGNLAFLD ASYSFIVAPR MLVDFLSEKK VISYRGCITQ
110 120 130 140 150
LFFLHFLGGG EGLLLVVMAF DRYIAICRPL HCSTVMNPRA CYAMMLALWL
160 170 180 190 200
GGFVHSIIQV VLILRLPFCG PNQLDNFFCD VRQVIKLACT DMFVVELLMV
210 220 230 240 250
FNSGLMTLLC FLGLLASYAV ILCHVRRAAS EGKNKAMSTC TTRVIIILLM
260 270 280 290 300
FGPAIFIYMC PFRALPADKM VSLFHTVIFP LMNPMIYTLR NQEVKTSMKR
310
LLSRHVVCQV DFIIRN
Length:316
Mass (Da):35,724
Last modified:December 16, 2008 - v2
Checksum:i826814BC3572C926
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611L → F.1 Publication
Corresponds to variant rs535034 [ dbSNP | Ensembl ].
VAR_048034
Natural varianti86 – 861L → F.1 Publication
Corresponds to variant rs2808136 [ dbSNP | Ensembl ].
VAR_048035
Natural varianti239 – 2391T → M.1 Publication
Corresponds to variant rs475947 [ dbSNP | Ensembl ].
VAR_048036
Natural varianti274 – 2741F → L.
Corresponds to variant rs3817271 [ dbSNP | Ensembl ].
VAR_048037

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065653 Genomic DNA. Translation: BAC05879.1.
AB065904 Genomic DNA. Translation: BAC06119.1.
CH878499 Genomic DNA. Translation: EAW50561.1.
BC136597 mRNA. Translation: AAI36598.1.
BC136598 mRNA. Translation: AAI36599.1.
BK004406 Genomic DNA. Translation: DAA04804.1.
BK004479 Genomic DNA. Translation: DAA04877.1.
CCDSiCCDS32173.1.
RefSeqiNP_001005241.2. NM_001005241.3.
XP_011544524.1. XM_011546222.1.
XP_011544526.1. XM_011546224.2.
UniGeneiHs.525666.

Genome annotation databases

EnsembliENST00000328795; ENSP00000332500; ENSG00000183706.
GeneIDi102723532.
283694.
KEGGihsa:102723532.
hsa:283694.
UCSCiuc010tzv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065653 Genomic DNA. Translation: BAC05879.1.
AB065904 Genomic DNA. Translation: BAC06119.1.
CH878499 Genomic DNA. Translation: EAW50561.1.
BC136597 mRNA. Translation: AAI36598.1.
BC136598 mRNA. Translation: AAI36599.1.
BK004406 Genomic DNA. Translation: DAA04804.1.
BK004479 Genomic DNA. Translation: DAA04877.1.
CCDSiCCDS32173.1.
RefSeqiNP_001005241.2. NM_001005241.3.
XP_011544524.1. XM_011546222.1.
XP_011544526.1. XM_011546224.2.
UniGeneiHs.525666.

3D structure databases

ProteinModelPortaliQ8N0Y3.
SMRiQ8N0Y3. Positions 55-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332500.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8N0Y3.
PhosphoSiteiQ8N0Y3.

Polymorphism and mutation databases

BioMutaiOR4N4.
DMDMi218511730.

Proteomic databases

PaxDbiQ8N0Y3.
PeptideAtlasiQ8N0Y3.
PRIDEiQ8N0Y3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328795; ENSP00000332500; ENSG00000183706.
GeneIDi102723532.
283694.
KEGGihsa:102723532.
hsa:283694.
UCSCiuc010tzv.3. human.

Organism-specific databases

CTDi283694.
GeneCardsiOR4N4.
H-InvDBHIX0017955.
HGNCiHGNC:15375. OR4N4.
HPAiHPA057442.
neXtProtiNX_Q8N0Y3.
PharmGKBiPA32332.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKT. Eukaryota.
ENOG41117FS. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8N0Y3.
KOiK04257.
OMAiSTCITHV.
OrthoDBiEOG091G0FBN.
PhylomeDBiQ8N0Y3.
TreeFamiTF338273.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4N4.
PROiQ8N0Y3.

Gene expression databases

CleanExiHS_OR4N4.
GenevisibleiQ8N0Y3. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4N4_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Y3
Secondary accession number(s): Q6IEY3, Q6IF56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.