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Q8N0W7

- FMR1N_HUMAN

UniProt

Q8N0W7 - FMR1N_HUMAN

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Protein
Fragile X mental retardation 1 neighbor protein
Gene
FMR1NB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation 1 neighbor protein
Alternative name(s):
Cancer/testis antigen 37
Short name:
CT37
Sarcoma antigen NY-SAR-35
Gene namesi
Name:FMR1NB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:26372. FMR1NB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei69 – 8921Helical; Reviewed prediction
Add
BLAST
Topological domaini90 – 18394Extracellular Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Topological domaini205 – 25551Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134927784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Fragile X mental retardation 1 neighbor protein
PRO_0000281735Add
BLAST

Proteomic databases

PaxDbiQ8N0W7.
PRIDEiQ8N0W7.

PTM databases

PhosphoSiteiQ8N0W7.

Expressioni

Tissue specificityi

Testis-specific. Expressed in melanoma, sarcoma, lung, breast, bladder, esophageal and ovarian cancers.1 Publication

Gene expression databases

BgeeiQ8N0W7.
CleanExiHS_FMR1NB.
GenevestigatoriQ8N0W7.

Organism-specific databases

HPAiCAB026403.
HPA011284.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359498.

Structurei

3D structure databases

ProteinModelPortaliQ8N0W7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 18460P-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45156.
HOGENOMiHOG000112622.
InParanoidiQ8N0W7.
OMAiKPCNELQ.
PhylomeDBiQ8N0W7.
TreeFamiTF338231.

Sequencei

Sequence statusi: Complete.

Q8N0W7-1 [UniParc]FASTAAdd to Basket

« Hide

MSSHRRKAKG RNRRSHRAMR VAHLELATYE LAATESNPES SHPGYEAAMA    50
DRPQPGWRES LKMRVSKPFG MLMLSIWILL FVCYYLSYYL CSGSSYFVLA 100
NGHILPNSEN AHGQSLEEDS ALEALLNFFF PTTCNLRENQ VAKPCNELQD 150
LSESECLRHK CCFSSSGTTS FKCFAPFRDV PKQMMQMFGL GAISLILVCL 200
PIYCRSLFWR SEPADDLQRQ DNRVVTGLKK QRRKRKRKSE MLQKAARGRE 250
EHGDE 255
Length:255
Mass (Da):29,241
Last modified:October 1, 2002 - v1
Checksum:iE4AAF48D171ED484
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421A → V.
Corresponds to variant rs764631 [ dbSNP | Ensembl ].
VAR_031254

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY211917 mRNA. Translation: AAO65170.1.
AK098602 mRNA. Translation: BAC05349.1.
CH471171 Genomic DNA. Translation: EAW61291.1.
CH471171 Genomic DNA. Translation: EAW61292.1.
BC034320 mRNA. Translation: AAH34320.1.
CCDSiCCDS14683.1.
RefSeqiNP_689791.1. NM_152578.2.
UniGeneiHs.128580.

Genome annotation databases

EnsembliENST00000370467; ENSP00000359498; ENSG00000176988.
ENST00000598268; ENSP00000471541; ENSG00000268827.
GeneIDi158521.
KEGGihsa:158521.
UCSCiuc004fcm.3. human.

Polymorphism databases

DMDMi74728471.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY211917 mRNA. Translation: AAO65170.1 .
AK098602 mRNA. Translation: BAC05349.1 .
CH471171 Genomic DNA. Translation: EAW61291.1 .
CH471171 Genomic DNA. Translation: EAW61292.1 .
BC034320 mRNA. Translation: AAH34320.1 .
CCDSi CCDS14683.1.
RefSeqi NP_689791.1. NM_152578.2.
UniGenei Hs.128580.

3D structure databases

ProteinModelPortali Q8N0W7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000359498.

PTM databases

PhosphoSitei Q8N0W7.

Polymorphism databases

DMDMi 74728471.

Proteomic databases

PaxDbi Q8N0W7.
PRIDEi Q8N0W7.

Protocols and materials databases

DNASUi 158521.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370467 ; ENSP00000359498 ; ENSG00000176988 .
ENST00000598268 ; ENSP00000471541 ; ENSG00000268827 .
GeneIDi 158521.
KEGGi hsa:158521.
UCSCi uc004fcm.3. human.

Organism-specific databases

CTDi 158521.
GeneCardsi GC0XP147062.
HGNCi HGNC:26372. FMR1NB.
HPAi CAB026403.
HPA011284.
neXtProti NX_Q8N0W7.
PharmGKBi PA134927784.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45156.
HOGENOMi HOG000112622.
InParanoidi Q8N0W7.
OMAi KPCNELQ.
PhylomeDBi Q8N0W7.
TreeFami TF338231.

Miscellaneous databases

GenomeRNAii 158521.
NextBioi 87763.
PROi Q8N0W7.

Gene expression databases

Bgeei Q8N0W7.
CleanExi HS_FMR1NB.
Genevestigatori Q8N0W7.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFMR1N_HUMAN
AccessioniPrimary (citable) accession number: Q8N0W7
Secondary accession number(s): D3DWT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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