Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fragile X mental retardation 1 neighbor protein

Gene

FMR1NB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation 1 neighbor protein
Alternative name(s):
Cancer/testis antigen 37
Short name:
CT37
Sarcoma antigen NY-SAR-35
Gene namesi
Name:FMR1NB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26372. FMR1NB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Topological domaini90 – 18394ExtracellularSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST
Topological domaini205 – 25551CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134927784.

Polymorphism and mutation databases

BioMutaiFMR1NB.
DMDMi74728471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Fragile X mental retardation 1 neighbor proteinPRO_0000281735Add
BLAST

Proteomic databases

PaxDbiQ8N0W7.
PRIDEiQ8N0W7.

PTM databases

PhosphoSiteiQ8N0W7.

Expressioni

Tissue specificityi

Testis-specific. Expressed in melanoma, sarcoma, lung, breast, bladder, esophageal and ovarian cancers.1 Publication

Gene expression databases

BgeeiQ8N0W7.
CleanExiHS_FMR1NB.
ExpressionAtlasiQ8N0W7. baseline and differential.
GenevestigatoriQ8N0W7.

Organism-specific databases

HPAiCAB026403.
HPA011284.

Interactioni

Protein-protein interaction databases

BioGridi127690. 9 interactions.
STRINGi9606.ENSP00000359498.

Structurei

3D structure databases

ProteinModelPortaliQ8N0W7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 18460P-typeAdd
BLAST

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45156.
GeneTreeiENSGT00390000007953.
HOGENOMiHOG000112622.
InParanoidiQ8N0W7.
OMAiKPCNELQ.
PhylomeDBiQ8N0W7.
TreeFamiTF338231.

Sequencei

Sequence statusi: Complete.

Q8N0W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHRRKAKG RNRRSHRAMR VAHLELATYE LAATESNPES SHPGYEAAMA
60 70 80 90 100
DRPQPGWRES LKMRVSKPFG MLMLSIWILL FVCYYLSYYL CSGSSYFVLA
110 120 130 140 150
NGHILPNSEN AHGQSLEEDS ALEALLNFFF PTTCNLRENQ VAKPCNELQD
160 170 180 190 200
LSESECLRHK CCFSSSGTTS FKCFAPFRDV PKQMMQMFGL GAISLILVCL
210 220 230 240 250
PIYCRSLFWR SEPADDLQRQ DNRVVTGLKK QRRKRKRKSE MLQKAARGRE

EHGDE
Length:255
Mass (Da):29,241
Last modified:October 1, 2002 - v1
Checksum:iE4AAF48D171ED484
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421A → V.
Corresponds to variant rs764631 [ dbSNP | Ensembl ].
VAR_031254

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY211917 mRNA. Translation: AAO65170.1.
AK098602 mRNA. Translation: BAC05349.1.
CH471171 Genomic DNA. Translation: EAW61291.1.
CH471171 Genomic DNA. Translation: EAW61292.1.
BC034320 mRNA. Translation: AAH34320.1.
CCDSiCCDS14683.1.
RefSeqiNP_689791.1. NM_152578.2.
UniGeneiHs.128580.

Genome annotation databases

EnsembliENST00000370467; ENSP00000359498; ENSG00000176988.
GeneIDi158521.
KEGGihsa:158521.
UCSCiuc004fcm.3. human.

Polymorphism and mutation databases

BioMutaiFMR1NB.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY211917 mRNA. Translation: AAO65170.1.
AK098602 mRNA. Translation: BAC05349.1.
CH471171 Genomic DNA. Translation: EAW61291.1.
CH471171 Genomic DNA. Translation: EAW61292.1.
BC034320 mRNA. Translation: AAH34320.1.
CCDSiCCDS14683.1.
RefSeqiNP_689791.1. NM_152578.2.
UniGeneiHs.128580.

3D structure databases

ProteinModelPortaliQ8N0W7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127690. 9 interactions.
STRINGi9606.ENSP00000359498.

PTM databases

PhosphoSiteiQ8N0W7.

Polymorphism and mutation databases

BioMutaiFMR1NB.
DMDMi74728471.

Proteomic databases

PaxDbiQ8N0W7.
PRIDEiQ8N0W7.

Protocols and materials databases

DNASUi158521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370467; ENSP00000359498; ENSG00000176988.
GeneIDi158521.
KEGGihsa:158521.
UCSCiuc004fcm.3. human.

Organism-specific databases

CTDi158521.
GeneCardsiGC0XP147062.
HGNCiHGNC:26372. FMR1NB.
HPAiCAB026403.
HPA011284.
neXtProtiNX_Q8N0W7.
PharmGKBiPA134927784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45156.
GeneTreeiENSGT00390000007953.
HOGENOMiHOG000112622.
InParanoidiQ8N0W7.
OMAiKPCNELQ.
PhylomeDBiQ8N0W7.
TreeFamiTF338231.

Miscellaneous databases

GenomeRNAii158521.
NextBioi87763.
PROiQ8N0W7.

Gene expression databases

BgeeiQ8N0W7.
CleanExiHS_FMR1NB.
ExpressionAtlasiQ8N0W7. baseline and differential.
GenevestigatoriQ8N0W7.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFMR1N_HUMAN
AccessioniPrimary (citable) accession number: Q8N0W7
Secondary accession number(s): D3DWT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.