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Protein

Fragile X mental retardation 1 neighbor protein

Gene

FMR1NB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176988-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation 1 neighbor protein
Alternative name(s):
Cancer/testis antigen 37
Short name:
CT37
Sarcoma antigen NY-SAR-35
Gene namesi
Name:FMR1NB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26372. FMR1NB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 183ExtracellularSequence analysisAdd BLAST94
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 255CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176988.
PharmGKBiPA134927784.

Polymorphism and mutation databases

BioMutaiFMR1NB.
DMDMi74728471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002817351 – 255Fragile X mental retardation 1 neighbor proteinAdd BLAST255

Proteomic databases

PaxDbiQ8N0W7.
PeptideAtlasiQ8N0W7.
PRIDEiQ8N0W7.

PTM databases

iPTMnetiQ8N0W7.
PhosphoSitePlusiQ8N0W7.

Expressioni

Tissue specificityi

Testis-specific. Expressed in melanoma, sarcoma, lung, breast, bladder, esophageal and ovarian cancers.1 Publication

Gene expression databases

BgeeiENSG00000176988.
CleanExiHS_FMR1NB.
ExpressionAtlasiQ8N0W7. baseline and differential.
GenevisibleiQ8N0W7. HS.

Organism-specific databases

HPAiCAB026403.
HPA011284.

Interactioni

Protein-protein interaction databases

BioGridi127690. 10 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N0W7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 184P-typeAdd BLAST60

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVQ6. Eukaryota.
ENOG4111AZD. LUCA.
GeneTreeiENSGT00390000007953.
HOGENOMiHOG000112622.
InParanoidiQ8N0W7.
OMAiKCCFSSL.
OrthoDBiEOG091G0WG8.
PhylomeDBiQ8N0W7.
TreeFamiTF338231.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR000519. P_trefoil_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N0W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHRRKAKG RNRRSHRAMR VAHLELATYE LAATESNPES SHPGYEAAMA
60 70 80 90 100
DRPQPGWRES LKMRVSKPFG MLMLSIWILL FVCYYLSYYL CSGSSYFVLA
110 120 130 140 150
NGHILPNSEN AHGQSLEEDS ALEALLNFFF PTTCNLRENQ VAKPCNELQD
160 170 180 190 200
LSESECLRHK CCFSSSGTTS FKCFAPFRDV PKQMMQMFGL GAISLILVCL
210 220 230 240 250
PIYCRSLFWR SEPADDLQRQ DNRVVTGLKK QRRKRKRKSE MLQKAARGRE

EHGDE
Length:255
Mass (Da):29,241
Last modified:October 1, 2002 - v1
Checksum:iE4AAF48D171ED484
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031254142A → V.Corresponds to variant rs764631dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY211917 mRNA. Translation: AAO65170.1.
AK098602 mRNA. Translation: BAC05349.1.
CH471171 Genomic DNA. Translation: EAW61291.1.
CH471171 Genomic DNA. Translation: EAW61292.1.
BC034320 mRNA. Translation: AAH34320.1.
CCDSiCCDS14683.1.
RefSeqiNP_689791.1. NM_152578.2.
UniGeneiHs.128580.

Genome annotation databases

EnsembliENST00000370467; ENSP00000359498; ENSG00000176988.
GeneIDi158521.
KEGGihsa:158521.
UCSCiuc004fcm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY211917 mRNA. Translation: AAO65170.1.
AK098602 mRNA. Translation: BAC05349.1.
CH471171 Genomic DNA. Translation: EAW61291.1.
CH471171 Genomic DNA. Translation: EAW61292.1.
BC034320 mRNA. Translation: AAH34320.1.
CCDSiCCDS14683.1.
RefSeqiNP_689791.1. NM_152578.2.
UniGeneiHs.128580.

3D structure databases

ProteinModelPortaliQ8N0W7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127690. 10 interactors.

PTM databases

iPTMnetiQ8N0W7.
PhosphoSitePlusiQ8N0W7.

Polymorphism and mutation databases

BioMutaiFMR1NB.
DMDMi74728471.

Proteomic databases

PaxDbiQ8N0W7.
PeptideAtlasiQ8N0W7.
PRIDEiQ8N0W7.

Protocols and materials databases

DNASUi158521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370467; ENSP00000359498; ENSG00000176988.
GeneIDi158521.
KEGGihsa:158521.
UCSCiuc004fcm.3. human.

Organism-specific databases

CTDi158521.
GeneCardsiFMR1NB.
HGNCiHGNC:26372. FMR1NB.
HPAiCAB026403.
HPA011284.
neXtProtiNX_Q8N0W7.
OpenTargetsiENSG00000176988.
PharmGKBiPA134927784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVQ6. Eukaryota.
ENOG4111AZD. LUCA.
GeneTreeiENSGT00390000007953.
HOGENOMiHOG000112622.
InParanoidiQ8N0W7.
OMAiKCCFSSL.
OrthoDBiEOG091G0WG8.
PhylomeDBiQ8N0W7.
TreeFamiTF338231.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176988-MONOMER.

Miscellaneous databases

GenomeRNAii158521.
PROiQ8N0W7.

Gene expression databases

BgeeiENSG00000176988.
CleanExiHS_FMR1NB.
ExpressionAtlasiQ8N0W7. baseline and differential.
GenevisibleiQ8N0W7. HS.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR000519. P_trefoil_dom.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFMR1N_HUMAN
AccessioniPrimary (citable) accession number: Q8N0W7
Secondary accession number(s): D3DWT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.