Q8N0W7 (FMR1N_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fragile X mental retardation 1 neighbor protein

Alternative name(s):
Cancer/testis antigen 37
Short name=CT37
Sarcoma antigen NY-SAR-35

Gene names

Name:

FMR1NB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Testis-specific. Expressed in melanoma, sarcoma, lung, breast, bladder, esophageal and ovarian cancers. Ref.1
Sequence similarities	Contains 1 P-type (trefoil) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Fragile X mental retardation 1 neighbor protein		PRO_0000281735
Regions
	Topological domain	1 – 68	68	Cytoplasmic Potential
	Transmembrane	69 – 89	21	Helical; Potential
	Topological domain	90 – 183	94	Extracellular Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Topological domain	205 – 255	51	Cytoplasmic Potential
	Domain	125 – 184	60	P-type
Natural variations
	Natural variant	142	1	A → V. Corresponds to variant rs764631 [ dbSNP | Ensembl ].		VAR_031254

Sequences

	Sequence		Length	Mass (Da)
	Q8N0W7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: E4AAF48D171ED484	FASTA	255	29,241
	10 20 30 40 50 60 MSSHRRKAKG RNRRSHRAMR VAHLELATYE LAATESNPES SHPGYEAAMA DRPQPGWRES 70 80 90 100 110 120 LKMRVSKPFG MLMLSIWILL FVCYYLSYYL CSGSSYFVLA NGHILPNSEN AHGQSLEEDS 130 140 150 160 170 180 ALEALLNFFF PTTCNLRENQ VAKPCNELQD LSESECLRHK CCFSSSGTTS FKCFAPFRDV 190 200 210 220 230 240 PKQMMQMFGL GAISLILVCL PIYCRSLFWR SEPADDLQRQ DNRVVTGLKK QRRKRKRKSE 250 MLQKAARGRE EHGDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Immunomic analysis of human sarcoma." Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B., Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J. Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY211917 mRNA. Translation: AAO65170.1. AK098602 mRNA. Translation: BAC05349.1. CH471171 Genomic DNA. Translation: EAW61291.1. CH471171 Genomic DNA. Translation: EAW61292.1. BC034320 mRNA. Translation: AAH34320.1.
IPI	IPI00166099.
RefSeq	NP_689791.1. NM_152578.2.
UniGene	Hs.128580.
3D structure databases
ProteinModelPortal	Q8N0W7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359498.
PTM databases
PhosphoSite	Q8N0W7.
Polymorphism databases
DMDM	74728471.
Proteomic databases
PaxDb	Q8N0W7.
PRIDE	Q8N0W7.
Protocols and materials databases
DNASU	158521.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370467; ENSP00000359498; ENSG00000176988. ENST00000598268; ENSP00000471541; ENSG00000268827.
GeneID	158521.
KEGG	hsa:158521.
UCSC	uc004fcm.3. human.
Organism-specific databases
CTD	158521.
GeneCards	GC0XP147062.
HGNC	HGNC:26372. FMR1NB.
HPA	CAB026403. HPA011284.
neXtProt	NX_Q8N0W7.
PharmGKB	PA134927784.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45156.
HOGENOM	HOG000112622.
InParanoid	Q8N0W7.
OMA	LMLSIWI.
OrthoDB	EOG4WDDCT.
PhylomeDB	Q8N0W7.
Gene expression databases
ArrayExpress	Q8N0W7.
Bgee	Q8N0W7.
CleanEx	HS_FMR1NB.
Genevestigator	Q8N0W7.
Family and domain databases
PROSITE	PS00025. P_TREFOIL_1. False negative. PS51448. P_TREFOIL_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	158521.
NextBio	87763.

Entry information

Entry name

FMR1N_HUMAN

Accession

Primary (citable) accession number: Q8N0W7
Secondary accession number(s): D3DWT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.