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Q8N0W4

- NLGNX_HUMAN

UniProt

Q8N0W4 - NLGNX_HUMAN

Protein

Neuroligin-4, X-linked

Gene

NLGN4X

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Putative neuronal cell surface protein involved in cell-cell-interactions.

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. chloride ion binding Source: UniProtKB
    3. neurexin family protein binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein homodimerization activity Source: UniProtKB
    6. receptor activity Source: RefGenome

    GO - Biological processi

    1. adult behavior Source: BHF-UCL
    2. brainstem development Source: BHF-UCL
    3. cell-cell junction organization Source: UniProtKB
    4. cerebellum development Source: BHF-UCL
    5. learning Source: BHF-UCL
    6. negative regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
    7. neuron cell-cell adhesion Source: BHF-UCL
    8. neuron differentiation Source: BHF-UCL
    9. organ growth Source: BHF-UCL
    10. presynaptic membrane assembly Source: BHF-UCL
    11. social behavior Source: UniProtKB
    12. synapse organization Source: UniProtKB
    13. vocalization behavior Source: BHF-UCL

    Keywords - Biological processi

    Cell adhesion

    Protein family/group databases

    MEROPSiS09.988.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroligin-4, X-linked
    Short name:
    Neuroligin X
    Alternative name(s):
    HNLX
    Gene namesi
    Name:NLGN4X
    Synonyms:KIAA1260, NLGN4
    ORF Names:UNQ365/PRO701
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:14287. NLGN4X.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell surface Source: UniProtKB
    3. dendrite Source: BHF-UCL
    4. excitatory synapse Source: BHF-UCL
    5. integral component of membrane Source: UniProtKB
    6. integral component of plasma membrane Source: UniProtKB
    7. plasma membrane Source: BHF-UCL
    8. postsynaptic density Source: UniProtKB-SubCell
    9. postsynaptic membrane Source: UniProtKB-KW
    10. synapse Source: BHF-UCL

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Autism, X-linked 2 (AUTSX2) [MIM:300495]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Asperger syndrome, X-linked, 2 (ASPGX2) [MIM:300497]: A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi300495. phenotype.
    300497. phenotype.
    Orphaneti1162. Asperger syndrome.
    106. Autism.
    PharmGKBiPA31650.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 41411 PublicationAdd
    BLAST
    Chaini42 – 816775Neuroligin-4, X-linkedPRO_0000008648Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)1 Publication
    Disulfide bondi110 ↔ 1461 Publication
    Disulfide bondi306 ↔ 3171 Publication
    Disulfide bondi476 ↔ 5101 Publication
    Glycosylationi511 – 5111N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N0W4.
    PRIDEiQ8N0W4.

    PTM databases

    PhosphoSiteiQ8N0W4.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ8N0W4.
    BgeeiQ8N0W4.
    CleanExiHS_NLGN4X.
    GenevestigatoriQ8N0W4.

    Organism-specific databases

    HPAiHPA001651.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Nrxn1Q633735EBI-2862707,EBI-1780696From a different organism.

    Protein-protein interaction databases

    BioGridi121567. 1 interaction.
    IntActiQ8N0W4. 3 interactions.
    STRINGi9606.ENSP00000275857.

    Structurei

    Secondary structure

    1
    816
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi47 – 504
    Beta strandi53 – 564
    Beta strandi58 – 603
    Beta strandi70 – 778
    Helixi84 – 863
    Beta strandi98 – 1025
    Turni116 – 1183
    Helixi119 – 1224
    Helixi128 – 1347
    Helixi136 – 1405
    Beta strandi148 – 1547
    Beta strandi166 – 1727
    Turni176 – 1783
    Helixi182 – 1843
    Helixi188 – 1947
    Beta strandi197 – 2015
    Helixi206 – 2105
    Helixi222 – 23716
    Helixi238 – 2414
    Beta strandi243 – 25311
    Helixi255 – 2639
    Helixi267 – 2693
    Turni270 – 2723
    Beta strandi274 – 2807
    Beta strandi283 – 2853
    Turni286 – 2883
    Helixi293 – 30311
    Helixi311 – 3199
    Helixi323 – 3275
    Beta strandi339 – 3413
    Beta strandi346 – 3494
    Helixi353 – 3586
    Helixi361 – 3644
    Beta strandi365 – 3728
    Turni373 – 3764
    Helixi377 – 3804
    Turni381 – 3833
    Helixi392 – 40615
    Beta strandi410 – 4123
    Helixi413 – 42311
    Helixi433 – 44816
    Helixi450 – 46112
    Beta strandi467 – 4726
    Beta strandi478 – 4814
    Turni489 – 4924
    Helixi493 – 4964
    Helixi499 – 5013
    Beta strandi505 – 5073
    Helixi514 – 53320
    Turni564 – 5663
    Beta strandi568 – 5758
    Beta strandi577 – 5815
    Helixi584 – 5918
    Helixi594 – 5963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WQZX-ray3.90A/B43-619[»]
    2XB6X-ray2.60A/B44-619[»]
    3BE8X-ray2.20A/B44-619[»]
    ProteinModelPortaliQ8N0W4.
    SMRiQ8N0W4. Positions 41-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N0W4.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini42 – 676635ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini698 – 816119CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei677 – 69721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni359 – 3646Interaction with NRXN1

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2272.
    HOGENOMiHOG000231424.
    HOVERGENiHBG008839.
    KOiK07378.
    OMAiHISFGPV.
    OrthoDBiEOG7RBZ7R.
    PhylomeDBiQ8N0W4.
    TreeFamiTF326187.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR01090. NEUROLIGIN.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N0W4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRPQGLLWL PLLFTPVCVM LNSNVLLWLT ALAIKFTLID SQAQYPVVNT    50
    NYGKIRGLRT PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGI 100
    RNTTQFAAVC PQHLDERSLL HDMLPIWFTA NLDTLMTYVQ DQNEDCLYLN 150
    IYVPTEDDIH DQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT 200
    INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI 250
    FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL 300
    ADKVGCNMLD TTDMVECLRN KNYKELIQQT ITPATYHIAF GPVIDGDVIP 350
    DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS 400
    NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV 450
    APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP 500
    MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK 550
    PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL 600
    NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS 650
    KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK 700
    DKRRHETHRR PSPQRNTTND IAHIQNEEIM SLQMKQLEHD HECESLQAHD 750
    TLRLTCPPDY TLTLRRSPDD IPLMTPNTIT MIPNTLTGMQ PLHTFNTFSG 800
    GQNSTNLPHG HSTTRV 816
    Length:816
    Mass (Da):91,915
    Last modified:October 1, 2002 - v1
    Checksum:iEA1320D690F76BBD
    GO
    Isoform 2 (identifier: Q8N0W4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         157-157: D → DGANTKKNADDITSNDRGEDE

    Note: No experimental confirmation available.

    Show »
    Length:836
    Mass (Da):94,047
    Checksum:iF82E9A2505E6CA96
    GO

    Sequence cautioni

    The sequence BAA86574.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti456 – 4561Missing in AAQ88925. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti214 – 2141G → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036576

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei157 – 1571D → DGANTKKNADDITSNDRGED E in isoform 2. 1 PublicationVSP_013270

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF376803 mRNA. Translation: AAM46112.1.
    AB033086 mRNA. Translation: BAA86574.1. Different initiation.
    BC034018 mRNA. Translation: AAH34018.1.
    AY358562 mRNA. Translation: AAQ88925.1.
    CCDSiCCDS14126.1. [Q8N0W4-1]
    RefSeqiNP_001269074.1. NM_001282145.1. [Q8N0W4-1]
    NP_001269075.1. NM_001282146.1. [Q8N0W4-1]
    NP_065793.1. NM_020742.3. [Q8N0W4-1]
    NP_851849.1. NM_181332.2. [Q8N0W4-1]
    XP_005274621.1. XM_005274564.1. [Q8N0W4-2]
    XP_005274622.1. XM_005274565.1. [Q8N0W4-2]
    XP_005274623.1. XM_005274566.2. [Q8N0W4-2]
    XP_005274625.1. XM_005274568.1. [Q8N0W4-2]
    XP_006724567.1. XM_006724504.1. [Q8N0W4-2]
    UniGeneiHs.21107.

    Genome annotation databases

    EnsembliENST00000275857; ENSP00000275857; ENSG00000146938. [Q8N0W4-1]
    ENST00000381092; ENSP00000370482; ENSG00000146938. [Q8N0W4-1]
    ENST00000381093; ENSP00000370483; ENSG00000146938. [Q8N0W4-2]
    ENST00000381095; ENSP00000370485; ENSG00000146938. [Q8N0W4-1]
    ENST00000538097; ENSP00000439203; ENSG00000146938. [Q8N0W4-1]
    GeneIDi57502.
    KEGGihsa:57502.
    UCSCiuc004crp.3. human. [Q8N0W4-2]
    uc004crq.3. human. [Q8N0W4-1]

    Polymorphism databases

    DMDMi31076821.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF376803 mRNA. Translation: AAM46112.1 .
    AB033086 mRNA. Translation: BAA86574.1 . Different initiation.
    BC034018 mRNA. Translation: AAH34018.1 .
    AY358562 mRNA. Translation: AAQ88925.1 .
    CCDSi CCDS14126.1. [Q8N0W4-1 ]
    RefSeqi NP_001269074.1. NM_001282145.1. [Q8N0W4-1 ]
    NP_001269075.1. NM_001282146.1. [Q8N0W4-1 ]
    NP_065793.1. NM_020742.3. [Q8N0W4-1 ]
    NP_851849.1. NM_181332.2. [Q8N0W4-1 ]
    XP_005274621.1. XM_005274564.1. [Q8N0W4-2 ]
    XP_005274622.1. XM_005274565.1. [Q8N0W4-2 ]
    XP_005274623.1. XM_005274566.2. [Q8N0W4-2 ]
    XP_005274625.1. XM_005274568.1. [Q8N0W4-2 ]
    XP_006724567.1. XM_006724504.1. [Q8N0W4-2 ]
    UniGenei Hs.21107.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WQZ X-ray 3.90 A/B 43-619 [» ]
    2XB6 X-ray 2.60 A/B 44-619 [» ]
    3BE8 X-ray 2.20 A/B 44-619 [» ]
    ProteinModelPortali Q8N0W4.
    SMRi Q8N0W4. Positions 41-599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121567. 1 interaction.
    IntActi Q8N0W4. 3 interactions.
    STRINGi 9606.ENSP00000275857.

    Protein family/group databases

    MEROPSi S09.988.

    PTM databases

    PhosphoSitei Q8N0W4.

    Polymorphism databases

    DMDMi 31076821.

    Proteomic databases

    PaxDbi Q8N0W4.
    PRIDEi Q8N0W4.

    Protocols and materials databases

    DNASUi 57502.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275857 ; ENSP00000275857 ; ENSG00000146938 . [Q8N0W4-1 ]
    ENST00000381092 ; ENSP00000370482 ; ENSG00000146938 . [Q8N0W4-1 ]
    ENST00000381093 ; ENSP00000370483 ; ENSG00000146938 . [Q8N0W4-2 ]
    ENST00000381095 ; ENSP00000370485 ; ENSG00000146938 . [Q8N0W4-1 ]
    ENST00000538097 ; ENSP00000439203 ; ENSG00000146938 . [Q8N0W4-1 ]
    GeneIDi 57502.
    KEGGi hsa:57502.
    UCSCi uc004crp.3. human. [Q8N0W4-2 ]
    uc004crq.3. human. [Q8N0W4-1 ]

    Organism-specific databases

    CTDi 57502.
    GeneCardsi GC0XM005758.
    GeneReviewsi NLGN4X.
    HGNCi HGNC:14287. NLGN4X.
    HPAi HPA001651.
    MIMi 300427. gene.
    300495. phenotype.
    300497. phenotype.
    neXtProti NX_Q8N0W4.
    Orphaneti 1162. Asperger syndrome.
    106. Autism.
    PharmGKBi PA31650.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2272.
    HOGENOMi HOG000231424.
    HOVERGENi HBG008839.
    KOi K07378.
    OMAi HISFGPV.
    OrthoDBi EOG7RBZ7R.
    PhylomeDBi Q8N0W4.
    TreeFami TF326187.

    Miscellaneous databases

    EvolutionaryTracei Q8N0W4.
    GeneWikii NLGN4X.
    GenomeRNAii 57502.
    NextBioi 63827.
    PROi Q8N0W4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N0W4.
    Bgeei Q8N0W4.
    CleanExi HS_NLGN4X.
    Genevestigatori Q8N0W4.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR01090. NEUROLIGIN.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
    2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-816 (ISOFORM 2).
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 42-56.
    6. Cited for: INTERACTION WITH DLG4.
    7. "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression."
      Bolliger M.F., Frei K., Winterhalter K.H., Gloor S.M.
      Biochem. J. 356:581-588(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DLG4, TISSUE SPECIFICITY.
    8. Cited for: INVOLVEMENT IN ATSX2 AND ASPGX2.
    9. "Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion."
      Fabrichny I.P., Leone P., Sulzenbacher G., Comoletti D., Miller M.T., Taylor P., Bourne Y., Marchot P.
      Neuron 56:979-991(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 44-619 ALONE AND IN COMPLEX WITH RAT NRXN1, GLYCOSYLATION AT ASN-102 AND ASN-511, SUBUNIT, DISULFIDE BONDS.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-214.

    Entry informationi

    Entry nameiNLGNX_HUMAN
    AccessioniPrimary (citable) accession number: Q8N0W4
    Secondary accession number(s): Q6UX10, Q9ULG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3