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Protein

L-fucose kinase

Gene

FUK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Catalytic activityi

ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi834 – 84512ATPSequence analysisAdd
BLAST

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fucokinase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.52. 2681.
ReactomeiR-HSA-6787639. GDP-fucose biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose kinase (EC:2.7.1.52)
Short name:
Fucokinase
Gene namesi
Name:FUK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29500. FUK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863646.

Polymorphism and mutation databases

BioMutaiFUK.
DMDMi73915340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10841084L-fucose kinasePRO_0000156672Add
BLAST

Proteomic databases

EPDiQ8N0W3.
MaxQBiQ8N0W3.
PaxDbiQ8N0W3.
PRIDEiQ8N0W3.

PTM databases

iPTMnetiQ8N0W3.
PhosphoSiteiQ8N0W3.

Expressioni

Gene expression databases

BgeeiQ8N0W3.
CleanExiHS_FUK.
ExpressionAtlasiQ8N0W3. baseline and differential.
GenevisibleiQ8N0W3. HS.

Organism-specific databases

HPAiHPA041971.

Interactioni

Protein-protein interaction databases

BioGridi128243. 3 interactions.
STRINGi9606.ENSP00000288078.

Structurei

3D structure databases

ProteinModelPortaliQ8N0W3.
SMRiQ8N0W3. Positions 143-239, 353-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family.Curated

Phylogenomic databases

eggNOGiKOG4644. Eukaryota.
ENOG4111FB6. LUCA.
GeneTreeiENSGT00390000002251.
HOGENOMiHOG000294126.
HOVERGENiHBG021773.
InParanoidiQ8N0W3.
KOiK05305.
OMAiARAFACI.
OrthoDBiEOG7X3QQC.
PhylomeDBiQ8N0W3.
TreeFamiTF314554.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR012887. Fucokinase.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF07959. Fucokinase. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N0W3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP
60 70 80 90 100
EKRVGSGGAT LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP
110 120 130 140 150
FDDCGRAFTC LPVENPEAPV EALVCNLDCL LDIMTYRLGP GSPPGVWVCS
160 170 180 190 200
TDMLLSVPAN PGISWDSFRG ARVIALPGSP AYAQNHGVYL TDPQGLVLDI
210 220 230 240 250
YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH VSPPLDACTY
260 270 280 290 300
LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL
310 320 330 340 350
QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI
360 370 380 390 400
VHSQVEEQQL LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL
410 420 430 440 450
VTGLDTAHSK ALHGRELRDL VLQGHHTRLH GSPGHAFTLV GRLDSWERQG
460 470 480 490 500
AGTYLNVPWS EFFKRTGVRA WDLWDPETLP AEYCLPSARL FPVLHPSREL
510 520 530 540 550
GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA ATLASRRDLF
560 570 580 590 600
FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP
610 620 630 640 650
GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV
660 670 680 690 700
EALAQERDKW LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL
710 720 730 740 750
PGPGQWVVAE CPARVDFSGG WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA
760 770 780 790 800
RARRIPEPEL WLAVGPRQDE MTVKIVCRCL ADLRDYCQPH APGALLKAAF
810 820 830 840 850
ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL GTSSILAGTA
860 870 880 890 900
LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS
910 920 930 940 950
RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY
960 970 980 990 1000
ARLPAVVQNA HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC
1010 1020 1030 1040 1050
EPLTVRRMMD VLAPHVHGQS LAGAGGGGFL YLLTKEPQQK EALEAVLAKT
1060 1070 1080
EGLGNYSIHL VEVDTQGLSL KLLGTEASTC CPFP
Length:1,084
Mass (Da):117,623
Last modified:August 30, 2005 - v2
Checksum:i153F91882F4B143C
GO
Isoform 2 (identifier: Q8N0W3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: T → TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ
     816-841: Missing.

Note: No experimental confirmation available.
Show »
Length:1,090
Mass (Da):118,393
Checksum:i8522A425A0832887
GO

Sequence cautioni

The sequence BAB71190.1 differs from that shown. Reason: Frameshift at position 19. Curated
The sequence CAD29647.1 differs from that shown. Reason: Frameshift at position 19. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti400 – 4001L → S in BAB71190 (PubMed:14702039).Curated
Sequence conflicti609 – 6091C → R in BAB71190 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461V → M.1 Publication
Corresponds to variant rs17881323 [ dbSNP | Ensembl ].
VAR_021327
Natural varianti521 – 5211A → T.1 Publication
Corresponds to variant rs17881069 [ dbSNP | Ensembl ].
VAR_021328
Natural varianti571 – 5711R → H.1 Publication
Corresponds to variant rs17886171 [ dbSNP | Ensembl ].
VAR_021329
Natural varianti701 – 7011P → L.1 Publication
Corresponds to variant rs17883716 [ dbSNP | Ensembl ].
VAR_021330
Natural varianti858 – 8581A → T.1 Publication
Corresponds to variant rs17884050 [ dbSNP | Ensembl ].
VAR_021331
Natural varianti861 – 8611V → M.1 Publication
Corresponds to variant rs17878599 [ dbSNP | Ensembl ].
VAR_021332
Natural varianti901 – 9011R → W.1 Publication
Corresponds to variant rs17881635 [ dbSNP | Ensembl ].
VAR_021333
Natural varianti939 – 9391R → Q.1 Publication
Corresponds to variant rs17886060 [ dbSNP | Ensembl ].
VAR_021334
Natural varianti939 – 9391R → W.1 Publication
Corresponds to variant rs17883248 [ dbSNP | Ensembl ].
VAR_021335

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei78 – 781T → TWICVGVSLWIRGCHPPGRL PEASVHRAFPLLQ in isoform 2. 1 PublicationVSP_015422
Alternative sequencei816 – 84126Missing in isoform 2. 1 PublicationVSP_015423Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ441184 mRNA. Translation: CAD29647.1. Frameshift.
AK056456 mRNA. Translation: BAB71190.1. Frameshift.
AK128387 mRNA. Translation: BAC87413.1.
AY829643 Genomic DNA. Translation: AAV67949.1.
BC013735 mRNA. Translation: AAH13735.1.
BC032542 mRNA. Translation: AAH32542.2.
CCDSiCCDS10891.2. [Q8N0W3-1]
PIRiJC7878.
RefSeqiNP_659496.2. NM_145059.2. [Q8N0W3-1]
XP_006721224.1. XM_006721161.1. [Q8N0W3-1]
XP_011521230.1. XM_011522928.1. [Q8N0W3-1]
XP_011521231.1. XM_011522929.1. [Q8N0W3-1]
UniGeneiHs.7907.

Genome annotation databases

EnsembliENST00000288078; ENSP00000288078; ENSG00000157353. [Q8N0W3-1]
ENST00000378912; ENSP00000368192; ENSG00000157353. [Q8N0W3-2]
GeneIDi197258.
KEGGihsa:197258.
UCSCiuc002eyy.4. human. [Q8N0W3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ441184 mRNA. Translation: CAD29647.1. Frameshift.
AK056456 mRNA. Translation: BAB71190.1. Frameshift.
AK128387 mRNA. Translation: BAC87413.1.
AY829643 Genomic DNA. Translation: AAV67949.1.
BC013735 mRNA. Translation: AAH13735.1.
BC032542 mRNA. Translation: AAH32542.2.
CCDSiCCDS10891.2. [Q8N0W3-1]
PIRiJC7878.
RefSeqiNP_659496.2. NM_145059.2. [Q8N0W3-1]
XP_006721224.1. XM_006721161.1. [Q8N0W3-1]
XP_011521230.1. XM_011522928.1. [Q8N0W3-1]
XP_011521231.1. XM_011522929.1. [Q8N0W3-1]
UniGeneiHs.7907.

3D structure databases

ProteinModelPortaliQ8N0W3.
SMRiQ8N0W3. Positions 143-239, 353-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128243. 3 interactions.
STRINGi9606.ENSP00000288078.

PTM databases

iPTMnetiQ8N0W3.
PhosphoSiteiQ8N0W3.

Polymorphism and mutation databases

BioMutaiFUK.
DMDMi73915340.

Proteomic databases

EPDiQ8N0W3.
MaxQBiQ8N0W3.
PaxDbiQ8N0W3.
PRIDEiQ8N0W3.

Protocols and materials databases

DNASUi197258.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288078; ENSP00000288078; ENSG00000157353. [Q8N0W3-1]
ENST00000378912; ENSP00000368192; ENSG00000157353. [Q8N0W3-2]
GeneIDi197258.
KEGGihsa:197258.
UCSCiuc002eyy.4. human. [Q8N0W3-1]

Organism-specific databases

CTDi197258.
GeneCardsiFUK.
H-InvDBHIX0013200.
HGNCiHGNC:29500. FUK.
HPAiHPA041971.
MIMi608675. gene.
neXtProtiNX_Q8N0W3.
PharmGKBiPA134863646.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4644. Eukaryota.
ENOG4111FB6. LUCA.
GeneTreeiENSGT00390000002251.
HOGENOMiHOG000294126.
HOVERGENiHBG021773.
InParanoidiQ8N0W3.
KOiK05305.
OMAiARAFACI.
OrthoDBiEOG7X3QQC.
PhylomeDBiQ8N0W3.
TreeFamiTF314554.

Enzyme and pathway databases

BRENDAi2.7.1.52. 2681.
ReactomeiR-HSA-6787639. GDP-fucose biosynthesis.

Miscellaneous databases

ChiTaRSiFUK. human.
GenomeRNAii197258.
NextBioi89626.
PROiQ8N0W3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N0W3.
CleanExiHS_FUK.
ExpressionAtlasiQ8N0W3. baseline and differential.
GenevisibleiQ8N0W3. HS.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR012887. Fucokinase.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF07959. Fucokinase. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Neuron and Thymus.
  3. SeattleSNPs variation discovery resource
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-146; THR-521; HIS-571; LEU-701; THR-858; MET-861; TRP-901; GLN-939 AND TRP-939.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Uterus.

Entry informationi

Entry nameiFUK_HUMAN
AccessioniPrimary (citable) accession number: Q8N0W3
Secondary accession number(s): Q5PSM3
, Q5XKL6, Q6ZRA0, Q96MT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: August 30, 2005
Last modified: March 16, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.