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Q8N0W3 (FUK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fucose kinase
Short name=Fucokinase
EC=2.7.1.52
Gene names
Name:FUK
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length1084 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Catalytic activity

ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.

Sequence similarities

Belongs to the GHMP kinase family.

Sequence caution

The sequence BAB71190.1 differs from that shown. Reason: Frameshift at position 19.

The sequence CAD29647.1 differs from that shown. Reason: Frameshift at position 19.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

fucokinase activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N0W3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N0W3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: T → TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ
     816-841: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10841084L-fucose kinase
PRO_0000156672

Regions

Nucleotide binding834 – 84512ATP Potential

Natural variations

Alternative sequence781T → TWICVGVSLWIRGCHPPGRL PEASVHRAFPLLQ in isoform 2.
VSP_015422
Alternative sequence816 – 84126Missing in isoform 2.
VSP_015423
Natural variant1461V → M. Ref.3
Corresponds to variant rs17881323 [ dbSNP | Ensembl ].
VAR_021327
Natural variant5211A → T. Ref.3
Corresponds to variant rs17881069 [ dbSNP | Ensembl ].
VAR_021328
Natural variant5711R → H. Ref.3
Corresponds to variant rs17886171 [ dbSNP | Ensembl ].
VAR_021329
Natural variant7011P → L. Ref.3
Corresponds to variant rs17883716 [ dbSNP | Ensembl ].
VAR_021330
Natural variant8581A → T. Ref.3
Corresponds to variant rs17884050 [ dbSNP | Ensembl ].
VAR_021331
Natural variant8611V → M. Ref.3
Corresponds to variant rs17878599 [ dbSNP | Ensembl ].
VAR_021332
Natural variant9011R → W. Ref.3
Corresponds to variant rs17881635 [ dbSNP | Ensembl ].
VAR_021333
Natural variant9391R → Q. Ref.3
Corresponds to variant rs17886060 [ dbSNP | Ensembl ].
VAR_021334
Natural variant9391R → W. Ref.3
Corresponds to variant rs17883248 [ dbSNP | Ensembl ].
VAR_021335

Experimental info

Sequence conflict4001L → S in BAB71190. Ref.2
Sequence conflict6091C → R in BAB71190. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 153F91882F4B143C

FASTA1,084117,623
        10         20         30         40         50         60 
MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT 

        70         80         90        100        110        120 
LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP FDDCGRAFTC LPVENPEAPV 

       130        140        150        160        170        180 
EALVCNLDCL LDIMTYRLGP GSPPGVWVCS TDMLLSVPAN PGISWDSFRG ARVIALPGSP 

       190        200        210        220        230        240 
AYAQNHGVYL TDPQGLVLDI YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH 

       250        260        270        280        290        300 
VSPPLDACTY LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL 

       310        320        330        340        350        360 
QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI VHSQVEEQQL 

       370        380        390        400        410        420 
LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL VTGLDTAHSK ALHGRELRDL 

       430        440        450        460        470        480 
VLQGHHTRLH GSPGHAFTLV GRLDSWERQG AGTYLNVPWS EFFKRTGVRA WDLWDPETLP 

       490        500        510        520        530        540 
AEYCLPSARL FPVLHPSREL GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA 

       550        560        570        580        590        600 
ATLASRRDLF FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP 

       610        620        630        640        650        660 
GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV EALAQERDKW 

       670        680        690        700        710        720 
LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL PGPGQWVVAE CPARVDFSGG 

       730        740        750        760        770        780 
WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA RARRIPEPEL WLAVGPRQDE MTVKIVCRCL 

       790        800        810        820        830        840 
ADLRDYCQPH APGALLKAAF ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL 

       850        860        870        880        890        900 
GTSSILAGTA LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS 

       910        920        930        940        950        960 
RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY ARLPAVVQNA 

       970        980        990       1000       1010       1020 
HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC EPLTVRRMMD VLAPHVHGQS 

      1030       1040       1050       1060       1070       1080 
LAGAGGGGFL YLLTKEPQQK EALEAVLAKT EGLGNYSIHL VEVDTQGLSL KLLGTEASTC 


CPFP

« Hide

Isoform 2 [UniParc].

Checksum: 8522A425A0832887
Show »

FASTA1,090118,393

References

« Hide 'large scale' references
[1]"Identification of human L-fucose kinase amino acid sequence."
Hinderlich S., Berger M., Blume A., Chen H., Ghaderi D., Bauer C.
Biochem. Biophys. Res. Commun. 294:650-654(2002) [PubMed: 12056818] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Neuron and Thymus.
[3]SeattleSNPs variation discovery resource
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-146; THR-521; HIS-571; LEU-701; THR-858; MET-861; TRP-901; GLN-939 AND TRP-939.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Uterus.

Web resources

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ441184 mRNA. Translation: CAD29647.1. Frameshift.
AK056456 mRNA. Translation: BAB71190.1. Frameshift.
AK128387 mRNA. Translation: BAC87413.1.
AY829643 Genomic DNA. Translation: AAV67949.1.
BC013735 mRNA. Translation: AAH13735.1.
BC032542 mRNA. Translation: AAH32542.2.
IPIIPI00418741.
IPI00645739.
PIRJC7878.
RefSeqNP_659496.2. NM_145059.2.
UniGeneHs.7907.

3D structure databases

ProteinModelPortalQ8N0W3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8N0W3.

PTM databases

PhosphoSiteQ8N0W3.

Polymorphism databases

DMDM73915340.

Proteomic databases

PRIDEQ8N0W3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288078; ENSP00000288078; ENSG00000157353.
GeneID197258.
KEGGhsa:197258.
NMPDRfig|9606.3.peg.12506.
UCSCuc002eyy.1. human.
uc010cft.1. human.

Organism-specific databases

CTD197258.
GeneCardsGC16P070488.
H-InvDBHIX0013200.
HGNCHGNC:29500. FUK.
HPAHPA041971.
MIM608675. gene.
neXtProtNX_Q8N0W3.
PharmGKBPA134863646.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18486.
HOVERGENHBG021773.
OMAWRLSWEQ.
PhylomeDBQ8N0W3.

Gene expression databases

ArrayExpressQ8N0W3.
BgeeQ8N0W3.
CleanExHS_FUK.
GenevestigatorQ8N0W3.
GermOnlineENSG00000157353. Homo sapiens.

Family and domain databases

InterProIPR012887. Fucokinase.
IPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 2 hits.
KOK05305.
PfamPF07959. Fucokinase. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSPR00959. MEVGALKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio89626.
SOURCESearch...

Entry information

Entry nameFUK_HUMAN
AccessionPrimary (citable) accession number: Q8N0W3
Secondary accession number(s): Q5PSM3 expand/collapse secondary AC list , Q5XKL6, Q6ZRA0, Q96MT9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: August 30, 2005
Last modified: January 25, 2012
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents