Reviewed, UniProtKB/Swiss-Prot Q8N0W3 (FUK_HUMAN)

Names and origin

Protein names

Recommended name:
    L-fucose kinase
      Short name=Fucokinase
    EC=2.7.1.52

Gene names

Name:

FUK

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1084 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.
Catalytic activity	ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.
Sequence similarities	Belongs to the GHMP kinase family.
Sequence caution	The sequence BAB71190.1 differs from that shown. Reason: Frameshift at position 19. The sequence CAD29647.1 differs from that shown. Reason: Frameshift at position 19.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fucokinase activity Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N0W3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N0W3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: T → TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ
     816-841: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1084	1084	L-fucose kinase		PRO_0000156672
Regions
	Nucleotide binding	834 – 845	12	ATP Potential
Natural variations
	Alternative sequence	78	1	T → TWICVGVSLWIRGCHPPGRL PEASVHRAFPLLQ in isoform 2.		VSP_015422
	Alternative sequence	816 – 841	26	Missing in isoform 2.		VSP_015423
	Natural variant	146	1	V → M Ref.3		VAR_021327
	Natural variant	521	1	A → T: dbSNP rs17881069. Ref.3		VAR_021328
	Natural variant	571	1	R → H: dbSNP rs17886171. Ref.3		VAR_021329
	Natural variant	701	1	P → L Ref.3		VAR_021330
	Natural variant	858	1	A → T Ref.3		VAR_021331
	Natural variant	861	1	V → M: dbSNP rs17878599. Ref.3		VAR_021332
	Natural variant	901	1	R → W Ref.3		VAR_021333
	Natural variant	939	1	R → Q Ref.3		VAR_021334
	Natural variant	939	1	R → W Ref.3		VAR_021335
Experimental info
	Sequence conflict	400	1	L → S in BAB71190. Ref.2
	Sequence conflict	609	1	C → R in BAB71190. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: 153F91882F4B143C	FASTA	1,084	117,623
	10 20 30 40 50 60 MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT 70 80 90 100 110 120 LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP FDDCGRAFTC LPVENPEAPV 130 140 150 160 170 180 EALVCNLDCL LDIMTYRLGP GSPPGVWVCS TDMLLSVPAN PGISWDSFRG ARVIALPGSP 190 200 210 220 230 240 AYAQNHGVYL TDPQGLVLDI YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH 250 260 270 280 290 300 VSPPLDACTY LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL 310 320 330 340 350 360 QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI VHSQVEEQQL 370 380 390 400 410 420 LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL VTGLDTAHSK ALHGRELRDL 430 440 450 460 470 480 VLQGHHTRLH GSPGHAFTLV GRLDSWERQG AGTYLNVPWS EFFKRTGVRA WDLWDPETLP 490 500 510 520 530 540 AEYCLPSARL FPVLHPSREL GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA 550 560 570 580 590 600 ATLASRRDLF FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP 610 620 630 640 650 660 GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV EALAQERDKW 670 680 690 700 710 720 LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL PGPGQWVVAE CPARVDFSGG 730 740 750 760 770 780 WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA RARRIPEPEL WLAVGPRQDE MTVKIVCRCL 790 800 810 820 830 840 ADLRDYCQPH APGALLKAAF ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL 850 860 870 880 890 900 GTSSILAGTA LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS 910 920 930 940 950 960 RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY ARLPAVVQNA 970 980 990 1000 1010 1020 HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC EPLTVRRMMD VLAPHVHGQS 1030 1040 1050 1060 1070 1080 LAGAGGGGFL YLLTKEPQQK EALEAVLAKT EGLGNYSIHL VEVDTQGLSL KLLGTEASTC CPFP
	Isoform 2. Checksum: 8522A425A0832887	FASTA	1,090	118,393
	10 20 30 40 50 60 MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT 70 80 90 100 110 120 LNALLVAAEH LSARAGFTWI CVGVSLWIRG CHPPGRLPEA SVHRAFPLLQ VVTSDVLHSA 130 140 150 160 170 180 WILILHMGRD FPFDDCGRAF TCLPVENPEA PVEALVCNLD CLLDIMTYRL GPGSPPGVWV 190 200 210 220 230 240 CSTDMLLSVP ANPGISWDSF RGARVIALPG SPAYAQNHGV YLTDPQGLVL DIYYQGTEAE 250 260 270 280 290 300 IQRCVRPDGR VPLVSGVVFF SVETAERLLA THVSPPLDAC TYLGLDSGAR PVQLSLFFDI 310 320 330 340 350 360 LHCMAENVTR EDFLVGRPPE LGQGDADVAG YLQSARAQLW RELRDQPLTM AYVSSGSYSY 370 380 390 400 410 420 MTSSASEFLL SLTLPGAPGA QIVHSQVEEQ QLLAAGSSVV SCLLEGPVQL GPGSVLQHCH 430 440 450 460 470 480 LQGPIHIGAG CLVTGLDTAH SKALHGRELR DLVLQGHHTR LHGSPGHAFT LVGRLDSWER 490 500 510 520 530 540 QGAGTYLNVP WSEFFKRTGV RAWDLWDPET LPAEYCLPSA RLFPVLHPSR ELGPQDLLWM 550 560 570 580 590 600 LDHQEDGGEA LRAWRASWRL SWEQLQPCLD RAATLASRRD LFFRQALHKA RHVLEARQDL 610 620 630 640 650 660 SLRPLIWAAV REGCPGPLLA TLDQVAAGAG DPGVAARALA CVADVLGCMA EGRGGLRSGP 670 680 690 700 710 720 AANPEWMRPF SYLECGDLAA GVEALAQERD KWLSRPALLV RAARHYEGAG QILIRQAVMS 730 740 750 760 770 780 AQHFVSTEQV ELPGPGQWVV AECPARVDFS GGWSDTPPLA YELGGAVLGL AVRVDGRRPI 790 800 810 820 830 840 GARARRIPEP ELWLAVGPRQ DEMTVKIVCR CLADLRDYCQ PHAPGALLKA AFICAGIVHV 850 860 870 880 890 900 HSELQLSTSS ILAGTALAAL QRAAGRVVGT EALIHAVLHL EQVLTTGGGW QDQVGGLMPG 910 920 930 940 950 960 IKVGRSRAQL PLKVEVEEVT VPEGFVQKLN DHLLLVYTGK TRLARNLLQD VLRSWYARLP 970 980 990 1000 1010 1020 AVVQNAHSLV RQTEECAEGF RQGSLPLLGQ CLTSYWEQKK LMAPGCEPLT VRRMMDVLAP 1030 1040 1050 1060 1070 1080 HVHGQSLAGA GGGGFLYLLT KEPQQKEALE AVLAKTEGLG NYSIHLVEVD TQGLSLKLLG 1090 TEASTCCPFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of human L-fucose kinase amino acid sequence." Hinderlich S., Berger M., Blume A., Chen H., Ghaderi D., Bauer C. Biochem. Biophys. Res. Commun. 294:650-654(2002) [PubMed: 12056818] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Neuron and Thymus.
[3]	SeattleSNPs variation discovery resource Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-146; THR-521; HIS-571; LEU-701; THR-858; MET-861; TRP-901; GLN-939 AND TRP-939.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Uterus.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ441184 mRNA. Translation: CAD29647.1. Frameshift. AK056456 mRNA. Translation: BAB71190.1. Frameshift. AK128387 mRNA. Translation: BAC87413.1. AY829643 Genomic DNA. Translation: AAV67949.1. BC013735 mRNA. Translation: AAH13735.1. BC032542 mRNA. Translation: AAH32542.2.
IPI	IPI00418741. IPI00645739.
PIR	JC7878.
RefSeq	NP_659496.2.
UniGene	Hs.7907
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8N0W3.
Proteomic databases
PRIDE	Q8N0W3.
Genome annotation databases
Ensembl	ENSG00000157353. Homo sapiens. [Contig view]
GeneID	197258.
KEGG	hsa:197258.
NMPDR	fig|9606.3.peg.12506.
Organism-specific databases
GeneCards	GC16P069045.
H-InvDB	HIX0013200.
HGNC	HGNC:29500. FUK.
MIM	608675. gene.
PharmGKB	PA134863646.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8N0W3.
OMA	Q8N0W3. ARVDFSG.
Enzyme and pathway databases
BRENDA	2.7.1.52. 247.
Gene expression databases
ArrayExpress	Q8N0W3.
Bgee	Q8N0W3.
CleanEx	HS_FUK.
GermOnline	ENSG00000157353. Homo sapiens.
Family and domain databases
InterPro	IPR012887. Fucokinase. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006206. Mev_galkinase. [Graphical view]
Pfam	PF07959. Fucokinase. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PRINTS	PR00959. MEVGALKINASE.
PROSITE	PS00627. GHMP_KINASES_ATP. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	89626.
SOURCE	Search...

Entry information

Entry name

FUK_HUMAN

Accession

Primary (citable) accession number: Q8N0W3
Secondary accession number(s): Q5PSM3 , Q5XKL6, Q6ZRA0, Q96MT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)