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Protein

Leucine-rich repeat LGI family member 2

Gene

LGI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat LGI family member 2
Alternative name(s):
LGI1-like protein 2
Leucine-rich glioma-inactivated protein 2
Gene namesi
Name:LGI2
Synonyms:KIAA1916, LGIL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:18710. LGI2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38654.

Polymorphism and mutation databases

BioMutaiLGI2.
DMDMi32469740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 545517Leucine-rich repeat LGI family member 2PRO_0000017708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N0V4.
PeptideAtlasiQ8N0V4.
PRIDEiQ8N0V4.

2D gel databases

REPRODUCTION-2DPAGEQ8N0V4.

PTM databases

iPTMnetiQ8N0V4.
PhosphoSiteiQ8N0V4.

Expressioni

Tissue specificityi

Brain, heart and placenta.1 Publication

Gene expression databases

BgeeiENSG00000153012.
CleanExiHS_LGI2.
ExpressionAtlasiQ8N0V4. baseline and differential.
GenevisibleiQ8N0V4. HS.

Organism-specific databases

HPAiHPA017140.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371548.

Structurei

3D structure databases

ProteinModelPortaliQ8N0V4.
SMRiQ8N0V4. Positions 36-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 6537LRRNTAdd
BLAST
Repeati86 – 10722LRR 1Add
BLAST
Repeati110 – 13122LRR 2Add
BLAST
Repeati134 – 15522LRR 3Add
BLAST
Domaini167 – 21751LRRCTAdd
BLAST
Repeati218 – 26144EAR 1Add
BLAST
Repeati264 – 30744EAR 2Add
BLAST
Repeati310 – 35849EAR 3Add
BLAST
Repeati359 – 40345EAR 4Add
BLAST
Repeati406 – 45045EAR 5Add
BLAST
Repeati451 – 49444EAR 6Add
BLAST
Repeati497 – 54044EAR 7Add
BLAST

Sequence similaritiesi

Contains 7 EAR repeats.PROSITE-ProRule annotation
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIXR. Eukaryota.
ENOG410XSZV. LUCA.
GeneTreeiENSGT00840000129728.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8N0V4.
OMAiNTQIFEH.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8N0V4.
TreeFamiTF333155.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03736. EPTP. 6 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N0V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRRGGCGA LGLLLLLLGA ACLIPRSAQV RRLARCPATC SCTKESIICV
60 70 80 90 100
GSSWVPRIVP GDISSLSLVN GTFSEIKDRM FSHLPSLQLL LLNSNSFTII
110 120 130 140 150
RDDAFAGLFH LEYLFIEGNK IETISRNAFR GLRDLTHLSL ANNHIKALPR
160 170 180 190 200
DVFSDLDSLI ELDLRGNKFE CDCKAKWLYL WLKMTNSTVS DVLCIGPPEY
210 220 230 240 250
QEKKLNDVTS FDYECTTTDF VVHQTLPYQS VSVDTFNSKN DVYVAIAQPS
260 270 280 290 300
MENCMVLEWD HIEMNFRSYD NITGQSIVGC KAILIDDQVF VVVAQLFGGS
310 320 330 340 350
HIYKYDESWT KFVKFQDIEV SRISKPNDIE LFQIDDETFF VIADSSKAGL
360 370 380 390 400
STVYKWNSKG FYSYQSLHEW FRDTDAEFVD IDGKSHLILS SRSQVPIILQ
410 420 430 440 450
WNKSSKKFVP HGDIPNMEDV LAVKSFRMQN TLYLSLTRFI GDSRVMRWNS
460 470 480 490 500
KQFVEIQALP SRGAMTLQPF SFKDNHYLAL GSDYTFSQIY QWDKEKQLFK
510 520 530 540
KFKEIYVQAP RSFTAVSTDR RDFFFASSFK GKTKIFEHII VDLSL
Length:545
Mass (Da):62,298
Last modified:October 1, 2002 - v1
Checksum:iFD29B51F01B3D7E2
GO

Sequence cautioni

The sequence BAA91746 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti524 – 5241F → L in CAD32305 (PubMed:12095917).Curated
Sequence conflicti524 – 5241F → L in BAB67809 (PubMed:11572484).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti444 – 4441R → Q.
Corresponds to variant rs2232026 [ dbSNP | Ensembl ].
VAR_030536
Natural varianti452 – 4521Q → R.
Corresponds to variant rs2232027 [ dbSNP | Ensembl ].
VAR_030537

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467955 mRNA. Translation: AAM49553.1.
AJ487958 mRNA. Translation: CAD32305.1.
AJ487516 mRNA. Translation: CAD31784.1.
BC101759 mRNA. Translation: AAI01760.1.
BC101761 mRNA. Translation: AAI01762.1.
AB067503 mRNA. Translation: BAB67809.1.
AK001537 mRNA. Translation: BAA91746.1. Different initiation.
CCDSiCCDS3431.1.
RefSeqiNP_060646.2. NM_018176.3.
UniGeneiHs.12488.

Genome annotation databases

EnsembliENST00000382114; ENSP00000371548; ENSG00000153012.
GeneIDi55203.
KEGGihsa:55203.
UCSCiuc003grf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467955 mRNA. Translation: AAM49553.1.
AJ487958 mRNA. Translation: CAD32305.1.
AJ487516 mRNA. Translation: CAD31784.1.
BC101759 mRNA. Translation: AAI01760.1.
BC101761 mRNA. Translation: AAI01762.1.
AB067503 mRNA. Translation: BAB67809.1.
AK001537 mRNA. Translation: BAA91746.1. Different initiation.
CCDSiCCDS3431.1.
RefSeqiNP_060646.2. NM_018176.3.
UniGeneiHs.12488.

3D structure databases

ProteinModelPortaliQ8N0V4.
SMRiQ8N0V4. Positions 36-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371548.

PTM databases

iPTMnetiQ8N0V4.
PhosphoSiteiQ8N0V4.

Polymorphism and mutation databases

BioMutaiLGI2.
DMDMi32469740.

2D gel databases

REPRODUCTION-2DPAGEQ8N0V4.

Proteomic databases

PaxDbiQ8N0V4.
PeptideAtlasiQ8N0V4.
PRIDEiQ8N0V4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382114; ENSP00000371548; ENSG00000153012.
GeneIDi55203.
KEGGihsa:55203.
UCSCiuc003grf.3. human.

Organism-specific databases

CTDi55203.
GeneCardsiLGI2.
HGNCiHGNC:18710. LGI2.
HPAiHPA017140.
MIMi608301. gene.
neXtProtiNX_Q8N0V4.
PharmGKBiPA38654.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIXR. Eukaryota.
ENOG410XSZV. LUCA.
GeneTreeiENSGT00840000129728.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8N0V4.
OMAiNTQIFEH.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8N0V4.
TreeFamiTF333155.

Enzyme and pathway databases

ReactomeiR-HSA-5682910. LGI-ADAM interactions.

Miscellaneous databases

GeneWikiiLGI2.
GenomeRNAii55203.
PROiQ8N0V4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153012.
CleanExiHS_LGI2.
ExpressionAtlasiQ8N0V4. baseline and differential.
GenevisibleiQ8N0V4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03736. EPTP. 6 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLGI2_HUMAN
AccessioniPrimary (citable) accession number: Q8N0V4
Secondary accession number(s): Q3MIN2
, Q8NDW6, Q96PX2, Q9NVK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.