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Protein

Putative ribosome-binding factor A, mitochondrial

Gene

RBFA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processrRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribosome-binding factor A, mitochondrial
Gene namesi
Name:RBFA
Synonyms:C18orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101546.12
HGNCiHGNC:26120 RBFA
neXtProtiNX_Q8N0V3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi79863
OpenTargetsiENSG00000101546
PharmGKBiPA134885774

Polymorphism and mutation databases

BioMutaiRBFA
DMDMi146334837

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000003022642 – 343Putative ribosome-binding factor A, mitochondrialAdd BLAST302

Proteomic databases

EPDiQ8N0V3
MaxQBiQ8N0V3
PaxDbiQ8N0V3
PeptideAtlasiQ8N0V3
PRIDEiQ8N0V3
ProteomicsDBi71465
71466 [Q8N0V3-2]

PTM databases

iPTMnetiQ8N0V3
PhosphoSitePlusiQ8N0V3

Expressioni

Gene expression databases

BgeeiENSG00000101546
CleanExiHS_C18orf22
GenevisibleiQ8N0V3 HS

Organism-specific databases

HPAiHPA040485
HPA041479

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CMTM5Q96DZ93EBI-3232108,EBI-2548702

Protein-protein interaction databases

BioGridi122951, 16 interactors
IntActiQ8N0V3, 14 interactors
MINTiQ8N0V3
STRINGi9606.ENSP00000305696

Structurei

Secondary structure

1343
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi88 – 107Combined sources20
Turni111 – 113Combined sources3
Helixi115 – 120Combined sources6
Beta strandi124 – 129Combined sources6
Beta strandi136 – 140Combined sources5
Helixi146 – 158Combined sources13
Helixi160 – 168Combined sources9
Beta strandi179 – 183Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7GNMR-A86-201[»]
ProteinModelPortaliQ8N0V3
SMRiQ8N0V3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N0V3

Family & Domainsi

Sequence similaritiesi

Belongs to the RbfA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4700 Eukaryota
ENOG4111QCT LUCA
GeneTreeiENSGT00390000011362
HOVERGENiHBG059992
InParanoidiQ8N0V3
OMAiVGAPEYE
OrthoDBiEOG091G0M09
PhylomeDBiQ8N0V3
TreeFamiTF328637

Family and domain databases

Gene3Di3.30.300.20, 1 hit
InterProiView protein in InterPro
IPR015946 KH_dom-like_a/b
IPR000238 RbfA
IPR023799 RbfA_dom_sf
IPR020053 Ribosome-bd_factorA_CS
PfamiView protein in Pfam
PF02033 RBFA, 1 hit
SUPFAMiSSF89919 SSF89919, 1 hit
PROSITEiView protein in PROSITE
PS01319 RBFA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N0V3-1) [UniParc]FASTAAdd to basket
Also known as: p38

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWAAAGGLWR SRAGLRALFR SRDAALFPGC ERGLHCSAVS CKNWLKKFAS
60 70 80 90 100
KTKKKVWYES PSLGSHSTYK PSKLEFLMRS TSKKTRKEDH ARLRALNGLL
110 120 130 140 150
YKALTDLLCT PEVSQELYDL NVELSKVSLT PDFSACRAYW KTTLSAEQNA
160 170 180 190 200
HMEAVLQRSA AHMRHLLMSQ QTLRNVPPIV FVQDKGNAAL AELDQLLAVA
210 220 230 240 250
DFGPRDERDN FVQNDFRDPD APQPCGTTEP TTSSSLCGID HEALNKQIME
260 270 280 290 300
YKRRKDKGLG GLVWQGQVAE LTTQMKKGRK RAKPRLEQDS SLKSYLSGEE
310 320 330 340
VEDDLDLVGA PEYECYAPDT EELEAERGGG RTEDGHSCGA SRE
Length:343
Mass (Da):38,359
Last modified:March 6, 2007 - v3
Checksum:iE8BE374855BEF403
GO
Isoform 2 (identifier: Q8N0V3-2) [UniParc]FASTAAdd to basket
Also known as: p27

The sequence of this isoform differs from the canonical sequence as follows:
     164-242: RHLLMSQQTL...SSSLCGIDHE → SLISYWQSQT...AWCGRGRWLS
     243-343: Missing.

Show »
Length:242
Mass (Da):27,062
Checksum:i4918C96F48B5CF45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326E → G in AAM20740 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023233122V → M. Corresponds to variant dbSNP:rs748338Ensembl.1
Natural variantiVAR_023234245N → H1 PublicationCorresponds to variant dbSNP:rs3744872Ensembl.1
Natural variantiVAR_023235276K → Q2 PublicationsCorresponds to variant dbSNP:rs3744873Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015118164 – 242RHLLM…GIDHE → SLISYWQSQTLDPGMKETTL YKMISGTLMPHNPAAPQSRP QAPVCVGSIMRRSTSRLWST KGGKIKGSGAWCGRGRWLS in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_015119243 – 343Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261073 mRNA Translation: AAM20740.1
AF439745 mRNA Translation: AAL32051.1
AK024825 mRNA Translation: BAB15022.1
BC014195 mRNA Translation: AAH14195.1
BC057772 mRNA Translation: AAH57772.1
CCDSiCCDS12021.1 [Q8N0V3-1]
CCDS54194.1 [Q8N0V3-2]
RefSeqiNP_001165438.1, NM_001171967.1 [Q8N0V3-2]
NP_079081.2, NM_024805.2 [Q8N0V3-1]
UniGeneiHs.728931

Genome annotation databases

EnsembliENST00000262197; ENSP00000262197; ENSG00000101546 [Q8N0V3-2]
ENST00000306735; ENSP00000305696; ENSG00000101546 [Q8N0V3-1]
GeneIDi79863
KEGGihsa:79863
UCSCiuc002lns.4 human [Q8N0V3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBFA_HUMAN
AccessioniPrimary (citable) accession number: Q8N0V3
Secondary accession number(s): Q6PF07, Q8WZ65, Q9H776
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 6, 2007
Last modified: June 20, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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