Q8N0U8 (VKORL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vitamin K epoxide reductase complex subunit 1-like protein 1
Short name=VKORC1-like protein 1

Gene names

Name:

VKORC1L1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the VKOR family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Vitamin K epoxide reductase complex subunit 1-like protein 1		PRO_0000191671
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8N0U8 [UniParc]. Last modified August 16, 2004. Version 2. Checksum: 1AB0FCDCC2B00E00	FASTA	176	19,836
	10 20 30 40 50 60 MAAPVLLRVS VPRWERVARY AVCAAGILLS IYAYHVEREK ERDPEHRALC DLGPWVKCSA 70 80 90 100 110 120 ALASRWGRGF GLLGSIFGKD GVLNQPNSVF GLIFYILQLL LGMTASAVAA LILMTSSIMS 130 140 150 160 170 VVGSLYLAYI LYFVLKEFCI ICIVTYVLNF LLLIINYKRL VYLNEAWKRQ LQPKQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2." Rost S., Fregin A., Ivaskevicius V., Conzelmann E., Hoertnagel K., Pelz H.-J., Lappegard K., Seifried E., Scharrer I., Tuddenham E.G.D., Mueller C.R., Strom T.M., Oldenburg J. Nature 427:537-541(2004) [PubMed: 14765194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-176. Tissue: Melanoma.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY423045 mRNA. Translation: AAR82915.1. BC027734 mRNA. Translation: AAH27734.2. CR627471 mRNA. Translation: CAH10673.1.
IPI	IPI00166079.
RefSeq	NP_775788.2. NM_173517.3.
UniGene	Hs.427232.
3D structure databases
ProteinModelPortal	Q8N0U8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N0U8.
Polymorphism databases
DMDM	62511214.
Proteomic databases
PRIDE	Q8N0U8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360768; ENSP00000353998; ENSG00000196715.
GeneID	154807.
KEGG	hsa:154807.
UCSC	uc003tul.1. human.
Organism-specific databases
CTD	154807.
GeneCards	GC07P065338.
HGNC	HGNC:21492. VKORC1L1.
MIM	608838. gene.
neXtProt	NX_Q8N0U8.
PharmGKB	PA134931578.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08789.
GeneTree	ENSGT00570000080420.
HOVERGEN	HBG076672.
InParanoid	Q8N0U8.
OMA	LMTSSIV.
OrthoDB	EOG45B1GN.
PhylomeDB	Q8N0U8.
Gene expression databases
ArrayExpress	Q8N0U8.
Bgee	Q8N0U8.
CleanEx	HS_VKORC1L1.
Genevestigator	Q8N0U8.
GermOnline	ENSG00000196715. Homo sapiens.
Family and domain databases
InterPro	IPR012932. VKOR. [Graphical view]
Pfam	PF07884. VKOR. 1 hit. [Graphical view]
SMART	SM00756. VKc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00170. Menadione. DB00682. Warfarin.
NextBio	87318.
SOURCE	Search...

Entry information

Entry name

VKORL_HUMAN

Accession

Primary (citable) accession number: Q8N0U8
Secondary accession number(s): Q6AHW9, Q6TEK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.