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Q8MZR6

- HYEP1_CTEFE

UniProt

Q8MZR6 - HYEP1_CTEFE

Protein

Juvenile hormone epoxide hydrolase 1

Gene

EH1

Organism
Ctenocephalides felis (Cat flea)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes juvenile hormone hydrolysis.1 Publication

    Catalytic activityi

    Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.1 Publication

    GO - Molecular functioni

    1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Juvenile hormone epoxide hydrolase 1 (EC:3.3.2.9)
    Alternative name(s):
    CfEH1
    Juvenile hormone epoxide hydrolase I
    Short name:
    JHEH I
    Juvenile hormone-specific epoxide hydrolase I
    Gene namesi
    Name:EH11 Publication
    OrganismiCtenocephalides felis (Cat flea)
    Taxonomic identifieri7515 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaSiphonapteraPulicidaeArchaeopsyllinaeCtenocephalides

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 464463Juvenile hormone epoxide hydrolase 1PRO_0000080860Add
    BLAST

    Expressioni

    Tissue specificityi

    Developing oocytes, fat body and midgut epithelium of adults.1 Publication

    Developmental stagei

    Expressed in all stages examined from first instar larva to adult. Expression remains relatively constant throughout the larval stages and elevates slightly in adults.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MZR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S33 family.Sequence Analysis

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view]
    PfamiPF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSiPR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8MZR6-1 [UniParc]FASTAAdd to Basket

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    MGKCCRMLIF AAIAGIAVLY YQITKELPKP NIPLDTWWGP GKPQNVDISI    50
    RPFKININNK VIENLKLKLN DVQYTLPLEG INFEYGFNTD SLKKIVDFWR 100
    TQYNWREREA LLNKYPHFKT NIQGLDIHYV HIKPQVSKNI EVLPLVMIHG 150
    WPGSFVEFYK IIPMLTTPRA GYNFVFELIL PSIPGYGFSQ AAAKPGLGST 200
    QVAVIMRNLM ERIGFKKYYV QGGDWGSMII SAMSTLFPEN VLGQHSNMCF 250
    VNTPSSNIKA IIGSFFPESF AGTGNAHKMY PMSEHFFTLL EEMGYLHLQA 300
    TKPDTVGVAL RDSPAGLAAY ILEKFSTWTN RSWRSVKDGN LLLKYNIPEL 350
    LDNVMIYYVT DSITTSMRLY AESFTKAHLA LNLDRVRNHV PAACAKFPNE 400
    LAYVTDCQLA EKYKTLLQSN DMPSGGHFAA FEEPGLLAED IFTAVKKFKE 450
    FYSKKAESQK KADL 464
    Length:464
    Mass (Da):52,614
    Last modified:January 23, 2007 - v3
    Checksum:iA3DA8725F7DCD9BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503908 mRNA. Translation: AAM22694.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503908 mRNA. Translation: AAM22694.1 .

    3D structure databases

    ProteinModelPortali Q8MZR6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view ]
    Pfami PF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSi PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, partial purification and in vivo developmental profile of expression of the juvenile hormone epoxide hydrolase of Ctenocephalides felis."
      Keiser K.C.L., Brandt K.S., Silver G.M., Wisnewski N.
      Arch. Insect Biochem. Physiol. 50:191-206(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-26, FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Larva1 Publication.

    Entry informationi

    Entry nameiHYEP1_CTEFE
    AccessioniPrimary (citable) accession number: Q8MZR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3