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Q8MZR6

- HYEP1_CTEFE

UniProt

Q8MZR6 - HYEP1_CTEFE

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Protein

Juvenile hormone epoxide hydrolase 1

Gene

EH1

Organism
Ctenocephalides felis (Cat flea)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes juvenile hormone hydrolysis.1 Publication

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.1 Publication

GO - Molecular functioni

  1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase 1 (EC:3.3.2.9)
Alternative name(s):
CfEH1
Juvenile hormone epoxide hydrolase I
Short name:
JHEH I
Juvenile hormone-specific epoxide hydrolase I
Gene namesi
Name:EH11 Publication
OrganismiCtenocephalides felis (Cat flea)
Taxonomic identifieri7515 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaSiphonapteraPulicidaeArchaeopsyllinaeCtenocephalides

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Signal-anchorSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 464463Juvenile hormone epoxide hydrolase 1PRO_0000080860Add
BLAST

Expressioni

Tissue specificityi

Developing oocytes, fat body and midgut epithelium of adults.1 Publication

Developmental stagei

Expressed in all stages examined from first instar larva to adult. Expression remains relatively constant throughout the larval stages and elevates slightly in adults.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8MZR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Sequence Analysis

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MZR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKCCRMLIF AAIAGIAVLY YQITKELPKP NIPLDTWWGP GKPQNVDISI
60 70 80 90 100
RPFKININNK VIENLKLKLN DVQYTLPLEG INFEYGFNTD SLKKIVDFWR
110 120 130 140 150
TQYNWREREA LLNKYPHFKT NIQGLDIHYV HIKPQVSKNI EVLPLVMIHG
160 170 180 190 200
WPGSFVEFYK IIPMLTTPRA GYNFVFELIL PSIPGYGFSQ AAAKPGLGST
210 220 230 240 250
QVAVIMRNLM ERIGFKKYYV QGGDWGSMII SAMSTLFPEN VLGQHSNMCF
260 270 280 290 300
VNTPSSNIKA IIGSFFPESF AGTGNAHKMY PMSEHFFTLL EEMGYLHLQA
310 320 330 340 350
TKPDTVGVAL RDSPAGLAAY ILEKFSTWTN RSWRSVKDGN LLLKYNIPEL
360 370 380 390 400
LDNVMIYYVT DSITTSMRLY AESFTKAHLA LNLDRVRNHV PAACAKFPNE
410 420 430 440 450
LAYVTDCQLA EKYKTLLQSN DMPSGGHFAA FEEPGLLAED IFTAVKKFKE
460
FYSKKAESQK KADL
Length:464
Mass (Da):52,614
Last modified:January 23, 2007 - v3
Checksum:iA3DA8725F7DCD9BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503908 mRNA. Translation: AAM22694.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503908 mRNA. Translation: AAM22694.1 .

3D structure databases

ProteinModelPortali Q8MZR6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSi PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, partial purification and in vivo developmental profile of expression of the juvenile hormone epoxide hydrolase of Ctenocephalides felis."
    Keiser K.C.L., Brandt K.S., Silver G.M., Wisnewski N.
    Arch. Insect Biochem. Physiol. 50:191-206(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-26, FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Larva1 Publication.

Entry informationi

Entry nameiHYEP1_CTEFE
AccessioniPrimary (citable) accession number: Q8MZR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3