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Protein

Juvenile hormone epoxide hydrolase 2

Gene

EH2

Organism
Ctenocephalides felis (Cat flea)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes juvenile hormone hydrolysis.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol.By similarity
1-(4-methoxyphenyl)-N-methyl-N-((3-methyloxetan-3-yl)methyl)methanamine + H2O = 2-((((4-methoxyphenyl)methyl)(methyl)amino)methyl)-2-methylpropane-1,3-diol.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224NucleophileBy similarity1
Active sitei370Proton donorBy similarity1
Active sitei427Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAromatic hydrocarbons catabolism

Protein family/group databases

ESTHERictefe-Q8MZR5 Epoxide_hydrolase
MEROPSiS33.971

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase 2 (EC:3.3.2.9By similarity)
Alternative name(s):
CfEH2
Juvenile hormone epoxide hydrolase II
Short name:
JHEH II
Juvenile hormone-specific epoxide hydrolase II
Gene namesi
Name:EH21 Publication
OrganismiCtenocephalides felis (Cat flea)
Taxonomic identifieri7515 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaSiphonapteraPulicidaeArchaeopsyllinaeCtenocephalides

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808611 – 465Juvenile hormone epoxide hydrolase 2Add BLAST465

Structurei

3D structure databases

ProteinModelPortaliQ8MZR5
SMRiQ8MZR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000639 Epox_hydrolase-like
IPR010497 Epoxide_hydro_N
IPR016292 Epoxide_hydrolase
PfamiView protein in Pfam
PF06441 EHN, 1 hit
PIRSFiPIRSF001112 Epoxide_hydrolase, 1 hit
PRINTSiPR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q8MZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNCCRILWI AIVIGLGVLY YEITKEFPKP NIPLDTWWGT GKSQKIDTSM
60 70 80 90 100
RPFKIAINDE VLNTLKVKLS DVSFTPPLEG IDFQYGFNTN TLKKLVDFWR
110 120 130 140 150
TQYNWREREA LLNKYPHFKT NIQGLDIHYV HIKPQVSKNI HVLPMIMVHG
160 170 180 190 200
WPGSFVEFYK IIPMLTTPRT DYNFVFELIL PSIPGYGFSQ AAAKPGLGAT
210 220 230 240 250
QIAVIMHNLM DRIGFKKYYV QGGDWGSRIV SAMSTLFPEN VLGHHSNLCF
260 270 280 290 300
LNTLSSNIKS FVGSLFPEWF AGKQNVHKIY PLSEHFFTLL EESGYFHIQA
310 320 330 340 350
TKPDTVGVAL RDSPAGLAAY ILEKFSTGTN KAWRSAKDGN LQSKFTFTEL
360 370 380 390 400
LDNVMIYYVT GSITTSMRIY AESYSWDHLS LNMDRVPTIV PTACAKFPHE
410 420 430 440 450
IAYKTDFQLA EKYKTLLQST IMPRGGHFAA LEEPLLLAED IFSAVKKFID
460
HHSKKDSKNQ ENRDL
Length:465
Mass (Da):53,025
Last modified:October 1, 2002 - v1
Checksum:iBB85199CCADA4860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503909 mRNA Translation: AAM22695.1

Entry informationi

Entry nameiHYEP2_CTEFE
AccessioniPrimary (citable) accession number: Q8MZR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health