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Q8MZR5

- HYEP2_CTEFE

UniProt

Q8MZR5 - HYEP2_CTEFE

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Protein

Juvenile hormone epoxide hydrolase 2

Gene
EH2
Organism
Ctenocephalides felis (Cat flea)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes juvenile hormone hydrolysis By similarity.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

  1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase 2 (EC:3.3.2.9)
Alternative name(s):
CfEH2
Juvenile hormone epoxide hydrolase II
Short name:
JHEH II
Juvenile hormone-specific epoxide hydrolase II
Gene namesi
Name:EH2
OrganismiCtenocephalides felis (Cat flea)
Taxonomic identifieri7515 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaSiphonapteraPulicidaeArchaeopsyllinaeCtenocephalides

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Signal-anchor; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Juvenile hormone epoxide hydrolase 2PRO_0000080861Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8MZR5.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MZR5-1 [UniParc]FASTAAdd to Basket

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MSNCCRILWI AIVIGLGVLY YEITKEFPKP NIPLDTWWGT GKSQKIDTSM    50
RPFKIAINDE VLNTLKVKLS DVSFTPPLEG IDFQYGFNTN TLKKLVDFWR 100
TQYNWREREA LLNKYPHFKT NIQGLDIHYV HIKPQVSKNI HVLPMIMVHG 150
WPGSFVEFYK IIPMLTTPRT DYNFVFELIL PSIPGYGFSQ AAAKPGLGAT 200
QIAVIMHNLM DRIGFKKYYV QGGDWGSRIV SAMSTLFPEN VLGHHSNLCF 250
LNTLSSNIKS FVGSLFPEWF AGKQNVHKIY PLSEHFFTLL EESGYFHIQA 300
TKPDTVGVAL RDSPAGLAAY ILEKFSTGTN KAWRSAKDGN LQSKFTFTEL 350
LDNVMIYYVT GSITTSMRIY AESYSWDHLS LNMDRVPTIV PTACAKFPHE 400
IAYKTDFQLA EKYKTLLQST IMPRGGHFAA LEEPLLLAED IFSAVKKFID 450
HHSKKDSKNQ ENRDL 465
Length:465
Mass (Da):53,025
Last modified:October 1, 2002 - v1
Checksum:iBB85199CCADA4860
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503909 mRNA. Translation: AAM22695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503909 mRNA. Translation: AAM22695.1 .

3D structure databases

ProteinModelPortali Q8MZR5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSi PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, partial purification and in vivo developmental profile of expression of the juvenile hormone epoxide hydrolase of Ctenocephalides felis."
    Keiser K.C.L., Brandt K.S., Silver G.M., Wisnewski N.
    Arch. Insect Biochem. Physiol. 50:191-206(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Larva.

Entry informationi

Entry nameiHYEP2_CTEFE
AccessioniPrimary (citable) accession number: Q8MZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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