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Q8MZR5

- HYEP2_CTEFE

UniProt

Q8MZR5 - HYEP2_CTEFE

Protein

Juvenile hormone epoxide hydrolase 2

Gene

EH2

Organism
Ctenocephalides felis (Cat flea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes juvenile hormone hydrolysis.By similarity

    Catalytic activityi

    Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

    GO - Molecular functioni

    1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Juvenile hormone epoxide hydrolase 2 (EC:3.3.2.9)
    Alternative name(s):
    CfEH2
    Juvenile hormone epoxide hydrolase II
    Short name:
    JHEH II
    Juvenile hormone-specific epoxide hydrolase II
    Gene namesi
    Name:EH21 Publication
    OrganismiCtenocephalides felis (Cat flea)
    Taxonomic identifieri7515 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaSiphonapteraPulicidaeArchaeopsyllinaeCtenocephalides

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Juvenile hormone epoxide hydrolase 2PRO_0000080861Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MZR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S33 family.Sequence Analysis

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view]
    PfamiPF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSiPR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8MZR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNCCRILWI AIVIGLGVLY YEITKEFPKP NIPLDTWWGT GKSQKIDTSM    50
    RPFKIAINDE VLNTLKVKLS DVSFTPPLEG IDFQYGFNTN TLKKLVDFWR 100
    TQYNWREREA LLNKYPHFKT NIQGLDIHYV HIKPQVSKNI HVLPMIMVHG 150
    WPGSFVEFYK IIPMLTTPRT DYNFVFELIL PSIPGYGFSQ AAAKPGLGAT 200
    QIAVIMHNLM DRIGFKKYYV QGGDWGSRIV SAMSTLFPEN VLGHHSNLCF 250
    LNTLSSNIKS FVGSLFPEWF AGKQNVHKIY PLSEHFFTLL EESGYFHIQA 300
    TKPDTVGVAL RDSPAGLAAY ILEKFSTGTN KAWRSAKDGN LQSKFTFTEL 350
    LDNVMIYYVT GSITTSMRIY AESYSWDHLS LNMDRVPTIV PTACAKFPHE 400
    IAYKTDFQLA EKYKTLLQST IMPRGGHFAA LEEPLLLAED IFSAVKKFID 450
    HHSKKDSKNQ ENRDL 465
    Length:465
    Mass (Da):53,025
    Last modified:October 1, 2002 - v1
    Checksum:iBB85199CCADA4860
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503909 mRNA. Translation: AAM22695.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503909 mRNA. Translation: AAM22695.1 .

    3D structure databases

    ProteinModelPortali Q8MZR5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view ]
    Pfami PF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSi PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, partial purification and in vivo developmental profile of expression of the juvenile hormone epoxide hydrolase of Ctenocephalides felis."
      Keiser K.C.L., Brandt K.S., Silver G.M., Wisnewski N.
      Arch. Insect Biochem. Physiol. 50:191-206(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Larva1 Publication.

    Entry informationi

    Entry nameiHYEP2_CTEFE
    AccessioniPrimary (citable) accession number: Q8MZR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3