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Protein

Juvenile hormone epoxide hydrolase 2

Gene

EH2

Organism
Ctenocephalides felis (Cat flea)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes juvenile hormone hydrolysis.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Protein family/group databases

ESTHERictefe-Q8MZR5. Epoxide_hydrolase.
MEROPSiS33.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase 2 (EC:3.3.2.9)
Alternative name(s):
CfEH2
Juvenile hormone epoxide hydrolase II
Short name:
JHEH II
Juvenile hormone-specific epoxide hydrolase II
Gene namesi
Name:EH21 Publication
OrganismiCtenocephalides felis (Cat flea)
Taxonomic identifieri7515 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaSiphonapteraPulicidaeArchaeopsyllinaeCtenocephalides

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Signal-anchorSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Juvenile hormone epoxide hydrolase 2PRO_0000080861Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8MZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Sequence Analysis

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNCCRILWI AIVIGLGVLY YEITKEFPKP NIPLDTWWGT GKSQKIDTSM
60 70 80 90 100
RPFKIAINDE VLNTLKVKLS DVSFTPPLEG IDFQYGFNTN TLKKLVDFWR
110 120 130 140 150
TQYNWREREA LLNKYPHFKT NIQGLDIHYV HIKPQVSKNI HVLPMIMVHG
160 170 180 190 200
WPGSFVEFYK IIPMLTTPRT DYNFVFELIL PSIPGYGFSQ AAAKPGLGAT
210 220 230 240 250
QIAVIMHNLM DRIGFKKYYV QGGDWGSRIV SAMSTLFPEN VLGHHSNLCF
260 270 280 290 300
LNTLSSNIKS FVGSLFPEWF AGKQNVHKIY PLSEHFFTLL EESGYFHIQA
310 320 330 340 350
TKPDTVGVAL RDSPAGLAAY ILEKFSTGTN KAWRSAKDGN LQSKFTFTEL
360 370 380 390 400
LDNVMIYYVT GSITTSMRIY AESYSWDHLS LNMDRVPTIV PTACAKFPHE
410 420 430 440 450
IAYKTDFQLA EKYKTLLQST IMPRGGHFAA LEEPLLLAED IFSAVKKFID
460
HHSKKDSKNQ ENRDL
Length:465
Mass (Da):53,025
Last modified:October 1, 2002 - v1
Checksum:iBB85199CCADA4860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503909 mRNA. Translation: AAM22695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503909 mRNA. Translation: AAM22695.1.

3D structure databases

ProteinModelPortaliQ8MZR5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERictefe-Q8MZR5. Epoxide_hydrolase.
MEROPSiS33.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning, partial purification and in vivo developmental profile of expression of the juvenile hormone epoxide hydrolase of Ctenocephalides felis."
    Keiser K.C.L., Brandt K.S., Silver G.M., Wisnewski N.
    Arch. Insect Biochem. Physiol. 50:191-206(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Larva1 Publication.

Entry informationi

Entry nameiHYEP2_CTEFE
AccessioniPrimary (citable) accession number: Q8MZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.