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Q8MZR5

- HYEP2_CTEFE

UniProt

Q8MZR5 - HYEP2_CTEFE

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Protein

Juvenile hormone epoxide hydrolase 2

Gene

EH2

Organism
Ctenocephalides felis (Cat flea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes juvenile hormone hydrolysis.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

  1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase 2 (EC:3.3.2.9)
Alternative name(s):
CfEH2
Juvenile hormone epoxide hydrolase II
Short name:
JHEH II
Juvenile hormone-specific epoxide hydrolase II
Gene namesi
Name:EH21 Publication
OrganismiCtenocephalides felis (Cat flea)
Taxonomic identifieri7515 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaSiphonapteraPulicidaeArchaeopsyllinaeCtenocephalides

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Signal-anchorSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Juvenile hormone epoxide hydrolase 2PRO_0000080861Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8MZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Sequence Analysis

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MZR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNCCRILWI AIVIGLGVLY YEITKEFPKP NIPLDTWWGT GKSQKIDTSM
60 70 80 90 100
RPFKIAINDE VLNTLKVKLS DVSFTPPLEG IDFQYGFNTN TLKKLVDFWR
110 120 130 140 150
TQYNWREREA LLNKYPHFKT NIQGLDIHYV HIKPQVSKNI HVLPMIMVHG
160 170 180 190 200
WPGSFVEFYK IIPMLTTPRT DYNFVFELIL PSIPGYGFSQ AAAKPGLGAT
210 220 230 240 250
QIAVIMHNLM DRIGFKKYYV QGGDWGSRIV SAMSTLFPEN VLGHHSNLCF
260 270 280 290 300
LNTLSSNIKS FVGSLFPEWF AGKQNVHKIY PLSEHFFTLL EESGYFHIQA
310 320 330 340 350
TKPDTVGVAL RDSPAGLAAY ILEKFSTGTN KAWRSAKDGN LQSKFTFTEL
360 370 380 390 400
LDNVMIYYVT GSITTSMRIY AESYSWDHLS LNMDRVPTIV PTACAKFPHE
410 420 430 440 450
IAYKTDFQLA EKYKTLLQST IMPRGGHFAA LEEPLLLAED IFSAVKKFID
460
HHSKKDSKNQ ENRDL
Length:465
Mass (Da):53,025
Last modified:October 1, 2002 - v1
Checksum:iBB85199CCADA4860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503909 mRNA. Translation: AAM22695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503909 mRNA. Translation: AAM22695.1 .

3D structure databases

ProteinModelPortali Q8MZR5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSi PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, partial purification and in vivo developmental profile of expression of the juvenile hormone epoxide hydrolase of Ctenocephalides felis."
    Keiser K.C.L., Brandt K.S., Silver G.M., Wisnewski N.
    Arch. Insect Biochem. Physiol. 50:191-206(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Larva1 Publication.

Entry informationi

Entry nameiHYEP2_CTEFE
AccessioniPrimary (citable) accession number: Q8MZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3