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Q8MXE7 (Q8MXE7_CAEEL) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:lag-1 EMBL CCD72376.1 WormBase K08B4.1b
ORF Names:CELE_K08B4.1 EMBL CCD72376.1, K08B4.1 WormBase K08B4.1b
OrganismCaenorhabditis elegans [Reference proteome] EMBL CCD72376.1
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Technical term3D-structure PDB 2FO1 PDB 1TTU PDB 3BRD
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from physical interaction PubMed 9003776. Source: WormBase

cell fate specification

Inferred from mutant phenotype PubMed 1769331. Source: WormBase

dauer exit

Inferred from genetic interaction PubMed 18599512. Source: WormBase

germ-line stem cell division

Inferred from mutant phenotype PubMed 1769331. Source: WormBase

nematode larval development

Inferred from mutant phenotype PubMed 1769331. Source: WormBase

oviposition

Inferred from mutant phenotype PubMed 12074555. Source: WormBase

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 12074555. Source: WormBase

positive regulation of vulval development

Inferred from mutant phenotype PubMed 12074555. Source: WormBase

regulation of cell fate specification

Inferred from mutant phenotype PubMed 12074555PubMed 14701877. Source: WormBase

   Cellular_componentnucleus

Inferred from direct assay PubMed 10903169PubMed 9003776. Source: WormBase

   Molecular_functionNotch binding

Inferred from physical interaction PubMed 9003776. Source: WormBase

RNA polymerase II core promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding

Inferred from direct assay PubMed 8625826. Source: WormBase

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8MXE7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 560701A892830E47

FASTA67174,750
        10         20         30         40         50         60 
MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIEAMFQSVS PLAGVAAAPS 

        70         80         90        100        110        120 
QIAALQQIQA LMTFQMQQNN LFPKIDTISK SPTPELASPS AKRMRLSPST SSHSDVASTS 

       130        140        150        160        170        180 
KGTNGQDQSK NSPTNSDPFY TIGQSTPNTS SFLDTSNSSF GAPSTVVANP MTNYQLAFQA 

       190        200        210        220        230        240 
KLGSLHSLIG DSVQSLTSDR MIDFLSNKEK YECVISIFHA KVAQKSYGNE KRFFCPPPCI 

       250        260        270        280        290        300 
YLIGQGWKLK KDRVAQLYKT LKASAQKDAA IENDPIHEQQ ATELVAYIGI GSDTSERQQL 

       310        320        330        340        350        360 
DFSTGKVRHP GDQRQDPNIY DYCAAKTLYI SDSDKRKYFD LNAQFFYGCG MEIGGFVSQR 

       370        380        390        400        410        420 
IKVISKPSKK KQSMKNTDCK YLCIASGTKV ALFNRLRSQT VSTRYLHVEG NAFHASSTKW 

       430        440        450        460        470        480 
GAFTIHLFDD ERGLQETDNF AVRDGFVYYG SVVKLVDSVT GIALPRLRIR KVDKQQVILD 

       490        500        510        520        530        540 
ASCSEEPVSQ LHKCAFQMID NELVYLCLSH DKIIQHQATA INEHRHQIND GAAWTIISTD 

       550        560        570        580        590        600 
KAEYRFFEAM GQVANPISPC PVVGSLEVDG HGEASRVELH GRDFKPNLKV WFGATPVETT 

       610        620        630        640        650        660 
FRSEESLHCS IPPVSQVRNE QTHWMFTNRT TGDVEVPISL VRDDGVVYSS GLTFSYKSLE 

       670 
RHGPCRIVSN Y 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA."
Kovall R.A., Hendrickson W.A.
EMBO J. 23:3441-3451(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 190-661.
[3]"Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA."
Wilson J.J., Kovall R.A.
Cell 124:985-996(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 190-661.
[4]"RAM-induced allostery facilitates assembly of a notch pathway active transcription complex."
Friedmann D.R., Wilson J.J., Kovall R.A.
J. Biol. Chem. 283:14781-14791(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 190-661.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081552 Genomic DNA. Translation: CCD72376.1.
RefSeqNP_001023278.1. NM_001028107.3.
UniGeneCel.18193.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortalQ8MXE7.
SMRQ8MXE7. Positions 193-658.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.K08B4.1a.

Proteomic databases

PaxDbQ8MXE7.
PRIDEQ8MXE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK08B4.1b; K08B4.1b; WBGene00002245.
GeneID177373.
KEGGcel:CELE_K08B4.1.
UCSCK08B4.1a. c. elegans.

Organism-specific databases

CTD177373.
WormBaseK08B4.1b; CE25048; WBGene00002245; lag-1.

Phylogenomic databases

eggNOGNOG295376.
GeneTreeENSGT00390000005197.
HOGENOMHOG000253907.
KOK06053.

Enzyme and pathway databases

SignaLinkQ8MXE7.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8MXE7.
NextBio896516.

Entry information

Entry nameQ8MXE7_CAEEL
AccessionPrimary (citable) accession number: Q8MXE7
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)