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Protein
Submitted name:

K08B4.1b

Gene

lag-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. Notch binding Source: WormBase
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: InterPro
  4. sequence-specific DNA binding Source: WormBase

GO - Biological processi

  1. cell fate specification Source: WormBase
  2. dauer exit Source: WormBase
  3. germ-line stem cell division Source: WormBase
  4. nematode larval development Source: WormBase
  5. Notch signaling pathway Source: WormBase
  6. oviposition Source: WormBase
  7. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  8. positive regulation of vulval development Source: WormBase
  9. regulation of cell fate specification Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8MXE7.

Names & Taxonomyi

Protein namesi
Submitted name:
K08B4.1bImported
Gene namesi
Name:lag-1Imported
ORF Names:CELE_K08B4.1Imported, K08B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08B4.1b; CE25048; WBGene00002245; lag-1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8MXE7.
PRIDEiQ8MXE7.

Expressioni

Gene expression databases

ExpressionAtlasiQ8MXE7. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08B4.1a.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortaliQ8MXE7.
SMRiQ8MXE7. Positions 193-658.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8MXE7.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
KOiK06053.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MXE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIEAMFQSVS
60 70 80 90 100
PLAGVAAAPS QIAALQQIQA LMTFQMQQNN LFPKIDTISK SPTPELASPS
110 120 130 140 150
AKRMRLSPST SSHSDVASTS KGTNGQDQSK NSPTNSDPFY TIGQSTPNTS
160 170 180 190 200
SFLDTSNSSF GAPSTVVANP MTNYQLAFQA KLGSLHSLIG DSVQSLTSDR
210 220 230 240 250
MIDFLSNKEK YECVISIFHA KVAQKSYGNE KRFFCPPPCI YLIGQGWKLK
260 270 280 290 300
KDRVAQLYKT LKASAQKDAA IENDPIHEQQ ATELVAYIGI GSDTSERQQL
310 320 330 340 350
DFSTGKVRHP GDQRQDPNIY DYCAAKTLYI SDSDKRKYFD LNAQFFYGCG
360 370 380 390 400
MEIGGFVSQR IKVISKPSKK KQSMKNTDCK YLCIASGTKV ALFNRLRSQT
410 420 430 440 450
VSTRYLHVEG NAFHASSTKW GAFTIHLFDD ERGLQETDNF AVRDGFVYYG
460 470 480 490 500
SVVKLVDSVT GIALPRLRIR KVDKQQVILD ASCSEEPVSQ LHKCAFQMID
510 520 530 540 550
NELVYLCLSH DKIIQHQATA INEHRHQIND GAAWTIISTD KAEYRFFEAM
560 570 580 590 600
GQVANPISPC PVVGSLEVDG HGEASRVELH GRDFKPNLKV WFGATPVETT
610 620 630 640 650
FRSEESLHCS IPPVSQVRNE QTHWMFTNRT TGDVEVPISL VRDDGVVYSS
660 670
GLTFSYKSLE RHGPCRIVSN Y
Length:671
Mass (Da):74,750
Last modified:October 1, 2002 - v1
Checksum:i560701A892830E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD72376.1.
RefSeqiNP_001023278.1. NM_001028107.3.
UniGeneiCel.18193.

Genome annotation databases

EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245.
GeneIDi177373.
KEGGicel:CELE_K08B4.1.
UCSCiK08B4.1a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD72376.1.
RefSeqiNP_001023278.1. NM_001028107.3.
UniGeneiCel.18193.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortaliQ8MXE7.
SMRiQ8MXE7. Positions 193-658.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K08B4.1a.

Proteomic databases

PaxDbiQ8MXE7.
PRIDEiQ8MXE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245.
GeneIDi177373.
KEGGicel:CELE_K08B4.1.
UCSCiK08B4.1a. c. elegans.

Organism-specific databases

CTDi177373.
WormBaseiK08B4.1b; CE25048; WBGene00002245; lag-1.

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
KOiK06053.

Enzyme and pathway databases

SignaLinkiQ8MXE7.

Miscellaneous databases

EvolutionaryTraceiQ8MXE7.
NextBioi896516.

Gene expression databases

ExpressionAtlasiQ8MXE7. baseline.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA."
    Kovall R.A., Hendrickson W.A.
    EMBO J. 23:3441-3451(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 190-661.
  3. "Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA."
    Wilson J.J., Kovall R.A.
    Cell 124:985-996(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 190-661.
  4. "RAM-induced allostery facilitates assembly of a notch pathway active transcription complex."
    Friedmann D.R., Wilson J.J., Kovall R.A.
    J. Biol. Chem. 283:14781-14791(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 190-661.

Entry informationi

Entry nameiQ8MXE7_CAEEL
AccessioniPrimary (citable) accession number: Q8MXE7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.