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Q8MXE7

- Q8MXE7_CAEEL

UniProt

Q8MXE7 - Q8MXE7_CAEEL

Protein
Submitted name:

Protein LAG-1, isoform b

Gene

lag-1

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Notch binding Source: WormBase
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: InterPro
    4. sequence-specific DNA binding Source: WormBase

    GO - Biological processi

    1. cell fate specification Source: WormBase
    2. dauer exit Source: WormBase
    3. germ-line stem cell division Source: WormBase
    4. nematode larval development Source: WormBase
    5. Notch signaling pathway Source: WormBase
    6. oviposition Source: WormBase
    7. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
    8. positive regulation of vulval development Source: WormBase
    9. regulation of cell fate specification Source: WormBase

    Enzyme and pathway databases

    SignaLinkiQ8MXE7.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein LAG-1, isoform bImported
    Gene namesi
    Name:lag-1Imported
    ORF Names:CELE_K08B4.1Imported, K08B4.1Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiK08B4.1b; CE25048; WBGene00002245; lag-1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: WormBase

    PTM / Processingi

    Proteomic databases

    PaxDbiQ8MXE7.
    PRIDEiQ8MXE7.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.K08B4.1a.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TTUX-ray2.85A190-661[»]
    3BRDX-ray2.21A190-661[»]
    ProteinModelPortaliQ8MXE7.
    SMRiQ8MXE7. Positions 193-658.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8MXE7.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG295376.
    GeneTreeiENSGT00390000005197.
    HOGENOMiHOG000253907.
    KOiK06053.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.1450. 1 hit.
    InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR015351. LAG1_DNA-bd.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view]
    PfamiPF09270. BTD. 1 hit.
    PF09271. LAG1-DNAbind. 1 hit.
    [Graphical view]
    SUPFAMiSSF110217. SSF110217. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8MXE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIEAMFQSVS    50
    PLAGVAAAPS QIAALQQIQA LMTFQMQQNN LFPKIDTISK SPTPELASPS 100
    AKRMRLSPST SSHSDVASTS KGTNGQDQSK NSPTNSDPFY TIGQSTPNTS 150
    SFLDTSNSSF GAPSTVVANP MTNYQLAFQA KLGSLHSLIG DSVQSLTSDR 200
    MIDFLSNKEK YECVISIFHA KVAQKSYGNE KRFFCPPPCI YLIGQGWKLK 250
    KDRVAQLYKT LKASAQKDAA IENDPIHEQQ ATELVAYIGI GSDTSERQQL 300
    DFSTGKVRHP GDQRQDPNIY DYCAAKTLYI SDSDKRKYFD LNAQFFYGCG 350
    MEIGGFVSQR IKVISKPSKK KQSMKNTDCK YLCIASGTKV ALFNRLRSQT 400
    VSTRYLHVEG NAFHASSTKW GAFTIHLFDD ERGLQETDNF AVRDGFVYYG 450
    SVVKLVDSVT GIALPRLRIR KVDKQQVILD ASCSEEPVSQ LHKCAFQMID 500
    NELVYLCLSH DKIIQHQATA INEHRHQIND GAAWTIISTD KAEYRFFEAM 550
    GQVANPISPC PVVGSLEVDG HGEASRVELH GRDFKPNLKV WFGATPVETT 600
    FRSEESLHCS IPPVSQVRNE QTHWMFTNRT TGDVEVPISL VRDDGVVYSS 650
    GLTFSYKSLE RHGPCRIVSN Y 671
    Length:671
    Mass (Da):74,750
    Last modified:October 1, 2002 - v1
    Checksum:i560701A892830E47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081552 Genomic DNA. Translation: CCD72376.1.
    RefSeqiNP_001023278.1. NM_001028107.3.
    UniGeneiCel.18193.

    Genome annotation databases

    EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245.
    GeneIDi177373.
    KEGGicel:CELE_K08B4.1.
    UCSCiK08B4.1a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081552 Genomic DNA. Translation: CCD72376.1 .
    RefSeqi NP_001023278.1. NM_001028107.3.
    UniGenei Cel.18193.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TTU X-ray 2.85 A 190-661 [» ]
    3BRD X-ray 2.21 A 190-661 [» ]
    ProteinModelPortali Q8MXE7.
    SMRi Q8MXE7. Positions 193-658.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.K08B4.1a.

    Proteomic databases

    PaxDbi Q8MXE7.
    PRIDEi Q8MXE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K08B4.1b ; K08B4.1b ; WBGene00002245 .
    GeneIDi 177373.
    KEGGi cel:CELE_K08B4.1.
    UCSCi K08B4.1a. c. elegans.

    Organism-specific databases

    CTDi 177373.
    WormBasei K08B4.1b ; CE25048 ; WBGene00002245 ; lag-1.

    Phylogenomic databases

    eggNOGi NOG295376.
    GeneTreei ENSGT00390000005197.
    HOGENOMi HOG000253907.
    KOi K06053.

    Enzyme and pathway databases

    SignaLinki Q8MXE7.

    Miscellaneous databases

    EvolutionaryTracei Q8MXE7.
    NextBioi 896516.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.1450. 1 hit.
    InterProi IPR015350. Beta-trefoil_DNA-bd_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR015351. LAG1_DNA-bd.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view ]
    Pfami PF09270. BTD. 1 hit.
    PF09271. LAG1-DNAbind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110217. SSF110217. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.
    2. "Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA."
      Kovall R.A., Hendrickson W.A.
      EMBO J. 23:3441-3451(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 190-661.
    3. "RAM-induced allostery facilitates assembly of a notch pathway active transcription complex."
      Friedmann D.R., Wilson J.J., Kovall R.A.
      J. Biol. Chem. 283:14781-14791(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 190-661.

    Entry informationi

    Entry nameiQ8MXE7_CAEEL
    AccessioniPrimary (citable) accession number: Q8MXE7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3