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Q8MXE7

- Q8MXE7_CAEEL

UniProt

Q8MXE7 - Q8MXE7_CAEEL

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Protein
Submitted name:

Protein LAG-1, isoform b

Gene

lag-1

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. Notch binding Source: WormBase
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: InterPro
  4. sequence-specific DNA binding Source: WormBase

GO - Biological processi

  1. cell fate specification Source: WormBase
  2. dauer exit Source: WormBase
  3. germ-line stem cell division Source: WormBase
  4. nematode larval development Source: WormBase
  5. Notch signaling pathway Source: WormBase
  6. oviposition Source: WormBase
  7. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  8. positive regulation of vulval development Source: WormBase
  9. regulation of cell fate specification Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_269089. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_270292. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_270666. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
SignaLinkiQ8MXE7.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein LAG-1, isoform bImported
Gene namesi
Name:lag-1Imported
ORF Names:CELE_K08B4.1Imported, K08B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK08B4.1b; CE25048; WBGene00002245; lag-1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8MXE7.
PRIDEiQ8MXE7.

Expressioni

Gene expression databases

ExpressionAtlasiQ8MXE7. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08B4.1a.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortaliQ8MXE7.
SMRiQ8MXE7. Positions 193-658.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8MXE7.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
KOiK06053.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MXE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIEAMFQSVS
60 70 80 90 100
PLAGVAAAPS QIAALQQIQA LMTFQMQQNN LFPKIDTISK SPTPELASPS
110 120 130 140 150
AKRMRLSPST SSHSDVASTS KGTNGQDQSK NSPTNSDPFY TIGQSTPNTS
160 170 180 190 200
SFLDTSNSSF GAPSTVVANP MTNYQLAFQA KLGSLHSLIG DSVQSLTSDR
210 220 230 240 250
MIDFLSNKEK YECVISIFHA KVAQKSYGNE KRFFCPPPCI YLIGQGWKLK
260 270 280 290 300
KDRVAQLYKT LKASAQKDAA IENDPIHEQQ ATELVAYIGI GSDTSERQQL
310 320 330 340 350
DFSTGKVRHP GDQRQDPNIY DYCAAKTLYI SDSDKRKYFD LNAQFFYGCG
360 370 380 390 400
MEIGGFVSQR IKVISKPSKK KQSMKNTDCK YLCIASGTKV ALFNRLRSQT
410 420 430 440 450
VSTRYLHVEG NAFHASSTKW GAFTIHLFDD ERGLQETDNF AVRDGFVYYG
460 470 480 490 500
SVVKLVDSVT GIALPRLRIR KVDKQQVILD ASCSEEPVSQ LHKCAFQMID
510 520 530 540 550
NELVYLCLSH DKIIQHQATA INEHRHQIND GAAWTIISTD KAEYRFFEAM
560 570 580 590 600
GQVANPISPC PVVGSLEVDG HGEASRVELH GRDFKPNLKV WFGATPVETT
610 620 630 640 650
FRSEESLHCS IPPVSQVRNE QTHWMFTNRT TGDVEVPISL VRDDGVVYSS
660 670
GLTFSYKSLE RHGPCRIVSN Y
Length:671
Mass (Da):74,750
Last modified:October 1, 2002 - v1
Checksum:i560701A892830E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081552 Genomic DNA. Translation: CCD72376.1.
RefSeqiNP_001023278.1. NM_001028107.3.
UniGeneiCel.18193.

Genome annotation databases

EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245.
GeneIDi177373.
KEGGicel:CELE_K08B4.1.
UCSCiK08B4.1a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081552 Genomic DNA. Translation: CCD72376.1 .
RefSeqi NP_001023278.1. NM_001028107.3.
UniGenei Cel.18193.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TTU X-ray 2.85 A 190-661 [» ]
2FO1 X-ray 3.12 A 190-661 [» ]
3BRD X-ray 2.21 A 190-661 [» ]
ProteinModelPortali Q8MXE7.
SMRi Q8MXE7. Positions 193-658.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K08B4.1a.

Proteomic databases

PaxDbi Q8MXE7.
PRIDEi Q8MXE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K08B4.1b ; K08B4.1b ; WBGene00002245 .
GeneIDi 177373.
KEGGi cel:CELE_K08B4.1.
UCSCi K08B4.1a. c. elegans.

Organism-specific databases

CTDi 177373.
WormBasei K08B4.1b ; CE25048 ; WBGene00002245 ; lag-1.

Phylogenomic databases

eggNOGi NOG295376.
GeneTreei ENSGT00390000005197.
HOGENOMi HOG000253907.
KOi K06053.

Enzyme and pathway databases

Reactomei REACT_269089. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_270292. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_270666. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
SignaLinki Q8MXE7.

Miscellaneous databases

EvolutionaryTracei Q8MXE7.
NextBioi 896516.

Gene expression databases

ExpressionAtlasi Q8MXE7. baseline.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProi IPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view ]
Pfami PF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view ]
SUPFAMi SSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA."
    Kovall R.A., Hendrickson W.A.
    EMBO J. 23:3441-3451(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 190-661.
  3. "Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA."
    Wilson J.J., Kovall R.A.
    Cell 124:985-996(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 190-661.
  4. "RAM-induced allostery facilitates assembly of a notch pathway active transcription complex."
    Friedmann D.R., Wilson J.J., Kovall R.A.
    J. Biol. Chem. 283:14781-14791(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 190-661.

Entry informationi

Entry nameiQ8MXE7_CAEEL
AccessioniPrimary (citable) accession number: Q8MXE7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3