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Protein
Submitted name:

Lin-12 And Glp-1 phenotype

Gene

lag-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell fate specification Source: WormBase
  • dauer exit Source: WormBase
  • germ-line stem cell division Source: WormBase
  • nematode larval development Source: WormBase
  • Notch signaling pathway Source: WormBase
  • oviposition Source: WormBase
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • positive regulation of vulval development Source: WormBase
  • regulation of cell fate specification Source: WormBase

Enzyme and pathway databases

SignaLinkiQ8MXE7

Names & Taxonomyi

Protein namesi
Submitted name:
Lin-12 And Glp-1 phenotypeImported
Gene namesi
Name:lag-1Imported
ORF Names:CELE_K08B4.1Imported, K08B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi

Organism-specific databases

WormBaseiK08B4.1b ; CE25048 ; WBGene00002245 ; lag-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiWBGene00002245
ExpressionAtlasiQ8MXE7 baseline and differential

Interactioni

Protein-protein interaction databases

ELMiQ8MXE7

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortaliQ8MXE7
SMRiQ8MXE7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8MXE7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 378LAG1_DNAbindInterPro annotationAdd BLAST165
Domaini382 – 534BTDInterPro annotationAdd BLAST153

Phylogenomic databases

eggNOGiKOG3743 Eukaryota
ENOG410XV7K LUCA
GeneTreeiENSGT00390000005197
HOGENOMiHOG000253907

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 2 hits
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q8MXE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIEAMFQSVS
60 70 80 90 100
PLAGVAAAPS QIAALQQIQA LMTFQMQQNN LFPKIDTISK SPTPELASPS
110 120 130 140 150
AKRMRLSPST SSHSDVASTS KGTNGQDQSK NSPTNSDPFY TIGQSTPNTS
160 170 180 190 200
SFLDTSNSSF GAPSTVVANP MTNYQLAFQA KLGSLHSLIG DSVQSLTSDR
210 220 230 240 250
MIDFLSNKEK YECVISIFHA KVAQKSYGNE KRFFCPPPCI YLIGQGWKLK
260 270 280 290 300
KDRVAQLYKT LKASAQKDAA IENDPIHEQQ ATELVAYIGI GSDTSERQQL
310 320 330 340 350
DFSTGKVRHP GDQRQDPNIY DYCAAKTLYI SDSDKRKYFD LNAQFFYGCG
360 370 380 390 400
MEIGGFVSQR IKVISKPSKK KQSMKNTDCK YLCIASGTKV ALFNRLRSQT
410 420 430 440 450
VSTRYLHVEG NAFHASSTKW GAFTIHLFDD ERGLQETDNF AVRDGFVYYG
460 470 480 490 500
SVVKLVDSVT GIALPRLRIR KVDKQQVILD ASCSEEPVSQ LHKCAFQMID
510 520 530 540 550
NELVYLCLSH DKIIQHQATA INEHRHQIND GAAWTIISTD KAEYRFFEAM
560 570 580 590 600
GQVANPISPC PVVGSLEVDG HGEASRVELH GRDFKPNLKV WFGATPVETT
610 620 630 640 650
FRSEESLHCS IPPVSQVRNE QTHWMFTNRT TGDVEVPISL VRDDGVVYSS
660 670
GLTFSYKSLE RHGPCRIVSN Y
Length:671
Mass (Da):74,750
Last modified:October 1, 2002 - v1
Checksum:i560701A892830E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD72376.1
RefSeqiNP_001023278.1, NM_001028107.3
UniGeneiCel.18193

Genome annotation databases

EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245
GeneIDi177373
UCSCiK08B4.1a c. elegans

Entry informationi

Entry nameiQ8MXE7_CAEEL
AccessioniPrimary (citable) accession number: Q8MXE7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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