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Protein
Submitted name:

Lin-12 And Glp-1 phenotype

Gene

lag-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell fate specification Source: WormBase
  • dauer exit Source: WormBase
  • germ-line stem cell division Source: WormBase
  • nematode larval development Source: WormBase
  • Notch signaling pathway Source: WormBase
  • oviposition Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • positive regulation of vulval development Source: WormBase
  • regulation of cell fate specification Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8MXE7.

Names & Taxonomyi

Protein namesi
Submitted name:
Lin-12 And Glp-1 phenotypeImported
Gene namesi
Name:lag-1Imported
ORF Names:CELE_K08B4.1Imported, K08B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08B4.1b; CE25048; WBGene00002245; lag-1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8MXE7.

Expressioni

Gene expression databases

BgeeiWBGene00002245.
ExpressionAtlasiQ8MXE7. differential.

Interactioni

GO - Molecular functioni

  • Notch binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.K08B4.1a.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortaliQ8MXE7.
SMRiQ8MXE7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8MXE7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 378LAG1_DNAbindInterPro annotationAdd BLAST165
Domaini382 – 534BTDInterPro annotationAdd BLAST153

Phylogenomic databases

eggNOGiKOG3743. Eukaryota.
ENOG410XV7K. LUCA.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SMARTiSM01268. BTD. 1 hit.
SM01267. LAG1_DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MXE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIEAMFQSVS
60 70 80 90 100
PLAGVAAAPS QIAALQQIQA LMTFQMQQNN LFPKIDTISK SPTPELASPS
110 120 130 140 150
AKRMRLSPST SSHSDVASTS KGTNGQDQSK NSPTNSDPFY TIGQSTPNTS
160 170 180 190 200
SFLDTSNSSF GAPSTVVANP MTNYQLAFQA KLGSLHSLIG DSVQSLTSDR
210 220 230 240 250
MIDFLSNKEK YECVISIFHA KVAQKSYGNE KRFFCPPPCI YLIGQGWKLK
260 270 280 290 300
KDRVAQLYKT LKASAQKDAA IENDPIHEQQ ATELVAYIGI GSDTSERQQL
310 320 330 340 350
DFSTGKVRHP GDQRQDPNIY DYCAAKTLYI SDSDKRKYFD LNAQFFYGCG
360 370 380 390 400
MEIGGFVSQR IKVISKPSKK KQSMKNTDCK YLCIASGTKV ALFNRLRSQT
410 420 430 440 450
VSTRYLHVEG NAFHASSTKW GAFTIHLFDD ERGLQETDNF AVRDGFVYYG
460 470 480 490 500
SVVKLVDSVT GIALPRLRIR KVDKQQVILD ASCSEEPVSQ LHKCAFQMID
510 520 530 540 550
NELVYLCLSH DKIIQHQATA INEHRHQIND GAAWTIISTD KAEYRFFEAM
560 570 580 590 600
GQVANPISPC PVVGSLEVDG HGEASRVELH GRDFKPNLKV WFGATPVETT
610 620 630 640 650
FRSEESLHCS IPPVSQVRNE QTHWMFTNRT TGDVEVPISL VRDDGVVYSS
660 670
GLTFSYKSLE RHGPCRIVSN Y
Length:671
Mass (Da):74,750
Last modified:October 1, 2002 - v1
Checksum:i560701A892830E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD72376.1.
RefSeqiNP_001023278.1. NM_001028107.3.
UniGeneiCel.18193.

Genome annotation databases

EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245.
GeneIDi177373.
UCSCiK08B4.1a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD72376.1.
RefSeqiNP_001023278.1. NM_001028107.3.
UniGeneiCel.18193.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortaliQ8MXE7.
SMRiQ8MXE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K08B4.1a.

Proteomic databases

PaxDbiQ8MXE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245.
GeneIDi177373.
UCSCiK08B4.1a. c. elegans.

Organism-specific databases

CTDi177373.
WormBaseiK08B4.1b; CE25048; WBGene00002245; lag-1.

Phylogenomic databases

eggNOGiKOG3743. Eukaryota.
ENOG410XV7K. LUCA.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.

Enzyme and pathway databases

SignaLinkiQ8MXE7.

Miscellaneous databases

EvolutionaryTraceiQ8MXE7.

Gene expression databases

BgeeiWBGene00002245.
ExpressionAtlasiQ8MXE7. differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SMARTiSM01268. BTD. 1 hit.
SM01267. LAG1_DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8MXE7_CAEEL
AccessioniPrimary (citable) accession number: Q8MXE7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.