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Q8MXE7

- Q8MXE7_CAEEL

UniProt

Q8MXE7 - Q8MXE7_CAEEL

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Protein
Submitted name: Protein LAG-1, isoform b
Gene
lag-1, CELE_K08B4.1, K08B4.1
Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. Notch binding Source: WormBase
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: InterPro
  4. sequence-specific DNA binding Source: WormBase

GO - Biological processi

  1. Notch signaling pathway Source: WormBase
  2. cell fate specification Source: WormBase
  3. dauer exit Source: WormBase
  4. germ-line stem cell division Source: WormBase
  5. nematode larval development Source: WormBase
  6. oviposition Source: WormBase
  7. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  8. positive regulation of vulval development Source: WormBase
  9. regulation of cell fate specification Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8MXE7.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein LAG-1, isoform bImported
Gene namesi
Name:lag-1Imported
ORF Names:CELE_K08B4.1Imported, K08B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK08B4.1b; CE25048; WBGene00002245; lag-1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8MXE7.
PRIDEiQ8MXE7.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08B4.1a.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A190-661[»]
2FO1X-ray3.12A190-661[»]
3BRDX-ray2.21A190-661[»]
ProteinModelPortaliQ8MXE7.
SMRiQ8MXE7. Positions 193-658.

Miscellaneous databases

EvolutionaryTraceiQ8MXE7.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
KOiK06053.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MXE7-1 [UniParc]FASTAAdd to Basket

« Hide

MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIEAMFQSVS    50
PLAGVAAAPS QIAALQQIQA LMTFQMQQNN LFPKIDTISK SPTPELASPS 100
AKRMRLSPST SSHSDVASTS KGTNGQDQSK NSPTNSDPFY TIGQSTPNTS 150
SFLDTSNSSF GAPSTVVANP MTNYQLAFQA KLGSLHSLIG DSVQSLTSDR 200
MIDFLSNKEK YECVISIFHA KVAQKSYGNE KRFFCPPPCI YLIGQGWKLK 250
KDRVAQLYKT LKASAQKDAA IENDPIHEQQ ATELVAYIGI GSDTSERQQL 300
DFSTGKVRHP GDQRQDPNIY DYCAAKTLYI SDSDKRKYFD LNAQFFYGCG 350
MEIGGFVSQR IKVISKPSKK KQSMKNTDCK YLCIASGTKV ALFNRLRSQT 400
VSTRYLHVEG NAFHASSTKW GAFTIHLFDD ERGLQETDNF AVRDGFVYYG 450
SVVKLVDSVT GIALPRLRIR KVDKQQVILD ASCSEEPVSQ LHKCAFQMID 500
NELVYLCLSH DKIIQHQATA INEHRHQIND GAAWTIISTD KAEYRFFEAM 550
GQVANPISPC PVVGSLEVDG HGEASRVELH GRDFKPNLKV WFGATPVETT 600
FRSEESLHCS IPPVSQVRNE QTHWMFTNRT TGDVEVPISL VRDDGVVYSS 650
GLTFSYKSLE RHGPCRIVSN Y 671
Length:671
Mass (Da):74,750
Last modified:October 1, 2002 - v1
Checksum:i560701A892830E47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081552 Genomic DNA. Translation: CCD72376.1.
RefSeqiNP_001023278.1. NM_001028107.3.
UniGeneiCel.18193.

Genome annotation databases

EnsemblMetazoaiK08B4.1b; K08B4.1b; WBGene00002245.
GeneIDi177373.
KEGGicel:CELE_K08B4.1.
UCSCiK08B4.1a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081552 Genomic DNA. Translation: CCD72376.1 .
RefSeqi NP_001023278.1. NM_001028107.3.
UniGenei Cel.18193.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TTU X-ray 2.85 A 190-661 [» ]
2FO1 X-ray 3.12 A 190-661 [» ]
3BRD X-ray 2.21 A 190-661 [» ]
ProteinModelPortali Q8MXE7.
SMRi Q8MXE7. Positions 193-658.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K08B4.1a.

Proteomic databases

PaxDbi Q8MXE7.
PRIDEi Q8MXE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K08B4.1b ; K08B4.1b ; WBGene00002245 .
GeneIDi 177373.
KEGGi cel:CELE_K08B4.1.
UCSCi K08B4.1a. c. elegans.

Organism-specific databases

CTDi 177373.
WormBasei K08B4.1b ; CE25048 ; WBGene00002245 ; lag-1.

Phylogenomic databases

eggNOGi NOG295376.
GeneTreei ENSGT00390000005197.
HOGENOMi HOG000253907.
KOi K06053.

Enzyme and pathway databases

SignaLinki Q8MXE7.

Miscellaneous databases

EvolutionaryTracei Q8MXE7.
NextBioi 896516.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProi IPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view ]
Pfami PF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view ]
SUPFAMi SSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA."
    Kovall R.A., Hendrickson W.A.
    EMBO J. 23:3441-3451(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 190-661.
  3. "Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA."
    Wilson J.J., Kovall R.A.
    Cell 124:985-996(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 190-661.
  4. "RAM-induced allostery facilitates assembly of a notch pathway active transcription complex."
    Friedmann D.R., Wilson J.J., Kovall R.A.
    J. Biol. Chem. 283:14781-14791(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 190-661.

Entry informationi

Entry nameiQ8MXE7_CAEEL
AccessioniPrimary (citable) accession number: Q8MXE7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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