Q8MU95 (BGBP_PLOIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Beta-1,3-glucan-binding protein Short name=BGBP Alternative name(s): Beta-1,3-glucan recognition protein Short name=BetaGRP
Organism	Plodia interpunctella (Indianmeal moth)
Taxonomic identifier	58824 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Pyraloidea › Pyralidae › Phycitinae › Plodia

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the recognition of invading micro-organisms. Binds specifically to beta-1,3-glucan, causing aggregation of invading micro-organisms and activation of the phenoloxidase cascade. Ref.1
Subunit structure	Monomer. Ref.1
Subcellular location	Secreted Ref.1.
Tissue specificity	Fat body and hemolymph. Ref.1
Developmental stage	Expression is maintained at a moderate level throughout development from embryo to adult. Ref.1
Post-translational modification	The N-terminus is blocked. Ref.1
Sequence similarities	Belongs to the insect beta-1,3-glucan binding protein family.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro innate immune response Inferred from electronic annotation. Source: UniProtKB-KW regulation of innate immune response Inferred from direct assay Ref.1. Source: UniProtKB
Cellular component	extracellular region Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	bacterial cell surface binding Inferred from direct assay Ref.1. Source: UniProtKB hydrolase activity, hydrolyzing O-glycosyl compounds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

17

Potential

Chain

18 – 488

471

Beta-1,3-glucan-binding protein

PRO_0000002823

Amino acid modifications

Glycosylation

373

1

N-linked (GlcNAc...) Potential

Glycosylation

453

1

N-linked (GlcNAc...) Potential

Secondary structure

1

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488

Helix Strand Turn

Details...

Beta strand

30 – 32

3

Beta strand

40 – 43

4

Beta strand

50 – 54

5

Beta strand

56 – 58

3

Beta strand

71 – 73

3

Beta strand

81 – 84

4

Beta strand

95 – 103

9

Sequences

	Sequence		Length	Mass (Da)
	Q8MU95 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 38E21D6C94D446F5	FASTA	488	55,213
	10 20 30 40 50 60 MFVTFICFLA CLTCSYGQPR AQQYVVPSAK LEAIYPKGLR VSIPDDGFSL FAFHGKLNEE 70 80 90 100 110 120 MDGLEAGHWA RDITKPKEGR WTFRDRNVKL KLGDKIYFWT YVIKDGLGYR QDNGEWTVTE 130 140 150 160 170 180 FVNEDGTPAD TSLEPTTAPT PVRPDQPNQP IPTHRPDPPC TVSATMVDGR KSVCQGTLLF 190 200 210 220 230 240 SEEFEKANLK DLANWEAEVK FPEEPDYPFN VYMVDGTLEL EDGSLVLTPK LLESRFHAGI 250 260 270 280 290 300 LNDALDLTNR CSGQVDTTEC RRQASGAQIL PPVMTGKITT KNKFTFKFGR VEVRAKLPAG 310 320 330 340 350 360 NWLLPEINLE PKDNVFGSRR YESGLMRVAF AKGNAVFAKK LNGGPVLADT EPFRSLLMKE 370 380 390 400 410 420 KIGIDNWNRD YHNYTLIWKQ DGIDMLVDGE KYGSISPGEG FYALGREHAV PHAAHWLRGS 430 440 450 460 470 480 VMAPLDQYFF LSLGLRVGGV HDFADSPDKP WKNRSNKAVL NFWNDRDNWF PTWFDANLKV DYVRVYAL

References

[1]

"cDNA cloning, purification, properties and function of a beta-1,3-glucan recognition protein from a pyralid moth, Plodia interpunctella." Fabrick J.A., Baker J.E., Kanost M.R. Insect Biochem. Mol. Biol. 33:579-594(2003) [PubMed: 12770576] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-30, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: HD198. Tissue: Larva and Larval plasma.

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Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF532603 mRNA. Translation: AAM95970.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KHA	NMR	-	A	18-135	[»]
3AQY	X-ray	1.58	A/B	24-127	[»]
3AQZ	X-ray	2.20	A/B	24-127	[»]

ProteinModelPortal

Q8MU95.

ModBase

Search...

Protein family/group databases

CAZy

CBM39. Carbohydrate-Binding Module Family 39.
GH16. Glycoside Hydrolase Family 16.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR008985. ConA-like_lec_gl.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view]

Gene3D

G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.

Pfam

PF00722. Glyco_hydro_16. 1 hit.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.

ProtoNet

Search...

Entry information

Entry name

BGBP_PLOIN

Accession

Primary (citable) accession number: Q8MU95

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	October 1, 2002
Last modified:	September 21, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)