Reviewed, UniProtKB/Swiss-Prot Q8MU95 (BGBP_PLOIN)

Names and origin

Protein names	Recommended name:     Beta-1,3-glucan-binding protein       Short name=BGBP Alternative name(s):     Beta-1,3-glucan recognition protein       Short name=BetaGRP
Organism	Plodia interpunctella (Indianmeal moth)
Taxonomic identifier	58824 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Pyraloidea › Pyralidae › Phycitinae › Plodia

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the recognition of invading micro-organisms. Binds specifically to beta-1,3-glucan, causing aggregation of invading micro-organisms and activation of the phenoloxidase cascade. Ref.1
Subunit structure	Monomer. Ref.1
Subcellular location	Secreted. Ref.1
Tissue specificity	Fat body and hemolymph. Ref.1
Developmental stage	Expression is maintained at a moderate level throughout development from embryo to adult. Ref.1
Post-translational modification	The N-terminus is blocked. Ref.1
Sequence similarities	Belongs to the insect beta-1,3-glucan binding protein family.

Ontologies

Keywords
Biological process	Immune response Innate immunity
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	innate immune response Inferred from electronic annotation. Source: UniProtKB-KW regulation of innate immune response Ref.1 Inferred from direct assay. Source: UniProtKB
Cellular component	extracellular region Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	bacterial binding Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 488	471	Beta-1,3-glucan-binding protein		PRO_0000002823
Amino acid modifications
	Glycosylation	373	1	N-linked (GlcNAc...) Potential
	Glycosylation	453	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8MU95-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 38E21D6C94D446F5	FASTA	488	55,213
	10 20 30 40 50 60 MFVTFICFLA CLTCSYGQPR AQQYVVPSAK LEAIYPKGLR VSIPDDGFSL FAFHGKLNEE 70 80 90 100 110 120 MDGLEAGHWA RDITKPKEGR WTFRDRNVKL KLGDKIYFWT YVIKDGLGYR QDNGEWTVTE 130 140 150 160 170 180 FVNEDGTPAD TSLEPTTAPT PVRPDQPNQP IPTHRPDPPC TVSATMVDGR KSVCQGTLLF 190 200 210 220 230 240 SEEFEKANLK DLANWEAEVK FPEEPDYPFN VYMVDGTLEL EDGSLVLTPK LLESRFHAGI 250 260 270 280 290 300 LNDALDLTNR CSGQVDTTEC RRQASGAQIL PPVMTGKITT KNKFTFKFGR VEVRAKLPAG 310 320 330 340 350 360 NWLLPEINLE PKDNVFGSRR YESGLMRVAF AKGNAVFAKK LNGGPVLADT EPFRSLLMKE 370 380 390 400 410 420 KIGIDNWNRD YHNYTLIWKQ DGIDMLVDGE KYGSISPGEG FYALGREHAV PHAAHWLRGS 430 440 450 460 470 480 VMAPLDQYFF LSLGLRVGGV HDFADSPDKP WKNRSNKAVL NFWNDRDNWF PTWFDANLKV DYVRVYAL

References

[1]

"cDNA cloning, purification, properties and function of a beta-1,3-glucan recognition protein from a pyralid moth, Plodia interpunctella." Fabrick J.A., Baker J.E., Kanost M.R. Insect Biochem. Mol. Biol. 33:579-594(2003) [PubMed: 12770576] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-30, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: HD198. Tissue: Larva and Larval plasma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF532603 mRNA. Translation: AAM95970.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	CBM39. Carbohydrate-Binding Module Family 39. GH16. Glycoside Hydrolase Family 16.
Family and domain databases
InterPro	IPR013320. ConA-like_subgrp. [Graphical view]
Gene3D	G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BGBP_PLOIN

Accession

Primary (citable) accession number: Q8MU95

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)