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Protein

Palmitoyltransferase

Gene

CG4483

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
ORF Names:CG4483Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0035970. CG4483.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 163HelicalUniRule annotationAdd BLAST27
Transmembranei183 – 208HelicalUniRule annotationAdd BLAST26

GO - Cellular componenti

  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8MSL3.
PRIDEiQ8MSL3.

Expressioni

Gene expression databases

BgeeiFBgn0035970.
ExpressionAtlasiQ8MSL3. differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 225DHHCInterPro annotationAdd BLAST136

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
OrthoDBiEOG091G0HOK.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MSL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIKLKDDLR RFMHWGPITL LTLTLIVTWT VIHMNSMWWA PGSSLESVLN
60 70 80 90 100
YALIWIQTFG TLYNFIRSLM VGPGFVPLKW HPQLAKDKMF LQFCTRCNGY
110 120 130 140 150
KAPRSHHCRR CDRCVMKMDH HCPWINTCVG WSNQDSFVYF LLFFMSGSIH
160 170 180 190 200
GGIIIVSAVI QGIKKRWLIR LGLRHMATVH LTQTNLLACV FSLGVIMGTV
210 220 230 240 250
LASIKLLYMQ MKSILKNQTE IENWIVKKAA FRRNAYPRKG IKPFVYPYNL
260 270 280 290 300
GWKTNIREVF LSTGDGISWP VLPECNEYSL TCEQLQQKKD KRARTRVFRC
310 320 330 340 350
IRPATGHWVP IFSQGLWVSL QIPCTDDPRI ALKPDDIIHV TRIQEYWLYG
360 370 380 390 400
EIMISEKQKE KIRARNGAIR GWFPSCCAIE ICEDSDSEND LAGGEPVKEQ
410 420 430
DTAAIESVET DQEIIDFMRD FSCNDGKKAK RLHIE
Length:435
Mass (Da):50,316
Last modified:October 1, 2002 - v1
Checksum:i5C5F14986016F232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY118715 mRNA. Translation: AAM50575.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ8MSL3_DROME
AccessioniPrimary (citable) accession number: Q8MSL3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: July 5, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)