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Q8MR63 (Q8MR63_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity. PIRNR PIRNR005096

Catalytic activity

Alpha-D-glucose = beta-D-glucose. PIRNR PIRNR005096

Pathway

Carbohydrate metabolism; hexose metabolism. PIRNR PIRNR005096

Sequence similarities

Belongs to the aldose epimerase family. PIRNR PIRNR005096

Ontologies

Keywords
   Biological processCarbohydrate metabolism PIRNR PIRNR005096
   Molecular functionIsomerase PIRNR PIRNR005096 EMBL AAN12184.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhexose metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionaldose 1-epimerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8MR63 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 11F1B71E6ECC8AE3

FASTA36740,811
        10         20         30         40         50         60 
MVRVIEDMFG IAVNPMTQKT DRVRRFTLVT ERGMSVSILT MGAIIQSLKV PDFNGKLEDV 

        70         80         90        100        110        120 
CLGYDDVAGY YRNQQYFFGA TIGRVANRTA HGRFKLCGKE VSVSRNLRDR HHQNGGFVGF 

       130        140        150        160        170        180 
DSVIWDVVGV HKDGVTLQHI SPDGHEGYPG ELTTNINFSL NETGCFGMRI EARTKATTAV 

       190        200        210        220        230        240 
NISNHSFFNL AGHGAGRDTL YQHMLMIKAQ KIVDVDQELL PTGKLMRVRT TPYDFSSLVS 

       250        260        270        280        290        300 
LGKRLNQVST CPLGGFDNHF CVDIPPNRVQ LVARVVHPCS GRFMEVHTNQ PGLQFSTANH 

       310        320        330        340        350        360 
LPSEDGSDIP IAGKDGVNYV RQGAFTLETQ KYPDAMNHCD FPSVVLNPGQ LYDHQVVYRF 


GSCPKRV 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence."
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. expand/collapse author list , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[5]"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[6]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley EMBL AAM52615.1.
[7]"Combined evidence annotation of transposable elements in genome sequences."
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[8]Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[9]"Drosophila melanogaster release 4 sequence."
Berkeley Drosophila Genome Project
Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[10]"The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
Smith C.D., Shu S., Mungall C.J., Karpen G.H.
Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[11]"Sequence finishing and mapping of Drosophila melanogaster heterochromatin."
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E.
Science 316:1625-1628(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[12]FlyBase
Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY122103 mRNA. Translation: AAM52615.1.
AE014296 Genomic DNA. Translation: AAN12184.1.
RefSeqNP_730671.1. NM_168931.2.
UniGeneDm.10939.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7227.FBpp0078079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0078425; FBpp0078079; FBgn0052445.
GeneID261603.
KEGGdme:Dmel_CG32445.
UCSCCG32445-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0052445. CG32445.

Phylogenomic databases

eggNOGCOG2017.
GeneTreeENSGT00510000047589.
InParanoidQ8MR63.
KOK01785.
OMAMEVHTNQ.
OrthoDBEOG7V7666.

Enzyme and pathway databases

UniPathwayUPA00242.

Family and domain databases

Gene3D2.70.98.10. 1 hit.
InterProIPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PANTHERPTHR10091. PTHR10091. 1 hit.
PfamPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFPIRSF005096. GALM. 1 hit.
SUPFAMSSF74650. SSF74650. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi261603.
NextBio843700.

Entry information

Entry nameQ8MR63_DROME
AccessionPrimary (citable) accession number: Q8MR63
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)