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Q8MR31 (SLIP1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Slo-interacting protein 1
Alternative name(s):
dSLIP1
Gene names
Name:Slip1
ORF Names:CG1783
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May selectively reduce calcium-activated potassium channel (Slo) currents by reducing the number of Slo channels in the plasma membrane. Ref.1

Subunit structure

Interacts with Slo. Ref.1

Tissue specificity

In embryos, it is expressed throughout the CNS and in several peripheral locations. Colocalizes with Slo. Ref.1

Sequence similarities

Contains 1 PDZ (DHR) domain.

Sequence caution

The sequence AAM52669.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionpotassium channel regulator activity

Inferred from direct assay Ref.1. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.1. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

sloQ037205EBI-123875,EBI-426805

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8MR31-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8MR31-2)

The sequence of this isoform differs from the canonical sequence as follows:
     215-520: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 767767Slo-interacting protein 1
PRO_0000071957

Regions

Domain202 – 28079PDZ

Natural variations

Alternative sequence215 – 520306Missing in isoform 2.
VSP_010098

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2004. Version 2.
Checksum: 8914206A7C34E46F

FASTA76785,846
        10         20         30         40         50         60 
MSIADVEYEY VVLKINGYDI SHLSRYEAVQ KFLQSKETLV VEIRRQKHNA LDLELKHGSN 

        70         80         90        100        110        120 
AKISKVDNPG ELSVLTDKSA EGTITAASAS QQINCPSSTS LKEIETKTPV VLTLRARSHE 

       130        140        150        160        170        180 
DRLGSLQAAS KETQTQSVVG TDVLKDNDLV NTITDNFIEH EHHLFEQCLE PEIDIEEVTL 

       190        200        210        220        230        240 
VKGVEQSSSN QIGLIVTSSG IQQSSTDTNK GDILGNVLEH SEDVFISGVQ PESIAYRDGR 

       250        260        270        280        290        300 
LRQGDQILRI NGLDVKNQEE LETQIARSST SVTLLVSRIL YPEDDDDEDI HFEYANTFLP 

       310        320        330        340        350        360 
DDYTNVVDKL DKVLLTHVKS LEELSNKSAM QSDECYHIPE KNSSDSNVKI SSLAKNIIEQ 

       370        380        390        400        410        420 
STKSCSKIKL RPNANLDYKK KFNLPLSQEE VHLQYEYDES EHIYETIPED SESEPVYCSP 

       430        440        450        460        470        480 
YQRSNDKTSI GCSSPIASRP AESLERTMQQ QTQRVAQWLG LKPQYQKTRQ TLVGRPPPLK 

       490        500        510        520        530        540 
LVQQPTCSRV FTLRSTLTNT SASSSSGVAY SSYGQNNVVT GNAAAPGEEV DNSSSAYNTG 

       550        560        570        580        590        600 
DSNNSASPHQ NTTNPDEAIA TGRKLDSTVI DSPNDHLDAT GVSTMLLLPF GKSGRIGLCS 

       610        620        630        640        650        660 
SNLPTAYVSE RYTNVGSENE IHPLKSDIEI LRVKPTDDSY SHCPQFNAPN LSSYHFVSSQ 

       670        680        690        700        710        720 
EVANRCHIST SLQKNATLLN GESAEEIPMV WKVKRRPDGT RYIVKRPVRN RPQVALRKNM 

       730        740        750        760 
RYNEVTTTED DTISEVKIGR YWTKEERKRH IERAREKRHH QTQQQQQ

« Hide

Isoform 2 [UniParc].

Checksum: C9849AF8BCB605FE
Show »

FASTA46151,273

References

« Hide 'large scale' references
[1]"dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels."
Xia X.-M., Hirschberg B., Smolik S., Forte M., Adelman J.P.
J. Neurosci. 18:2360-2369(1998) [PubMed: 9502797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH SLO.
Tissue: Head.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Berkeley.
Tissue: Embryo.
[5]"Nucleotide variation along the Drosophila melanogaster fourth chromosome."
Wang W., Thornton K., Berry A., Long M.
Science 295:134-137(2002) [PubMed: 11778050] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 252-282.
Strain: 253.27 and 253.30.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014135 Genomic DNA. Translation: AAF59321.1.
AY122157 mRNA. Translation: AAM52669.1. Different initiation.
AF433691 Genomic DNA. Translation: AAM17954.1.
AF433692 Genomic DNA. Translation: AAM17955.1.
RefSeqNP_651933.1. NM_143676.1.
UniGeneDm.11434.

3D structure databases

ProteinModelPortalQ8MR31.
SMRQ8MR31. Positions 4-47, 175-279.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-18620N.
IntActQ8MR31. 1 interaction.
MINTMINT-1029104.
STRINGQ8MR31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0089090; FBpp0088159; FBgn0024728.
GeneID43809.
KEGGdme:Dmel_CG1783.
UCSCCG1783-RA. d. melanogaster.

Organism-specific databases

CTD43809.
FlyBaseFBgn0024728. Slip1.

Phylogenomic databases

eggNOGmeNOG10045.
GeneTreeEMGT00050000011704.
InParanoidQ8MR31.
OMAFEQCLEP.
OrthoDBEOG41VHJ5.
PhylomeDBQ8MR31.

Gene expression databases

BgeeQ8MR31.
GermOnlineCG1783. Drosophila melanogaster.

Family and domain databases

InterProIPR001478. PDZ/DHR/GLGF.
[Graphical view]
PfamPF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. PDZ. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio835990.

Entry information

Entry nameSLIP1_DROME
AccessionPrimary (citable) accession number: Q8MR31
Secondary accession number(s): Q8STH5, Q9V4F2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents