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Q8MQU6

- CISYP_DICDI

UniProt

Q8MQU6 - CISYP_DICDI

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Protein

Citrate synthase, peroxisomal

Gene

cshA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Peroxisomal protein involved in the cellular biosynthesis of citrate, and required primarily for cell growth and modulation of multicellular development.1 Publication

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei307 – 3071PROSITE-ProRule annotation
Active sitei346 – 3461PROSITE-ProRule annotation
Active sitei402 – 4021PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: dictyBase

GO - Biological processi

  1. cell proliferation Source: dictyBase
  2. endocytosis Source: dictyBase
  3. glyoxylate cycle Source: dictyBase
  4. phagocytosis Source: dictyBase
  5. pinocytosis Source: dictyBase
  6. positive regulation of phagocytosis Source: dictyBase
  7. sorocarp morphogenesis Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, peroxisomal (EC:2.3.3.16)
Gene namesi
Name:cshA
ORF Names:DDB_G0267426
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0267426. cshA.

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. peroxisome Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 492Citrate synthase, peroxisomalPRO_0000327837
Transit peptidei1 – ?PeroxisomeSequence Analysis

Proteomic databases

PRIDEiQ8MQU6.

Expressioni

Developmental stagei

Maximally expressed during vegetative growth and gradually decreased through subsequent developmental stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0191110.

Structurei

3D structure databases

ProteinModelPortaliQ8MQU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
InParanoidiQ8MQU6.
KOiK01647.
OMAiTIAACAW.
PhylomeDBiQ8MQU6.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MQU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHIDRINIL ANHLSKEEEE ENELLTSPVS ADKKKETVTV TDNRNGKSYD
60 70 80 90 100
FKIKNDTINA LNFKELQLAK GDGGLMIYDP GFQNTAVVTS YITYIDGDKG
110 120 130 140 150
ILRYRGYPIE ELAERSNFLE VAYLLINGNL PNKSQLDGWS NKIMTHTFLH
160 170 180 190 200
ENLVGLMKTF RYDAHPMGML ISTVAALGTF YPEANPALAG GDIFKSENVR
210 220 230 240 250
NKQIYRIVGK LPTIAACAWR HRIGRPYNTP VNHLGYTENF LYMLDKLSEP
260 270 280 290 300
DYKPNPVLCR ALEILFILHA DHELNCSTAA MRHISSSGTD PYTSVAGAAG
310 320 330 340 350
ALYGPSHGGA NEAVLDMLIH IGSKENIPQF ISDVKSKKKK LMGFGHRIYK
360 370 380 390 400
NYDPRAKIIR RVAYEVFESL GKEPLIEVAT ELEKQALEDE YFVSRKLYPN
410 420 430 440 450
VDFYSGLIYK AMGFPTDMFP VLFTIPRAVG WLAHWVEHLE DPETKIYRPR
460 470 480 490
QVYKGEWFRN YVPIDGRPPA KVRSQDSYSS ATTKRYSKVT SH
Length:492
Mass (Da):55,749
Last modified:October 1, 2002 - v1
Checksum:i2008B6988B19A597
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY124377 mRNA. Translation: AAM92490.1.
AAFI02000003 Genomic DNA. Translation: EAL73165.1.
RefSeqiXP_647596.1. XM_642504.1.

Genome annotation databases

EnsemblProtistsiDDB0191110; DDB0191110; DDB_G0267426.
GeneIDi8616408.
KEGGiddi:DDB_G0267426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY124377 mRNA. Translation: AAM92490.1 .
AAFI02000003 Genomic DNA. Translation: EAL73165.1 .
RefSeqi XP_647596.1. XM_642504.1.

3D structure databases

ProteinModelPortali Q8MQU6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191110.

Proteomic databases

PRIDEi Q8MQU6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191110 ; DDB0191110 ; DDB_G0267426 .
GeneIDi 8616408.
KEGGi ddi:DDB_G0267426.

Organism-specific databases

dictyBasei DDB_G0267426. cshA.

Phylogenomic databases

eggNOGi COG0372.
InParanoidi Q8MQU6.
KOi K01647.
OMAi TIAACAW.
PhylomeDBi Q8MQU6.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the peroxisomal citrate synthase CshA affects cell growth and multicellular development in Dictyostelium discoideum."
    Huang Y.-C., Chen Y.-H., Lo S.-R., Liu C.-I., Wang C.-W., Chang W.-T.
    Mol. Microbiol. 53:81-91(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Strain: AX2.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCISYP_DICDI
AccessioniPrimary (citable) accession number: Q8MQU6
Secondary accession number(s): Q55FD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3