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Q8MQU6

- CISYP_DICDI

UniProt

Q8MQU6 - CISYP_DICDI

Protein

Citrate synthase, peroxisomal

Gene

cshA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Peroxisomal protein involved in the cellular biosynthesis of citrate, and required primarily for cell growth and modulation of multicellular development.1 Publication

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei307 – 3071PROSITE-ProRule annotation
    Active sitei346 – 3461PROSITE-ProRule annotation
    Active sitei402 – 4021PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: dictyBase

    GO - Biological processi

    1. cell proliferation Source: dictyBase
    2. endocytosis Source: dictyBase
    3. glyoxylate cycle Source: dictyBase
    4. phagocytosis Source: dictyBase
    5. pinocytosis Source: dictyBase
    6. positive regulation of phagocytosis Source: dictyBase
    7. sorocarp morphogenesis Source: dictyBase

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase, peroxisomal (EC:2.3.3.16)
    Gene namesi
    Name:cshA
    ORF Names:DDB_G0267426
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0267426. cshA.

    Subcellular locationi

    Peroxisome 1 Publication

    GO - Cellular componenti

    1. peroxisome Source: dictyBase

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 492Citrate synthase, peroxisomalPRO_0000327837
    Transit peptidei1 – ?PeroxisomeSequence Analysis

    Proteomic databases

    PRIDEiQ8MQU6.

    Expressioni

    Developmental stagei

    Maximally expressed during vegetative growth and gradually decreased through subsequent developmental stages.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0191110.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MQU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    KOiK01647.
    OMAiTIAACAW.
    PhylomeDBiQ8MQU6.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8MQU6-1 [UniParc]FASTAAdd to Basket

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    MAHIDRINIL ANHLSKEEEE ENELLTSPVS ADKKKETVTV TDNRNGKSYD    50
    FKIKNDTINA LNFKELQLAK GDGGLMIYDP GFQNTAVVTS YITYIDGDKG 100
    ILRYRGYPIE ELAERSNFLE VAYLLINGNL PNKSQLDGWS NKIMTHTFLH 150
    ENLVGLMKTF RYDAHPMGML ISTVAALGTF YPEANPALAG GDIFKSENVR 200
    NKQIYRIVGK LPTIAACAWR HRIGRPYNTP VNHLGYTENF LYMLDKLSEP 250
    DYKPNPVLCR ALEILFILHA DHELNCSTAA MRHISSSGTD PYTSVAGAAG 300
    ALYGPSHGGA NEAVLDMLIH IGSKENIPQF ISDVKSKKKK LMGFGHRIYK 350
    NYDPRAKIIR RVAYEVFESL GKEPLIEVAT ELEKQALEDE YFVSRKLYPN 400
    VDFYSGLIYK AMGFPTDMFP VLFTIPRAVG WLAHWVEHLE DPETKIYRPR 450
    QVYKGEWFRN YVPIDGRPPA KVRSQDSYSS ATTKRYSKVT SH 492
    Length:492
    Mass (Da):55,749
    Last modified:October 1, 2002 - v1
    Checksum:i2008B6988B19A597
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY124377 mRNA. Translation: AAM92490.1.
    AAFI02000003 Genomic DNA. Translation: EAL73165.1.
    RefSeqiXP_647596.1. XM_642504.1.

    Genome annotation databases

    EnsemblProtistsiDDB0191110; DDB0191110; DDB_G0267426.
    GeneIDi8616408.
    KEGGiddi:DDB_G0267426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY124377 mRNA. Translation: AAM92490.1 .
    AAFI02000003 Genomic DNA. Translation: EAL73165.1 .
    RefSeqi XP_647596.1. XM_642504.1.

    3D structure databases

    ProteinModelPortali Q8MQU6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0191110.

    Proteomic databases

    PRIDEi Q8MQU6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0191110 ; DDB0191110 ; DDB_G0267426 .
    GeneIDi 8616408.
    KEGGi ddi:DDB_G0267426.

    Organism-specific databases

    dictyBasei DDB_G0267426. cshA.

    Phylogenomic databases

    eggNOGi COG0372.
    KOi K01647.
    OMAi TIAACAW.
    PhylomeDBi Q8MQU6.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Disruption of the peroxisomal citrate synthase CshA affects cell growth and multicellular development in Dictyostelium discoideum."
      Huang Y.-C., Chen Y.-H., Lo S.-R., Liu C.-I., Wang C.-W., Chang W.-T.
      Mol. Microbiol. 53:81-91(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
      Strain: AX2.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCISYP_DICDI
    AccessioniPrimary (citable) accession number: Q8MQU6
    Secondary accession number(s): Q55FD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3