ID   Q8MPT2_CAEEL            Unreviewed;       475 AA.
AC   Q8MPT2;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 3.
DT   27-MAR-2024, entry version 162.
DE   SubName: Full=SH3 domain-containing protein {ECO:0000313|EMBL:CCD69974.1};
GN   ORFNames=CELE_T04C9.1 {ECO:0000313|EMBL:CCD69974.1}, T04C9.1
GN   {ECO:0000313|EMBL:CCD69974.1, ECO:0000313|WormBase:T04C9.1c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD69974.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD69974.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69974.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- INTERACTION:
CC       Q8MPT2; P91419: abu-11; NbExp=3; IntAct=EBI-2315635, EBI-313979;
CC       Q8MPT2; Q17865: C09G1.4; NbExp=6; IntAct=EBI-2315635, EBI-317562;
CC       Q8MPT2; Q95ZV9: CELE_F08F8.9; NbExp=5; IntAct=EBI-2315635, EBI-327570;
CC       Q8MPT2; O01299: CELE_F09C8.2; NbExp=3; IntAct=EBI-2315635, EBI-2006306;
CC       Q8MPT2; H2KZV4: F23H11.4; NbExp=4; IntAct=EBI-2315635, EBI-2315656;
CC       Q8MPT2; O16299: figl-1; NbExp=5; IntAct=EBI-2315635, EBI-320880;
CC       Q8MPT2; Q93637: hpo-34; NbExp=5; IntAct=EBI-2315635, EBI-312549;
CC       Q8MPT2; Q20357: hum-10; NbExp=4; IntAct=EBI-2315635, EBI-2317438;
CC       Q8MPT2; Q19289: ifb-1; NbExp=5; IntAct=EBI-2315635, EBI-316236;
CC       Q8MPT2; Q9TYX9: M57.1; NbExp=4; IntAct=EBI-2315635, EBI-2315745;
CC       Q8MPT2; G5EBF5: rde-4; NbExp=4; IntAct=EBI-2315635, EBI-328046;
CC       Q8MPT2; Q9N4G4: sop-3; NbExp=6; IntAct=EBI-2315635, EBI-2315681;
CC       Q8MPT2; H2KZH5: toe-2; NbExp=7; IntAct=EBI-2315635, EBI-319539;
CC       Q8MPT2; G5EDS1: vab-3; NbExp=7; IntAct=EBI-2315635, EBI-319610;
CC       Q8MPT2; O02174: zfp-3; NbExp=6; IntAct=EBI-2315635, EBI-2315779;
CC       Q8MPT2; Q19418: ztf-2; NbExp=3; IntAct=EBI-2315635, EBI-2315670;
CC       Q8MPT2; Q86PI8; NbExp=5; IntAct=EBI-2315635, EBI-2315811;
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DR   EMBL; BX284603; CCD69974.1; -; Genomic_DNA.
DR   RefSeq; NP_001293638.1; NM_001306709.1.
DR   AlphaFoldDB; Q8MPT2; -.
DR   SMR; Q8MPT2; -.
DR   IntAct; Q8MPT2; 27.
DR   PeptideAtlas; Q8MPT2; -.
DR   EnsemblMetazoa; T04C9.1c.1; T04C9.1c.1; WBGene00020209.
DR   GeneID; 175849; -.
DR   UCSC; T04C9.1a; c. elegans.
DR   AGR; WB:WBGene00020209; -.
DR   WormBase; T04C9.1c; CE34595; WBGene00020209; -.
DR   GeneTree; ENSGT00940000168384; -.
DR   HOGENOM; CLU_011532_0_0_1; -.
DR   OrthoDB; 5395569at2759; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00020209; Expressed in larva and 4 other cell types or tissues.
DR   ExpressionAtlas; Q8MPT2; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04374; RhoGAP_Graf; 1.
DR   CDD; cd11882; SH3_GRAF-like; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR047234; GRAF_fam.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR   PANTHER; PTHR12552:SF1; RHO GTPASE-ACTIVATING PROTEIN GRAF; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:Q8MPT2,
KW   ECO:0007829|PeptideAtlas:Q8MPT2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          63..250
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          416..475
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          254..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  52535 MW;  7BD4E331290C0357 CRC64;
     MSVYEKQRSS SFGDNTQQMY AMAQHHHQTM GASPRKFNIT DGLRSFHKAS AFLPGFVVDN
     CNAQLDDIGF EFVQQCIDIL EESGIHEQGV YRNCGVTSKV QKMMMLGLDR RKASEKGGLN
     LRDDEWETKT ISSAVKTFLR NLPEPLMTFE LHNVFINAAK MGDATMRIDH IHFYVHQLPA
     QHLRMLEIVV RHLKRVADLS NENLMTVSNL GVCFGPTLLR PKEETVAAIM DIKFCNVVVE
     VLISNYDKIF KSKPKSSFGS AVPPKPDHHT SYDNGRPLAT RSFGVGSKIV RSTQVVSSSY
     SRGMQKRDAM YPSEIARHGI GFDVGELGDF QIENNRSPLT SPTGIAPLAS GSIEEIDEVA
     KKERNSSDSL NSLGSFGSVG DESTATVVAA PDGFGKSIVK PKYSVSYAST YNRIPADSRR
     VKTLYACTPD HHSELSFEPG QIITNVYESN EDGWLVGTLN GKTGLIPSNY VEPLP
//