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Protein
Submitted name:

Cathepsin B-like peptidase (C01 family)

Gene

cb1.1

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin B-like peptidase (C01 family)Imported
Submitted name:
Cathepsin B1 isotype 1Imported
Gene namesi
Name:cb1.1Imported
ORF Names:Smp_103610Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
Proteomesi
  • UP000008854 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_500775125018 – 340UniRule annotationAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi102 ↔ 131Combined sources
Disulfide bondi114 ↔ 158Combined sources
Disulfide bondi150 ↔ 216Combined sources
Disulfide bondi151 ↔ 154Combined sources
Disulfide bondi187 ↔ 220Combined sources
Disulfide bondi195 ↔ 206Combined sources

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_103610__mRNA.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QSDX-ray1.30A87-340[»]
3S3QX-ray1.80A87-340[»]
3S3RX-ray2.64A/B/C87-340[»]
4I04X-ray1.95A/B/C/D18-340[»]
4I05X-ray1.90A56-340[»]
4I07X-ray1.30A87-340[»]
ProteinModelPortaliQ8MNY2.
SMRiQ8MNY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 338Pept_C1InterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
OMAiLAPCGET.
OrthoDBiEOG091G094Z.
PhylomeDBiQ8MNY2.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR012599. Propeptide_C1A.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
PF08127. Propeptide_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MNY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSILCIAS LITFLEAHIS VKNEKFEPLS DDIISYINEH PNAGWRAEKS
60 70 80 90 100
NRFHSLDDAR IQMGARREEP DLRRTRRPTV DHNDWNVEIP SSFDSRKKWP
110 120 130 140 150
RCKSIATIRD QSRCGSCWAF GAVEAMSDRS CIQSGGKQNV ELSAVDLLSC
160 170 180 190 200
CESCGLGCEG GILGPAWDYW VKEGIVTGSS KENHTGCEPY PFPKCEHHTK
210 220 230 240 250
GKYPPCGSKI YKTPRCKQTC QKKYKTPYTQ DKHRGKSSYN VKNDEKAIQK
260 270 280 290 300
EIMKYGPVEA GFTVYEDFLN YKSGIYKHIT GETLGGHAIR IIGWGVENKT
310 320 330 340
PYWLIANSWN EDWGENGYFR IVRGRDECSI ESEVTAGRIN
Length:340
Mass (Da):38,568
Last modified:October 1, 2002 - v1
Checksum:iC5522426039C712E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ506157 Genomic DNA. Translation: CAD44624.1.
HE601624 Genomic DNA. Translation: CCD74613.1.

Genome annotation databases

EnsemblMetazoaiSmp_103610.1; Smp_103610.1:pep; Smp_103610.
GeneDBiSmp_103610.1:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ506157 Genomic DNA. Translation: CAD44624.1.
HE601624 Genomic DNA. Translation: CCD74613.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QSDX-ray1.30A87-340[»]
3S3QX-ray1.80A87-340[»]
3S3RX-ray2.64A/B/C87-340[»]
4I04X-ray1.95A/B/C/D18-340[»]
4I05X-ray1.90A56-340[»]
4I07X-ray1.30A87-340[»]
ProteinModelPortaliQ8MNY2.
SMRiQ8MNY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_103610__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_103610.1; Smp_103610.1:pep; Smp_103610.
GeneDBiSmp_103610.1:pep.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
OMAiLAPCGET.
OrthoDBiEOG091G094Z.
PhylomeDBiQ8MNY2.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR012599. Propeptide_C1A.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
PF08127. Propeptide_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8MNY2_SCHMA
AccessioniPrimary (citable) accession number: Q8MNY2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.