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Q8MMF9

- OB57D_DROME

UniProt

Q8MMF9 - OB57D_DROME

Protein

General odorant-binding protein 57d

Gene

Obp57d

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.Curated

    GO - Molecular functioni

    1. odorant binding Source: UniProtKB

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. sensory perception of chemical stimulus Source: FlyBase
    3. sensory perception of smell Source: UniProtKB-KW
    4. transport Source: UniProtKB

    Keywords - Biological processi

    Olfaction, Sensory transduction, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General odorant-binding protein 57d
    Gene namesi
    Name:Obp57dImported
    ORF Names:CG30150
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0043536. Obp57d.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: FlyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 136107General odorant-binding protein 57dSequence AnalysisPRO_0000012575Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 70By similarity
    Disulfide bondi66 ↔ 118By similarity
    Disulfide bondi107 ↔ 127By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MMF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PBP/GOBP family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG264569.
    InParanoidiQ8MMF9.
    OrthoDBiEOG7NKKN3.

    Family and domain databases

    Gene3Di1.10.238.20. 1 hit.
    InterProiIPR006170. PBP_GOBP.
    IPR023316. PBP_GOBP_dom.
    [Graphical view]
    PfamiPF01395. PBP_GOBP. 1 hit.
    [Graphical view]
    SUPFAMiSSF47565. SSF47565. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8MMF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEKMSLRLV PHLACIIFIL EIQFRIADSN DPCPHNQGID EDIAESILGD    50
    WPANVDLTSV KRSHKCYVTC ILQYYNIVTT SGEIFLDKYY DTGVIDELAV 100
    APKINRCRYE FRMETDYCSR IFAIFNCLRQ EILTKS 136
    Length:136
    Mass (Da):15,747
    Last modified:March 1, 2005 - v2
    Checksum:i3073A70754EE7A4F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801T → A in AAM68388. (PubMed:10731132)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101V → I in strain: Canton-S, KY02013G20 and KY02073G20.
    Natural varianti28 – 281D → E in strain: KY02106G9 and MEL6G59.
    Natural varianti58 – 581T → I in strain: Canton-S, KY02010G20, KY02013G20 and KY02073G20.
    Natural varianti87 – 871D → E in strain: KY02106G9. 1 Publication
    Natural varianti87 – 871D → N in strain: Canton-S, KY02010G20, KY02073G20 and KY02013G20.
    Natural varianti99 – 991A → T in strain: KY02106G9. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF457149 mRNA. Translation: AAM69287.1.
    AB189644 Genomic DNA. Translation: BAD83885.1.
    AB189645 Genomic DNA. Translation: BAD83887.1.
    AB189646 Genomic DNA. Translation: BAD83889.1.
    AB189647 Genomic DNA. Translation: BAD83891.1.
    AB189648 Genomic DNA. Translation: BAD83893.1.
    AB189649 Genomic DNA. Translation: BAD83894.1.
    AB189650 Genomic DNA. Translation: BAD83895.1.
    AB189651 Genomic DNA. Translation: BAD83896.1.
    AB189652 Genomic DNA. Translation: BAD83897.1.
    AB189653 Genomic DNA. Translation: BAD83898.1.
    AB189654 Genomic DNA. Translation: BAD83899.1.
    AB189655 Genomic DNA. Translation: BAD83900.1.
    AB189656 Genomic DNA. Translation: BAD83901.1.
    AB189657 Genomic DNA. Translation: BAD83902.1.
    AB189658 Genomic DNA. Translation: BAD83903.1.
    AB189659 Genomic DNA. Translation: BAD83904.1.
    AB189660 Genomic DNA. Translation: BAD83905.1.
    AB189661 Genomic DNA. Translation: BAD83907.1.
    AB189663 Genomic DNA. Translation: BAD83910.1.
    AB189664 Genomic DNA. Translation: BAD83911.1.
    AB189665 Genomic DNA. Translation: BAD83912.1.
    AB189666 Genomic DNA. Translation: BAD83913.1.
    AB189667 Genomic DNA. Translation: BAD83915.1.
    AE013599 Genomic DNA. Translation: AAM68388.1.
    RefSeqiNP_725973.1. NM_166397.2.
    UniGeneiDm.4636.

    Genome annotation databases

    GeneIDi246671.
    KEGGidme:Dmel_CG30150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF457149 mRNA. Translation: AAM69287.1 .
    AB189644 Genomic DNA. Translation: BAD83885.1 .
    AB189645 Genomic DNA. Translation: BAD83887.1 .
    AB189646 Genomic DNA. Translation: BAD83889.1 .
    AB189647 Genomic DNA. Translation: BAD83891.1 .
    AB189648 Genomic DNA. Translation: BAD83893.1 .
    AB189649 Genomic DNA. Translation: BAD83894.1 .
    AB189650 Genomic DNA. Translation: BAD83895.1 .
    AB189651 Genomic DNA. Translation: BAD83896.1 .
    AB189652 Genomic DNA. Translation: BAD83897.1 .
    AB189653 Genomic DNA. Translation: BAD83898.1 .
    AB189654 Genomic DNA. Translation: BAD83899.1 .
    AB189655 Genomic DNA. Translation: BAD83900.1 .
    AB189656 Genomic DNA. Translation: BAD83901.1 .
    AB189657 Genomic DNA. Translation: BAD83902.1 .
    AB189658 Genomic DNA. Translation: BAD83903.1 .
    AB189659 Genomic DNA. Translation: BAD83904.1 .
    AB189660 Genomic DNA. Translation: BAD83905.1 .
    AB189661 Genomic DNA. Translation: BAD83907.1 .
    AB189663 Genomic DNA. Translation: BAD83910.1 .
    AB189664 Genomic DNA. Translation: BAD83911.1 .
    AB189665 Genomic DNA. Translation: BAD83912.1 .
    AB189666 Genomic DNA. Translation: BAD83913.1 .
    AB189667 Genomic DNA. Translation: BAD83915.1 .
    AE013599 Genomic DNA. Translation: AAM68388.1 .
    RefSeqi NP_725973.1. NM_166397.2.
    UniGenei Dm.4636.

    3D structure databases

    ProteinModelPortali Q8MMF9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 246671.
    KEGGi dme:Dmel_CG30150.

    Organism-specific databases

    CTDi 246671.
    FlyBasei FBgn0043536. Obp57d.

    Phylogenomic databases

    eggNOGi NOG264569.
    InParanoidi Q8MMF9.
    OrthoDBi EOG7NKKN3.

    Miscellaneous databases

    GenomeRNAii 246671.
    NextBioi 843429.

    Family and domain databases

    Gene3Di 1.10.238.20. 1 hit.
    InterProi IPR006170. PBP_GOBP.
    IPR023316. PBP_GOBP_dom.
    [Graphical view ]
    Pfami PF01395. PBP_GOBP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47565. SSF47565. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The odorant-binding proteins of Drosophila melanogaster: annotation and characterization of a divergent gene family."
      Graham L.A., Davies P.L.
      Gene 292:43-55(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Canton-SImported.
    2. "A high frequency null mutant of an odrant-binding protein gene, Obp57e, in Drosophila melanogaster."
      Takahashi A., Takano-Shimizu T.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AlgeriaImported, CA1Imported, KSA2Imported, KY02001G20Imported, KY02002G20Imported, KY02003G20Imported, KY02006G20Imported, KY02010G20Imported, KY02013G20Imported, KY02016G18Imported, KY02070G20Imported, KY02073G20Imported, KY02074G20Imported, KY02101G9Imported, KY02102G9Imported, KY02104G9Imported, KY02106G9Imported, KY02109G9Imported, MEL6G59Imported, MEL7Imported, MEL8Imported and TaiwanG23Imported.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. "Genome-wide analysis of the odorant-binding protein gene family in Drosophila melanogaster."
      Hekmat-Scafe D.S., Scafe C.R., McKinney A.J., Tanouye M.A.
      Genome Res. 12:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiOB57D_DROME
    AccessioniPrimary (citable) accession number: Q8MMF9
    Secondary accession number(s): Q5KS14
    , Q5KS20, Q5KS26, Q5KS32, Q5KS34, Q8MVX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3