Q8MMF9 (OB57D_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
General odorant-binding protein 57d

Gene names

Name:	Obp57d
ORF Names:	CG30150

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Sequence similarities	Belongs to the PBP/GOBP family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction Transport
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of chemical stimulus Inferred from sequence alignment Ref.5. Source: FlyBase sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW transport Non-traceable author statement Ref.5. Source: UniProtKB
Cellular_component	extracellular region Inferred from sequence model PubMed 21527792. Source: FlyBase
Molecular_function	odorant binding Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 136	107	General odorant-binding protein 57d		PRO_0000012575
Amino acid modifications
	Disulfide bond	33 ↔ 70		By similarity
	Disulfide bond	66 ↔ 118		By similarity
	Disulfide bond	107 ↔ 127		By similarity
Natural variations
	Natural variant	10	1	V → I in strain: Canton-S, KY02013G20 and KY02073G20. Ref.2
	Natural variant	28	1	D → E in strain: KY02106G9 and MEL6G59. Ref.2
	Natural variant	58	1	T → I in strain: Canton-S, KY02010G20, KY02013G20 and KY02073G20. Ref.2
	Natural variant	87	1	D → E in strain: KY02106G9. Ref.2
	Natural variant	87	1	D → N in strain: Canton-S, KY02010G20, KY02073G20 and KY02013G20.
	Natural variant	99	1	A → T in strain: KY02106G9. Ref.2
Experimental info
	Sequence conflict	80	1	T → A in AAM68388. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8MMF9 [UniParc]. Last modified March 1, 2005. Version 2. Checksum: 3073A70754EE7A4F	FASTA	136	15,747
	10 20 30 40 50 60 MPEKMSLRLV PHLACIIFIL EIQFRIADSN DPCPHNQGID EDIAESILGD WPANVDLTSV 70 80 90 100 110 120 KRSHKCYVTC ILQYYNIVTT SGEIFLDKYY DTGVIDELAV APKINRCRYE FRMETDYCSR 130 IFAIFNCLRQ EILTKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The odorant-binding proteins of Drosophila melanogaster: annotation and characterization of a divergent gene family." Graham L.A., Davies P.L. Gene 292:43-55(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Canton-S.
[2]	"A high frequency null mutant of an odrant-binding protein gene, Obp57e, in Drosophila melanogaster." Takahashi A., Takano-Shimizu T. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Algeria, CA1, KSA2, KY02001G20, KY02002G20, KY02003G20, KY02006G20, KY02010G20, KY02013G20, KY02016G18, KY02070G20, KY02073G20, KY02074G20, KY02101G9, KY02102G9, KY02104G9, KY02106G9, KY02109G9, MEL6G59, MEL7, MEL8 and TaiwanG23.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"Genome-wide analysis of the odorant-binding protein gene family in Drosophila melanogaster." Hekmat-Scafe D.S., Scafe C.R., McKinney A.J., Tanouye M.A. Genome Res. 12:1357-1369(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF457149 mRNA. Translation: AAM69287.1. AB189644 Genomic DNA. Translation: BAD83885.1. AB189645 Genomic DNA. Translation: BAD83887.1. AB189646 Genomic DNA. Translation: BAD83889.1. AB189647 Genomic DNA. Translation: BAD83891.1. AB189648 Genomic DNA. Translation: BAD83893.1. AB189649 Genomic DNA. Translation: BAD83894.1. AB189650 Genomic DNA. Translation: BAD83895.1. AB189651 Genomic DNA. Translation: BAD83896.1. AB189652 Genomic DNA. Translation: BAD83897.1. AB189653 Genomic DNA. Translation: BAD83898.1. AB189654 Genomic DNA. Translation: BAD83899.1. AB189655 Genomic DNA. Translation: BAD83900.1. AB189656 Genomic DNA. Translation: BAD83901.1. AB189657 Genomic DNA. Translation: BAD83902.1. AB189658 Genomic DNA. Translation: BAD83903.1. AB189659 Genomic DNA. Translation: BAD83904.1. AB189660 Genomic DNA. Translation: BAD83905.1. AB189661 Genomic DNA. Translation: BAD83907.1. AB189663 Genomic DNA. Translation: BAD83910.1. AB189664 Genomic DNA. Translation: BAD83911.1. AB189665 Genomic DNA. Translation: BAD83912.1. AB189666 Genomic DNA. Translation: BAD83913.1. AB189667 Genomic DNA. Translation: BAD83915.1. AE013599 Genomic DNA. Translation: AAM68388.1.
RefSeq	NP_725973.1. NM_166397.2.
UniGene	Dm.4636.
3D structure databases
ProteinModelPortal	Q8MMF9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	246671.
KEGG	dme:Dmel_CG30150.
Organism-specific databases
CTD	246671.
FlyBase	FBgn0043536. Obp57d.
Phylogenomic databases
eggNOG	NOG264569.
InParanoid	Q8MMF9.
OrthoDB	EOG451C74.
Gene expression databases
GermOnline	CG30150. Drosophila melanogaster.
Family and domain databases
Gene3D	1.10.238.20. 1 hit.
InterPro	IPR006170. PBP_GOBP. IPR023316. PBP_GOBP_dom. [Graphical view]
Pfam	PF01395. PBP_GOBP. 1 hit. [Graphical view]
SUPFAM	SSF47565. PBP_GOBP. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	246671.
NextBio	843429.

Entry information

Entry name

OB57D_DROME

Accession

Primary (citable) accession number: Q8MMF9
Secondary accession number(s): Q5KS14 , Q5KS20, Q5KS26, Q5KS32, Q5KS34, Q8MVX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	April 3, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project