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Protein

40S ribosomal protein S8

Gene

RpS8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • larval lymph gland hemopoiesis Source: FlyBase
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Gene namesi
Name:RpS8
ORF Names:CG7808
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039713 RpS8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222491 – 20840S ribosomal protein S8Add BLAST208

Proteomic databases

PaxDbiQ8MLY8
PRIDEiQ8MLY8

Expressioni

Gene expression databases

BgeeiFBgn0039713
ExpressionAtlasiQ8MLY8 differential
GenevisibleiQ8MLY8 DM

Interactioni

Protein-protein interaction databases

BioGridi68391, 37 interactors
IntActiQ8MLY8, 35 interactors
MINTiQ8MLY8
STRINGi7227.FBpp0099686

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AI1-208[»]
ProteinModelPortaliQ8MLY8
SMRiQ8MLY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3283 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000012433
InParanoidiQ8MLY8
KOiK02995
OMAiAWGSEHV
OrthoDBiEOG091G0MF7
PhylomeDBiQ8MLY8

Family and domain databases

InterProiView protein in InterPro
IPR001047 Ribosomal_S8e
IPR022309 Ribosomal_S8e/biogenesis_NSA2
IPR018283 Ribosomal_S8e_CS
PANTHERiPTHR10394 PTHR10394, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit
TIGRFAMsiTIGR00307 eS8, 1 hit
PROSITEiView protein in PROSITE
PS01193 RIBOSOMAL_S8E, 1 hit

Sequencei

Sequence statusi: Complete.

Q8MLY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISRDSAHK RRATGGKRKS LRKKRKFELG RPAANTKLGS GRVHKVRTRG
60 70 80 90 100
GNTKLRALRL ETGNFAWASE GVARKTRIAD VVYNASNNEL VRTKTLVKNS
110 120 130 140 150
IVVIDATPFR QWYEAHYVLP LGRKRNPKHA QKEDENDVLT KKRSEKVMKK
160 170 180 190 200
YLERQKYGKV EQALEDQFTS GRILACISSR PGQCGRSDGY ILEGKELEFY

LKKIKSKK
Length:208
Mass (Da):23,759
Last modified:October 1, 2002 - v1
Checksum:iEC96C28BCCF6FE0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAN14192.1
AY118424 mRNA Translation: AAM48453.1
AY118446 mRNA Translation: AAM48475.1
RefSeqiNP_001247362.1, NM_001260433.3
NP_001287596.1, NM_001300667.1
NP_001287597.1, NM_001300668.1
NP_651740.1, NM_143483.3
UniGeneiDm.20574

Genome annotation databases

EnsemblMetazoaiFBtr0085489; FBpp0099686; FBgn0039713
FBtr0310274; FBpp0301957; FBgn0039713
FBtr0346158; FBpp0311986; FBgn0039713
FBtr0346159; FBpp0311987; FBgn0039713
GeneIDi43532
KEGGidme:Dmel_CG7808

Similar proteinsi

Entry informationi

Entry nameiRS8_DROME
AccessioniPrimary (citable) accession number: Q8MLY8
Secondary accession number(s): Q9VAF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health