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Protein

40S ribosomal protein S8

Gene

RpS8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • larval lymph gland hemopoiesis Source: FlyBase
  • neurogenesis Source: FlyBase
  • translation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Gene namesi
Name:RpS8
ORF Names:CG7808
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039713. RpS8.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: FlyBase
  • ribosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20820840S ribosomal protein S8PRO_0000122249Add
BLAST

Proteomic databases

PaxDbiQ8MLY8.
PRIDEiQ8MLY8.

Expressioni

Gene expression databases

GenevisibleiQ8MLY8. DM.

Interactioni

Protein-protein interaction databases

BioGridi68391. 34 interactions.
IntActiQ8MLY8. 5 interactions.
MINTiMINT-828441.
STRINGi7227.FBpp0099686.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AI1-208[»]
ProteinModelPortaliQ8MLY8.
SMRiQ8MLY8. Positions 2-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S8e family.Curated

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
InParanoidiQ8MLY8.
KOiK02995.
OMAiNYSWASE.
OrthoDBiEOG7V1FRW.
PhylomeDBiQ8MLY8.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MLY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISRDSAHK RRATGGKRKS LRKKRKFELG RPAANTKLGS GRVHKVRTRG
60 70 80 90 100
GNTKLRALRL ETGNFAWASE GVARKTRIAD VVYNASNNEL VRTKTLVKNS
110 120 130 140 150
IVVIDATPFR QWYEAHYVLP LGRKRNPKHA QKEDENDVLT KKRSEKVMKK
160 170 180 190 200
YLERQKYGKV EQALEDQFTS GRILACISSR PGQCGRSDGY ILEGKELEFY

LKKIKSKK
Length:208
Mass (Da):23,759
Last modified:October 1, 2002 - v1
Checksum:iEC96C28BCCF6FE0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN14192.1.
AY118424 mRNA. Translation: AAM48453.1.
AY118446 mRNA. Translation: AAM48475.1.
RefSeqiNP_001247362.1. NM_001260433.3.
NP_001287596.1. NM_001300667.1.
NP_001287597.1. NM_001300668.1.
NP_651740.1. NM_143483.3.
UniGeneiDm.20574.

Genome annotation databases

EnsemblMetazoaiFBtr0085489; FBpp0099686; FBgn0039713.
FBtr0310274; FBpp0301957; FBgn0039713.
FBtr0346158; FBpp0311986; FBgn0039713.
FBtr0346159; FBpp0311987; FBgn0039713.
GeneIDi43532.
KEGGidme:Dmel_CG7808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN14192.1.
AY118424 mRNA. Translation: AAM48453.1.
AY118446 mRNA. Translation: AAM48475.1.
RefSeqiNP_001247362.1. NM_001260433.3.
NP_001287596.1. NM_001300667.1.
NP_001287597.1. NM_001300668.1.
NP_651740.1. NM_143483.3.
UniGeneiDm.20574.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AI1-208[»]
ProteinModelPortaliQ8MLY8.
SMRiQ8MLY8. Positions 2-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68391. 34 interactions.
IntActiQ8MLY8. 5 interactions.
MINTiMINT-828441.
STRINGi7227.FBpp0099686.

Proteomic databases

PaxDbiQ8MLY8.
PRIDEiQ8MLY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085489; FBpp0099686; FBgn0039713.
FBtr0310274; FBpp0301957; FBgn0039713.
FBtr0346158; FBpp0311986; FBgn0039713.
FBtr0346159; FBpp0311987; FBgn0039713.
GeneIDi43532.
KEGGidme:Dmel_CG7808.

Organism-specific databases

CTDi6202.
FlyBaseiFBgn0039713. RpS8.

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
InParanoidiQ8MLY8.
KOiK02995.
OMAiNYSWASE.
OrthoDBiEOG7V1FRW.
PhylomeDBiQ8MLY8.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpS8. fly.
GenomeRNAii43532.
NextBioi834402.
PROiQ8MLY8.

Gene expression databases

GenevisibleiQ8MLY8. DM.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo and Head.
  4. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.

Entry informationi

Entry nameiRS8_DROME
AccessioniPrimary (citable) accession number: Q8MLY8
Secondary accession number(s): Q9VAF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.