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Protein

40S ribosomal protein S8

Gene

RpS8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • larval lymph gland hemopoiesis Source: FlyBase
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Gene namesi
Name:RpS8
ORF Names:CG7808
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039713. RpS8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222491 – 20840S ribosomal protein S8Add BLAST208

Proteomic databases

PaxDbiQ8MLY8.
PRIDEiQ8MLY8.

Expressioni

Gene expression databases

BgeeiFBgn0039713.
ExpressionAtlasiQ8MLY8. differential.
GenevisibleiQ8MLY8. DM.

Interactioni

Protein-protein interaction databases

BioGridi68391. 37 interactors.
IntActiQ8MLY8. 36 interactors.
MINTiMINT-828441.
STRINGi7227.FBpp0099686.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AI1-208[»]
ProteinModelPortaliQ8MLY8.
SMRiQ8MLY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
InParanoidiQ8MLY8.
KOiK02995.
OMAiAWGSEHV.
OrthoDBiEOG091G0MF7.
PhylomeDBiQ8MLY8.

Family and domain databases

InterProiView protein in InterPro
IPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiView protein in Pfam
PF01201. Ribosomal_S8e. 1 hit.
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiView protein in PROSITE
PS01193. RIBOSOMAL_S8E. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MLY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISRDSAHK RRATGGKRKS LRKKRKFELG RPAANTKLGS GRVHKVRTRG
60 70 80 90 100
GNTKLRALRL ETGNFAWASE GVARKTRIAD VVYNASNNEL VRTKTLVKNS
110 120 130 140 150
IVVIDATPFR QWYEAHYVLP LGRKRNPKHA QKEDENDVLT KKRSEKVMKK
160 170 180 190 200
YLERQKYGKV EQALEDQFTS GRILACISSR PGQCGRSDGY ILEGKELEFY

LKKIKSKK
Length:208
Mass (Da):23,759
Last modified:October 1, 2002 - v1
Checksum:iEC96C28BCCF6FE0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN14192.1.
AY118424 mRNA. Translation: AAM48453.1.
AY118446 mRNA. Translation: AAM48475.1.
RefSeqiNP_001247362.1. NM_001260433.3.
NP_001287596.1. NM_001300667.1.
NP_001287597.1. NM_001300668.1.
NP_651740.1. NM_143483.3.
UniGeneiDm.20574.

Genome annotation databases

EnsemblMetazoaiFBtr0085489; FBpp0099686; FBgn0039713.
FBtr0310274; FBpp0301957; FBgn0039713.
FBtr0346158; FBpp0311986; FBgn0039713.
FBtr0346159; FBpp0311987; FBgn0039713.
GeneIDi43532.
KEGGidme:Dmel_CG7808.

Similar proteinsi

Entry informationi

Entry nameiRS8_DROME
AccessioniPrimary (citable) accession number: Q8MLY8
Secondary accession number(s): Q9VAF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families