Q8MLW2 (Q8MLW2_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Domino, isoform D EMBL AAM70870.1
EC=3.6.1.3 EMBL AAM70870.1

Gene names

Name:	dom EMBL AAM70870.1
ORF Names:	Dmel_CG9696 EMBL AAM70870.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	3183 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Hydrolase EMBL AAM70870.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chromatin organization Inferred from mutant phenotype. Source: FlyBase dendrite guidance Inferred from mutant phenotype. Source: FlyBase gene silencing Inferred from genetic interaction. Source: FlyBase hemopoiesis Traceable author statement. Source: FlyBase instar larval or pupal development Inferred from mutant phenotype. Source: FlyBase negative regulation of hemocyte proliferation Traceable author statement. Source: FlyBase oogenesis Inferred from mutant phenotype. Source: FlyBase positive regulation of Notch signaling pathway Inferred from genetic interaction. Source: FlyBase regulation of alternative nuclear mRNA splicing, via spliceosome Inferred from mutant phenotype. Source: FlyBase wing disc pattern formation Inferred from genetic interaction. Source: FlyBase
Cellular component	nucleus Inferred from direct assay. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity Inferred from electronic annotation. Source: EC DNA binding Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8MLW2 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: C4AE07312BEB50D8	FASTA	3,183	348,386
	10 20 30 40 50 60 MNEGNSAGGG HEGLSPAPPA VPDRVTPHST EISVAPANST STTVRAAGSV GAALPATRHH 70 80 90 100 110 120 QHIATQVKGI ASSSSKQQKQ LASAQLPVPL SPLPQQQQQT AEATAAAAAP AHSNVSVSSS 130 140 150 160 170 180 TIEASVLPPQ AKRQRLDDNE DRTSAASIVG PAESSNIVSS LLPASVASSS EVGGLSSTAL 190 200 210 220 230 240 QDLNALKKRI LQQKLQILRN LKERHLENVS EYFYLQNGGS MMDYPAWRKK TPTPQFISYS 250 260 270 280 290 300 NANRIDQLIH EDKPSTSAAA AAAQNQKYTT QQTDSVESSL VSGIGTGATK GAPLDGNISN 310 320 330 340 350 360 STVKTNTQSQ VPSKIGSFTE STPAATESNS STTVPGTATS GAATSTSATS AEASGNVLAV 370 380 390 400 410 420 EAEIKIPAVG ATPVAISTKL PAAVVQLTQQ GGTPLLPCNT SAGSTALRRP QGQNNASSGS 430 440 450 460 470 480 AAASGGGGSL TPTPLYTGNG PAALGGSGGL TPGTPTSGSL LSPALGGGSG TPNSAAQEFS 490 500 510 520 530 540 FKAKQEVYVM QRISELQREG LWTERRLPKL QEPSRPKAHW DYLLEEMVWL AADFAQERKW 550 560 570 580 590 600 KKNAAKKCAK MVQKYFQDKA TAAQRAEKAQ ELQLKRVASF IAREVKSFWS NVEKLVEYKH 610 620 630 640 650 660 QTKIEEKRKQ ALDQHLSFIV DQTEKFSQQL VEGMNKSVAD TPSLNSSRLT SPKRESDDDF 670 680 690 700 710 720 RPESGSEDDE ETIAKAEEDA ADVKEEVTAL AKESEMDFDD FLNDLPPGYL ENRDKLMKEE 730 740 750 760 770 780 QSSAIKTETP DDSDDSEFEA KEASDDDENT ISKQEEAEQE IDHKKEIDEL EADNDLSVEQ 790 800 810 820 830 840 LLAKYKSEQP PSPKRRKLAP RDPELDSDDD STAVDSTEES EDAATEDEED LSTVKTDTDM 850 860 870 880 890 900 EEQDEQEDGL KSLMADADAT SGAAGSGSTA GASGNKDDML NDAAALAESL QPKGNTLSST 910 920 930 940 950 960 NVVTPVPFLL KHSLREYQHI GLDWLVTMNE RKLNGILADE MGLGKTIQTI ALLAHLACAK 970 980 990 1000 1010 1020 GNWGPHLIVV PSSVMLNWEM EFKKWCPGFK ILTYYGSQKE RKLKRVGWTK PNAFHVCITS 1030 1040 1050 1060 1070 1080 YKLVVQDQQS FRRKKWKYLI LDEAQNIKNF KSQRWQLLLN FSTERRLLLT GTPLQNDLME 1090 1100 1110 1120 1130 1140 LWSLMHFLMP YVFSSHREFK EWFSNPMTGM IEGNMEYNET LITRLHKVIR PFLLRRLKKE 1150 1160 1170 1180 1190 1200 VEKQMPKKYE HVITCRLSNR QRYLYEDFMS RAKTRETLQT GNLLSVINVL MQLRKVCNHP 1210 1220 1230 1240 1250 1260 NMFEARPTIS PFQMDGITFH TPRLVCDIME YDPFTQINLE TLNLLLLHLE QTMTAYVSHK 1270 1280 1290 1300 1310 1320 SRLLAPPRKL IEDIDTAPLP APRCPNGKYR FHIRVRSAEL AQRIKLNAVK VGASPAMRLE 1330 1340 1350 1360 1370 1380 GSKIMPMRNL LPSGRVLKRV SASINPVNMA LKPVVINSVV TTTSSSTTAS SPTGALSVLS 1390 1400 1410 1420 1430 1440 NSKLLGARSQ INAPTPAKVA KTMQDGKPFF YLTPATNSGA AGARLTLTSK TTASASTTTS 1450 1460 1470 1480 1490 1500 RTTVTASTTS GQQLIRDPIV KDLATHVKST VQKQSIANGK TEPEEETEAE DPYKVQELIQ 1510 1520 1530 1540 1550 1560 MRKEQRLAAL KRMAMINRRR TDATPIYGED CREAIQRCMQ ATRSLKRSTW QTRGYANCCT 1570 1580 1590 1600 1610 1620 AMAHRNGWSL NHLLKSFEER CADLKPVFAN FVIYVPSVCA PRIRRYVQNL SSTHWQHEQR 1630 1640 1650 1660 1670 1680 IENIVDQALR PKLALLHPII SEMTTKFPDP RLIQYDCGKL QTMDRLLRQL KVNGHRVLIF 1690 1700 1710 1720 1730 1740 TQMTKMLDVL EAFLNYHGHI YLRLDGSTRV EQRQILMERF NGDKRIFCFI LSTRSGGVGI 1750 1760 1770 1780 1790 1800 NLTGADTVIF YDSDWNPTMD AQAQDRCHRI GQTRDVHIYR LVSERTIEVN ILKKANQKRM 1810 1820 1830 1840 1850 1860 LSDMAIEGGN FTTTYFKSST IKDLFTMEQS EQDESSQEKS ENKDRIVATT TLSDTPSTVV 1870 1880 1890 1900 1910 1920 ETEKQSLRAF EHALAAAEDE QDVQATKTAK AEVAADLAEF DENIPIATED PNAEGGPQVE 1930 1940 1950 1960 1970 1980 LSKADLEMQN LVKQLSPIER YAMRFVEETG AAWTAEQLRA AEAELEAQKR EWEANRLAAM 1990 2000 2010 2020 2030 2040 HKEEELLKQE TEAEEMLTYS RKDSSNQVWI SRNTMEQMPM WCPPTPPQDN DNDIYIDYSL 2050 2060 2070 2080 2090 2100 SFMYELEPIA ETDLPPVYVR KEHKRSRTDA GYDGSRRPNK MRREDNYVPP RSLFDRPTPQ 2110 2120 2130 2140 2150 2160 LARLRRELKS QRFRGSFKPN MPIPGLKPQL PTKPLTEPEA MAEWCVFEDM AILHVLVNLQ 2170 2180 2190 2200 2210 2220 GLPCSLMLLS PGQTPNWDLV SEMVNFCSKT YRSARQCRWR YETHIQPREE GKVVESPKKQ 2230 2240 2250 2260 2270 2280 KKLKPTLRTE YLKSPLRYLR TTQLYVSDNN ASFYKTMRSR FDSIKTAYLK KAPPPKRQFS 2290 2300 2310 2320 2330 2340 APSLMNPKHM EVLQEFGILN YDQPVSPQNI AAMKANKIRE KQRGQQMSQP PVGVGVVQQM 2350 2360 2370 2380 2390 2400 QQQSQQQQQP APPPLPQQQQ PQQVVQQVQQ QQQQQQQQQQ QQVVQQQLPT VSNVQQTLPV 2410 2420 2430 2440 2450 2460 QQTVELVQQQ PTTTTTVAVP AAGGQLQQLQ IQHLTSSNVS PGQQTAILLH QPQQQLRTHP 2470 2480 2490 2500 2510 2520 GQGGQSNTQQ LVKTIVGTSS SLTAGQLQQL AQQSAVASGG QSSVSVVLTT PVQTLPSVVQ 2530 2540 2550 2560 2570 2580 PQIGSGAQIV SISSQTLPVN SSPQLGSIVQ TQSLPQVVSV STLPTVGTVL TTTANQPQQQ 2590 2600 2610 2620 2630 2640 HQTTAVTTLN TTMLRGQRIV STAAGNTLQQ RTTAGGQSIV SMPNLGQGAS PSQFQTQLRL 2650 2660 2670 2680 2690 2700 AAVPTSPATQ TTQLVTTKGI PVSALQQGGK TTVIPVTQQS GGAHIQLYRQ RSLKVLQTTT 2710 2720 2730 2740 2750 2760 QAVPSGSAGA TGATANLVQA GGTIIQASNM ATHVTSQKVA VSGMPGTSTT VQAGNVVSSV 2770 2780 2790 2800 2810 2820 QMHGQARTQF IKQMAAGKQQ LQRQVVSADG TTTTTAAGDM LLVKRHNILA AQKAQQASGA 2830 2840 2850 2860 2870 2880 LFTTTTGQQQ QQQQQQGQLP VAGQPQQVTQ HQIASLVKAS TAAAASGSSV NAGGVTVSAT 2890 2900 2910 2920 2930 2940 NPTVQAGSVN MTLPQLKPGS QIKVTMPNQM RHLQMQQQLT MPRKISRMTQ LVSASGQPTA 2950 2960 2970 2980 2990 3000 TNIITTTGPQ QQQQGVTVSG GGTLPTVASQ QQQQQHQQKV GGGNSVQAQL LHIQNTKGLS 3010 3020 3030 3040 3050 3060 NSVTMQQIQQ VMRSGQQGTL ATTNLVLGKT SVGRVIPVSV ASQANQRQTI QVVSAASAQA 3070 3080 3090 3100 3110 3120 LAAGNLRTHV AGPSIASTLK VAAPGSAGGQ TTQQTLIAAL QHNQRQNASP VRLQTTAGGN 3130 3140 3150 3160 3170 3180 LLAVVQQQQQ QQHTSIAGPT AGPAEVMTIT QTTTTLPTVG SLQQQQQQQQ QQGGISQPTT QQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAM70870.1.
RefSeq	NP_726065.1. NM_166446.2.
UniGene	Dm.7802.
3D structure databases
ProteinModelPortal	Q8MLW2.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1624766.
STRING	Q8MLW2.
Proteomic databases
PRIDE	Q8MLW2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0071602; FBpp0071528; FBgn0020306.
GeneID	45655.
KEGG	dme:Dmel_CG9696.
UCSC	CG9696-RA. d. melanogaster.
Organism-specific databases
CTD	45655.
FlyBase	FBgn0020306. dom.
Phylogenomic databases
eggNOG	inNOG08341.
InParanoid	Q8MLW2.
PhylomeDB	Q8MLW2.
Gene expression databases
ArrayExpress	Q8MLW2.
Bgee	Q8MLW2.
Family and domain databases
InterPro	IPR014001. DEAD-like_helicase. IPR013999. HAS_subgr. IPR014012. Helicase/SANT-assoc_DNA-bd. IPR001650. Helicase_C. IPR006562. HSA. IPR017877. MYB-like. IPR000330. SNF2_N. [Graphical view]
KO	K11320.
Pfam	PF00271. Helicase_C. 1 hit. PF07529. HSA. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00573. HSA. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51204. HSA. 1 hit. PS50090. MYB_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	838265.

Entry information

Entry name

Q8MLW2_DROME

Accession

Primary (citable) accession number: Q8MLW2

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)