Q8MLW0 (Q8MLW0_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Epidermal growth factor receptor, isoform A EMBL AAM70919.1
EC=2.7.10.- EMBL AAM70919.1

Gene names

Name:	Egfr EMBL AAM70919.1
ORF Names:	Dmel_CG10079 EMBL AAM70919.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1377 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS020635
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307 Contains 1 protein kinase domain. SAAS SAAS020635

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS020635 RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Receptor EMBL AAM70919.1 Transferase Tyrosine-protein kinase SAAS SAAS020635 RuleBase RU000307
PTM	Phosphoprotein SAAS SAAS009030
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8MLW0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 38AFA4AEA9D5C954	FASTA	1,377	153,602
	10 20 30 40 50 60 MMIISMWMSI SRGLWDSSSI WSVLLILACM ASITTSSSVS NAGYVDNGNM KVCIGTKSRL 70 80 90 100 110 120 SVPSNKEHHY RNLRDRYTNC TYVDGNLELT WLPNENLDLS FLDNIREVTG YILISHVDVK 130 140 150 160 170 180 KVVFPKLQII RGRTLFSLSV EEEKYALFVT YSKMYTLEIP DLRDVLNGQV GFHNNYNLCH 190 200 210 220 230 240 MRTIQWSEIV SNGTDAYYNY DFTAPERECP KCHESCTHGC WGEGPKNCQK FSKLTCSPQC 250 260 270 280 290 300 AGGRCYGPKP RECCHLFCAG GCTGPTQKDC IACKNFFDEG VCKEECPPMR KYNPTTYVLE 310 320 330 340 350 360 TNPEGKYAYG ATCVKECPGH LLRDNGACVR SCPQDKMDKG GECVPCNGPC PKTCPGVTVL 370 380 390 400 410 420 HAGNIDSFRN CTVIDGNIRI LDQTFSGFQD VYANYTMGPR YIPLDPERLE VFSTVKEITG 430 440 450 460 470 480 YLNIEGTHPQ FRNLSYFRNL ETIHGRQLME SMFAALAIVK SSLYSLEMRN LKQISSGSVV 490 500 510 520 530 540 IQHNRDLCYV SNIRWPAIQK EPEQKVWVNE NLRADLCEKN GTICSDQCNE DGCWGAGTDQ 550 560 570 580 590 600 CLTCKNFNFN GTCIADCGYI SNAYKFDNRT CKICHPECRT CNGAGADHCQ ECVHVRDGQH 610 620 630 640 650 660 CVSECPKNKY NDRGVCRECH ATCDGCTGPK DTIGIGACTT CNLAIINNDA TVKRCLLKDD 670 680 690 700 710 720 KCPDGYFWEY VHPQEQGSLK PLAGRAVCRK CHPLCELCTN YGYHEQVCSK CTHYKRREQC 730 740 750 760 770 780 ETECPADHYT DEEQRECFQC HPECNGCTGP GADDCKSCRN FKLFDANETG PYVNSTMFNC 790 800 810 820 830 840 TSKCPLEMRH VNYQYTAIGP YCAASPPRSS KITANLDVNM IFIITGAVLV PTICILCVVT 850 860 870 880 890 900 YICRQKQKAK KETVKMTMAL SGCEDSEPLR PSNIGANLCK LRIVKDAELR KGGVLGMGAF 910 920 930 940 950 960 GRVYKGVWVP EGENVKIPVA IKELLKSTGA ESSEEFLREA YIMASVEHVN LLKLLAVCMS 970 980 990 1000 1010 1020 SQMMLITQLM PLGCLLDYVR NNRDKIGSKA LLNWSTQIAK GMSYLEEKRL VHRDLAARNV 1030 1040 1050 1060 1070 1080 LVQTPSLVKI TDFGLAKLLS SDSNEYKAAG GKMPIKWLAL ECIRNRVFTS KSDVWAFGVT 1090 1100 1110 1120 1130 1140 IWELLTFGQR PHENIPAKDI PDLIEVGLKL EQPEICSLDI YCTLLSCWHL DAAMRPTFKQ 1150 1160 1170 1180 1190 1200 LTTVFAEFAR DPGRYLAIPG DKFTRLPAYT SQDEKDLIRK LAPTTDGSEA IAEPDDYLQP 1210 1220 1230 1240 1250 1260 KAAPGPSHRT DCTDEIPKLN RYCKDPSNKN SSTGDDETDS SAREVGVGNL RLDLPVDEDD 1270 1280 1290 1300 1310 1320 YLMPTCQPGP NNNNNINNPN QNNMAAVGVA AGYMDLIGVP VSVDNPEYLL NAQTLGVGES 1330 1340 1350 1360 1370 PIPTQTIGIP VMGVPGTMEV KVPMPGSEPT SSDHEYYNDT QRELQPLHRN RNTETRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAM70919.1.
PIR	A27131.
RefSeq	NP_476758.1. NM_057410.3.
UniGene	Dm.20748.
3D structure databases
ProteinModelPortal	Q8MLW0.
SMR	Q8MLW0. Positions 48-790, 877-1161.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8MLW0.
Proteomic databases
PRIDE	Q8MLW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0071653; FBpp0071570; FBgn0003731.
GeneID	37455.
KEGG	dme:Dmel_CG10079.
UCSC	CG10079-RA. d. melanogaster.
Organism-specific databases
CTD	1956.
FlyBase	FBgn0003731. Egfr.
Phylogenomic databases
InParanoid	Q8MLW0.
Gene expression databases
ArrayExpress	Q8MLW0.
Bgee	Q8MLW0.
Family and domain databases
InterPro	IPR000494. EGF_rcpt_L. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
KO	K04361.
Pfam	PF00757. Furin-like. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00261. FU. 7 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 3 hits. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	803734.

Entry information

Entry name

Q8MLW0_DROME

Accession

Primary (citable) accession number: Q8MLW0

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)