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Protein

Sphingomyelin phosphodiesterase

Gene

CG3376

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Converts sphingomyelin to ceramide.UniRule annotation

Catalytic activityi

Sphingomyelin + H2O = N-acylsphingosine + phosphocholine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-1660662. Glycosphingolipid metabolism.
SignaLinkiQ8MLP3.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingomyelin phosphodiesteraseUniRule annotation (EC:3.1.4.12UniRule annotation)
Gene namesi
ORF Names:CG3376Imported, Dmel_CG3376Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034997. CG3376.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 46HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8MLP3.
PRIDEiQ8MLP3.

Expressioni

Gene expression databases

BgeeiFBgn0034997.
ExpressionAtlasiQ8MLP3. baseline.
GenevisibleiQ8MLP3. DM.

Interactioni

Protein-protein interaction databases

IntActiQ8MLP3. 1 interactor.
MINTiMINT-1670298.
STRINGi7227.FBpp0300565.

Structurei

3D structure databases

ProteinModelPortaliQ8MLP3.
SMRiQ8MLP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 238Saposin B-typeInterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the acid sphingomyelinase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3770. Eukaryota.
ENOG410YYPB. LUCA.
GeneTreeiENSGT00530000063095.
HOGENOMiHOG000264206.
OrthoDBiEOG091G03M6.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MLP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQQPPWPS PISSSSSNPR GKCWLILVLM AVLPLVADVG ALPFLFTHIK
60 70 80 90 100
PQINWTQPEM ESWVIEEQPR SIEPHLEPVL HPNRTHRALS SDSTDAEFLQ
110 120 130 140 150
RLVSIRHNQT ASSRMLWYDV AGGDGLVYPP FVDKALKLLN LKQVAFEIEN
160 170 180 190 200
SVMSKVTCTA CRAGAGMLQH QIQSGKTDAE LIRMITDYCT NLNIQSARVC
210 220 230 240 250
QGVAQLFGSE LIYVLKRVNL SPDELCSFVI GDGCADVYNP YHEWEVIFPP
260 270 280 290 300
VPKPPRLPDL PIPMEAAPFF KVLHISDTHY DPHYAEGSNA DCNEPLCCRL
310 320 330 340 350
SSGRPATPNA AAGKWGDYRK CDTPKRTVDH MLSHIAETHK DIDYILWTGD
360 370 380 390 400
LPPHDVWNQT KEENLAIIKD TVKQMVEMFP GVPIFPALGN HESAPVNSFP
410 420 430 440 450
PPYVNQVDIS ISWLYDELDI QWRRWLPQSV THTVRRGAFY SVLVRPGFRI
460 470 480 490 500
ISLNMNYCNN KNWWLLLNST DPATELQWFI YELQSAEFSN EKVHVIGHIP
510 520 530 540 550
PGHSDCLKVW SRNFYKIISR YESTVTAQFY GHTHYDEFEM FYDPHDLNHP
560 570 580 590 600
NGIAYIGPSV SPYYDLNPGY RIYYVDGDHD ATTRLVIDHE SWIMNLKEAN
610 620 630 640 650
LYGYPIWYKL YTARAAYNMK ALRPSDWNNL LNELTNNQEL FELYYKYYWK
660 670 680 690 700
NSPARPTCDA ECKKRLICDC RSGRSHDRKH FCAEVESKID EESSKSWKSW

FYKGLTNS
Length:708
Mass (Da):81,395
Last modified:October 1, 2002 - v1
Checksum:i0B7940567A2F8712
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAM68308.1.
RefSeqiNP_726435.1. NM_166665.2.
UniGeneiDm.4051.

Genome annotation databases

EnsemblMetazoaiFBtr0072265; FBpp0072172; FBgn0034997.
GeneIDi37884.
UCSCiCG3376-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAM68308.1.
RefSeqiNP_726435.1. NM_166665.2.
UniGeneiDm.4051.

3D structure databases

ProteinModelPortaliQ8MLP3.
SMRiQ8MLP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8MLP3. 1 interactor.
MINTiMINT-1670298.
STRINGi7227.FBpp0300565.

Proteomic databases

PaxDbiQ8MLP3.
PRIDEiQ8MLP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072265; FBpp0072172; FBgn0034997.
GeneIDi37884.
UCSCiCG3376-RB. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0034997. CG3376.

Phylogenomic databases

eggNOGiKOG3770. Eukaryota.
ENOG410YYPB. LUCA.
GeneTreeiENSGT00530000063095.
HOGENOMiHOG000264206.
OrthoDBiEOG091G03M6.

Enzyme and pathway databases

ReactomeiR-DME-1660662. Glycosphingolipid metabolism.
SignaLinkiQ8MLP3.

Miscellaneous databases

ChiTaRSiCG3376. fly.
GenomeRNAii37884.

Gene expression databases

BgeeiFBgn0034997.
ExpressionAtlasiQ8MLP3. baseline.
GenevisibleiQ8MLP3. DM.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8MLP3_DROME
AccessioniPrimary (citable) accession number: Q8MLP3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.