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Protein
Submitted name:

Brca2 protein

Gene

Brca2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Brca2 proteinImported
Gene namesi
Name:Brca2Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

PTM / Processingi

Proteomic databases

PaxDbiQ8MKI9.

Interactioni

Protein-protein interaction databases

IntActiQ8MKI9. 1 interaction.
STRINGi9615.ENSCAFP00000009557.

Structurei

3D structure databases

ProteinModelPortaliQ8MKI9.
SMRiQ8MKI9. Positions 1523-1553, 2498-3203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2850 – 289142TowerInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG4751. Eukaryota.
ENOG410Y06W. LUCA.
HOGENOMiHOG000139693.
HOVERGENiHBG050731.
KOiK08775.

Family and domain databases

Gene3Di2.40.50.140. 4 hits.
InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
IPR015187. BRCA2_OB_1.
IPR015188. BRCA2_OB_3.
IPR002093. BRCA2_repeat.
IPR012340. NA-bd_OB-fold.
IPR015205. Tower_dom.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 2 hits.
PfamiPF09169. BRCA-2_helical. 1 hit.
PF09103. BRCA-2_OB1. 1 hit.
PF09104. BRCA-2_OB3. 1 hit.
PF00634. BRCA2. 7 hits.
PF09121. Tower. 1 hit.
[Graphical view]
PIRSFiPIRSF002397. BRCA2. 1 hit.
SMARTiSM01341. Tower. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
SSF81872. SSF81872. 1 hit.
PROSITEiPS50138. BRCA2_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MKI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVGCKERPT FFEIFKTRCN QADLGPISLN WFEELSLEAP PYNSEPTEES
60 70 80 90 100
GYKISYEPNL FKTPQRKPYN QLASTPIVFR EPIYQQSPLK ELDKYRLDSG
110 120 130 140 150
KDITDSKHKS CCTMKSKMDR ANDVTSPPLN SYLSESPVLR CTHVTPQREK
160 170 180 190 200
SVVCGSLFHT PKLMKGQTPK RISESLGAEV DSDMSWSSSL ATPPTLSSTV
210 220 230 240 250
LIVRDEEVSA AVFPNDTTAI FKSCFSNHDE SLKKNDRFIP CGPGKENKNQ
260 270 280 290 300
REAKSQSLGN SFGKVNSTKD HFVKSTPNVL EDEVHEKVLD VSEEEDSFSL
310 320 330 340 350
CVPKYKTRNL QKIKTSKTRK NIFNETKTSE CEEAKKQMKE NKHSLVSEME
360 370 380 390 400
PNDSHPLDWN VTHEKPFGNG TDKISKEIVL SSASGCSDLT LSSLNGAQME
410 420 430 440 450
KTPLLHTSYD QNNSEKDLII TDKECTNFIT LENSWPQISN VPKYSEKTLN
460 470 480 490 500
EEIVVNKINE GQCLESHEDS VVSVKQAIYE TTLIASPLQG IRKSIFRIRE
510 520 530 540 550
SPEGMSNAMF SNNMTNPNFK EPEASESGLE KHTICSQKED SLCTSSIDDG
560 570 580 590 600
SWPATIKHTS VALKNLGLIS SLKKKTKKFI YVINDETSNQ GLKTQKDQES
610 620 630 640 650
RLINLSTQFE ANAFEGPLTF TNADSGLLHS SSIKKNCLQN DSEKPALSLT
660 670 680 690 700
SSFGTILRKV SSNGASSPNN KIISQDPDYK EAKINKKKLE SFITTETDCL
710 720 730 740 750
SSLQEKHWED DAKKQRVSDI KEKVLPTVSH PPVPHSEVEG SDIHFQSPES
760 770 780 790 800
FSFDCDNTSL LTPSSRDSPS SLVVMSRGKE SYKISEKLKC KNHETGFELT
810 820 830 840 850
KNIPMEKNQD IHVLNADSKN AKLLSTEKHI TVASSSVKVQ FNQNANLTTI
860 870 880 890 900
QKDQKETTLI SKITVNPNSE ELFPDDENNF VLKITNESNT PVLGNTKELH
910 920 930 940 950
DSNLCCVRDS VPKNSTMVVC TDLDDKQTAK VSIMKDCYSS SIDDLTERNR
960 970 980 990 1000
STIKQQLKMT LDQDSKSDIT SDIVRKSNGN SDYMDNWARL SDPISNHSFE
1010 1020 1030 1040 1050
NGFKTASNKE IKLSENNIRK SKMLFKDIEE HYPTNLACLE IVNTSSLESQ
1060 1070 1080 1090 1100
KKPSKSHALD PQSINIISGF VQNSTYVSDS ESGHTAPPTL SLKQDFDSNR
1110 1120 1130 1140 1150
NLTPSQKAEI TELSTILEES GSQFEFTQFR KPSHIIQKNP FEMPENQLTI
1160 1170 1180 1190 1200
LNSTSKEWKD DDLHLTTNAP SISQVDSKKS EGIIGGKQKF ACLSRTSCNR
1210 1220 1230 1240 1250
SASGYSTDKN EVEFRGFYSA RGTKLNVGSE ALQKAKKLFS DLENINEETS
1260 1270 1280 1290 1300
VEVDRSFSSS KYNDSVSMIQ IEDCNDKNLN EKNNKCRLIL QNNIEMTTDI
1310 1320 1330 1340 1350
FVEEYTESYR RNTENEGNQC TDAGRNTCNS ESDGSDSSKN DTVYIHEEEN
1360 1370 1380 1390 1400
GLPCIDQHNI DLKLFSQFMK EGNTQIKEGL SDLTCLEVMK AEETSHVTMS
1410 1420 1430 1440 1450
NKQQLTANTG QNIKDFDTFY LSFQTASRKN IRVSKESLNK ARSLLNQKWT
1460 1470 1480 1490 1500
EEELNNFSDS LNSELLPGID IKKTDISNHE VIENTERKDK ITKESDLIGT
1510 1520 1530 1540 1550
ENILLILQQR PESKIKKIKE SAVLGFHTAS GKKIEITKES LDKVKNLFEE
1560 1570 1580 1590 1600
KEQDNSEITN FSHRGAKMSK DREECKDGRE LACGTTEITT TPEYEETHSS
1610 1620 1630 1640 1650
LEKKKLVSNE IAALRPRLLS DNLYKQTENL KISDHASQKV DVHENTEKET
1660 1670 1680 1690 1700
AKKPTMYTNQ STYSAIENSP LTFYTGHGRK ISVSEASLFE AKKWLREGEW
1710 1720 1730 1740 1750
DDQSERINAA KVNCLKEYPD DYVENPSCGN SSNSAITEND KNHLSEKQGS
1760 1770 1780 1790 1800
TYLSNSTMSN SYSYHPGFCH SSEVYNKSEY LSRSKIDNSG IEPVIKNIRE
1810 1820 1830 1840 1850
RKNIGFSEIM SPGREADTDP QSVNEDICVE KLATNSSCKN KNTAIKVAIS
1860 1870 1880 1890 1900
DSNNFNTIQK LNSDSNNSVP AYSTVNSKRV FVAHQTKVTE GFTDNCSMVT
1910 1920 1930 1940 1950
KQNTKSKSDT CHAEIVADYP KALDDSEAIF PNSLGAIECS PSHKVFADIQ
1960 1970 1980 1990 2000
SEQTSQLNQS MSGLEKVSET PPCQINSKTS DRCELPRGKL PKSVSYTNAC
2010 2020 2030 2040 2050
GIFSTASGKS VQVSDAAIQK AREVFSKLED SAKQLFPEVS LKDNEEHSEK
2060 2070 2080 2090 2100
FTNEENTVIY TSQNLLSSAF SGFRTASGKQ VPVSESALCK VKGMLEEFNL
2110 2120 2130 2140 2150
IRTESCLQHS STSRQDVSKM PPPSCIGKRT PEHSRNSKLD KACNKEFRLS
2160 2170 2180 2190 2200
SNCNNQSGSS ENHHSIKVSP CPSQLKRDKP QLLVGSKGSL VENIHPLGKE
2210 2220 2230 2240 2250
QALPKNIKTE IGKAETFPNL PVKTNIEFCS TYSKDPENYF ETETVEIAKA
2260 2270 2280 2290 2300
FMEDGELTDS ELLSHAKHFV FTCQNTKEMV LLNSRIGKRR GDALVSVGEP
2310 2320 2330 2340 2350
PIKRNLLNEF DRIIKNQETS LKASKSTPDG ILKDRSLFMH HISLEPISCG
2360 2370 2380 2390 2400
PFRTTEERQE IQNPNFTAPG QEFLPKSHFY EHLASEKSSS NLSVSRQPFC
2410 2420 2430 2440 2450
MVPATGNEKR RHLIAPGKPV KVFVPPFKTK SHFHRDEQCI SKNTKLEKNK
2460 2470 2480 2490 2500
QNSKDIDELG SGDSEKNIND SGIHQLKKNN SNQAATIIFT KNEKEPLDLI
2510 2520 2530 2540 2550
TNLQNARDIQ DMRIKKKQRQ HIFPQPGSLY LAKTSTLPRI SLREAVEGRV
2560 2570 2580 2590 2600
PSACSHKQLY MYGVSKHCVK INSKNAESFQ FHAQDYFGKE GLWSGEGIQL
2610 2620 2630 2640 2650
ADGGWLIPSN DGKIGKEEFY RALCDTPGVD PNCISRVWVY NHYRWIIWKL
2660 2670 2680 2690 2700
AAMEFAFPKE FANRCLSPER VLLQLKYRYD VEIDKSRRSA IKKIMERDDT
2710 2720 2730 2740 2750
AAKTLVLCIS EIISSSADIS ETSSSKTSSV GTKKVGIIEL TDGWYAIKAQ
2760 2770 2780 2790 2800
LDPPLLALVK NGRLTVGQKI TIHGAELVGS PDACTPLEAP ESLMLKISAN
2810 2820 2830 2840 2850
STRPACWYTK LGFSPDPRPF PLPLSSLFSD GGNVGCVDVV VQRAYPIQWM
2860 2870 2880 2890 2900
ERTPSGLCIF RNEREEEKEA TKYAEIQQKK LEVLFNKIQA EFEKNDENIT
2910 2920 2930 2940 2950
KQCIPSCALT RQQICALQDG AELYEAVTNA PDPSDLEGYF SEEQLRALNN
2960 2970 2980 2990 3000
HRQMLNDKKQ AQIQLEFKKA MESAEQGEQI LPRDVTTVWK LRIISYRKKE
3010 3020 3030 3040 3050
KDSVTLSIWR PSPDLYSLLI EGKRYRIYHL AASQSKSKSG KANTQLTATK
3060 3070 3080 3090 3100
KTQYQQLPAS DEILSQVYQP REPLYFNKLL DPDFQPPCSE VDLIGFVVSV
3110 3120 3130 3140 3150
VKKIGLAPVV YLSDECHNLL AIKFWTDFNE DIIKPYTLIA ASNLQWRPEA
3160 3170 3180 3190 3200
KSGIPTLFAG DFSRFSASPK EEHFQETFHK MKNTVENIGM FYNDAENKLV
3210 3220 3230 3240 3250
HILNANDPKL STPTKDYASE PHTAQIVLGI GNKFLMSSPN NEMNYQSPLS
3260 3270 3280 3290 3300
LCKPKEKSVP IPGSTQMTSK SYCKEEKEMD DPKTCKKRRA LDFLSRVPLP
3310 3320 3330 3340 3350
PSVSPICTFV SPAAQKAFQP PRSCGTKYET LMKKELNSPQ MTPRKFNDLS
3360 3370 3380 3390 3400
LLESDSIADE ELAMINTQAL LLGSPGEHQL VSVSDSTRTA PTSSKDYLGL
3410 3420 3430 3440
KRHSTAPGVR GPESPQACTR KREPRVQNTS DLKRTSLRLQ RQQTQK
Length:3,446
Mass (Da):386,662
Last modified:March 15, 2005 - v2
Checksum:i0CE8B77D2911945B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043895 mRNA. Translation: BAB91245.3.
RefSeqiNP_001006654.2. NM_001006653.4.
UniGeneiCfa.9868.

Genome annotation databases

GeneIDi474180.
KEGGicfa:474180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043895 mRNA. Translation: BAB91245.3.
RefSeqiNP_001006654.2. NM_001006653.4.
UniGeneiCfa.9868.

3D structure databases

ProteinModelPortaliQ8MKI9.
SMRiQ8MKI9. Positions 1523-1553, 2498-3203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8MKI9. 1 interaction.
STRINGi9615.ENSCAFP00000009557.

Proteomic databases

PaxDbiQ8MKI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi474180.
KEGGicfa:474180.

Organism-specific databases

CTDi675.

Phylogenomic databases

eggNOGiKOG4751. Eukaryota.
ENOG410Y06W. LUCA.
HOGENOMiHOG000139693.
HOVERGENiHBG050731.
KOiK08775.

Family and domain databases

Gene3Di2.40.50.140. 4 hits.
InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
IPR015187. BRCA2_OB_1.
IPR015188. BRCA2_OB_3.
IPR002093. BRCA2_repeat.
IPR012340. NA-bd_OB-fold.
IPR015205. Tower_dom.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 2 hits.
PfamiPF09169. BRCA-2_helical. 1 hit.
PF09103. BRCA-2_OB1. 1 hit.
PF09104. BRCA-2_OB3. 1 hit.
PF00634. BRCA2. 7 hits.
PF09121. Tower. 1 hit.
[Graphical view]
PIRSFiPIRSF002397. BRCA2. 1 hit.
SMARTiSM01341. Tower. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
SSF81872. SSF81872. 1 hit.
PROSITEiPS50138. BRCA2_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing full length of canine Brca2 and Rad51 cDNA."
    Ochiai K., Morimatsu M., Tomizawa N., Syuto B.
    J. Vet. Med. Sci. 63:1103-1108(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8MKI9_CANLF
AccessioniPrimary (citable) accession number: Q8MKI9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.