Reviewed, UniProtKB/Swiss-Prot Q8MKE8 (PGAM4_PANTR)

Names and origin

Protein names

Recommended name:
    Probable phosphoglycerate mutase 4
    EC=5.4.2.1
    EC=5.4.2.4
    EC=3.1.3.13

Gene names

Name:	PGAM4
Synonyms:	PGAM3

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. 2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate.
Miscellaneous	This is the product of a processed gene created by retroposition from mRNA of an expressed gene. This gene seems to be expressed.
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Hydrolase Isomerase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity Inferred from electronic annotation. Source: EC bisphosphoglycerate mutase activity Inferred from electronic annotation. Source: EC phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Probable phosphoglycerate mutase 4		PRO_0000179833
Regions
	Compositional bias	122 – 131	10	Pro-rich
Sites
	Active site	11	1	Tele-phosphohistidine intermediate By similarity
	Active site	186	1	By similarity
	Site	62	1	Interaction with carboxyl group of phosphoglycerates By similarity
Amino acid modifications
	Modified residue	92	1	Phosphotyrosine By similarity
	Modified residue	106	1	N6-acetyllysine By similarity
	Modified residue	118	1	Phosphoserine By similarity
	Modified residue	119	1	Phosphotyrosine By similarity
	Modified residue	133	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8MKE8-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0F073CDE449EDD39	FASTA	254	28,809
	10 20 30 40 50 60 MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY EFDICLTSVQ 70 80 90 100 110 120 KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTALNK AETAAKHGEA QVKIWRRSYD 130 140 150 160 170 180 VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSYESPKDTI ARALPFWNEE IVPQIKEGKR 190 200 210 220 230 240 VLIAAHGNSL QGIAKHVEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC 250 KAMEAVAAQG KAKK

References

[1]	"Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene." Betran E., Wang W., Jin L., Long M. Mol. Biol. Evol. 19:654-663(2002) [PubMed: 11961099] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Emergence of young human genes after a burst of retroposition in primates." Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H. PLoS Biol. 3:1970-1979(2005) [PubMed: 16201836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF465746 Genomic DNA. Translation: AAM27297.1. DQ120648 Genomic DNA. Translation: ABB92433.1.
RefSeq	NP_001009163.1.
3D structure databases
HSSP	HSSP built from PDB template 1E58 based on UniProtKB P31217.
SMR	Q8MKE8. Positions 2-246.
ModBase	Search...
Genome annotation databases
GeneID	494122.
KEGG	ptr:494122.
Phylogenomic databases
HOVERGEN	Q8MKE8.
OMA	Q8MKE8. RVLPYWY.
Enzyme and pathway databases
BRENDA	3.1.3.13. 264977. 5.4.2.1. 264977. 5.4.2.4. 264977.
Family and domain databases
InterPro	IPR001345. PG/BPGM_mutase. IPR013078. PG_mutase. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGAM4_PANTR

Accession

Primary (citable) accession number: Q8MKE8
Secondary accession number(s): Q2VIN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)