Q8MKE4 (MT3_SHEEP) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 39.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein-3 Short name=MT-3 Alternative name(s): Metallothionein-III Short name=MT-III | ||
| Gene names |
| ||
| Organism | Ovis aries (Sheep) | ||
| Taxonomic identifier | 9940 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Protein attributes
| Sequence length | 65 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium By similarity. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Copper Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | removal of superoxide radicals Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxiaInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 65 | 65 | Metallothionein-3 | PRO_0000253583 | |||||
Regions | |||||||||
| Region | 1 – 30 | 30 | Beta | ||||||
| Region | 31 – 65 | 35 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 39 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 46 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 48 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 61 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 63 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 64 | 1 | Divalent metal cation; cluster A By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
Sequences
References
| [1] | "Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III." Chung R.S., Holloway A.F., Eckhardt B.L., Harris J.A., Vickers J.C., Chuah M.I., West A.K. Biochem. J. 365:323-328(2002) [PubMed: 11931634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF500199 mRNA. Translation: AAM21134.1. |
| RefSeq | NP_001009755.1. NM_001009755.1. |
| UniGene | Oar.980. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JI9 based on UniProtKB P28184. |
| ProteinModelPortal | Q8MKE4. |
| SMR | Q8MKE4. Positions 32-65. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 443168. |
Organism-specific databases | |
| CTD | 4504. |
Phylogenomic databases | |
| HOVERGEN | HBG009063. |
Family and domain databases | |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT3_SHEEP | ||||||||
| Accession | Primary (citable) accession number: Q8MKE4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |