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Protein

Metallothionein-3

Gene

MT3

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi39 – 391Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi46 – 461Divalent metal cation; cluster ABy similarity
Metal bindingi48 – 481Divalent metal cation; cluster ABy similarity
Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity
Metal bindingi63 – 631Divalent metal cation; cluster ABy similarity
Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:MT3
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Metallothionein-3PRO_0000253583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei33 – 331PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8MKE4.
SMRiQ8MKE4. Positions 32-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030BetaAdd
BLAST
Regioni31 – 6535AlphaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG009063.
KOiK14740.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MKE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEACPCPT GGSCTCSDSC KCEGCTCASS KKSCCPAECE KCAKDCVCKG
60
GEGAEAEEKK CGCCQ
Length:65
Mass (Da):6,574
Last modified:October 1, 2002 - v1
Checksum:iEC5778D87D508798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF500199 mRNA. Translation: AAM21134.1.
RefSeqiNP_001009755.1. NM_001009755.1.
UniGeneiOar.980.

Genome annotation databases

GeneIDi443168.
KEGGioas:443168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF500199 mRNA. Translation: AAM21134.1.
RefSeqiNP_001009755.1. NM_001009755.1.
UniGeneiOar.980.

3D structure databases

ProteinModelPortaliQ8MKE4.
SMRiQ8MKE4. Positions 32-65.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443168.
KEGGioas:443168.

Organism-specific databases

CTDi4504.

Phylogenomic databases

HOVERGENiHBG009063.
KOiK14740.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
SUPFAMiSSF57868. SSF57868. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III."
    Chung R.S., Holloway A.F., Eckhardt B.L., Harris J.A., Vickers J.C., Chuah M.I., West A.K.
    Biochem. J. 365:323-328(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMT3_SHEEP
AccessioniPrimary (citable) accession number: Q8MKE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: December 9, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.