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Q8MKE4

- MT3_SHEEP

UniProt

Q8MKE4 - MT3_SHEEP

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Protein

Metallothionein-3

Gene

MT3

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi39 – 391Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi46 – 461Divalent metal cation; cluster ABy similarity
Metal bindingi48 – 481Divalent metal cation; cluster ABy similarity
Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity
Metal bindingi63 – 631Divalent metal cation; cluster ABy similarity
Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. cadmium ion binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  4. drug binding Source: UniProtKB
  5. protein kinase activator activity Source: UniProtKB
  6. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. activation of protein kinase B activity Source: UniProtKB
  2. astrocyte development Source: UniProtKB
  3. cadmium ion homeostasis Source: UniProtKB
  4. cellular lipid catabolic process Source: UniProtKB
  5. cellular response to cadmium ion Source: UniProtKB
  6. cellular response to drug Source: UniProtKB
  7. cellular response to hypoxia Source: Ensembl
  8. cellular response to nitric oxide Source: UniProtKB
  9. cellular response to oxidative stress Source: UniProtKB
  10. cellular zinc ion homeostasis Source: UniProtKB
  11. cholesterol catabolic process Source: UniProtKB
  12. energy reserve metabolic process Source: UniProtKB
  13. ERK1 and ERK2 cascade Source: UniProtKB
  14. histone modification Source: UniProtKB
  15. leptin-mediated signaling pathway Source: UniProtKB
  16. negative regulation of apoptotic process Source: UniProtKB
  17. negative regulation of autophagy Source: UniProtKB
  18. negative regulation of axon extension Source: UniProtKB
  19. negative regulation of cell growth Source: UniProtKB
  20. negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
  21. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  22. negative regulation of necrotic cell death Source: UniProtKB
  23. negative regulation of neuron apoptotic process Source: UniProtKB
  24. negative regulation of oxidoreductase activity Source: UniProtKB
  25. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
  26. negative regulation of transcription, DNA-templated Source: UniProtKB
  27. positive regulation of catalytic activity Source: UniProtKB
  28. positive regulation of cell death Source: UniProtKB
  29. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  30. positive regulation of gene expression Source: UniProtKB
  31. positive regulation of lysosomal membrane permeability Source: UniProtKB
  32. positive regulation of necrotic cell death Source: UniProtKB
  33. positive regulation of oxygen metabolic process Source: UniProtKB
  34. positive regulation of protein phosphorylation Source: UniProtKB
  35. positive regulation of transcription, DNA-templated Source: UniProtKB
  36. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
  37. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
  38. protein import into nucleus, translocation Source: UniProtKB
  39. protein kinase B signaling Source: UniProtKB
  40. protein stabilization Source: UniProtKB
  41. regulation of protein glycosylation Source: UniProtKB
  42. regulation of response to food Source: UniProtKB
  43. removal of superoxide radicals Source: UniProtKB
  44. response to hypoxia Source: UniProtKB
  45. zinc ion homeostasis Source: UniProtKB
  46. zinc ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:MT3
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. inclusion body Source: UniProtKB
  2. intracellular Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
  5. synaptic vesicle Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Metallothionein-3PRO_0000253583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliQ8MKE4.
SMRiQ8MKE4. Positions 32-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030BetaAdd
BLAST
Regioni31 – 6535AlphaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG009063.
KOiK14740.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MKE4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDPEACPCPT GGSCTCSDSC KCEGCTCASS KKSCCPAECE KCAKDCVCKG
60
GEGAEAEEKK CGCCQ
Length:65
Mass (Da):6,574
Last modified:October 1, 2002 - v1
Checksum:iEC5778D87D508798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF500199 mRNA. Translation: AAM21134.1.
RefSeqiNP_001009755.1. NM_001009755.1.
UniGeneiOar.980.

Genome annotation databases

GeneIDi443168.
KEGGioas:443168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF500199 mRNA. Translation: AAM21134.1 .
RefSeqi NP_001009755.1. NM_001009755.1.
UniGenei Oar.980.

3D structure databases

ProteinModelPortali Q8MKE4.
SMRi Q8MKE4. Positions 32-65.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443168.
KEGGi oas:443168.

Organism-specific databases

CTDi 4504.

Phylogenomic databases

HOVERGENi HBG009063.
KOi K14740.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
SUPFAMi SSF57868. SSF57868. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III."
    Chung R.S., Holloway A.F., Eckhardt B.L., Harris J.A., Vickers J.C., Chuah M.I., West A.K.
    Biochem. J. 365:323-328(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMT3_SHEEP
AccessioniPrimary (citable) accession number: Q8MKE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3