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Q8MKE4

- MT3_SHEEP

UniProt

Q8MKE4 - MT3_SHEEP

Protein

Metallothionein-3

Gene

MT3

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
    Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
    Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
    Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
    Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
    Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
    Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
    Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
    Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
    Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
    Metal bindingi39 – 391Divalent metal cation; cluster ABy similarity
    Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
    Metal bindingi46 – 461Divalent metal cation; cluster ABy similarity
    Metal bindingi48 – 481Divalent metal cation; cluster ABy similarity
    Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity
    Metal bindingi63 – 631Divalent metal cation; cluster ABy similarity
    Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. cadmium ion binding Source: UniProtKB
    2. copper ion binding Source: UniProtKB
    3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    4. drug binding Source: UniProtKB
    5. protein kinase activator activity Source: UniProtKB
    6. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase B activity Source: UniProtKB
    2. astrocyte development Source: UniProtKB
    3. cadmium ion homeostasis Source: UniProtKB
    4. cellular lipid catabolic process Source: UniProtKB
    5. cellular response to cadmium ion Source: UniProtKB
    6. cellular response to drug Source: UniProtKB
    7. cellular response to hypoxia Source: Ensembl
    8. cellular response to nitric oxide Source: UniProtKB
    9. cellular response to oxidative stress Source: UniProtKB
    10. cellular zinc ion homeostasis Source: UniProtKB
    11. cholesterol catabolic process Source: UniProtKB
    12. energy reserve metabolic process Source: UniProtKB
    13. ERK1 and ERK2 cascade Source: UniProtKB
    14. histone modification Source: UniProtKB
    15. leptin-mediated signaling pathway Source: UniProtKB
    16. negative regulation of apoptotic process Source: UniProtKB
    17. negative regulation of autophagy Source: UniProtKB
    18. negative regulation of axon extension Source: UniProtKB
    19. negative regulation of cell growth Source: UniProtKB
    20. negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
    21. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    22. negative regulation of necrotic cell death Source: UniProtKB
    23. negative regulation of neuron apoptotic process Source: UniProtKB
    24. negative regulation of oxidoreductase activity Source: UniProtKB
    25. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
    26. negative regulation of transcription, DNA-templated Source: UniProtKB
    27. positive regulation of catalytic activity Source: UniProtKB
    28. positive regulation of cell death Source: UniProtKB
    29. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    30. positive regulation of gene expression Source: UniProtKB
    31. positive regulation of lysosomal membrane permeability Source: UniProtKB
    32. positive regulation of necrotic cell death Source: UniProtKB
    33. positive regulation of oxygen metabolic process Source: UniProtKB
    34. positive regulation of protein phosphorylation Source: UniProtKB
    35. positive regulation of transcription, DNA-templated Source: UniProtKB
    36. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
    37. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
    38. protein import into nucleus, translocation Source: UniProtKB
    39. protein kinase B signaling Source: UniProtKB
    40. protein stabilization Source: UniProtKB
    41. regulation of protein glycosylation Source: UniProtKB
    42. regulation of response to food Source: UniProtKB
    43. removal of superoxide radicals Source: UniProtKB
    44. response to hypoxia Source: UniProtKB
    45. zinc ion homeostasis Source: UniProtKB
    46. zinc ion transport Source: UniProtKB

    Keywords - Ligandi

    Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-3
    Short name:
    MT-3
    Alternative name(s):
    Metallothionein-III
    Short name:
    MT-III
    Gene namesi
    Name:MT3
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. inclusion body Source: UniProtKB
    2. intracellular Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB
    5. synaptic vesicle Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6565Metallothionein-3PRO_0000253583Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MKE4.
    SMRiQ8MKE4. Positions 32-65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3030BetaAdd
    BLAST
    Regioni31 – 6535AlphaAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG009063.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    SUPFAMiSSF57868. SSF57868. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8MKE4-1 [UniParc]FASTAAdd to Basket

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    MDPEACPCPT GGSCTCSDSC KCEGCTCASS KKSCCPAECE KCAKDCVCKG   50
    GEGAEAEEKK CGCCQ 65
    Length:65
    Mass (Da):6,574
    Last modified:October 1, 2002 - v1
    Checksum:iEC5778D87D508798
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF500199 mRNA. Translation: AAM21134.1.
    RefSeqiNP_001009755.1. NM_001009755.1.
    UniGeneiOar.980.

    Genome annotation databases

    GeneIDi443168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF500199 mRNA. Translation: AAM21134.1 .
    RefSeqi NP_001009755.1. NM_001009755.1.
    UniGenei Oar.980.

    3D structure databases

    ProteinModelPortali Q8MKE4.
    SMRi Q8MKE4. Positions 32-65.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443168.

    Organism-specific databases

    CTDi 4504.

    Phylogenomic databases

    HOVERGENi HBG009063.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57868. SSF57868. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III."
      Chung R.S., Holloway A.F., Eckhardt B.L., Harris J.A., Vickers J.C., Chuah M.I., West A.K.
      Biochem. J. 365:323-328(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiMT3_SHEEP
    AccessioniPrimary (citable) accession number: Q8MKE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3