Reviewed,
UniProtKB/Swiss-Prot Q8MKE4 (MT3_SHEEP)
Last modified
November 24, 2009.
Version 31.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Metallothionein-3 Short name=MT-3 Alternative name(s): Metallothionein-III Short name=MT-III | ||
| Gene names |
| ||
| Organism | Ovis aries (Sheep) | ||
| Taxonomic identifier | 9940 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Protein attributes
| Sequence length | 65 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium By similarity. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Copper Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | removal of superoxide radicals Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxiaInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 65 | 65 | Metallothionein-3 | PRO_0000253583 | |||||
Regions | |||||||||
| Region | 1 – 30 | 30 | Beta | ||||||
| Region | 31 – 65 | 35 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 6 | 1 | Cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Cluster A By similarity | ||||||
| Metal binding | 39 | 1 | Cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Cluster A By similarity | ||||||
| Metal binding | 46 | 1 | Cluster A By similarity | ||||||
| Metal binding | 48 | 1 | Cluster A By similarity | ||||||
| Metal binding | 61 | 1 | Cluster A By similarity | ||||||
| Metal binding | 63 | 1 | Cluster A By similarity | ||||||
| Metal binding | 64 | 1 | Cluster A By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
Sequences
References
| [1] | "Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III." Chung R.S., Holloway A.F., Eckhardt B.L., Harris J.A., Vickers J.C., Chuah M.I., West A.K. Biochem. J. 365:323-328(2002) [PubMed: 11931634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AF500199 mRNA. Translation: AAM21134.1. | |
| RefSeq | NP_001009755.1. |
| UniGene | Oar.980 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JI9 based on UniProtKB P28184. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 443168. |
Organism-specific databases | |
| CTD | 443168. |
Phylogenomic databases | |
| HOVERGEN | Q8MKE4. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT3_SHEEP | ||||||||
| Accession | Primary (citable) accession number: Q8MKE4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |
