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Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. phosphatidylinositol phospholipase C activity Source: Ensembl
  3. phospholipase activator activity Source: Ensembl
  4. protein kinase activity Source: Ensembl
  5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

GO - Biological processi

  1. activation of phospholipase D activity Source: Ensembl
  2. calcium ion transport Source: Ensembl
  3. cell-cell signaling Source: Ensembl
  4. cellular calcium ion homeostasis Source: Ensembl
  5. cellular protein complex assembly Source: Ensembl
  6. cellular response to fibroblast growth factor stimulus Source: Ensembl
  7. cellular response to interferon-gamma Source: Ensembl
  8. cellular response to interleukin-1 Source: Ensembl
  9. cellular response to organic cyclic compound Source: Ensembl
  10. cellular response to tumor necrosis factor Source: Ensembl
  11. chemokine-mediated signaling pathway Source: UniProtKB
  12. eosinophil chemotaxis Source: Ensembl
  13. exocytosis Source: Ensembl
  14. G-protein coupled receptor signaling pathway Source: UniProtKB
  15. inflammatory response Source: UniProtKB-KW
  16. leukocyte cell-cell adhesion Source: Ensembl
  17. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  18. MAPK cascade Source: Ensembl
  19. negative regulation by host of viral transcription Source: Ensembl
  20. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
  21. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  22. negative regulation of macrophage apoptotic process Source: Ensembl
  23. negative regulation of T cell apoptotic process Source: Ensembl
  24. negative regulation of viral genome replication Source: Ensembl
  25. neutrophil activation Source: Ensembl
  26. positive regulation of calcium ion transport Source: Ensembl
  27. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
  28. positive regulation of cellular biosynthetic process Source: Ensembl
  29. positive regulation of epithelial cell proliferation Source: Ensembl
  30. positive regulation of macrophage chemotaxis Source: Ensembl
  31. positive regulation of monocyte chemotaxis Source: Ensembl
  32. positive regulation of natural killer cell chemotaxis Source: Ensembl
  33. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  34. positive regulation of smooth muscle cell migration Source: Ensembl
  35. positive regulation of smooth muscle cell proliferation Source: Ensembl
  36. positive regulation of T cell apoptotic process Source: Ensembl
  37. positive regulation of T cell chemotaxis Source: Ensembl
  38. positive regulation of T cell proliferation Source: Ensembl
  39. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  40. protein kinase B signaling Source: Ensembl
  41. protein tetramerization Source: Ensembl
  42. regulation of insulin secretion Source: UniProtKB
  43. regulation of neuron death Source: UniProtKB
  44. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ8MKD0.
SMRiQ8MKD0. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8MKD0.
KOiK12499.
OMAiQEYFYTS.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MKD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVFAAALAV ILATATFCTP ASASPYASDT TPCCFAYISR PLPRAHIQEY
60 70 80 90
FYTSSKCSIP AVVFVTRKKR QVCANPEKKW VREYINTLEM S
Length:91
Mass (Da):10,159
Last modified:October 1, 2002 - v1
Checksum:iAEB253E8CD4ED7FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506970 mRNA. Translation: AAM34212.1.
RefSeqiNP_001075332.1. NM_001081863.1.
UniGeneiEca.1046.

Genome annotation databases

EnsembliENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
GeneIDi100033925.
KEGGiecb:100033925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506970 mRNA. Translation: AAM34212.1.
RefSeqiNP_001075332.1. NM_001081863.1.
UniGeneiEca.1046.

3D structure databases

ProteinModelPortaliQ8MKD0.
SMRiQ8MKD0. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
GeneIDi100033925.
KEGGiecb:100033925.

Organism-specific databases

CTDi6352.

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8MKD0.
KOiK12499.
OMAiQEYFYTS.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Equus caballus RANTES mRNA."
    Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL5_HORSE
AccessioniPrimary (citable) accession number: Q8MKD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.