Q8MKD0 (CCL5_HORSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 5

Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES

Gene names

Name:	CCL5
Synonyms:	SCYA5

Organism

Equus caballus (Horse) [Reference proteome]

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from electronic annotation. Source: Compara activation of phospholipase D activity Inferred from electronic annotation. Source: Compara calcium ion transport Inferred from electronic annotation. Source: Compara cell-cell signaling Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular protein complex assembly Inferred from electronic annotation. Source: Compara cellular response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to interferon-gamma Inferred from electronic annotation. Source: Compara cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cellular response to organic cyclic compound Inferred from electronic annotation. Source: Compara cellular response to tumor necrosis factor Inferred from electronic annotation. Source: Compara eosinophil chemotaxis Inferred from electronic annotation. Source: Compara exocytosis Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW leukocyte cell-cell adhesion Inferred from electronic annotation. Source: Compara lipopolysaccharide-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation by host of viral transcription Inferred from electronic annotation. Source: Compara negative regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of T cell apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of chemokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of macrophage apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of viral genome replication Inferred from electronic annotation. Source: Compara neutrophil activation Inferred from electronic annotation. Source: Compara positive regulation of T cell apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of T cell chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of calcium ion transport Inferred from electronic annotation. Source: Compara positive regulation of cell-cell adhesion mediated by integrin Inferred from electronic annotation. Source: Compara positive regulation of cellular biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of homotypic cell-cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of macrophage chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of monocyte chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of natural killer cell chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell migration Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of STAT protein Inferred from electronic annotation. Source: Compara protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara protein tetramerization Inferred from electronic annotation. Source: Compara response to toxin Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemoattractant activity Inferred from electronic annotation. Source: Compara phosphatidylinositol phospholipase C activity Inferred from electronic annotation. Source: Compara phospholipase activator activity Inferred from electronic annotation. Source: Compara protein kinase activity Inferred from electronic annotation. Source: Compara receptor signaling protein tyrosine kinase activator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 91	68	C-C motif chemokine 5		PRO_0000005174
Amino acid modifications
	Disulfide bond	33 ↔ 57		By similarity
	Disulfide bond	34 ↔ 73		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8MKD0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: AEB253E8CD4ED7FD	FASTA	91	10,159
	10 20 30 40 50 60 MKVFAAALAV ILATATFCTP ASASPYASDT TPCCFAYISR PLPRAHIQEY FYTSSKCSIP 70 80 90 AVVFVTRKKR QVCANPEKKW VREYINTLEM S

References

[1]	"Equus caballus RANTES mRNA." Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF506970 mRNA. Translation: AAM34212.1.
RefSeq	NP_001075332.1. NM_001081863.1.
UniGene	Eca.1046.
3D structure databases
ProteinModelPortal	Q8MKD0.
SMR	Q8MKD0. Positions 24-91.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
GeneID	100033925.
KEGG	ecb:100033925.
Organism-specific databases
CTD	6352.
Phylogenomic databases
eggNOG	NOG38896.
GeneTree	ENSGT00560000077010.
HOGENOM	HOG000036685.
HOVERGEN	HBG017871.
InParanoid	Q8MKD0.
KO	K12499.
OMA	QEYFYTS.
OrthoDB	EOG4W3SPN.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCL5_HORSE

Accession

Primary (citable) accession number: Q8MKD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program