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Q8MKD0

- CCL5_HORSE

UniProt

Q8MKD0 - CCL5_HORSE

Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.By similarity

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. phosphatidylinositol phospholipase C activity Source: Ensembl
    3. phospholipase activator activity Source: Ensembl
    4. protein kinase activity Source: Ensembl
    5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

    GO - Biological processi

    1. activation of phospholipase D activity Source: Ensembl
    2. calcium ion transport Source: Ensembl
    3. cell-cell signaling Source: Ensembl
    4. cellular calcium ion homeostasis Source: Ensembl
    5. cellular protein complex assembly Source: Ensembl
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to interferon-gamma Source: Ensembl
    8. cellular response to interleukin-1 Source: Ensembl
    9. cellular response to organic cyclic compound Source: Ensembl
    10. cellular response to tumor necrosis factor Source: Ensembl
    11. eosinophil chemotaxis Source: Ensembl
    12. exocytosis Source: Ensembl
    13. inflammatory response Source: UniProtKB-KW
    14. leukocyte cell-cell adhesion Source: Ensembl
    15. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    16. MAPK cascade Source: Ensembl
    17. negative regulation by host of viral transcription Source: Ensembl
    18. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
    19. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    20. negative regulation of macrophage apoptotic process Source: Ensembl
    21. negative regulation of T cell apoptotic process Source: Ensembl
    22. negative regulation of viral genome replication Source: Ensembl
    23. neutrophil activation Source: Ensembl
    24. positive regulation of calcium ion transport Source: Ensembl
    25. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
    26. positive regulation of cellular biosynthetic process Source: Ensembl
    27. positive regulation of epithelial cell proliferation Source: Ensembl
    28. positive regulation of homotypic cell-cell adhesion Source: Ensembl
    29. positive regulation of macrophage chemotaxis Source: Ensembl
    30. positive regulation of monocyte chemotaxis Source: Ensembl
    31. positive regulation of natural killer cell chemotaxis Source: Ensembl
    32. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    33. positive regulation of smooth muscle cell migration Source: Ensembl
    34. positive regulation of smooth muscle cell proliferation Source: Ensembl
    35. positive regulation of T cell apoptotic process Source: Ensembl
    36. positive regulation of T cell chemotaxis Source: Ensembl
    37. positive regulation of T cell proliferation Source: Ensembl
    38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
    39. protein kinase B signaling Source: Ensembl
    40. protein tetramerization Source: Ensembl
    41. response to toxic substance Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 5
    Alternative name(s):
    Small-inducible cytokine A5
    T-cell-specific protein RANTES
    Gene namesi
    Name:CCL5
    Synonyms:SCYA5
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168C-C motif chemokine 5PRO_0000005174Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MKD0.
    SMRiQ8MKD0. Positions 24-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38896.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8MKD0.
    KOiK12499.
    OMAiCSIPAVV.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8MKD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVFAAALAV ILATATFCTP ASASPYASDT TPCCFAYISR PLPRAHIQEY   50
    FYTSSKCSIP AVVFVTRKKR QVCANPEKKW VREYINTLEM S 91
    Length:91
    Mass (Da):10,159
    Last modified:October 1, 2002 - v1
    Checksum:iAEB253E8CD4ED7FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF506970 mRNA. Translation: AAM34212.1.
    RefSeqiNP_001075332.1. NM_001081863.1.
    UniGeneiEca.1046.

    Genome annotation databases

    EnsembliENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
    GeneIDi100033925.
    KEGGiecb:100033925.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF506970 mRNA. Translation: AAM34212.1 .
    RefSeqi NP_001075332.1. NM_001081863.1.
    UniGenei Eca.1046.

    3D structure databases

    ProteinModelPortali Q8MKD0.
    SMRi Q8MKD0. Positions 24-91.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSECAT00000026840 ; ENSECAP00000022430 ; ENSECAG00000024888 .
    GeneIDi 100033925.
    KEGGi ecb:100033925.

    Organism-specific databases

    CTDi 6352.

    Phylogenomic databases

    eggNOGi NOG38896.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8MKD0.
    KOi K12499.
    OMAi CSIPAVV.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Equus caballus RANTES mRNA."
      Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL5_HORSE
    AccessioniPrimary (citable) accession number: Q8MKD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3