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Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000517424 – 91C-C motif chemokine 5Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8MKD0.

Expressioni

Gene expression databases

BgeeiENSECAG00000024888.
ExpressionAtlasiQ8MKD0. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000022430.

Structurei

3D structure databases

ProteinModelPortaliQ8MKD0.
SMRiQ8MKD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XH. Eukaryota.
ENOG410ZUYI. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8MKD0.
KOiK12499.
OMAiCCFAYLS.
OrthoDBiEOG091G14Y2.
TreeFamiTF334888.

Family and domain databases

InterProiView protein in InterPro
IPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PANTHERiPTHR12015:SF136. PTHR12015:SF136. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MKD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVFAAALAV ILATATFCTP ASASPYASDT TPCCFAYISR PLPRAHIQEY
60 70 80 90
FYTSSKCSIP AVVFVTRKKR QVCANPEKKW VREYINTLEM S
Length:91
Mass (Da):10,159
Last modified:October 1, 2002 - v1
Checksum:iAEB253E8CD4ED7FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506970 mRNA. Translation: AAM34212.1.
RefSeqiNP_001075332.1. NM_001081863.2.
UniGeneiEca.1046.

Genome annotation databases

EnsembliENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
GeneIDi100033925.
KEGGiecb:100033925.

Similar proteinsi

Entry informationi

Entry nameiCCL5_HORSE
AccessioniPrimary (citable) accession number: Q8MKD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families