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Q8MKD0

- CCL5_HORSE

UniProt

Q8MKD0 - CCL5_HORSE

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Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. chemokine-mediated signaling pathway Source: UniProtKB
  3. G-protein coupled receptor signaling pathway Source: UniProtKB
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. negative regulation of macrophage apoptotic process Source: Ensembl
  7. positive regulation of epithelial cell proliferation Source: Ensembl
  8. positive regulation of monocyte chemotaxis Source: Ensembl
  9. regulation of insulin secretion Source: UniProtKB
  10. regulation of neuron death Source: UniProtKB
  11. response to tumor necrosis factor Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ8MKD0.
SMRiQ8MKD0. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8MKD0.
KOiK12499.
OMAiCSIPAVV.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MKD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVFAAALAV ILATATFCTP ASASPYASDT TPCCFAYISR PLPRAHIQEY
60 70 80 90
FYTSSKCSIP AVVFVTRKKR QVCANPEKKW VREYINTLEM S
Length:91
Mass (Da):10,159
Last modified:October 1, 2002 - v1
Checksum:iAEB253E8CD4ED7FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF506970 mRNA. Translation: AAM34212.1.
RefSeqiNP_001075332.1. NM_001081863.1.
UniGeneiEca.1046.

Genome annotation databases

EnsembliENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
GeneIDi100033925.
KEGGiecb:100033925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF506970 mRNA. Translation: AAM34212.1 .
RefSeqi NP_001075332.1. NM_001081863.1.
UniGenei Eca.1046.

3D structure databases

ProteinModelPortali Q8MKD0.
SMRi Q8MKD0. Positions 24-91.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000026840 ; ENSECAP00000022430 ; ENSECAG00000024888 .
GeneIDi 100033925.
KEGGi ecb:100033925.

Organism-specific databases

CTDi 6352.

Phylogenomic databases

eggNOGi NOG38896.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q8MKD0.
KOi K12499.
OMAi CSIPAVV.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Equus caballus RANTES mRNA."
    Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL5_HORSE
AccessioniPrimary (citable) accession number: Q8MKD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3