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Q8MKD0

- CCL5_HORSE

UniProt

Q8MKD0 - CCL5_HORSE

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Protein
C-C motif chemokine 5
Gene
CCL5, SCYA5
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. phosphatidylinositol phospholipase C activity Source: Ensembl
  3. phospholipase activator activity Source: Ensembl
  4. protein kinase activity Source: Ensembl
  5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. activation of phospholipase D activity Source: Ensembl
  3. calcium ion transport Source: Ensembl
  4. cell-cell signaling Source: Ensembl
  5. cellular calcium ion homeostasis Source: Ensembl
  6. cellular protein complex assembly Source: Ensembl
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cellular response to interferon-gamma Source: Ensembl
  9. cellular response to interleukin-1 Source: Ensembl
  10. cellular response to organic cyclic compound Source: Ensembl
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. eosinophil chemotaxis Source: Ensembl
  13. exocytosis Source: Ensembl
  14. inflammatory response Source: UniProtKB-KW
  15. leukocyte cell-cell adhesion Source: Ensembl
  16. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  17. negative regulation by host of viral transcription Source: Ensembl
  18. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  19. negative regulation of T cell apoptotic process Source: Ensembl
  20. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
  21. negative regulation of macrophage apoptotic process Source: Ensembl
  22. negative regulation of viral genome replication Source: Ensembl
  23. neutrophil activation Source: Ensembl
  24. positive regulation of T cell apoptotic process Source: Ensembl
  25. positive regulation of T cell chemotaxis Source: Ensembl
  26. positive regulation of T cell proliferation Source: Ensembl
  27. positive regulation of calcium ion transport Source: Ensembl
  28. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
  29. positive regulation of cellular biosynthetic process Source: Ensembl
  30. positive regulation of epithelial cell proliferation Source: Ensembl
  31. positive regulation of homotypic cell-cell adhesion Source: Ensembl
  32. positive regulation of macrophage chemotaxis Source: Ensembl
  33. positive regulation of monocyte chemotaxis Source: Ensembl
  34. positive regulation of natural killer cell chemotaxis Source: Ensembl
  35. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  36. positive regulation of smooth muscle cell migration Source: Ensembl
  37. positive regulation of smooth muscle cell proliferation Source: Ensembl
  38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  39. protein kinase B signaling Source: Ensembl
  40. protein tetramerization Source: Ensembl
  41. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 9168C-C motif chemokine 5
PRO_0000005174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ8MKD0.
SMRiQ8MKD0. Positions 24-91.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8MKD0.
KOiK12499.
OMAiCSIPAVV.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MKD0-1 [UniParc]FASTAAdd to Basket

« Hide

MKVFAAALAV ILATATFCTP ASASPYASDT TPCCFAYISR PLPRAHIQEY   50
FYTSSKCSIP AVVFVTRKKR QVCANPEKKW VREYINTLEM S 91
Length:91
Mass (Da):10,159
Last modified:October 1, 2002 - v1
Checksum:iAEB253E8CD4ED7FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF506970 mRNA. Translation: AAM34212.1.
RefSeqiNP_001075332.1. NM_001081863.1.
UniGeneiEca.1046.

Genome annotation databases

EnsembliENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
GeneIDi100033925.
KEGGiecb:100033925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF506970 mRNA. Translation: AAM34212.1 .
RefSeqi NP_001075332.1. NM_001081863.1.
UniGenei Eca.1046.

3D structure databases

ProteinModelPortali Q8MKD0.
SMRi Q8MKD0. Positions 24-91.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000026840 ; ENSECAP00000022430 ; ENSECAG00000024888 .
GeneIDi 100033925.
KEGGi ecb:100033925.

Organism-specific databases

CTDi 6352.

Phylogenomic databases

eggNOGi NOG38896.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q8MKD0.
KOi K12499.
OMAi CSIPAVV.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Equus caballus RANTES mRNA."
    Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL5_HORSE
AccessioniPrimary (citable) accession number: Q8MKD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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