Q8MK68 (GBRAP_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor-associated protein

Alternative name(s):
GABA(A) receptor-associated protein

Gene names

Name:

GABARAP

Organism

Oryctolagus cuniculus (Rabbit) [Complete proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton By similarity.
Subunit structure	Interacts with CALR, GABRG2, TUBA1, GPHN, ULK1, NSF and beta-tubulin By similarity.
Subcellular location	Endomembrane system By similarity. Cytoplasm › cytoskeleton By similarity. Golgi apparatus membrane By similarity. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus Membrane Microtubule
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Gamma-aminobutyric acid receptor-associated protein		PRO_0000212365
Regions
	Region	1 – 22	22	Interaction with beta-tubulin By similarity
	Region	36 – 117	82	Interaction with GPHN By similarity
	Region	36 – 68	33	Interaction with GABRG2 Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8MK68 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: BC0B84B8A51C1E32	FASTA	117	13,918
	10 20 30 40 50 60 MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 70 80 90 100 110 YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

References

[1]	"Activity-dependent expression of GABARAP in rabbit flocculus modulated by optokinetic stimulation." Qian Z., Barmack N.H. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY094174 mRNA. Translation: AAM22501.1.
RefSeq	NP_001075611.1. NM_001082142.1.
UniGene	Ocu.6215.
3D structure databases
ProteinModelPortal	Q8MK68.
SMR	Q8MK68. Positions 1-116.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSOCUT00000006994; ENSOCUP00000006049; ENSOCUG00000006997.
GeneID	100008883.
Organism-specific databases
CTD	11337.
Phylogenomic databases
eggNOG	maNOG19744.
GeneTree	ENSGT00390000012937.
HOVERGEN	HBG051706.
OrthoDB	EOG4T4CWW.
Family and domain databases
InterPro	IPR004241. Atg8_ubiquitin-like. [Graphical view]
PANTHER	PTHR10969. MAP1_LC3. 1 hit.
Pfam	PF02991. Atg8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GBRAP_RABIT

Accession

Primary (citable) accession number: Q8MK68

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	October 1, 2002
Last modified:	November 16, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program