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Protein

Neuropeptide B

Gene

NPB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
bPPL7
Cleaved into the following chain:
Neuropeptide B-29
Short name:
NPB29
Alternative name(s):
L7C
Gene namesi
Name:NPB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001983425 – 53Neuropeptide B-29Add BLAST29
PropeptideiPRO_000001983556 – 122Sequence analysisAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256'-bromotryptophan2 Publications1

Keywords - PTMi

Bromination, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8MJV4.
PRIDEiQ8MJV4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013898.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018455.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8MJV4.
KOiK05267.
OMAiWYKPAAG.
OrthoDBiEOG091G0VSK.
TreeFamiTF333179.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MJV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPAMLVAA ALALCLLLAS PGLAWYKPTA GQGYYSVGRA AGLLSGFHRS
60 70 80 90 100
PYARRSEPRG GTRSLGGVGT FREMRPNLRS LAVCVEEVTP NLQSCEPLPD
110 120
GRATFQCKAD VFLSLSASDC RK
Length:122
Mass (Da):12,919
Last modified:October 1, 2002 - v1
Checksum:i62EEAE117840D118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085943 mRNA. Translation: BAC07176.1.
RefSeqiNP_776369.1. NM_173944.1.
UniGeneiBt.12289.

Genome annotation databases

EnsembliENSBTAT00000018455; ENSBTAP00000018455; ENSBTAG00000013898.
GeneIDi280880.
KEGGibta:280880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085943 mRNA. Translation: BAC07176.1.
RefSeqiNP_776369.1. NM_173944.1.
UniGeneiBt.12289.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018455.

Proteomic databases

PaxDbiQ8MJV4.
PRIDEiQ8MJV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018455; ENSBTAP00000018455; ENSBTAG00000013898.
GeneIDi280880.
KEGGibta:280880.

Organism-specific databases

CTDi256933.

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8MJV4.
KOiK05267.
OMAiWYKPAAG.
OrthoDBiEOG091G0VSK.
TreeFamiTF333179.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSBTAG00000013898.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNPB_BOVIN
AccessioniPrimary (citable) accession number: Q8MJV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.