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Protein

Neuropeptide B

Gene

NPB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
bPPL7
Cleaved into the following chain:
Neuropeptide B-29
Short name:
NPB29
Alternative name(s):
L7C
Gene namesi
Name:NPB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001983425 – 53Neuropeptide B-29Add BLAST29
PropeptideiPRO_000001983556 – 122Sequence analysisAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256'-bromotryptophan2 Publications1

Keywords - PTMi

Bromination, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8MJV4.
PRIDEiQ8MJV4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013898.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018455.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8MJV4.
KOiK05267.
OMAiWYKPAAG.
OrthoDBiEOG091G0VSK.
TreeFamiTF333179.

Family and domain databases

InterProiView protein in InterPro
IPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
PfamiView protein in Pfam
PF15180. NPBW. 1 hit.
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD685249. PD685249. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MJV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPAMLVAA ALALCLLLAS PGLAWYKPTA GQGYYSVGRA AGLLSGFHRS
60 70 80 90 100
PYARRSEPRG GTRSLGGVGT FREMRPNLRS LAVCVEEVTP NLQSCEPLPD
110 120
GRATFQCKAD VFLSLSASDC RK
Length:122
Mass (Da):12,919
Last modified:October 1, 2002 - v1
Checksum:i62EEAE117840D118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085943 mRNA. Translation: BAC07176.1.
RefSeqiNP_776369.1. NM_173944.1.
UniGeneiBt.12289.

Genome annotation databases

EnsembliENSBTAT00000018455; ENSBTAP00000018455; ENSBTAG00000013898.
GeneIDi280880.
KEGGibta:280880.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNPB_BOVIN
AccessioniPrimary (citable) accession number: Q8MJV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: May 10, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families