Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropeptide B

Gene

NPB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
bPPL7
Cleaved into the following chain:
Neuropeptide B-29
Short name:
NPB29
Alternative name(s):
L7C
Gene namesi
Name:NPB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:32192 NPB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001983425 – 53Neuropeptide B-29Add BLAST29
PropeptideiPRO_000001983556 – 122Sequence analysisAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256'-bromotryptophan2 Publications1

Keywords - PTMi

Bromination, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8MJV4
PRIDEiQ8MJV4

Expressioni

Gene expression databases

BgeeiENSBTAG00000013898

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018455

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G Eukaryota
ENOG41120QH LUCA
GeneTreeiENSGT00390000013683
HOGENOMiHOG000231239
HOVERGENiHBG039578
InParanoidiQ8MJV4
KOiK05267
OMAiWYKPAAG
OrthoDBiEOG091G0VSK
TreeFamiTF333179

Family and domain databases

InterProiView protein in InterPro
IPR013298 Neuropept_B_pre
IPR013297 Neuropept_BW_pre
PANTHERiPTHR28553 PTHR28553, 1 hit
PfamiView protein in Pfam
PF15180 NPBW, 1 hit
PRINTSiPR01888 NROPEPTIDEBW
PR01889 PPNRPEPTIDEB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD685249 PD685249, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MJV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPAMLVAA ALALCLLLAS PGLAWYKPTA GQGYYSVGRA AGLLSGFHRS
60 70 80 90 100
PYARRSEPRG GTRSLGGVGT FREMRPNLRS LAVCVEEVTP NLQSCEPLPD
110 120
GRATFQCKAD VFLSLSASDC RK
Length:122
Mass (Da):12,919
Last modified:October 1, 2002 - v1
Checksum:i62EEAE117840D118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085943 mRNA Translation: BAC07176.1
RefSeqiNP_776369.1, NM_173944.1
UniGeneiBt.12289

Genome annotation databases

EnsembliENSBTAT00000018455; ENSBTAP00000018455; ENSBTAG00000013898
GeneIDi280880
KEGGibta:280880

Similar proteinsi

Entry informationi

Entry nameiNPB_BOVIN
AccessioniPrimary (citable) accession number: Q8MJV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health