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Protein

Neuropeptides B/W receptor type 1

Gene

NPBWR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 1
Alternative name(s):
G-protein coupled receptor 7
Gene namesi
Name:NPBWR1
Synonyms:GPR7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 66Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini67 – 75CytoplasmicSequence analysis9
Transmembranei76 – 100Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini101 – 115ExtracellularSequence analysisAdd BLAST15
Transmembranei116 – 135Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini136 – 160CytoplasmicSequence analysisAdd BLAST25
Transmembranei161 – 180Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini181 – 205ExtracellularSequence analysisAdd BLAST25
Transmembranei206 – 227Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini228 – 251CytoplasmicSequence analysisAdd BLAST24
Transmembranei252 – 276Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini277 – 286ExtracellularSequence analysis10
Transmembranei287 – 301Helical; Name=7Sequence analysisAdd BLAST15
Topological domaini302 – 331CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695171 – 331Neuropeptides B/W receptor type 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8MJV3.
PRIDEiQ8MJV3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021510.

Structurei

3D structure databases

ProteinModelPortaliQ8MJV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ8MJV3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERiPTHR24229:SF47. PTHR24229:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MJV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNASYWGPE RANTSCPAPA PTLGCPNASG PAPPLPPPLA VAVPVVYAVI
60 70 80 90 100
CAVGLAGNSA VLFVLLRAPR RKTVTNLFIL NLAVADELFT LVPPVNIADF
110 120 130 140 150
LLRRWPFGEL LCKLVVAVDQ YNTFSSLYFL TVMSADRYLV VLATAESRRV
160 170 180 190 200
AGRTYGAARA VSLAVWGVAT LVVLPFAVFA RLDEEQGRRQ CVLVFPQPEA
210 220 230 240 250
LWWRASRLYT LVLGFAIPVS TICVLYTSLL CRLRAIRLDS HAKALDRAKK
260 270 280 290 300
RVTVLVVAIL AVCLLVWTPY HLSTVVALTT DLPQTPLVIA VSYFITSLSY
310 320 330
ANSCLNPFLY AFLDDSFRRS LRQLLACRTT S
Length:331
Mass (Da):36,268
Last modified:October 1, 2002 - v1
Checksum:iA474CA041EDF3B57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085946 mRNA. Translation: BAC07179.1.
UniGeneiBt.12288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085946 mRNA. Translation: BAC07179.1.
UniGeneiBt.12288.

3D structure databases

ProteinModelPortaliQ8MJV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021510.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ8MJV3.
PRIDEiQ8MJV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ8MJV3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERiPTHR24229:SF47. PTHR24229:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPBW1_BOVIN
AccessioniPrimary (citable) accession number: Q8MJV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.