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Protein

Neuropeptides B/W receptor type 2

Gene

NPBWR2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 2
Alternative name(s):
G-protein coupled receptor 8
Gene namesi
Name:NPBWR2
Synonyms:GPR8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence analysisAdd
BLAST
Transmembranei46 – 6823Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini69 – 8012CytoplasmicSequence analysisAdd
BLAST
Transmembranei81 – 10323Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 12724ExtracellularSequence analysisAdd
BLAST
Transmembranei128 – 14619Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini147 – 16519CytoplasmicSequence analysisAdd
BLAST
Transmembranei166 – 18823Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini189 – 21325ExtracellularSequence analysisAdd
BLAST
Transmembranei214 – 23623Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini237 – 25620CytoplasmicSequence analysisAdd
BLAST
Transmembranei257 – 27923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini280 – 29314ExtracellularSequence analysisAdd
BLAST
Transmembranei294 – 31623Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini317 – 33620CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Neuropeptides B/W receptor type 2PRO_0000069521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi117 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8MJV2.
PRIDEiQ8MJV2.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054391.

Structurei

3D structure databases

ProteinModelPortaliQ8MJV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106919.
InParanoidiQ8MJV2.
KOiK08377.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027349. NPBW2.
[Graphical view]
PANTHERiPTHR24229:SF18. PTHR24229:SF18. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MJV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEATGLEGL ESTSSPCPGS TGTGLSWDNG TRHNATFPEP LPALYVLLPV
60 70 80 90 100
VYSVICAVGL VGNAAVICVI LRAPKMKTVT HVFILNLAIA DGLFTLVLPT
110 120 130 140 150
NIAEHLLQRW PFGEVLCKLV LAIDHCNIFS SVYFLAAMSI DRYLVVLATA
160 170 180 190 200
RSRRMPRRTV HRAKVASLCV WLGVTVAVLP FLTFAGVYNN ELQVTSCGLS
210 220 230 240 250
FPRPERAWFQ ASRIYTLVLG FVVPMCTLCV LYADLLRRLR ALRLHSGAKA
260 270 280 290 300
LGKAKRKVSL LVLAVLAVGL LCWTPFHLAS IVALTTDLPQ TPLVIIVSYV
310 320 330
VTSLSYTSSC LNPFLYAFLD HSFRKSLRTA CRCQGA
Length:336
Mass (Da):36,727
Last modified:October 1, 2002 - v1
Checksum:i98E346053518891B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085947 mRNA. Translation: BAC07180.1.
RefSeqiNP_776500.1. NM_174075.1.
UniGeneiBt.12287.

Genome annotation databases

GeneIDi281208.
KEGGibta:281208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085947 mRNA. Translation: BAC07180.1.
RefSeqiNP_776500.1. NM_174075.1.
UniGeneiBt.12287.

3D structure databases

ProteinModelPortaliQ8MJV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054391.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ8MJV2.
PRIDEiQ8MJV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281208.
KEGGibta:281208.

Organism-specific databases

CTDi2832.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106919.
InParanoidiQ8MJV2.
KOiK08377.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027349. NPBW2.
[Graphical view]
PANTHERiPTHR24229:SF18. PTHR24229:SF18. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7."
    Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y., Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M.
    J. Biol. Chem. 277:34010-34016(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNPBW2_BOVIN
AccessioniPrimary (citable) accession number: Q8MJV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.