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Protein

Cyclic nucleotide-gated cation channel beta-3

Gene

CNGB3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei587 – 5871cGMPBy similarity
Binding sitei599 – 5991cGMPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi527 – 671145cGMPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel beta-3
Alternative name(s):
Cone photoreceptor cGMP-gated channel subunit beta
Cyclic nucleotide-gated cation channel modulatory subunit
Cyclic nucleotide-gated channel beta-3
Short name:
CNG channel beta-3
Gene namesi
Name:CNGB3
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 211211CytoplasmicSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=H1Sequence analysisAdd
BLAST
Topological domaini233 – 24513ExtracellularSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=H2Sequence analysisAdd
BLAST
Topological domaini267 – 29731CytoplasmicSequence analysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=H3Sequence analysisAdd
BLAST
Topological domaini319 – 41294ExtracellularSequence analysisAdd
BLAST
Transmembranei413 – 43321Helical; Name=H4Sequence analysisAdd
BLAST
Topological domaini434 – 49360CytoplasmicSequence analysisAdd
BLAST
Transmembranei494 – 51421Helical; Name=H5Sequence analysisAdd
BLAST
Topological domaini515 – 57258ExtracellularSequence analysisAdd
BLAST
Transmembranei573 – 59321Helical; Name=H6Sequence analysisAdd
BLAST
Topological domaini594 – 782189CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in CNGB3 are a cause of cone degeneration (cd). Cd is characterized by day-blindness and absence of retinal cone function. This autosomal recessive disorder occurs naturally in the Alaskan Malamute and German Shorthaired Pointer breeds.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Cyclic nucleotide-gated cation channel beta-3PRO_0000219319Add
BLAST

Proteomic databases

PaxDbiQ8MJD7.

Interactioni

Subunit structurei

Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000036190.

Structurei

3D structure databases

ProteinModelPortaliQ8MJD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0499. Eukaryota.
ENOG410ZJ5U. LUCA.
HOGENOMiHOG000231425.
HOVERGENiHBG051038.
InParanoidiQ8MJD7.
KOiK04953.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032943. CNG6.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF385. PTHR10217:SF385. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MJD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKSLTIKSN KVKPREENDE NKQDPDPSNQ PQQSTRQGEN KSENKSLQTK
60 70 80 90 100
MTPVTFEESH AKMQDKISEK NSLRDLTTNP NHQHPTESKG AMSEQKEMET
110 120 130 140 150
GKEGLVSPKS KPLGVPVINE YADAQLHNLV RRMRQRTMLY KKKLAEGDIS
160 170 180 190 200
SPEASPQTAK PTAVPSTQES NAKLKEEHYY HILCFKFQKM PLTEYLKRFR
210 220 230 240 250
LPGSIDSYTD RLYLLWLLLV TIAYNWNCWL IPLRLVFPYQ TPDNTHYWFI
260 270 280 290 300
TDITCDIIYL CDMLLIQPRL QFIKGGDIMV DSNELKRHYR SSTKFQLDVA
310 320 330 340 350
SVMPFDVFYL FFGFNPVFRM NRILKYTSFF EFNHHLESIM DKAYIYRVIR
360 370 380 390 400
TTGYLLYTLH INACIYYWAS DYEGIGSTKW VYNGEGNKYL RCYYWAVRTL
410 420 430 440 450
ITIGGLPEPQ TSFEIVFQLL NFFSGVFVFS SLIGQMQDVI GAATANQNNF
460 470 480 490 500
RISMDHTISY MNTYSIPKNV QNRVRTWYEY TWDSQRMLDE SDLLCTLPVT
510 520 530 540 550
MQLALTVDVN LSIISKVELF KGCDTQMIYD MLLRLKSTVY LPGDFVCKKG
560 570 580 590 600
EIGKEMYIIK QGEVQVLGGS DGAQVLVTLK AGAVFGEISL LAGRGGNRRT
610 620 630 640 650
ANVIAHGFAN LLTLDKKTLQ EILVHYPDSE KLLMKKASVL LKKKAPATET
660 670 680 690 700
TPPRKGLAFL FPPKQETPKI FKALLGGTGK AGLTRLLKLK REQTIQKTSE
710 720 730 740 750
NSEEGGGKRR EYEDKEREPS EKILDSSECR ANCIIAEEMP QSIRRAALPR
760 770 780
GTTRQSLIIS MAPSAEAGEE VLTIEVKEKA KQ
Length:782
Mass (Da):89,424
Last modified:October 1, 2002 - v1
Checksum:i7139EF3B86268A79
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti262 – 2621D → N in cd; in a German Shorthaired Pointer. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490511 mRNA. Translation: AAM89224.1.
DQ497639 Genomic DNA. Translation: ABF58779.1.
RefSeqiNP_001003030.1. NM_001003030.1.
UniGeneiCfa.72.

Genome annotation databases

GeneIDi403554.
KEGGicfa:403554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490511 mRNA. Translation: AAM89224.1.
DQ497639 Genomic DNA. Translation: ABF58779.1.
RefSeqiNP_001003030.1. NM_001003030.1.
UniGeneiCfa.72.

3D structure databases

ProteinModelPortaliQ8MJD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000036190.

Proteomic databases

PaxDbiQ8MJD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403554.
KEGGicfa:403554.

Organism-specific databases

CTDi54714.

Phylogenomic databases

eggNOGiKOG0499. Eukaryota.
ENOG410ZJ5U. LUCA.
HOGENOMiHOG000231425.
HOVERGENiHBG051038.
InParanoidiQ8MJD7.
KOiK04953.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032943. CNG6.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF385. PTHR10217:SF385. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGB3_CANLF
AccessioniPrimary (citable) accession number: Q8MJD7
Secondary accession number(s): Q1G1Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.