Q8MJD5 (HOP_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeodomain-only protein

Alternative name(s):
Odd homeobox protein 1

Gene names

Name:	HOP
Synonyms:	HOD, OB1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	73 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy By similarity.
Subunit structure	Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such as HDAC2 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Molecular function	Developmental protein Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	heart development Inferred from electronic annotation. Source: Compara histone deacetylation Inferred from electronic annotation. Source: Compara lung alveolus development Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of skeletal muscle tissue regeneration Inferred from electronic annotation. Source: Compara positive regulation of striated muscle cell differentiation Inferred from electronic annotation. Source: Compara regulation of heart contraction Inferred from electronic annotation. Source: Compara regulation of protein binding Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW trophectodermal cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 73	73	Homeodomain-only protein		PRO_0000049128
Regions
	DNA binding	3 – 62	60	Homeobox; atypical

Sequences

	Sequence		Length	Mass (Da)
	Q8MJD5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9214F86B3B58034E	FASTA	73	8,299
	10 20 30 40 50 60 MSTETASGPT EDQVEILEYN FNKVNKHPDP TTLCLIAAEA GLSEEETQKW FKQRLAQWRR 70 SEGLPSECRS VTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development." Adu J., Leong F.T., Smith N.R., Leek J.P., Markham A.F., Robinson P.A., Mighell A.J. Mech. Dev. 119:S43-S47(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF492683 mRNA. Translation: AAM46835.1. BC102635 mRNA. Translation: AAI02636.1.
IPI	IPI00705826.
RefSeq	NP_776522.1. NM_174097.2.
UniGene	Bt.9549.
3D structure databases
ProteinModelPortal	Q8MJD5.
SMR	Q8MJD5. Positions 1-73.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000003013; ENSBTAP00000003013; ENSBTAG00000002333.
GeneID	281270.
KEGG	bta:281270.
Organism-specific databases
CTD	84525.
Phylogenomic databases
eggNOG	NOG319963.
GeneTree	ENSGT00390000017143.
HOGENOM	HOG000112932.
HOVERGEN	HBG051921.
InParanoid	Q8MJD5.
OMA	WRQSEGL.
OrthoDB	EOG4M39B5.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805306.

Entry information

Entry name

HOP_BOVIN

Accession

Primary (citable) accession number: Q8MJD5
Secondary accession number(s): Q3SZZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program