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Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri347 – 372C2H2-typeAdd BLAST26
DNA bindingi505 – 595Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Gene namesi
Name:FOXP2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918841 – 716Forkhead box protein P2Add BLAST716

Proteomic databases

PaxDbiQ8MJA0.

Expressioni

Gene expression databases

BgeeiENSPTRG00000019608.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033573.

Structurei

3D structure databases

ProteinModelPortaliQ8MJA0.
SMRiQ8MJA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni389 – 410Leucine-zipperAdd BLAST22
Regioni423 – 427CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 269Gln-richAdd BLAST217

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri347 – 372C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ8MJA0.
KOiK09409.
OMAiPETKLCV.
OrthoDBiEOG091G08HY.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MJA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQHPGKQAKE
210 220 230 240 250
QQQQQQQQQQ LAAQQLVFQQ QLLQMQQLQQ QQHLLSLQRQ GLISIPPGQA
260 270 280 290 300
ALPVQSLPQA GLSPAEIQQL WKEVTGVHSM EDNGIKHGGL DLTTNNSSST
310 320 330 340 350
TSSTTSKASP PITHHSIVNG QSSVLNARRD SSSHEETGAS HTLYGHGVCK
360 370 380 390 400
WPGCESICED FGQFLKHLNN EHALDDRSTA QCRVQMQVVQ QLEIQLSKER
410 420 430 440 450
ERLQAMMTHL HMRPSEPKPS PKPLNLVSSV TMSKNMLETS PQSLPQTPTT
460 470 480 490 500
PTAPVTPITQ GPSVITPASV PNVGAIRRRH SDKYNIPMSS EIAPNYEFYK
510 520 530 540 550
NADVRPPFTY ATLIRQAIME SSDRQLTLNE IYSWFTRTFA YFRRNAATWK
560 570 580 590 600
NAVRHNLSLH KCFVRVENVK GAVWTVDEVE YQKRRSQKIT GSPTLVKNIP
610 620 630 640 650
TSLGYGAALN ASLQAALAES SLPLLSNPGL INNASSGLLQ AVHEDLNGSL
660 670 680 690 700
DHIDSNGNSS PGCSPQPHIH SIHVKEEPVI AEDEDCPMSL VTTANHSPEL
710
EDDREIEEEP LSEDLE
Length:716
Mass (Da):80,061
Last modified:October 1, 2002 - v1
Checksum:i3169A2786B42F79F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512947 mRNA. Translation: AAN03385.1.
AF515051 Genomic DNA. Translation: AAN03409.1.
AF515052 Genomic DNA. Translation: AAN03410.1.
AY143178 mRNA. Translation: AAN60056.1.
AY064549 mRNA. Translation: AAL57735.1.
AY064565
, AY064551, AY064552, AY064553, AY064554, AY064555, AY064556, AY064557, AY064558, AY064559, AY064560, AY064561, AY064562, AY064563, AY064564 Genomic DNA. Translation: AAL57731.1.
RefSeqiNP_001009020.1. NM_001009020.3.
UniGeneiPtr.6303.

Genome annotation databases

EnsembliENSPTRT00000036314; ENSPTRP00000033573; ENSPTRG00000019608.
GeneIDi449627.
KEGGiptr:449627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512947 mRNA. Translation: AAN03385.1.
AF515051 Genomic DNA. Translation: AAN03409.1.
AF515052 Genomic DNA. Translation: AAN03410.1.
AY143178 mRNA. Translation: AAN60056.1.
AY064549 mRNA. Translation: AAL57735.1.
AY064565
, AY064551, AY064552, AY064553, AY064554, AY064555, AY064556, AY064557, AY064558, AY064559, AY064560, AY064561, AY064562, AY064563, AY064564 Genomic DNA. Translation: AAL57731.1.
RefSeqiNP_001009020.1. NM_001009020.3.
UniGeneiPtr.6303.

3D structure databases

ProteinModelPortaliQ8MJA0.
SMRiQ8MJA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033573.

Proteomic databases

PaxDbiQ8MJA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000036314; ENSPTRP00000033573; ENSPTRG00000019608.
GeneIDi449627.
KEGGiptr:449627.

Organism-specific databases

CTDi93986.

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ8MJA0.
KOiK09409.
OMAiPETKLCV.
OrthoDBiEOG091G08HY.
TreeFamiTF326978.

Gene expression databases

BgeeiENSPTRG00000019608.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXP2_PANTR
AccessioniPrimary (citable) accession number: Q8MJA0
Secondary accession number(s): Q8MHX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.