Q8MJA0 (FOXP2_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein P2

Gene names

Name:

FOXP2

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential By similarity.
Subunit structure	Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 By similarity.
Subcellular location	Nucleus Probable.
Domain	The leucine-zipper is required for dimerization and transcriptional repression By similarity.
Sequence similarities	Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	camera-type eye development Inferred from Biological aspect of Ancestor. Source: RefGenome caudate nucleus development Inferred from sequence or structural similarity. Source: UniProtKB cerebellum development Inferred from Biological aspect of Ancestor. Source: RefGenome cerebral cortex development Inferred from Biological aspect of Ancestor. Source: RefGenome embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome growth Inferred from Biological aspect of Ancestor. Source: RefGenome lung alveolus development Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of epithelial cell proliferation involved in lung morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of mesenchymal cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome post-embryonic development Inferred from Biological aspect of Ancestor. Source: RefGenome putamen development Inferred from sequence or structural similarity. Source: UniProtKB regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome righting reflex Inferred from Biological aspect of Ancestor. Source: RefGenome skeletal muscle tissue development Inferred from Biological aspect of Ancestor. Source: RefGenome smooth muscle tissue development Inferred from Biological aspect of Ancestor. Source: RefGenome vocal learning Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome chromatin binding Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome protein heterodimerization activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: Compara transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 716	716	Forkhead box protein P2		PRO_0000091884
Regions
	Zinc finger	347 – 372	26	C2H2-type
	DNA binding	505 – 595	91	Fork-head
	Region	389 – 410	22	Leucine-zipper
	Region	423 – 427	5	CTBP1-binding By similarity
	Compositional bias	53 – 269	217	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q8MJA0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 3169A2786B42F79F	FASTA	716	80,061
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 90 100 110 120 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 130 140 150 160 170 180 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 190 200 210 220 230 240 QQQQQQQQQQ QQHPGKQAKE QQQQQQQQQQ LAAQQLVFQQ QLLQMQQLQQ QQHLLSLQRQ 250 260 270 280 290 300 GLISIPPGQA ALPVQSLPQA GLSPAEIQQL WKEVTGVHSM EDNGIKHGGL DLTTNNSSST 310 320 330 340 350 360 TSSTTSKASP PITHHSIVNG QSSVLNARRD SSSHEETGAS HTLYGHGVCK WPGCESICED 370 380 390 400 410 420 FGQFLKHLNN EHALDDRSTA QCRVQMQVVQ QLEIQLSKER ERLQAMMTHL HMRPSEPKPS 430 440 450 460 470 480 PKPLNLVSSV TMSKNMLETS PQSLPQTPTT PTAPVTPITQ GPSVITPASV PNVGAIRRRH 490 500 510 520 530 540 SDKYNIPMSS EIAPNYEFYK NADVRPPFTY ATLIRQAIME SSDRQLTLNE IYSWFTRTFA 550 560 570 580 590 600 YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE YQKRRSQKIT GSPTLVKNIP 610 620 630 640 650 660 TSLGYGAALN ASLQAALAES SLPLLSNPGL INNASSGLLQ AVHEDLNGSL DHIDSNGNSS 670 680 690 700 710 PGCSPQPHIH SIHVKEEPVI AEDEDCPMSL VTTANHSPEL EDDREIEEEP LSEDLE

References

[1]	"Molecular evolution of FOXP2, a gene involved in speech and language." Enard W., Przeworski M., Fisher S.E., Lai C.S.L., Wiebe V., Kitano T., Monaco A.P., Paeaebo S. Nature 418:869-872(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Accelerated protein evolution and origins of human-specific features: Foxp2 as an example." Zhang J., Webb D.M., Podlaha O. Genetics 162:1825-1835(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The FOXP2 gene, implicated in language development, is conserved in mammalian evolution." Walter N.A.R., Thompson J., McGoldrick D.J., Messier W. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Blood.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF512947 mRNA. Translation: AAN03385.1. AF515051 Genomic DNA. Translation: AAN03409.1. AF515052 Genomic DNA. Translation: AAN03410.1. AY143178 mRNA. Translation: AAN60056.1. AY064549 mRNA. Translation: AAL57735.1. AY064565 , AY064551, AY064552, AY064553, AY064554, AY064555, AY064556, AY064557, AY064558, AY064559, AY064560, AY064561, AY064562, AY064563, AY064564 Genomic DNA. Translation: AAL57731.1.
RefSeq	NP_001009020.1. NM_001009020.2.
UniGene	Ptr.6303.
3D structure databases
ProteinModelPortal	Q8MJA0.
SMR	Q8MJA0. Positions 504-585.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000036314; ENSPTRP00000033573; ENSPTRG00000019608.
GeneID	449627.
KEGG	ptr:449627.
Organism-specific databases
CTD	93986.
Phylogenomic databases
eggNOG	COG5025.
GeneTree	ENSGT00690000101938.
HOGENOM	HOG000092089.
HOVERGEN	HBG051657.
KO	K09409.
OMA	PETKLCV.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. False negative. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20832734.

Entry information

Entry name

FOXP2_PANTR

Accession

Primary (citable) accession number: Q8MJA0
Secondary accession number(s): Q8MHX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program