Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8MJA0

- FOXP2_PANTR

UniProt

Q8MJA0 - FOXP2_PANTR

Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri347 – 37226C2H2-typeAdd
    BLAST
    DNA bindingi505 – 59591Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein homodimerization activity Source: UniProtKB
    4. sequence-specific DNA binding Source: Ensembl
    5. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. camera-type eye development Source: Ensembl
    2. caudate nucleus development Source: UniProtKB
    3. cerebellum development Source: Ensembl
    4. cerebral cortex development Source: Ensembl
    5. embryo development Source: Ensembl
    6. growth Source: Ensembl
    7. lung alveolus development Source: Ensembl
    8. negative regulation of transcription, DNA-templated Source: Ensembl
    9. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    10. positive regulation of mesenchymal cell proliferation Source: Ensembl
    11. post-embryonic development Source: Ensembl
    12. putamen development Source: UniProtKB
    13. righting reflex Source: Ensembl
    14. skeletal muscle tissue development Source: Ensembl
    15. smooth muscle tissue development Source: Ensembl
    16. transcription, DNA-templated Source: UniProtKB-KW
    17. vocal learning Source: Ensembl

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein P2
    Gene namesi
    Name:FOXP2
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 7

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 716716Forkhead box protein P2PRO_0000091884Add
    BLAST

    Interactioni

    Subunit structurei

    Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MJA0.
    SMRiQ8MJA0. Positions 504-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni389 – 41022Leucine-zipperAdd
    BLAST
    Regioni423 – 4275CTBP1-bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi53 – 269217Gln-richAdd
    BLAST

    Domaini

    The leucine-zipper is required for dimerization and transcriptional repression.By similarity

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Curated
    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri347 – 37226C2H2-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117475.
    HOGENOMiHOG000092089.
    HOVERGENiHBG051657.
    KOiK09409.
    OMAiPETKLCV.
    OrthoDBiEOG7M6D7G.
    TreeFamiTF326978.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8MJA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL    50
    HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT 100
    PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL 150
    LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQHPGKQAKE 200
    QQQQQQQQQQ LAAQQLVFQQ QLLQMQQLQQ QQHLLSLQRQ GLISIPPGQA 250
    ALPVQSLPQA GLSPAEIQQL WKEVTGVHSM EDNGIKHGGL DLTTNNSSST 300
    TSSTTSKASP PITHHSIVNG QSSVLNARRD SSSHEETGAS HTLYGHGVCK 350
    WPGCESICED FGQFLKHLNN EHALDDRSTA QCRVQMQVVQ QLEIQLSKER 400
    ERLQAMMTHL HMRPSEPKPS PKPLNLVSSV TMSKNMLETS PQSLPQTPTT 450
    PTAPVTPITQ GPSVITPASV PNVGAIRRRH SDKYNIPMSS EIAPNYEFYK 500
    NADVRPPFTY ATLIRQAIME SSDRQLTLNE IYSWFTRTFA YFRRNAATWK 550
    NAVRHNLSLH KCFVRVENVK GAVWTVDEVE YQKRRSQKIT GSPTLVKNIP 600
    TSLGYGAALN ASLQAALAES SLPLLSNPGL INNASSGLLQ AVHEDLNGSL 650
    DHIDSNGNSS PGCSPQPHIH SIHVKEEPVI AEDEDCPMSL VTTANHSPEL 700
    EDDREIEEEP LSEDLE 716
    Length:716
    Mass (Da):80,061
    Last modified:October 1, 2002 - v1
    Checksum:i3169A2786B42F79F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF512947 mRNA. Translation: AAN03385.1.
    AF515051 Genomic DNA. Translation: AAN03409.1.
    AF515052 Genomic DNA. Translation: AAN03410.1.
    AY143178 mRNA. Translation: AAN60056.1.
    AY064549 mRNA. Translation: AAL57735.1.
    AY064565
    , AY064551, AY064552, AY064553, AY064554, AY064555, AY064556, AY064557, AY064558, AY064559, AY064560, AY064561, AY064562, AY064563, AY064564 Genomic DNA. Translation: AAL57731.1.
    RefSeqiNP_001009020.1. NM_001009020.2.
    UniGeneiPtr.6303.

    Genome annotation databases

    EnsembliENSPTRT00000036314; ENSPTRP00000033573; ENSPTRG00000019608.
    GeneIDi449627.
    KEGGiptr:449627.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF512947 mRNA. Translation: AAN03385.1 .
    AF515051 Genomic DNA. Translation: AAN03409.1 .
    AF515052 Genomic DNA. Translation: AAN03410.1 .
    AY143178 mRNA. Translation: AAN60056.1 .
    AY064549 mRNA. Translation: AAL57735.1 .
    AY064565
    , AY064551 , AY064552 , AY064553 , AY064554 , AY064555 , AY064556 , AY064557 , AY064558 , AY064559 , AY064560 , AY064561 , AY064562 , AY064563 , AY064564 Genomic DNA. Translation: AAL57731.1 .
    RefSeqi NP_001009020.1. NM_001009020.2.
    UniGenei Ptr.6303.

    3D structure databases

    ProteinModelPortali Q8MJA0.
    SMRi Q8MJA0. Positions 504-585.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000036314 ; ENSPTRP00000033573 ; ENSPTRG00000019608 .
    GeneIDi 449627.
    KEGGi ptr:449627.

    Organism-specific databases

    CTDi 93986.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117475.
    HOGENOMi HOG000092089.
    HOVERGENi HBG051657.
    KOi K09409.
    OMAi PETKLCV.
    OrthoDBi EOG7M6D7G.
    TreeFami TF326978.

    Miscellaneous databases

    NextBioi 20832734.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular evolution of FOXP2, a gene involved in speech and language."
      Enard W., Przeworski M., Fisher S.E., Lai C.S.L., Wiebe V., Kitano T., Monaco A.P., Paeaebo S.
      Nature 418:869-872(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Accelerated protein evolution and origins of human-specific features: Foxp2 as an example."
      Zhang J., Webb D.M., Podlaha O.
      Genetics 162:1825-1835(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The FOXP2 gene, implicated in language development, is conserved in mammalian evolution."
      Walter N.A.R., Thompson J., McGoldrick D.J., Messier W.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Blood.

    Entry informationi

    Entry nameiFOXP2_PANTR
    AccessioniPrimary (citable) accession number: Q8MJA0
    Secondary accession number(s): Q8MHX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3