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Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
Gene namesi
Name:MCHR1
Synonyms:GPR24
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 80›80ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini102 – 11413CytoplasmicSequence analysisAdd
BLAST
Transmembranei115 – 13521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini136 – 15318ExtracellularSequence analysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini175 – 19622CytoplasmicSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini218 – 23922ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini261 – 29232CytoplasmicSequence analysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini314 – 32916ExtracellularSequence analysisAdd
BLAST
Transmembranei330 – 35021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini351 – 38838CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2029193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 388›388Melanin-concentrating hormone receptor 1PRO_0000069735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000022864.

Chemistry

BindingDBiQ8MJ89.

Structurei

3D structure databases

ProteinModelPortaliQ8MJ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ8MJ89.
KOiK04320.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8MJ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ACAPGQGGRR WRLPQPAWVE GSSAWLWEPA TGTGWMDLEA SLLPTGPNTS
60 70 80 90 100
NTSDGPDNLT SAGSPPRSGS VSYINIIMPS VFGTICLLGI IGNSMVIFAV
110 120 130 140 150
VKKSKLHWCN NVPDIFIINL SVVDLLFLLG MPFMIHQLMG NGVWHFGETM
160 170 180 190 200
CTLITAMDAN SQFTSTYILT AMAIDRYLAT VHPISSTKFR KPSVATLVIC
210 220 230 240 250
LLWALSFISI TPVWLYARLI PFPGGAVGCG IRLPNPDTDL YWFTLYQFFL
260 270 280 290 300
AFALPFVVIT AAYVRILQRM TSSVAPASQR SIRLRTKRVT RTAIAICLVF
310 320 330 340 350
FVCWAPYYVL QLTQLSISRP TLTFVYLYNA AISLGYANSC LNPFVYIVLC
360 370 380
ETFRKRLVLS VKPAAQGQLR AVSNAQTADE ERTESKGT
Length:388
Mass (Da):42,777
Last modified:August 15, 2003 - v2
Checksum:i7F8528967DC431C1
GO

Sequence cautioni

The sequence AAM49793.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513988 mRNA. Translation: AAM49793.1. Different initiation.
AY078245 mRNA. Translation: AAL80003.1.
RefSeqiNP_001028057.1. NM_001032885.1.
UniGeneiMmu.3645.

Genome annotation databases

GeneIDi574232.
KEGGimcc:574232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513988 mRNA. Translation: AAM49793.1. Different initiation.
AY078245 mRNA. Translation: AAL80003.1.
RefSeqiNP_001028057.1. NM_001032885.1.
UniGeneiMmu.3645.

3D structure databases

ProteinModelPortaliQ8MJ89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000022864.

Chemistry

BindingDBiQ8MJ89.
ChEMBLiCHEMBL2029193.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574232.
KEGGimcc:574232.

Organism-specific databases

CTDi2847.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ8MJ89.
KOiK04320.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of rhesus monkey MCH-R1 and MCH-R2."
    Fried S., O'Neill K., Hawes B.E.
    Peptides 23:1401-1408(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-388.

Entry informationi

Entry nameiMCHR1_MACMU
AccessioniPrimary (citable) accession number: Q8MJ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.