Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
Gene namesi
Name:MCHR1
Synonyms:GPR24
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 80ExtracellularSequence analysisAdd BLAST›80
Transmembranei81 – 101Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini102 – 114CytoplasmicSequence analysisAdd BLAST13
Transmembranei115 – 135Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini136 – 153ExtracellularSequence analysisAdd BLAST18
Transmembranei154 – 174Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini175 – 196CytoplasmicSequence analysisAdd BLAST22
Transmembranei197 – 217Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini218 – 239ExtracellularSequence analysisAdd BLAST22
Transmembranei240 – 260Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini261 – 292CytoplasmicSequence analysisAdd BLAST32
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini314 – 329ExtracellularSequence analysisAdd BLAST16
Transmembranei330 – 350Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini351 – 388CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2029193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000069735‹1 – 388Melanin-concentrating hormone receptor 1Add BLAST›388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000022864.

Chemistry databases

BindingDBiQ8MJ89.

Structurei

3D structure databases

ProteinModelPortaliQ8MJ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ8MJ89.
KOiK04320.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8MJ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ACAPGQGGRR WRLPQPAWVE GSSAWLWEPA TGTGWMDLEA SLLPTGPNTS
60 70 80 90 100
NTSDGPDNLT SAGSPPRSGS VSYINIIMPS VFGTICLLGI IGNSMVIFAV
110 120 130 140 150
VKKSKLHWCN NVPDIFIINL SVVDLLFLLG MPFMIHQLMG NGVWHFGETM
160 170 180 190 200
CTLITAMDAN SQFTSTYILT AMAIDRYLAT VHPISSTKFR KPSVATLVIC
210 220 230 240 250
LLWALSFISI TPVWLYARLI PFPGGAVGCG IRLPNPDTDL YWFTLYQFFL
260 270 280 290 300
AFALPFVVIT AAYVRILQRM TSSVAPASQR SIRLRTKRVT RTAIAICLVF
310 320 330 340 350
FVCWAPYYVL QLTQLSISRP TLTFVYLYNA AISLGYANSC LNPFVYIVLC
360 370 380
ETFRKRLVLS VKPAAQGQLR AVSNAQTADE ERTESKGT
Length:388
Mass (Da):42,777
Last modified:August 15, 2003 - v2
Checksum:i7F8528967DC431C1
GO

Sequence cautioni

The sequence AAM49793 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513988 mRNA. Translation: AAM49793.1. Different initiation.
AY078245 mRNA. Translation: AAL80003.1.
RefSeqiNP_001028057.1. NM_001032885.1.
UniGeneiMmu.3645.

Genome annotation databases

GeneIDi574232.
KEGGimcc:574232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513988 mRNA. Translation: AAM49793.1. Different initiation.
AY078245 mRNA. Translation: AAL80003.1.
RefSeqiNP_001028057.1. NM_001032885.1.
UniGeneiMmu.3645.

3D structure databases

ProteinModelPortaliQ8MJ89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000022864.

Chemistry databases

BindingDBiQ8MJ89.
ChEMBLiCHEMBL2029193.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574232.
KEGGimcc:574232.

Organism-specific databases

CTDi2847.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ8MJ89.
KOiK04320.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCHR1_MACMU
AccessioniPrimary (citable) accession number: Q8MJ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.